Page last updated: 2024-12-05

nitrosomethylurethane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Nitrosomethylurethane: An alkylating carcinogen that produces gastrointestinal and probably lung and nervous system tumors. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID12001
CHEMBL ID3188414
CHEBI ID82373
SCHEMBL ID102165
MeSH IDM0014923

Synonyms (67)

Synonym
nitrosomethylurethan
ethylester kyseliny n-methyl-n-nitrosokarbaminove
unii-741gdm4803
741gdm4803 ,
LS-12997
n-nitroso-n-methylurethane
nsc2860
mnun
n-nitro-n-methylurethan
nitrosomethylurethane
ethyl ester of methylnitroso-carbamic acid
methylnitrosourethane
n-methyl-n-nitrosocarbamic acid, ethyl ester
n-methyl-n-nitrosoethylcarbamate
615-53-2
nmut
n-methyl-n-nitroso-urethane
nsc 2860
ethyl n-methylnitrosocarbamate
methyl-n-nitrosourethane
n-methyl-n-nitrosourethane
methylnitrosourethan
nsc-2860
wln: onn1&vo2
ethyl methyl(nitroso)carbamate
hsdb 5113
brn 1763954
rcra waste number u178
nitrosomethylurethan [german]
methylnitrosourethan [german]
carbamic acid, n-methyl-n-nitroso-, ethyl ester
ethyl methylnitrosocarbamate
n-nitrosomethylurethane
ethylester kyseliny n-methyl-n-nitrosokarbaminove [czech]
ai3-19393
rcra waste no. u178
einecs 210-432-3
ccris 471
carbamic acid, methylnitroso-, ethyl ester
nm-urethane
nm-urethan
ethyl n-methyl-n-nitroso-carbamate
methylnitrosocarbamic acid, ethyl ester
n-ethoxycarbonyl-n-methylnitrosamine
N0265
ethyl n-methyl-n-nitrosocarbamate
A833295
C19301
NCGC00256477-01
cas-615-53-2
dtxsid4021472 ,
dtxcid801472
tox21_302872
FT-0632573
AKOS015850671
n-nitroso-n-methylurethane [hsdb]
n-methyl-n-nitrosourethane [iarc]
SCHEMBL102165
CHEBI:82373 ,
ethyl 1-methyl-2-oxohydrazinecarboxylate #
CHEMBL3188414
F16700
Q26840976
AMY41354
carbamic acid, methylnitroso-allyl ester
n-nitroso-n-methylurethan
n-methyl-n-nitrosocarbamic acid ethyl ester

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"Oral administration of NMU at maximally tolerated doses of guinea-pigs from day 34 to 58 of pregnancy induced embryotoxic effects, as evidenced by a high incidence of stillbirths and reduction in birth weight, and postnatal toxic effects, as evidenced by stunting, progressive mortality and extensive fatty degeneration of the liver in F1 progeny."( Prenatal and postnatal toxicity induced in guinea-pigs by nitrosomethylurea.
Epstein, SS; Hasumi, K; Iobal, ZM, 1976
)
0.26
" Similar administration of N-nitrosomethylurethane at maximally tolerated doses did not induce such toxic effects."( Pre- and postnatal toxicity induced in guinea pigs by N-nitrosomethylurea.
Berkowitz, J; Epstein, SS; Hasumi, K; Wilber, JH; Wilber, RG, 1975
)
0.55
" According to median lethalities, all three known carcinogens were substantially more toxic than nitrosocimetidine whether administered by the intravenous, intraperitoneal, or oral routes."( Comparison of the acute toxicity of N-nitrosocimetidine with three structurally related carcinogens in the rat.
Hard, GC; Jensen, DE; Magee, PN; Ogiu, T, 1986
)
0.27
" It can be hypothesized that toxic effects of perfluoroisobutylene are determined by its influence on epithelial (pneumocytes and cells of nonkeratinized stratified ciliated epithelium) and endothelial cells."( Mechanisms of Pulmonary Toxicity of Perfluoro-n-Alkane Pyrolysis Products with Consideration of the Structural Features of the Blood-Air Barriers.
Alekseeva, II; Basharin, VA; Chepur, SV; Solovyeva, TS; Tolkach, PG; Vladimirova, OO, 2020
)
0.56

Dosage Studied

ExcerptRelevanceReference
" Further effect on the inhibition of DNA synthesis by these carcinogens was obtained by dose-response studies and its results indicated that there was a correlation between pancreatic carcinogens and the inhibition of DNA synthesis after partial pancreatectomy in rats."( Effect of chemical carcinogens on pancreatic DNA synthesis in vivo.
Denda, A; Kondo, H; Konishi, Y; Sunagawa, M; Takahashi, S, 1976
)
0.26
"A dose-response study on the carcinogenicity of N-ethyl-N-nitrosourethane (ENUR) was undertaken to examine its effect at low doses."( Dose-response carcinogenicity in rats on low-dose levels of N-ethyl-N-nitrosourethane.
Hayashi, Y; Kodama, Y; Maekawa, A; Matsushima, Y; Nagaoka, T; Onodera, H; Shibutani, M; Todate, A, 1989
)
0.28
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
carboxylic esterAn ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (102)

TimeframeStudies, This Drug (%)All Drugs %
pre-199074 (72.55)18.7374
1990's20 (19.61)18.2507
2000's6 (5.88)29.6817
2010's1 (0.98)24.3611
2020's1 (0.98)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 9.29

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index9.29 (24.57)
Research Supply Index4.70 (2.92)
Research Growth Index3.99 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (9.29)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (0.92%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other108 (99.08%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]