Page last updated: 2024-08-07 18:26:35
Solute carrier organic anion transporter family member 1A4
A solute carrier organic anion transporter family member 1A4 that is encoded in the genome of rat. [OMA:O35913, PRO:DNx]
Synonyms
Brain digoxin carrier protein;
Brain-specific organic anion transporter;
OATP-B1;
Sodium-independent organic anion-transporting polypeptide 2;
Solute carrier family 21 member 5
Research
Bioassay Publications (11)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (20)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| amiodarone | Rattus norvegicus (Norway rat) | Ki | 1.8000 | 1 | 1 |
| ibuprofen | Rattus norvegicus (Norway rat) | Ki | 2,430.0000 | 1 | 1 |
| probenecid | Rattus norvegicus (Norway rat) | Ki | 72.9000 | 1 | 1 |
| triiodothyronine | Rattus norvegicus (Norway rat) | IC50 | 50.4000 | 1 | 1 |
| taurocholic acid | Rattus norvegicus (Norway rat) | IC50 | 1,480.0000 | 1 | 1 |
| taurocholic acid | Rattus norvegicus (Norway rat) | Ki | 97.7000 | 2 | 2 |
| quinidine | Rattus norvegicus (Norway rat) | Ki | 120.0000 | 1 | 1 |
| digoxin | Rattus norvegicus (Norway rat) | Ki | 0.3085 | 2 | 2 |
| quinine | Rattus norvegicus (Norway rat) | Ki | 3.8100 | 1 | 1 |
| rifamycin sv | Rattus norvegicus (Norway rat) | Ki | 7.3000 | 1 | 1 |
| rifampin | Rattus norvegicus (Norway rat) | Ki | 1.4300 | 2 | 2 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| fexofenadine | Rattus norvegicus (Norway rat) | Km | 6.0000 | 1 | 1 |
| thyroxine | Rattus norvegicus (Norway rat) | Km | 6.5300 | 1 | 1 |
| triiodothyronine | Rattus norvegicus (Norway rat) | Km | 5.8700 | 1 | 1 |
| taurocholic acid | Rattus norvegicus (Norway rat) | Km | 89.4000 | 3 | 3 |
| dehydroepiandrosterone sulfate | Rattus norvegicus (Norway rat) | Km | 17.0000 | 1 | 1 |
| pravastatin | Rattus norvegicus (Norway rat) | Km | 37.5000 | 1 | 1 |
| taurochenodeoxycholic acid | Rattus norvegicus (Norway rat) | Km | 12.0000 | 1 | 1 |
| ouabain | Rattus norvegicus (Norway rat) | Km | 470.0000 | 1 | 1 |
| bq 123 | Rattus norvegicus (Norway rat) | Km | 30.0000 | 1 | 1 |
| digoxin | Rattus norvegicus (Norway rat) | Km | 0.5297 | 3 | 3 |
| estrone sulfate | Rattus norvegicus (Norway rat) | Km | 11.0000 | 1 | 1 |
| estradiol-17 beta-glucuronide | Rattus norvegicus (Norway rat) | Km | 10.0000 | 2 | 2 |
| ursodoxicoltaurine | Rattus norvegicus (Norway rat) | Km | 17.0000 | 1 | 1 |