Fibroblast growth factor 1

A fibroblast growth factor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05230]

Synonyms

FGF-1;
Acidic fibroblast growth factor;
aFGF;
Endothelial cell growth factor;
ECGF;
Heparin-binding growth factor 1;
HBGF-1

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (33.33)	29.6817
2010's	2 (66.67)	24.3611
2020's	0 (0.00)	2.80

Compounds (3)

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sulfasalazine	Homo sapiens (human)	Kd	609.0000	1	1
phosphomannopentaose sulfate	Homo sapiens (human)	Kd	0.2400	1	1
pg 545	Homo sapiens (human)	Kd	0.0080	1	1

Enables

This protein enables 7 target(s):

Target	Category	Definition
fibroblast growth factor receptor binding	molecular function	Binding to a fibroblast growth factor receptor (FGFR). [GOC:ceb]
integrin binding	molecular function	Binding to an integrin. [GOC:ceb]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
growth factor activity	molecular function	The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. [ISBN:0815316194]
heparin binding	molecular function	Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. [GOC:jl, ISBN:0198506732]
Hsp70 protein binding	molecular function	Binding to a Hsp70 protein, heat shock proteins around 70kDa in size. [ISBN:0198506732]
S100 protein binding	molecular function	Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. [GOC:jid]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
cell cortex	cellular component	The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. [GOC:mah, ISBN:0815316194]
extracellular matrix	cellular component	A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]

Active In

This protein is active in 3 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Involved In

This protein is involved in 30 target(s):

Target	Category	Definition
angiogenesis	biological process	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]
organ induction	biological process	The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ. [ISBN:0878932437]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
positive regulation of cell population proliferation	biological process	Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
fibroblast growth factor receptor signaling pathway	biological process	The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. [GOC:ceb]
anatomical structure morphogenesis	biological process	The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. [GOC:go_curators, ISBN:0521436125]
positive regulation of endothelial cell migration	biological process	Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. [GOC:BHF, GOC:dph, GOC:tb]
lung development	biological process	The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. [GOC:jid, UBERON:0002048]
positive regulation of cell migration	biological process	Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]
activation of protein kinase B activity	biological process	Any process that initiates the activity of the inactive enzyme protein kinase B. [GOC:pg]
cellular response to heat	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. [GOC:mah]
wound healing	biological process	The series of events that restore integrity to a damaged tissue, following an injury. [GOC:bf, PMID:15269788]
positive regulation of MAP kinase activity	biological process	Any process that activates or increases the frequency, rate or extent of MAP kinase activity. [GOC:dph, GOC:go_curators]
positive regulation of cholesterol biosynthetic process	biological process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. [GOC:go_curators]
positive regulation of angiogenesis	biological process	Any process that activates or increases angiogenesis. [GOC:go_curators]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
epithelial cell proliferation	biological process	The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. [ISBN:0721662544]
positive regulation of cell division	biological process	Any process that activates or increases the frequency, rate or extent of cell division. [GOC:ai]
branch elongation involved in ureteric bud branching	biological process	The growth of a branch of the ureteric bud along its axis. [GOC:dph, PMID:16916378]
positive regulation of ERK1 and ERK2 cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah]
mesonephric epithelium development	biological process	The process whose specific outcome is the progression of an epithelium in the mesonephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. [GOC:mtg_kidney_jan10]
regulation of endothelial tube morphogenesis	biological process	Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis. [GOC:dph, GOC:TermGenie]
positive regulation of intracellular signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]
positive regulation of sprouting angiogenesis	biological process	Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:16756958]
positive regulation of hepatocyte proliferation	biological process	Any process that activates or increases the frequency, rate or extent of hepatocyte proliferation. [GOC:BHF, GOC:mah]
regulation of endothelial cell chemotaxis to fibroblast growth factor	biological process	Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor. [GOC:obol]
cell differentiation	biological process	The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]
positive regulation of gene expression	biological process	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
animal organ morphogenesis	biological process	Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]
regulation of cell migration	biological process	Any process that modulates the frequency, rate or extent of cell migration. [GOC:go_curators]