Proteins > Hydroxycarboxylic acid receptor 2
Page last updated: 2024-08-07 19:35:09
Hydroxycarboxylic acid receptor 2
A hydroxycarboxylic acid receptor 2 that is encoded in the genome of mouse. [OMA:Q9EP66, PRO:DNx]
Synonyms
G-protein coupled receptor 109;
G-protein coupled receptor 109A;
G-protein coupled receptor HM74;
Niacin receptor 1;
Nicotinic acid receptor;
Protein PUMA-G
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (3)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| niacin | Mus musculus (house mouse) | IC50 | 0.1400 | 3 | 3 |
| mk 0354 | Mus musculus (house mouse) | IC50 | 1.2000 | 2 | 2 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| niacin | Mus musculus (house mouse) | EC50 | 0.1093 | 3 | 3 |
| mk 0354 | Mus musculus (house mouse) | EC50 | 0.7400 | 2 | 2 |
| mk 6892 | Mus musculus (house mouse) | EC50 | 0.2400 | 1 | 1 |
Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia.ACS medicinal chemistry letters, , Jan-12, Volume: 3, Issue:1, 2012
Discovery of a potent nicotinic Acid receptor agonist for the treatment of dyslipidemia.ACS medicinal chemistry letters, , Feb-10, Volume: 2, Issue:2, 2011
GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
GPR109a agonists. Part 1: 5-Alkyl and 5-aryl-pyrazole-tetrazoles as agonists of the human orphan G-protein coupled receptor GPR109a.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 19, Issue:8, 2009
Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.Journal of medicinal chemistry, , Dec-13, Volume: 50, Issue:25, 2007
GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
GPR109a agonists. Part 1: 5-Alkyl and 5-aryl-pyrazole-tetrazoles as agonists of the human orphan G-protein coupled receptor GPR109a.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 19, Issue:8, 2009
3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice.Journal of medicinal chemistry, , Aug-28, Volume: 51, Issue:16, 2008