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Prostaglandin G/H synthase 1
A prostaglandin G/H synthase 1 that is encoded in the genome of mouse. [OMA:P22437, PRO:DNx]
Synonyms
EC 1.14.99.1;
Cyclooxygenase-1;
COX-1;
Prostaglandin H2 synthase 1;
PGH synthase 1;
PGHS-1;
PHS 1;
Prostaglandin-endoperoxide synthase 1
Research
Bioassay Publications (14)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
Compounds (9)
Drugs with Inhibition Measurements
Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyethyl sulfides and related compounds as Cyclooxygenase-2 inhibitors containing a nitric oxide donor moiety endowed with vasorelaxant properties.European journal of medicinal chemistry, , Nov-05, Volume: 241, 2022
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity.Bioorganic & medicinal chemistry, , Jul-01, Volume: 21, Issue:13, 2013
Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties.Journal of medicinal chemistry, , Nov-24, Volume: 54, Issue:22, 2011
Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.Bioorganic & medicinal chemistry, , Sep-01, Volume: 16, Issue:17, 2008
Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity.Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors.Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives: a new series of potent and selective COX-2 inhibitors in which a sulfonyl group is not a structural requisite.Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors.Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
Dibenzoxepinone hydroxylamines and hydroxamic acids: dual inhibitors of cyclooxygenase and 5-lipoxygenase with potent topical antiinflammatory activity.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.Bioorganic & medicinal chemistry, , Jan-15, Volume: 18, Issue:2, 2010
Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities.Bioorganic & medicinal chemistry letters, , May-17, Volume: 14, Issue:10, 2004
Synthetic approaches to the 2012 new drugs.Bioorganic & medicinal chemistry, , Apr-01, Volume: 22, Issue:7, 2014
Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 19, Issue:8, 2009