Proteins > Metabotropic glutamate receptor 4
Page last updated: 2024-08-07 16:28:36
Metabotropic glutamate receptor 4
A metabotropic glutamate receptor 4 that is encoded in the genome of rat. [OMA:P31423, PRO:DNx]
Synonyms
mGluR4
Research
Bioassay Publications (20)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 12 (60.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (26)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| d-glutamate | Rattus norvegicus (Norway rat) | EC50 | 56.0000 | 2 | 2 |
| glutamic acid | Rattus norvegicus (Norway rat) | EC50 | 6.3776 | 8 | 10 |
| quisqualic acid | Rattus norvegicus (Norway rat) | EC50 | 109.6667 | 2 | 3 |
| plasmenylserine | Rattus norvegicus (Norway rat) | EC50 | 52.0000 | 2 | 2 |
| L-2-aminoadipic acid | Rattus norvegicus (Norway rat) | EC50 | 3,000.0000 | 2 | 2 |
| 1-amino-1,3-dicarboxycyclopentane | Rattus norvegicus (Norway rat) | EC50 | 259.7500 | 3 | 4 |
| 1-amino-3-(phosphonomethylene)cyclobutane-1-carboxylic acid | Rattus norvegicus (Norway rat) | EC50 | 4.5000 | 1 | 1 |
| homocysteic acid | Rattus norvegicus (Norway rat) | EC50 | 100.0000 | 1 | 1 |
| 2-amino-4-phosphonobutyric acid | Rattus norvegicus (Norway rat) | EC50 | 14.6229 | 15 | 16 |
| eglumetad | Rattus norvegicus (Norway rat) | EC50 | 100.0000 | 1 | 1 |
| 3,5-dihydroxyphenylglycine | Rattus norvegicus (Norway rat) | EC50 | 100.0000 | 1 | 1 |
| n-(3-chlorophenyl)picolinamide | Rattus norvegicus (Norway rat) | EC50 | 0.3100 | 2 | 2 |
| l-2-(carboxypropyl)glycine | Rattus norvegicus (Norway rat) | EC50 | 4.0000 | 1 | 1 |
| 2-(2,3-dicarboxycyclopropyl)glycine | Rattus norvegicus (Norway rat) | EC50 | 511.5000 | 2 | 2 |
| 2r,4r-4-aminopyrrolidine-2,4-dicarboxylate | Rattus norvegicus (Norway rat) | EC50 | 100.0000 | 1 | 1 |
| upf 596 | Rattus norvegicus (Norway rat) | EC50 | 550.0000 | 2 | 2 |
| 4-carboxy-3-hydroxyphenylglycine | Rattus norvegicus (Norway rat) | EC50 | 100.0000 | 1 | 1 |
| 1-amino-1,3-dicarboxycyclopentane, cis-(1s,3s)-isomer | Rattus norvegicus (Norway rat) | EC50 | 100.0000 | 1 | 1 |
| 1-aminocyclopentane-1,3,4-tricarboxylic acid | Rattus norvegicus (Norway rat) | EC50 | 36.3133 | 3 | 3 |
| 3,4-dicarboxyphenylglycine | Rattus norvegicus (Norway rat) | EC50 | 39.2000 | 3 | 3 |
| vu0361737 | Rattus norvegicus (Norway rat) | EC50 | 0.1100 | 1 | 1 |
| 5-methyl-n-(4-methylpyrimidin-2-yl)-4-(1h-pyrazol-4-yl)thiazol-2-amine | Rattus norvegicus (Norway rat) | EC50 | 0.0090 | 1 | 1 |
Virtual screening workflow development guided by the "receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4.Journal of medicinal chemistry, , Apr-07, Volume: 48, Issue:7, 2005
(S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.Journal of medicinal chemistry, , Feb-11, Volume: 59, Issue:3, 2016
Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 25, Issue:12, 2015
Α-amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4.Bioorganic & medicinal chemistry, , Aug-01, Volume: 20, Issue:15, 2012
Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.Bioorganic & medicinal chemistry, , May-01, Volume: 15, Issue:9, 2007
Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 16, Issue:1, 2006
Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.Journal of medicinal chemistry, , Sep-12, Volume: 45, Issue:19, 2002
Metabotropic glutamate receptors: novel targets for drug development.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Virtual screening workflow development guided by the "receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4.Journal of medicinal chemistry, , Apr-07, Volume: 48, Issue:7, 2005
Metabotropic glutamate receptors: novel targets for drug development.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Virtual screening workflow development guided by the "receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4.Journal of medicinal chemistry, , Apr-07, Volume: 48, Issue:7, 2005
Metabotropic glutamate receptors: novel targets for drug development.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.Journal of medicinal chemistry, , Sep-12, Volume: 45, Issue:19, 2002
(S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
Virtual screening workflow development guided by the "receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4.Journal of medicinal chemistry, , Apr-07, Volume: 48, Issue:7, 2005
Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids.Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Metabotropic glutamate receptors: novel targets for drug development.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.Journal of medicinal chemistry, , Feb-11, Volume: 59, Issue:3, 2016
Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 25, Issue:12, 2015
Α-amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4.Bioorganic & medicinal chemistry, , Aug-01, Volume: 20, Issue:15, 2012
A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.Journal of medicinal chemistry, , Apr-08, Volume: 53, Issue:7, 2010
Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.Bioorganic & medicinal chemistry, , May-01, Volume: 15, Issue:9, 2007
L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency.Journal of medicinal chemistry, , Sep-20, Volume: 50, Issue:19, 2007
Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 16, Issue:1, 2006
Virtual screening workflow development guided by the "receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4.Journal of medicinal chemistry, , Apr-07, Volume: 48, Issue:7, 2005
(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.Journal of medicinal chemistry, , Jan-15, Volume: 47, Issue:2, 2004
(S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
Metabotropic glutamate receptors: novel targets for drug development.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 25, Issue:18, 2015
Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).Journal of medicinal chemistry, , Jul-23, Volume: 52, Issue:14, 2009
(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.Journal of medicinal chemistry, , Jan-15, Volume: 47, Issue:2, 2004
Metabotropic glutamate receptors: novel targets for drug development.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.Journal of medicinal chemistry, , Apr-08, Volume: 53, Issue:7, 2010
Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 16, Issue:18, 2006
Virtual screening workflow development guided by the "receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4.Journal of medicinal chemistry, , Apr-07, Volume: 48, Issue:7, 2005
Virtual screening workflow development guided by the "receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4.Journal of medicinal chemistry, , Apr-07, Volume: 48, Issue:7, 2005
(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.Journal of medicinal chemistry, , Jan-15, Volume: 47, Issue:2, 2004
Radiosynthesis and evaluation of an 18F-labeled positron emission tomography (PET) radioligand for metabotropic glutamate receptor subtype 4 (mGlu4).Journal of medicinal chemistry, , Nov-13, Volume: 57, Issue:21, 2014
Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).Journal of medicinal chemistry, , Jul-23, Volume: 52, Issue:14, 2009