Insulin-like growth factor-binding protein 5

An insulin-like growth factor-binding protein 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P24593]

Synonyms

IBP-5;
IGF-binding protein 5;
IGFBP-5

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (3)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
nbi 31772	Homo sapiens (human)	Ki	0.0054	2	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
dimethyl sulfoxide	Homo sapiens (human)	Kd	696,000.0000	7	7
npc 15199	Homo sapiens (human)	Kd	1,088.0000	1	1

Enables

This protein enables 4 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
insulin-like growth factor I binding	molecular function	Binding to insulin-like growth factor I. [GOC:mah]
fibronectin binding	molecular function	Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. [GOC:hjd]
insulin-like growth factor II binding	molecular function	Binding to insulin-like growth factor II. [GOC:mah]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
endoplasmic reticulum lumen	cellular component	The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
insulin-like growth factor binding protein complex	cellular component	A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development. [GOC:jl]
insulin-like growth factor ternary complex	cellular component	A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development. [GOC:jl, PMID:12239079]

Involved In

This protein is involved in 29 target(s):

Target	Category	Definition
regulation of cell growth	biological process	Any process that modulates the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
osteoblast differentiation	biological process	The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. [CL:0000062, GO_REF:0000034, GOC:jid]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
female pregnancy	biological process	The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. [ISBN:0192800825]
negative regulation of smooth muscle cell migration	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration. [CL:0000192, GOC:mtg_muscle]
negative regulation of translation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. [GOC:isa_complete]
negative regulation of cell migration	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. [GOC:go_curators]
hair follicle morphogenesis	biological process	The process in which the anatomical structures of the hair follicle are generated and organized. [GOC:ln]
intracellular signal transduction	biological process	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
glucose homeostasis	biological process	Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. [GOC:go_curators]
positive regulation of insulin-like growth factor receptor signaling pathway	biological process	Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling. [GOC:bf]
negative regulation of insulin-like growth factor receptor signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling. [GOC:bf]
type B pancreatic cell proliferation	biological process	The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin. [GOC:jl, GOC:yaf]
negative regulation of osteoblast differentiation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation. [GOC:go_curators]
negative regulation of growth	biological process	Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. [GOC:go_curators]
insulin-like growth factor receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to an insulin-like growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]
lung alveolus development	biological process	The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. [GOC:mtg_lung, PMID:9751757]
negative regulation of smooth muscle cell proliferation	biological process	Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. [CL:0000192, GOC:ebc]
striated muscle cell differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. [CL:0000737, GOC:ai]
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]
mammary gland involution	biological process	The tissue remodeling that removes differentiated mammary epithelia during weaning. [GOC:dph, PMID:15282149]
response to growth hormone	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. [GOC:BHF, GOC:dph]
cellular response to cAMP	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. [GOC:mah]
cellular response to organic cyclic compound	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. [GOC:mah]
negative regulation of muscle tissue development	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development. [GOC:TermGenie, GOC:yaf, PMID:23150719]
negative regulation of skeletal muscle hypertrophy	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy. [GO_REF:0000058, GOC:TermGenie, PMID:23470307]
positive regulation of vascular associated smooth muscle cell proliferation	biological process	Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
positive regulation of vascular associated smooth muscle cell migration	biological process	Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]
regulation of insulin-like growth factor receptor signaling pathway	biological process	Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling. [GOC:bf]

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