Page last updated: 2024-11-05

tilorone and Necrosis

tilorone has been researched along with Necrosis in 3 studies

Tilorone: An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.
tilorone : A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"Necrosis of the spinal cord was produced by administering tilorone to rats before or during the incubation period of experimental allergic encephalomyelitis (EAE)."7.65Necrotic myelopathy (myelomalacia) in rats with allergic encephalomyelitis treated with tilorone. ( Levine, S; Sowinski, R, 1976)
"Necrosis of the spinal cord was produced by administering tilorone to rats before or during the incubation period of experimental allergic encephalomyelitis (EAE)."3.65Necrotic myelopathy (myelomalacia) in rats with allergic encephalomyelitis treated with tilorone. ( Levine, S; Sowinski, R, 1976)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19903 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Levine, S3
Sowinski, R3

Other Studies

3 other studies available for tilorone and Necrosis

ArticleYear
T-Lymphocyte depletion and lesions of choroid plexus and kidney induced by tertiary amines in rats.
    Toxicology and applied pharmacology, 1977, Volume: 40, Issue:1

    Topics: Amines; Animals; Choroid Plexus; Female; Kidney; Male; Necrosis; Piperazines; Piperidines; Polycycli

1977
Endotoxin toxicity in rats is enhanced by tilorone.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1976, Volume: 151, Issue:2

    Topics: Adrenalectomy; Animals; Drug Synergism; Endotoxins; Escherichia coli; Fluorenes; Intestine, Small; K

1976
Necrotic myelopathy (myelomalacia) in rats with allergic encephalomyelitis treated with tilorone.
    The American journal of pathology, 1976, Volume: 82, Issue:2

    Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Female; Fluorenes; Immunization, Passive; Immu

1976