Proteins > Solute carrier organic anion transporter family member 1A4
Page last updated: 2024-08-07 18:26:35
Solute carrier organic anion transporter family member 1A4
A solute carrier organic anion transporter family member 1A4 that is encoded in the genome of rat. [OMA:O35913, PRO:DNx]
Synonyms
Brain digoxin carrier protein;
Brain-specific organic anion transporter;
OATP-B1;
Sodium-independent organic anion-transporting polypeptide 2;
Solute carrier family 21 member 5
Research
Bioassay Publications (11)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (20)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| amiodarone | Rattus norvegicus (Norway rat) | Ki | 1.8000 | 1 | 1 |
| ibuprofen | Rattus norvegicus (Norway rat) | Ki | 2,430.0000 | 1 | 1 |
| probenecid | Rattus norvegicus (Norway rat) | Ki | 72.9000 | 1 | 1 |
| triiodothyronine | Rattus norvegicus (Norway rat) | IC50 | 50.4000 | 1 | 1 |
| taurocholic acid | Rattus norvegicus (Norway rat) | IC50 | 1,480.0000 | 1 | 1 |
| taurocholic acid | Rattus norvegicus (Norway rat) | Ki | 97.7000 | 2 | 2 |
| quinidine | Rattus norvegicus (Norway rat) | Ki | 120.0000 | 1 | 1 |
| digoxin | Rattus norvegicus (Norway rat) | Ki | 0.3085 | 2 | 2 |
| quinine | Rattus norvegicus (Norway rat) | Ki | 3.8100 | 1 | 1 |
| rifamycin sv | Rattus norvegicus (Norway rat) | Ki | 7.3000 | 1 | 1 |
| rifampin | Rattus norvegicus (Norway rat) | Ki | 1.4300 | 2 | 2 |
Drugs with Other Measurements
Effect of 17 beta-estradiol-D-17 beta-glucuronide on the rat organic anion transporting polypeptide 2-mediated transport differs depending on substrates.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 30, Issue:2, 2002
Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OAT-K2.The Journal of pharmacology and experimental therapeutics, , Volume: 299, Issue:1, 2001
Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier.The Journal of pharmacology and experimental therapeutics, , Volume: 298, Issue:1, 2001
Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2.The Journal of biological chemistry, , Aug-28, Volume: 273, Issue:35, 1998
Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain.Proceedings of the National Academy of Sciences of the United States of America, , Sep-16, Volume: 94, Issue:19, 1997
Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport.Pharmaceutical research, , Volume: 19, Issue:2, 2002
Effect of 17 beta-estradiol-D-17 beta-glucuronide on the rat organic anion transporting polypeptide 2-mediated transport differs depending on substrates.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 30, Issue:2, 2002
Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier.The Journal of pharmacology and experimental therapeutics, , Volume: 298, Issue:1, 2001
Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain.Proceedings of the National Academy of Sciences of the United States of America, , Sep-16, Volume: 94, Issue:19, 1997
Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport.Pharmaceutical research, , Volume: 19, Issue:2, 2002
Rifamycin SV and rifampicin exhibit differential inhibition of the hepatic rat organic anion transporting polypeptides, Oatp1 and Oatp2.Hepatology (Baltimore, Md.), , Volume: 32, Issue:1, 2000