A DNA (cytosine-5)-methyltransferase 3B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBC3]
Dnmt3b;
EC 2.1.1.37;
DNA methyltransferase HsaIIIB;
DNA MTase HsaIIIB;
M.HsaIIIB
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 5,5'-methylenedisalicylic acid | Homo sapiens (human) | IC50 | 31.0000 | 2 | 2 |
| s-tubercidinylhomocysteine | Homo sapiens (human) | IC50 | 0.3000 | 1 | 1 |
| s-adenosyl-3-thiopropylamine | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| s-adenosylhomocysteine | Homo sapiens (human) | IC50 | 10.2900 | 5 | 5 |
| nanaomycin a | Homo sapiens (human) | IC50 | 0.8075 | 4 | 4 |
| rg108 | Homo sapiens (human) | IC50 | 0.9000 | 1 | 1 |
| sgi-1027 | Homo sapiens (human) | IC50 | 7.5000 | 1 | 1 |
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| transcription corepressor activity | molecular function | A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867] |
| DNA (cytosine-5-)-methyltransferase activity | molecular function | Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. [EC:2.1.1.37] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| DNA-methyltransferase activity | molecular function | Catalysis of the transfer of a methyl group to a DNA molecule. [GOC:jl, ISBN:0198506732, PMID:7862522] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates | molecular function | Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA). [EC:2.1.1.37, PMID:15689527] |
| DNA binding | molecular function | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| catalytic complex | cellular component | A protein complex which is capable of catalytic activity. [GOC:bhm, GOC:TermGenie, PMID:8077207] |
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |
| positive regulation of gene expression | biological process | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018] |
| methylation | biological process | The process in which a methyl group is covalently attached to a molecule. [GOC:mah] |