Solute carrier organic anion transporter family member 1A2

A solute carrier organic anion transporter family member 1A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46721]

Synonyms

OATP-A;
Organic anion-transporting polypeptide 1;
OATP-1;
Sodium-independent organic anion transporter;
Solute carrier family 21 member 3

Research

Bioassay Publications (10)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	5 (50.00)	18.2507
2000's	4 (40.00)	29.6817
2010's	1 (10.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (13)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
rifamycin sv	Homo sapiens (human)	Ki	11.0000	1	1
rifampin	Homo sapiens (human)	Ki	51.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
fexofenadine	Homo sapiens (human)	Km	6.4000	1	1
thyroxine	Homo sapiens (human)	Km	8.0000	1	1
triiodothyronine	Homo sapiens (human)	Km	6.5000	1	1
sulfobromophthalein sodium	Homo sapiens (human)	Km	20.0000	1	1
taurocholic acid	Homo sapiens (human)	Km	58.2250	3	4
dehydroepiandrosterone sulfate	Homo sapiens (human)	Km	6.6000	1	1
ouabain	Homo sapiens (human)	Km	5,500.0000	1	1
cyanoginosin lr	Homo sapiens (human)	Km	20.0000	1	1
estrone sulfate	Homo sapiens (human)	Km	28.2333	3	3
ursodoxicoltaurine	Homo sapiens (human)	Km	19.0000	1	1
deltorphin ii, ala(2)-	Homo sapiens (human)	Km	330.0000	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
organic anion transmembrane transporter activity	molecular function	Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai]
organic cation transmembrane transporter activity	molecular function	Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
bile acid transmembrane transporter activity	molecular function	Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. [GOC:ai]
transmembrane transporter activity	molecular function	Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
sodium-independent organic anion transmembrane transporter activity	molecular function	Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. [GOC:go_curators]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
basal plasma membrane	cellular component	The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
basolateral plasma membrane	cellular component	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]

Involved In

This protein is involved in 7 target(s):

Target	Category	Definition
xenobiotic metabolic process	biological process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
monoatomic ion transport	biological process	The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]
organic cation transport	biological process	The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. [GOC:ai]
organic anion transport	biological process	The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai, GOC:krc]
bile acid and bile salt transport	biological process	The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511]
sodium-independent organic anion transport	biological process	The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators]
transmembrane transport	biological process	The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid]