Solute carrier family 15 member 2

A solute carrier family 15 member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16348]

Synonyms

Kidney H(+)/peptide cotransporter;
Oligopeptide transporter, kidney isoform;
Peptide transporter 2

Research

Bioassay Publications (4)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (75.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (25.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (54)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cephaloridine	Homo sapiens (human)	Ki	8,505.6900	1	2
penicillin g	Homo sapiens (human)	Ki	10,982.4000	1	2
cephalothin	Homo sapiens (human)	Ki	8,308.8200	1	2
cloxacillin	Homo sapiens (human)	Ki	952.4965	1	2
oxacillin	Homo sapiens (human)	Ki	3,305.6550	1	2
ampicillin	Homo sapiens (human)	Ki	1,294.1250	1	2
glycylglycine	Homo sapiens (human)	Ki	53.8516	1	2
levulinic acid	Homo sapiens (human)	Ki	229.5435	1	2
dicloxacillin	Homo sapiens (human)	Ki	418.4345	1	2
cyclacillin	Homo sapiens (human)	IC50	610.0000	1	1
cyclacillin	Homo sapiens (human)	Ki	40.8879	3	4
cephalexin	Homo sapiens (human)	Ki	73.0193	2	3
amoxicillin	Homo sapiens (human)	Ki	428.2900	1	2
cefmetazole	Homo sapiens (human)	Ki	4,282.9000	1	2
cefadroxil anhydrous	Homo sapiens (human)	IC50	66.0000	1	1
cefadroxil anhydrous	Homo sapiens (human)	Ki	2.8300	3	4
cefaclor anhydrous	Homo sapiens (human)	Ki	28.9202	1	2
leucyl-glycyl-glycine	Homo sapiens (human)	Ki	18.0985	1	2
glycyl-histidyl-lysine	Homo sapiens (human)	Ki	3,095.1500	1	2
alanylproline	Homo sapiens (human)	Ki	12.0113	1	2
Trp-Trp	Homo sapiens (human)	Ki	0.7972	1	2
glycylsarcosine	Homo sapiens (human)	IC50	81.0000	1	0
glycylsarcosine	Homo sapiens (human)	Ki	64.0000	1	1
prolyl-glycyl-glycine	Homo sapiens (human)	Ki	10,982.4000	1	2
prolylglutamic acid	Homo sapiens (human)	Ki	2,585.2000	1	2
carnosine	Homo sapiens (human)	IC50	28.0000	1	0
cysteinylglycine	Homo sapiens (human)	Ki	28.9202	1	2
cefamandole	Homo sapiens (human)	Ki	2,809.1900	1	2
aspartyl-aspartic acid	Homo sapiens (human)	Ki	150.6780	1	2
n-glycylalanine	Homo sapiens (human)	Ki	3.4837	1	2
trimethionine	Homo sapiens (human)	Ki	1.9976	1	2
7432 s	Homo sapiens (human)	Ki	90.0000	1	1
cefodizime	Homo sapiens (human)	Ki	8,956.2550	1	2
cefixime	Homo sapiens (human)	Ki	2,585.2000	1	2
alanyl-alanyl-alanine	Homo sapiens (human)	Ki	18.0985	1	2
cefuroxime	Homo sapiens (human)	Ki	12,594.6500	1	2
cefepime	Homo sapiens (human)	Ki	10,982.4000	1	2
alanylalanine	Homo sapiens (human)	Ki	6.0085	2	3
phenylalanylalanine	Homo sapiens (human)	Ki	15.9244	1	2
alanyltyrosine	Homo sapiens (human)	Ki	4.3826	1	2
cefotaxime	Homo sapiens (human)	Ki	19,976.3000	1	2
cefpodoxime	Homo sapiens (human)	Ki	30,951.5000	1	2
aspartyllysine	Homo sapiens (human)	Ki	8.0000	1	1
methampicillin	Homo sapiens (human)	Ki	727.2180	1	2
phenylalanylglycine	Homo sapiens (human)	Ki	14.0627	1	2
glutamylalanine	Homo sapiens (human)	Ki	30.0998	1	2
phenylalanylphenylalanine	Homo sapiens (human)	Ki	37.0768	1	2
phenylalanyl-valine	Homo sapiens (human)	Ki	3.8009	1	2
alanylglycine	Homo sapiens (human)	Ki	7.0397	1	2
valyltyrosine	Homo sapiens (human)	Ki	2.5059	1	2
Ala-Lys	Homo sapiens (human)	Ki	18.9696	2	3
glycylhistidine	Homo sapiens (human)	Ki	38.9522	1	2
isoleucyl-tyrosine	Homo sapiens (human)	Ki	7.9716	1	2
valyl-prolyl-proline	Homo sapiens (human)	Ki	22.9543	1	2
prolylvaline	Homo sapiens (human)	Ki	38.9522	1	2
isoleucyl-valyl-tyrosine	Homo sapiens (human)	Ki	14.0627	1	2
cephapirin sodium	Homo sapiens (human)	Ki	11,160.1000	1	2

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
glycylsarcosine	Homo sapiens (human)	Km	61.0000	2	2

Enables

This protein enables 4 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
peptide:proton symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement. [GOC:mtg_transport, TC:2.A.17.-.-]
tripeptide transmembrane transporter activity	molecular function	Enables the transfer of a tripeptide, a compound containing three amino acids linked together by peptide bonds, from one side of a membrane to the other. [GOC:jl]
dipeptide transmembrane transporter activity	molecular function	Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond. [GOC:mah]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 3 target(s):

Target	Category	Definition
phagocytic vesicle membrane	cellular component	The lipid bilayer surrounding a phagocytic vesicle. [GOC:mah]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 14 target(s):

Target	Category	Definition
monoatomic ion transport	biological process	The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]
protein transport	biological process	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
peptide transport	biological process	The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
peptidoglycan transport	biological process	The directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
xenobiotic transport	biological process	The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc]
dipeptide transport	biological process	The directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]
renal absorption	biological process	A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). [GOC:dph, GOC:mah, GOC:yaf]
regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	biological process	Any process that modulates the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway. [GOC:add]
dipeptide import across plasma membrane	biological process	The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol. [PMID:22226946]
tripeptide import across plasma membrane	biological process	The directed movement of a tripeptide from outside of a cell, across the plasma membrane and into the cytosol. [PMID:22226946]
antibacterial innate immune response	biological process	An defense response against a bacteria mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. [PMID:16177355, PMID:23006328]
transport across blood-brain barrier	biological process	The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008]
proton transmembrane transport	biological process	The directed movement of a proton across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]
xenobiotic detoxification by transmembrane export across the plasma membrane	biological process	A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. [PMID:28355133]