Page last updated: 2024-12-06

thulium

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Occurs in Manufacturing Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Thulium (Tm) is a rare earth element with atomic number 69. It is a silvery-white, malleable, and ductile metal. Thulium is found in small amounts in various minerals, including monazite and bastnasite. It is primarily obtained as a byproduct of the extraction of other rare earth elements. Thulium is not found in its elemental form in nature. It is synthesized through the reduction of its oxide or fluoride with calcium or lanthanum. Thulium has limited practical applications due to its high cost and scarcity. It is used in lasers, high-intensity light sources, and in some specialized alloys. Thulium is also studied for its potential applications in nuclear energy and medical imaging. Thulium-170 is a radioactive isotope used in portable X-ray sources for medical imaging. Thulium is a key element for research in areas like nuclear physics, laser technology, and materials science. Thulium exhibits paramagnetism, a magnetic property that allows it to be attracted to a magnet. It is also known for its high melting point and good electrical conductivity. The study of thulium is important for understanding the properties of rare earth elements, their potential applications, and their role in various fields. '

Thulium: An element of the rare earth family of metals. It has the atomic symbol Tm, atomic number 69, and atomic weight 168.93. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID23961
CHEBI ID33380
MeSH IDM0021442

Synonyms (43)

Synonym
tulio
7440-30-4
thulium
69tm
tm
thulium atom
CHEBI:33380
thulium, powder, ~40 mesh, 99.9% trace metals basis
thulium, chips, 99.9% trace metals basis
thulium, ingot, 99.9%
thulium trihydride
einecs 231-140-2
8rkc5ati4p ,
unii-8rkc5ati4p
thulium, elemental
thulium [mi]
DTXSID8064692
AKOS024257646
thulium foil, 0.1mm (0.004in) thick
thulium pieces, sublimed dendritic
thulium foil, 0.25mm (0.01in) thick
thulium pieces
thulium foil
mfcd00011281
thulium powder
thulium, wire, 0.1m, diameter 0.6mm, 99%
thulium, rod, 27mm, diameter 6mm, cast, 99%
thulium, foil, not light tested, 25x25mm, thickness 0.005mm, as rolled, 99%
thulium, foil, 25x25mm, thickness 0.1mm, as rolled, 99%
thulium, foil, not light tested, 25x25mm, thickness 0.025mm, as rolled, 99%
thulium, foil, not light tested, 25x25mm, thickness 0.002mm, as rolled, 99%
thulium, foil, not light tested, 50x50mm, thickness 0.025mm, as rolled, 99%
thulium, foil, not light tested, 12.5x12.5mm, thickness 0.005mm, as rolled, 99%
thulium, foil, not light tested, 12.5x12.5mm, thickness 0.002mm, as rolled, 99%
thulium, foil, 25x25mm, thickness 0.15mm, as rolled, 99%
thulium, foil, 50x50mm, thickness 0.15mm, as rolled, 99%
thulium, foil, 50x50mm, thickness 0.1mm, as rolled, 99%
thulium nanofoil
Q1853
ultra thin thulium nanofoil
thulium standard: tm @ 1000 microg/ml in 5% hno3
thulium standard: tm @ 10000 microg/ml in 5% hno3
thulium - tm @ 1000 microg/ml in 5% hno3

Research Excerpts

Overview

Thulium fiber laser is a promising new lithoptripsy technology never before studied in the pediatric population. Thulium laser seems to be a suitable tool for the endoscopic treatment of BPH.

ExcerptReferenceRelevance
"The thulium fiber laser is a promising new lithoptripsy technology never before studied in the pediatric population. "( Comparing Pediatric Ureteroscopy Outcomes with SuperPulsed Thulium Fiber Laser and Low-Power Holmium:YAG Laser.
Cilento, BG; Jaeger, CD; Kurtz, MP; Logvinenko, T; Nelson, CP, 2022
)
1.52
"Thulium laser is a new source of energy with growing expectations and promising in-vitro results."( Recent advances in percutaneous lithotripsy techniques.
Arcaniolo, D; Creta, M; De Sio, M; Fusco, F; Manfredi, C; Mirone, V, 2021
)
1.34
"The thulium laser seems to be a suitable tool for the endoscopic treatment of BPH."( Endoscopic vaporesection of the prostate using the continuous-wave 2-microm thulium laser: outcome and demonstration of the surgical technique.
Götschl, R; Paras, L; Razmaria, A; Schmeller, NT; Szlauer, R, 2009
)
1.14
"The thulium laser proved to be a useful tool during coagulation, shrinking, and resection of the basal implant of the tumor. "( Use of 2-μm continuous-wave thulium laser for surgical removal of a tentorial meningioma: case report.
Anichini, G; Delfinis, CP; Lenzi, J; Passacantilli, E; Santoro, A, 2011
)
1.22
"The thulium laser appears to be an interesting tool in the management of laryngotracheal diseases such as subglottic stenosis, tracheal granuloma and laryngomalacia. "( Thulium laser in airway diseases in children.
Ayari-Khalfallah, S; Froehlich, P; Fuchsmann, C, 2008
)
2.35
"The thulium-YAG laser is a useful tool for assessment of impaired pain sensitivity. "( Clinical evaluation criteria for the assessment of impaired pain sensitivity by thulium-laser evoked potentials.
Hansen, C; Spiegel, J; Treede, RD, 2000
)
1.09

Effects

Thulium fiber laser has recently been tested as a potential alternative to the Holmium:YAG laser for lithotripsy. The thulium laser has been described in treating urinary tract abnormalities and recently airways diseases in adults. There are no reports of other uses for this technique in the pediatric airway.

ExcerptReferenceRelevance
"The Thulium fiber laser has recently been tested as a potential alternative to the Holmium:YAG laser for lithotripsy. "( Thulium fiber laser lithotripsy using tapered fibers.
Blackmon, RL; Fried, NM; Irby, PB, 2010
)
2.36
"The thulium laser has been described in treating urinary tract abnormalities and recently airways diseases in adults, but there are no reports of other uses for this technique in the pediatric airway."( Thulium laser in airway diseases in children.
Ayari-Khalfallah, S; Froehlich, P; Fuchsmann, C, 2008
)
2.27

Toxicity

Thulium vapoenucleation and holmium laser enucleation of the prostate are safe and effective procedures for the treatment of large volume benign prostatic hyperplasia. This retrospective chart review of single-session, same-day facial treatments using a low-energy, low-density 1927 nm fractional thulium fiber laser and cosmetic injectables found no adverse events related to this combination approach.

ExcerptReferenceRelevance
" In order to evaluate possible toxic effects of scandium, chromium, lanthanum, samarium, europium, dysprosium, terbium, thulium, and ytterbium oxides, and barium sulfate upon growth, general development, reproduction, and lactation, mice were fed different levels of these compounds for three generations."( Studies of nutritional safety of some heavy metals in mice.
Gray, DH; Hutcheson, DP; Luckey, TD; Venugopal, B, 1975
)
0.46
"VapoEnucleation is a safe and effective minimal invasive treatment modality for BPO."( Thulium:YAG laser enucleation (VapoEnucleation) of the prostate: safety and durability during intermediate-term follow-up.
Bach, T; Gross, AJ; Haecker, A; Herrmann, TR; Michel, MS; Netsch, C, 2010
)
1.8
"The 2-microm continuous-wave laser system showed promising capabilities for highly precise and safe dissection during NOTES procedures."( A 2-microm continuous-wave laser system for safe and high-precision dissection during NOTES procedures.
Assumpcao, L; Buscaglia, JM; Donatelli, G; Dray, X; Dubcenco, E; Giday, SA; Kalloo, AN; Kantsevoy, SV; Krishnamurty, DM; Magno, P; Marohn, MR; Pipitone, LJ; Shin, EJ; Wroblewski, RJ, 2010
)
0.36
"ThuVEP is a safe procedure in patients with therapeutic anticoagulation, bleeding disorders and platelet aggregation inhibitor medication."( Thulium laser (Revolix) vapoenucleation of the prostate is a safe procedure in patients with an increased risk of hemorrhage.
Ellinger, J; Fechner, G; Hauser, S; Müller, SC; Rogenhofer, S; Strunk, T, 2012
)
1.82
"Thulium VapoEnucleation of the prostate seems to be a safe and efficacious procedure for the treatment of symptomatic BPO in patients at high cardiopulmonary risk on OA."( Safety and effectiveness of Thulium VapoEnucleation of the prostate (ThuVEP) in patients on anticoagulant therapy.
Bach, T; Brüning, M; Gabuev, A; Gross, AJ; Herrmann, TR; Netsch, C; Stoehrer, M, 2014
)
2.14
" TmLRP-TT is a safe and effective surgical endoscopic technique associated with a low complication rate in large prostates as assessed during an 18-month follow-up period."( Safety and efficiency of thulium laser prostate resection for the treatment of benign prostatic hyperplasia in large prostates.
Cui, D; Liang, SJ; Pang, K; Shao, Y; Sun, XW; Wei, HB; Xia, SJ; Yu, JJ; Zhao, FJ; Zhuo, J, 2014
)
0.71
"Thulium laser vaporization of the prostate appears to be a safe and effective outpatient technique for the treatment of BPH with durable outcomes at 3 months."( High-power thulium laser vaporization of the prostate: short-term outcomes of safety and effectiveness.
Chung, DE; Famakinwa, OJ; Pariser, JJ; Pearce, SM, 2014
)
2.23
"The disconnection procedure is a safe and effective treatment strategy to treat drug-resistant epilepsy in patients with HHs."( Endoscopic disconnection of hypothalamic hamartomas: safety and feasibility of robot-assisted, thulium laser-based procedures.
Bulteau, C; Calisto, A; Conti, A; Delalande, O; Dorfmüller, G; Fohlen, M, 2014
)
0.62
"120-W ThuVEP and HoLEP are potent, safe and efficient modalities of minimally invasive surgeries for patients with LUTS due to BPH."( Efficacy and safety of 120-W thulium:yttrium-aluminum-garnet vapoenucleation of prostates compared with holmium laser enucleation of prostates for benign prostatic hyperplasia.
Hong, K; Huang, Y; Liu, YQ; Lu, J; Ma, LL; Xiao, CL, 2015
)
0.71
"TmLRP is a safe and effective procedure for treatment of benign prostatic hyperplasia."( Safety and Efficacy of Thulium Laser Prostatectomy Versus Transurethral Resection of Prostate for Treatment of Benign Prostate Hyperplasia: A Meta-Analysis.
Jiang, H; Zhou, Y, 2016
)
0.74
"ThuVEP and HoLEP are safe and effective procedures for the treatment of symptomatic BPO."( A prospective, randomized trial comparing thulium vapoenucleation with holmium laser enucleation of the prostate for the treatment of symptomatic benign prostatic obstruction: perioperative safety and efficacy.
Becci, AV; Becker, B; Gross, AJ; Herrmann, TRW; Moritz, C; Netsch, C; Tiburtius, C, 2017
)
0.72
"In this study, high power TL-PVP is a safe and effective alternative with subjective and objective functional results that are comparable to the "gold standard" technique."( [Mid-term safety and efficacy of high power thulium laser vaporization.]
Benedicto, A; Durán-Rivera, A; Miralles, J; Morán, E; Palmero, JL; Panach-Navarrete, J, 2017
)
0.72
"Thulium vapoenucleation and holmium laser enucleation of the prostate are safe and effective procedures for the treatment of large volume benign prostatic hyperplasia."( Thulium vapoenucleation of the prostate versus holmium laser enucleation of the prostate for the treatment of large volume prostates: preliminary 6-month safety and efficacy results of a prospective randomized trial.
Becker, B; Gross, AJ; Herrmann, TRW; Netsch, C, 2018
)
3.37
"High-power ThuLEP is safe and effective for patients with large prostate glands (> 80 mL)."( Safety and effectiveness of high-power thulium laser enucleation of the prostate in patients with glands larger than 80 mL.
Chang, CH; Huang, JY; Lin, TP, 2019
)
0.78
" This retrospective chart review of single-session, same-day facial treatments using a low-energy, low-density 1927 nm fractional thulium fiber laser and cosmetic injectables found no adverse events related to this combination approach."( Combining cosmetic injectables with low-energy, low-density 1927 nm fractional thulium fiber laser: A 2.5-year examination on the safety of same-day treatments.
Akintilo, L; Geronemus, RG; Wang, JV, 2021
)
1.05
"To evaluate if thulium laser vapoenucleation of the prostate (ThuVEP) is equally safe and effective in a selected cohort of elderly patients when compared to "younger" patients."( Is thulium laser vapoenucleation of the prostate equally safe and effective in elderly patients? A propensity score matched analysis of early perioperative and functional outcomes.
Bertolo, R; Bove, P; Cipriani, C; Ferro, M; Iacovelli, V; Maiorino, F; Panei, M; Petta, F; Toschi, N; Travaglia, S; Vittori, M, 2021
)
1.6
"In our hands, even in elderly patients affected by BPH, ThuVEP appears to be a safe and effective treatment option."( Is thulium laser vapoenucleation of the prostate equally safe and effective in elderly patients? A propensity score matched analysis of early perioperative and functional outcomes.
Bertolo, R; Bove, P; Cipriani, C; Ferro, M; Iacovelli, V; Maiorino, F; Panei, M; Petta, F; Toschi, N; Travaglia, S; Vittori, M, 2021
)
1.24
" Adverse effects include transient pain, erythema, edema, and increase of acne."( Efficacy and safety comparison between 1927 nm thulium laser and 2940 nm Er:YAG laser in the treatment of facial atrophic acne scarring: a prospective, simultaneous spilt-face clinical trial.
Cai, S; Lu, K, 2022
)
0.98
" NAFL is effective and safe for improving periorbital wrinkles, but IR-RF might be more suitable for elderly patients, particularly those with low pain tolerance."( Effectiveness and safety of nonablative fractional laser and infrared bipolar radiofrequency for treating periorbital wrinkles.
Cen, Q; Lin, X; Shang, Y; Wu, X; Zhu, J, 2022
)
0.72
" However, the safe clinical application of this technology requires an understanding of core principles as well as awareness of the safety and technical aspects that can help in protecting patient, surgeon and operating staff."( Holmium and Thulium Fiber Laser Safety in Endourological Practice: What Does the Clinician Need to Know?
Beisland, C; Gjengstø, P; Juliebø-Jones, P; Somani, BK; Ulvik, Ø; Æsøy, MS, 2023
)
1.29
"TmL-ERBT is safe and feasible for complete resection of NMIBC with a short learning curve and adequate cancer control."( Safety, feasibility, and quality of thulium laser en-bloc resection for treatment of non-muscle invasive bladder cancer.
Abdelwahed, M; Assem, A; Kassem, A; Lotfi, A; Sherif, M, 2023
)
1.19
" (HoLEP) and (RASP) are both effective and safe procedures for treating large-volume benign prostatic hyperplasia."( Efficacy and safety of transurethral thulium laser enucleation versus robot-assisted prostatectomy for large-volume benign prostatic hyperplasia: a systematic review and meta-analysis.
Chen, CX; Chen, LL; Deng, XZ; Liu, Y; Wang, CJ; Wang, L; Wen, Z; Yang, XS, 2023
)
1.18

Compound-Compound Interactions

Ureteroscopy operations combined with holmium or thulium laser resection are effective methods for treating UFP. PKRP combined with thuliam laser is superior than PKRP only for better surgical duration, lessbleeding, higher efficiency and much quicker recovery.

ExcerptReferenceRelevance
" We compared the effect of UFP by ureteroscopy combined with holmium laser or thulium laser."( Treatment of Ureteral Fibroepithelial Polyp by Ureteroscopy Combined with Holmium Laser or Thulium Laser: A Retrospective Study.
Qian, WQ; Sheng, L; Sun, ZQ; Zhang, HJ; Zhang, ZY, 2016
)
0.88
"Ureteroscopy operations, combined with holmium or thulium laser resection, are effective methods for treating UFP, but thulium laser does better in reducing the incidence of ureterostenosis."( Treatment of Ureteral Fibroepithelial Polyp by Ureteroscopy Combined with Holmium Laser or Thulium Laser: A Retrospective Study.
Qian, WQ; Sheng, L; Sun, ZQ; Zhang, HJ; Zhang, ZY, 2016
)
0.91
"To evaluate the clinical curative effect and safety of transurethral (bipolar) plasmakinetic resection of theprostate (PKRP) combined with thulium laser in the treatment of large prostates (> 80mL)."( The Effectiveness and Safety of Transurethral (Bipolar) Plasmakinetic Resection of Prostate Combined with Thulium Laser for Large Benign Prostatic Hyperplasia (>80ml).
Lai, P; Luo, M; Xie, T; Xu, Y, 2016
)
0.85
"From January 2014 to December 2015, 61 patients with benign prostate hyperplasia(BPH) were treated with PKRP combined with thulium laser (n = 25) or PKRP only (n = 36)."( The Effectiveness and Safety of Transurethral (Bipolar) Plasmakinetic Resection of Prostate Combined with Thulium Laser for Large Benign Prostatic Hyperplasia (>80ml).
Lai, P; Luo, M; Xie, T; Xu, Y, 2016
)
0.85
"PKRP combined with thulium laser is superior than PKRP only for better surgical duration, lessbleeding, higher efficiency and much quicker recovery."( The Effectiveness and Safety of Transurethral (Bipolar) Plasmakinetic Resection of Prostate Combined with Thulium Laser for Large Benign Prostatic Hyperplasia (>80ml).
Lai, P; Luo, M; Xie, T; Xu, Y, 2016
)
0.98

Dosage Studied

ExcerptRelevanceReference
" Both 90Sr and 170Tm sources show area effects for dose-response curves."( Nonstochastic effects of different energy beta emitters on the mouse skin.
Charles, MW; Coggle, JE; Hansen, LS; Wells, J, 1984
)
0.27
" Furthermore, the shape and size of the products can be further manipulated by adjusting the dosage of Cit(3-) and pH values in the initial solution."( Highly uniform and monodisperse GdOF:Ln3+ (Ln = Eu, Tb, Tm, Dy, Ho, Sm) microspheres: hydrothermal synthesis and tunable-luminescence properties.
Cheng, Z; Geng, D; Kang, X; Li, X; Lian, H; Lin, J; Shang, M; Wu, Y; Zhang, Y, 2013
)
0.39
" The remaining ten pigs underwent uniportal thoracoscopy; talc poudrage was performed using the current clinical practice dosage (1 g/18 kg) with accurate talc powder spread over the whole pleural surface."( Pleurodesis with Thulium Cyber Laser versus talc poudrage: a comparative experimental study.
Bellezza, G; Bottoli, MC; Bufalari, A; Daddi, N; De Angelis, V; De Monte, V; Droghetti, A; Giovanardi, M; Marulli, G; Moriconi, F; Puma, F; Vannucci, J, 2016
)
0.77
" Despite the positive response to our case, clinical studies are lacking and further analysis could be performed on a wider population to better define correct dosage and safety profile."( Penile Lichen Sclerosus Treated with 1927 nm Thulium Fiber Laser and Photodynamic Therapy: A New Possible Therapeutic Approach.
Bartolucci, M; Brianti, P; Dattola, A; Foti, A; Mercuri, SR; Nisticò, SP, 2018
)
0.74
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Occurs in Manufacturing (1 Product(s))

Product Categories

Product CategoryProducts
Vitamins & Supplements1

Products

ProductBrandCategoryCompounds Matched from IngredientsDate Retrieved
Heaven Sent Wellgenix Balanced Essentials + Plus Liquid Vitamins Berry -- 32 fl ozHeaven SentVitamins & Supplementscitric acid, Antimony, Arginine, Vitamin C, Aspartic Acid, Kelp, Barium, Beryllium, Biotin, Bismuth, Boron, Bromide, Omega 3, Cerium, Cesium, Chromium, citric acid, Cobalt, Cystine, Vitamin E, fructose, Dysprosium, Erbium, Europium, Fluoride, Folate, Gadolinium, Gallium, Vitamin E, Glycine, Gold, Hafnium, Histidine, Holmium, Inositol, Iodine, Iodine, Isoleucine, Lanthanum, Leucine, Calcium Carbonate, Lithium, Lutetium, Lysine, Manganese, Methionine, Molybdenum, Neodymium, Niacin, Nickel, Niobium, Pantothenic Acid, Phenylalanine, Phosphorus, Praseodymium, Proline, Vitamin B6, Vitamin A, Rhenium, Riboflavin, Rubidium, Samarium, Scandium, Selenium, Serine, Silicon, Silver, Strontium, Tantalum, Tellurium, Terbium, Thallium, Thiamin, Thorium, Threonine, Thulium, Tin, Titanium, Tryptophan, Tungsten, Tyrosine, Valine, Vanadium, Vitamin B12, Vitamin B6, Vitamin K, Ytterbium, Yttrium, Zirconium2024-11-29 10:47:42

Drug Classes (2)

ClassDescription
lanthanoid atom
f-block element atom
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (849)

TimeframeStudies, This Drug (%)All Drugs %
pre-199090 (10.60)18.7374
1990's22 (2.59)18.2507
2000's96 (11.31)29.6817
2010's381 (44.88)24.3611
2020's260 (30.62)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 75.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index75.31 (24.57)
Research Supply Index6.86 (2.92)
Research Growth Index5.32 (4.65)
Search Engine Demand Index132.00 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (75.31)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials74 (8.45%)5.53%
Reviews62 (7.08%)6.00%
Case Studies32 (3.65%)4.05%
Observational7 (0.80%)0.25%
Other701 (80.02%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]