An aldo-keto reductase family 1 member C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q04828]
EC 1.1.1.-;
EC 1.1.1.112;
EC 1.1.1.209;
EC 1.1.1.210;
EC 1.1.1.357;
EC 1.1.1.51;
EC 1.1.1.53;
EC 1.1.1.62;
EC 1.3.1.20;
20-alpha-hydroxysteroid dehydrogenase;
20-alpha-HSD;
1.1.1.149;
Chlordecone reductase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 8 (72.73) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| benzbromarone | Homo sapiens (human) | IC50 | 0.0480 | 1 | 1 |
| flufenamic acid | Homo sapiens (human) | IC50 | 2.6400 | 2 | 2 |
| flurbiprofen | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| gliclazide | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| glimepiride | Homo sapiens (human) | IC50 | 6.8600 | 1 | 1 |
| indomethacin | Homo sapiens (human) | IC50 | 108.6667 | 3 | 3 |
| meclofenamic acid | Homo sapiens (human) | IC50 | 2.3533 | 3 | 3 |
| mefenamic acid | Homo sapiens (human) | IC50 | 3.9100 | 1 | 1 |
| mefenamic acid | Homo sapiens (human) | Ki | 0.8100 | 1 | 1 |
| medroxyprogesterone acetate | Homo sapiens (human) | IC50 | 1.8000 | 1 | 1 |
| 3,5-dichlorosalicylic acid | Homo sapiens (human) | IC50 | 0.0060 | 1 | 1 |
| 3,5-dichlorosalicylic acid | Homo sapiens (human) | Ki | 7.0775 | 11 | 18 |
| 3,5-dibromosalicylic acid | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| 3,5-dibromosalicylic acid | Homo sapiens (human) | Ki | 0.0090 | 1 | 1 |
| dexibuprofen | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| octyl gallate | Homo sapiens (human) | IC50 | 5.4800 | 1 | 1 |
| naproxen | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| alpha-phenylcinnamate | Homo sapiens (human) | IC50 | 7.9000 | 1 | 1 |
| jasmonic acid | Homo sapiens (human) | Ki | 106.0000 | 1 | 1 |
| caffeic acid phenethyl ester | Homo sapiens (human) | IC50 | 21.1200 | 2 | 2 |
This protein enables 21 target(s):
| Target | Category | Definition |
|---|---|---|
| aldose reductase (NADPH) activity | molecular function | Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. [EC:1.1.1.21] |
| aldo-keto reductase (NADPH) activity | molecular function | Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. [GOC:ai] |
| estradiol 17-beta-dehydrogenase [NAD(P)] activity | molecular function | Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor. [EC:1.1.1.62] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | molecular function | Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. [GOC:ai] |
| phenanthrene 9,10-monooxygenase activity | molecular function | Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide. [UM-BBD_reactionID:r0495] |
| testosterone dehydrogenase [NAD(P)] activity | molecular function | Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+. [EC:1.1.1.51] |
| carboxylic acid binding | molecular function | Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-). [GOC:mah, ISBN:0198506732] |
| bile acid binding | molecular function | Binding to a bile acid, a steroid carboxylic acids occurring in bile. [GOC:rph] |
| 3beta-hydroxy-5beta-steroid dehydrogenase activity | molecular function | Catalysis of the reaction: 3beta-hydroxy-5beta-pregnane-20-one + NADP+ = 5beta-pregnan-3,20-dione + H+ + NADPH. [EC:1.1.1.277, RHEA:22944] |
| steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | molecular function | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative. [GOC:mah] |
| dihydrotestosterone 17-beta-dehydrogenase activity | molecular function | Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH. [GOC:ecd, http://www.brenda-enzymes.org/php/result_flat.php4?ecno=1.1.1.63, PMID:4152755] |
| 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity | molecular function | Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone. [EC:1.1.1.149, MetaCyc:1.1.1.149-RXN] |
| 5alpha-androstane-3beta,17beta-diol dehydrogenase activity | molecular function | Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP+ = 17beta-hydroxy-5alpha-androstan-3-one + H+ + NADPH. [EC:1.1.1.210, RHEA:16297] |
| androsterone dehydrogenase (B-specific) activity | molecular function | Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+. [EC:1.1.1.50, MetaCyc:1.1.1.50-RXN] |
| androstan-3-alpha,17-beta-diol dehydrogenase activity | molecular function | Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+. [EC:1.1.1.53, MetaCyc:1.1.1.53-RXN] |
| testosterone 17-beta-dehydrogenase (NADP+) activity | molecular function | Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione. [EC:1.1.1.64, MetaCyc:1.1.1.64-RXN] |
| ketosteroid monooxygenase activity | molecular function | Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate. [EC:1.14.13.54, MetaCyc:1.14.13.54-RXN] |
| trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity | molecular function | Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol. [EC:1.3.1.20, MetaCyc:1.3.1.20-RXN] |
| indanol dehydrogenase activity | molecular function | Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+. [EC:1.1.1.112, MetaCyc:INDANOL-DEHYDROGENASE-RXN] |
| androsterone dehydrogenase activity | molecular function | Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. [EC:1.1.1.209, MetaCyc:1.1.1.209-RXN] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is involved in 16 target(s):
| Target | Category | Definition |
|---|---|---|
| retinoid metabolic process | biological process | The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. [ISBN:0198506732] |
| xenobiotic metabolic process | biological process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc] |
| digestion | biological process | The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:isa_complete, ISBN:0198506732] |
| bile acid metabolic process | biological process | The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. [GOC:go_curators] |
| bile acid and bile salt transport | biological process | The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511] |
| intestinal cholesterol absorption | biological process | Uptake of cholesterol into the blood by absorption from the small intestine. [GOC:mah] |
| epithelial cell differentiation | biological process | The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. [GOC:ecd, PMID:11839751] |
| progesterone metabolic process | biological process | The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. [GOC:jl, http://www.cogsci.princeton.edu/] |
| retinal metabolic process | biological process | The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A. [ISBN:0198506732] |
| cholesterol homeostasis | biological process | Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators] |
| daunorubicin metabolic process | biological process | The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer. [PMID:20837989] |
| doxorubicin metabolic process | biological process | The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy. [PMID:10200167] |
| response to organophosphorus | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors. [ISBN:0721662544] |
| cellular response to jasmonic acid stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus. [GOC:mah] |
| positive regulation of reactive oxygen species metabolic process | biological process | Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah] |
| prostaglandin metabolic process | biological process | The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. [ISBN:0198506732] |