tilorone has been researched along with Necrosis in 3 studies
Tilorone: An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.
tilorone : A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Necrosis of the spinal cord was produced by administering tilorone to rats before or during the incubation period of experimental allergic encephalomyelitis (EAE)." | 7.65 | Necrotic myelopathy (myelomalacia) in rats with allergic encephalomyelitis treated with tilorone. ( Levine, S; Sowinski, R, 1976) |
| "Necrosis of the spinal cord was produced by administering tilorone to rats before or during the incubation period of experimental allergic encephalomyelitis (EAE)." | 3.65 | Necrotic myelopathy (myelomalacia) in rats with allergic encephalomyelitis treated with tilorone. ( Levine, S; Sowinski, R, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Levine, S | 3 |
| Sowinski, R | 3 |
3 other studies available for tilorone and Necrosis
| Article | Year |
|---|---|
T-Lymphocyte depletion and lesions of choroid plexus and kidney induced by tertiary amines in rats.
Topics: Amines; Animals; Choroid Plexus; Female; Kidney; Male; Necrosis; Piperazines; Piperidines; Polycycli | 1977 |
Endotoxin toxicity in rats is enhanced by tilorone.
Topics: Adrenalectomy; Animals; Drug Synergism; Endotoxins; Escherichia coli; Fluorenes; Intestine, Small; K | 1976 |
Necrotic myelopathy (myelomalacia) in rats with allergic encephalomyelitis treated with tilorone.
Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Female; Fluorenes; Immunization, Passive; Immu | 1976 |