Proteins > Serine/threonine-protein kinase mTOR
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Serine/threonine-protein kinase mTOR
A serine/threonine-protein kinase mTOR that is encoded in the genome of mouse. [OMA:Q9JLN9, PRO:DNx]
Synonyms
EC 2.7.11.1;
FK506-binding protein 12-rapamycin complex-associated protein 1;
FKBP12-rapamycin complex-associated protein;
Mammalian target of rapamycin;
mTOR;
Mechanistic target of rapamycin;
Rapamycin target protein 1;
RAPT1
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| sirolimus | Mus musculus (house mouse) | IC50 | 0.0000 | 1 | 1 |
| buparlisib | Mus musculus (house mouse) | IC50 | 0.8320 | 1 | 1 |
| torin 1 | Mus musculus (house mouse) | IC50 | 0.0020 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| torin 1 | Mus musculus (house mouse) | EC50 | 0.0020 | 1 | 1 |
| torin 2 | Mus musculus (house mouse) | EC50 | 0.0002 | 1 | 1 |
Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.Journal of medicinal chemistry, , Mar-10, Volume: 54, Issue:5, 2011
Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer.Journal of medicinal chemistry, , Oct-14, Volume: 53, Issue:19, 2010