Page last updated: 2024-08-07 13:11:49

Transketolase

A transketolase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29401]

Synonyms

TK;
EC 2.2.1.1

Research

Bioassay Publications (1)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Compounds (2)

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
thiamineHomo sapiens (human)Kd6,800.000011
thiamine thiazolone pyrophosphateHomo sapiens (human)Kd0.016011

Enables

This protein enables 6 target(s):

TargetCategoryDefinition
magnesium ion bindingmolecular functionBinding to a magnesium (Mg) ion. [GOC:ai]
transketolase activitymolecular functionCatalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor. [GOC:fmc, RHEA:10508]
calcium ion bindingmolecular functionBinding to a calcium ion (Ca2+). [GOC:ai]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
protein homodimerization activitymolecular functionBinding to an identical protein to form a homodimer. [GOC:jl]
thiamine pyrophosphate bindingmolecular functionBinding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. [GOC:mlg]

Located In

This protein is located in 6 target(s):

TargetCategoryDefinition
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
peroxisomecellular componentA small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
nuclear bodycellular componentExtra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182]
vesiclecellular componentAny small, fluid-filled, spherical organelle enclosed by membrane. [GOC:mah, GOC:pz, GOC:vesicles]
extracellular exosomecellular componentA vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
endoplasmic reticulum membranecellular componentThe lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

Involved In

This protein is involved in 5 target(s):

TargetCategoryDefinition
pentose-phosphate shuntbiological processThe metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate). [GOC:pde, ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]
pentose-phosphate shunt, non-oxidative branchbiological processThe branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P. [ISBN:0198506732, MetaCyc:NONOXIPENT-PWY]
regulation of growthbiological processAny process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. [GOC:ems, GOC:mah]
glyceraldehyde-3-phosphate biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis. [GOC:ai]
xylulose 5-phosphate biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of xylulose 5-phosphate. [GOC:bf, GOC:TermGenie]