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Protein kinase C theta type
A protein kinase C theta type that is encoded in the genome of rat. [OMA:Q9WTQ0, PRO:DNx]
Synonyms
EC 2.7.11.13;
nPKC-theta
Research
Bioassay Publications (15)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (53.33) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
Compounds (21)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| bisindolylmaleimide iv | Rattus norvegicus (Norway rat) | IC50 | 0.3250 | 2 | 2 |
| ro 31-8425 | Rattus norvegicus (Norway rat) | IC50 | 0.0076 | 1 | 1 |
| 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether | Rattus norvegicus (Norway rat) | IC50 | 98.0000 | 1 | 2 |
| 2-hydroxy-5-(2,5-dihydrobenzyl)aminobenzoic acid | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| olomoucine | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| trifluoperazine | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| staurosporine | Rattus norvegicus (Norway rat) | IC50 | 0.2740 | 11 | 11 |
| corilagin | Rattus norvegicus (Norway rat) | IC50 | 20.0000 | 1 | 2 |
| ruboxistaurin | Rattus norvegicus (Norway rat) | IC50 | 0.3200 | 1 | 1 |
| enzastaurin | Rattus norvegicus (Norway rat) | IC50 | 0.7000 | 1 | 1 |
| 1,4-dideoxy-1,4-iminoarabinitol, (2r-(2alpha,3beta,4beta))-isomer | Rattus norvegicus (Norway rat) | IC50 | 18.0000 | 1 | 1 |
| 1,4-dideoxy-1,4-imino-d-arabinitol | Rattus norvegicus (Norway rat) | IC50 | 290.0000 | 1 | 1 |
| tamoxifen | Rattus norvegicus (Norway rat) | IC50 | 75.0000 | 1 | 1 |
| sf 2370 | Rattus norvegicus (Norway rat) | IC50 | 0.1250 | 2 | 2 |
| 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| sphingosine | Rattus norvegicus (Norway rat) | IC50 | 34.3333 | 2 | 3 |
| acteoside | Rattus norvegicus (Norway rat) | IC50 | 15.3560 | 3 | 3 |
| acteoside | Rattus norvegicus (Norway rat) | Ki | 25.0000 | 2 | 2 |
| alvocidib | Rattus norvegicus (Norway rat) | IC50 | 14.0000 | 1 | 1 |
| kn 93 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| ly 338522 | Rattus norvegicus (Norway rat) | IC50 | 0.1600 | 1 | 1 |
| butyrolactone i | Rattus norvegicus (Norway rat) | IC50 | 160.0000 | 1 | 1 |
Variegatic acid from the edible mushroom Tylopilus ballouii inhibits TNF-α production and PKCβ1 activity in leukemia cells.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 30, Issue:4, 2020
Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta.Bioorganic & medicinal chemistry letters, , Jun-02, Volume: 13, Issue:11, 2003
Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives.Bioorganic & medicinal chemistry letters, , Aug-02, Volume: 9, Issue:15, 1999
Fused pyrrolo[2,3-c]carbazol-6-ones: novel immunostimulants that enhance human interferon-gamma activity.Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997
(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.Journal of medicinal chemistry, , Jul-05, Volume: 39, Issue:14, 1996
Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction.Journal of medicinal chemistry, , Jan-08, Volume: 36, Issue:1, 1993
Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides.Journal of medicinal chemistry, , Volume: 35, Issue:1, 1992
(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.Journal of medicinal chemistry, , Jul-05, Volume: 39, Issue:14, 1996
Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives.Journal of medicinal chemistry, , Jun-06, Volume: 40, Issue:12, 1997
Fused pyrrolo[2,3-c]carbazol-6-ones: novel immunostimulants that enhance human interferon-gamma activity.Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997
(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.Journal of medicinal chemistry, , Jul-05, Volume: 39, Issue:14, 1996