losartan has been researched along with Necrosis in 11 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pathophysiologic levels of angiotensin II (AII) produce myocyte necrosis." | 7.69 | Angiotensin II (AII)-induced myocyte necrosis: role of the AII receptor. ( Henegar, JR; Janicki, JS; Kabour, A, 1994) |
| "Angiotensin II related cardiomyocyte necrosis and coronary vascular damage are angiotensin type 1 receptor mediated and completely preventable with the receptor antagonist losartan." | 7.69 | Prevention of angiotensin II induced myocyte necrosis and coronary vascular damage by lisinopril and losartan in the rat. ( Devineni, VR; Henegar, JR; Janicki, JS; Kabour, A, 1995) |
| "To produce arrhythmia, the left main coronary artery was occluded for 7 min, followed by 7 min of reperfusion and to produce necrosis, the the left main coronary artery was occluded for 30 min, followed by 120 min of reperfusion." | 5.31 | Effects of captopril and losartan on myocardial ischemia-reperfusion induced arrhythmias and necrosis in rats. ( Acet, A; Birincioglu, M; Ozer, MK; Sahna, E, 2002) |
| " Hindlimb ischemia was induced in wild-type (WT), Cx40(-/-), and losartan-treated Cx40(-/-) mice by using surgical procedures that either maintained (mild surgery) or compromised (severe surgery) perfusion of major collateral vessels supplying the distal limb." | 3.79 | Compromised regulation of tissue perfusion and arteriogenesis limit, in an AT1R-independent fashion, recovery of ischemic tissue in Cx40(-/-) mice. ( Angelov, SN; Burt, JM; Fang, JS; Simon, AM, 2013) |
| "We investigated the role of angiotensin II and endothelin-1 using the angiotensin AT1 receptor antagonist losartan and the endothelin ETA receptor antagonist atrasentan, in malignant hypertension and renal failure and damage induced by nitric oxide (NO) synthase inhibition in Harlan Sprague-Dawley (SD) rats." | 3.75 | Protective effects of angiotensin AT1 receptor blockade in malignant hypertension in the rat. ( Agharazii, M; Bélanger, S; Larivière, R; Lebel, M; Lemieux, P; Therrien, F, 2009) |
| "The therapeutic efficacy of angiotensin II receptor antagonist, losartan, was studied in patients with nonalcoholic steatohepatitis (NASH)." | 3.72 | Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis. ( Aso, K; Haneda, M; Hasegawa, T; Miyokawa, N; Nakamura, K; Okada, M; Okamoto, S; Tokusashi, Y; Yokohama, S; Yoneda, M, 2004) |
| "Pathophysiologic levels of angiotensin II (AII) produce myocyte necrosis." | 3.69 | Angiotensin II (AII)-induced myocyte necrosis: role of the AII receptor. ( Henegar, JR; Janicki, JS; Kabour, A, 1994) |
| "Angiotensin II related cardiomyocyte necrosis and coronary vascular damage are angiotensin type 1 receptor mediated and completely preventable with the receptor antagonist losartan." | 3.69 | Prevention of angiotensin II induced myocyte necrosis and coronary vascular damage by lisinopril and losartan in the rat. ( Devineni, VR; Henegar, JR; Janicki, JS; Kabour, A, 1995) |
| "To produce arrhythmia, the left main coronary artery was occluded for 7 min, followed by 7 min of reperfusion and to produce necrosis, the the left main coronary artery was occluded for 30 min, followed by 120 min of reperfusion." | 1.31 | Effects of captopril and losartan on myocardial ischemia-reperfusion induced arrhythmias and necrosis in rats. ( Acet, A; Birincioglu, M; Ozer, MK; Sahna, E, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peña, C | 1 |
| Hernández-Fonseca, JP | 1 |
| Pedreañez, A | 1 |
| Viera, N | 1 |
| Mosquera, J | 1 |
| Therrien, F | 1 |
| Lemieux, P | 1 |
| Bélanger, S | 1 |
| Agharazii, M | 1 |
| Lebel, M | 1 |
| Larivière, R | 1 |
| Oztürk, CN | 1 |
| Tezel, E | 1 |
| Yalçın, O | 1 |
| Parlakpinar, H | 1 |
| Ozer, MK | 2 |
| Acet, A | 2 |
| Fang, JS | 1 |
| Angelov, SN | 1 |
| Simon, AM | 1 |
| Burt, JM | 1 |
| Yokohama, S | 1 |
| Yoneda, M | 1 |
| Haneda, M | 1 |
| Okamoto, S | 1 |
| Okada, M | 1 |
| Aso, K | 1 |
| Hasegawa, T | 1 |
| Tokusashi, Y | 1 |
| Miyokawa, N | 1 |
| Nakamura, K | 1 |
| Kabour, A | 2 |
| Henegar, JR | 2 |
| Janicki, JS | 2 |
| Lambert, C | 1 |
| Massillon, Y | 1 |
| Meloche, S | 1 |
| Devineni, VR | 1 |
| Lazareth, I | 1 |
| Sahna, E | 1 |
| Birincioglu, M | 1 |
1 review available for losartan and Necrosis
| Article | Year |
|---|---|
[Management of Raynaud's phenomenon].
Topics: Adult; Age Distribution; Calcium Channel Blockers; Female; Humans; Iloprost; Losartan; Male; Middle | 2001 |
10 other studies available for losartan and Necrosis
| Article | Year |
|---|---|
Renal oxidative stress and renal CD8(+) T-cell infiltration in mercuric chloride-induced nephropathy in rats: role of angiotensin II.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; A | 2016 |
Protective effects of angiotensin AT1 receptor blockade in malignant hypertension in the rat.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Atrasenta | 2009 |
Evaluation of the effects of losartan on a random pattern skin flap model in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Dermatologic Surgical Procedures; Ischemia; Losart | 2011 |
Effects of captopril and angiotensin II receptor blockers (AT1, AT2) on myocardial ischemia-reperfusion induced infarct size.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arteries; Blood | 2011 |
Compromised regulation of tissue perfusion and arteriogenesis limit, in an AT1R-independent fashion, recovery of ischemic tissue in Cx40(-/-) mice.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Connexins; Gap Junction alpha-5 Protein; Hindlimb; | 2013 |
Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis.
Topics: Adult; Angiotensin Receptor Antagonists; Biomarkers; Fatty Liver; Female; Ferritins; Hepatitis; Huma | 2004 |
Angiotensin II (AII)-induced myocyte necrosis: role of the AII receptor.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Heart; Imidazoles; Lo | 1994 |
Upregulation of cardiac angiotensin II AT1 receptors in congenital cardiomyopathic hamsters.
Topics: Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Cardiomy | 1995 |
Prevention of angiotensin II induced myocyte necrosis and coronary vascular damage by lisinopril and losartan in the rat.
Topics: Angiotensin I; Angiotensin II; Animals; Biphenyl Compounds; Coronary Vessels; Dose-Response Relation | 1995 |
Effects of captopril and losartan on myocardial ischemia-reperfusion induced arrhythmias and necrosis in rats.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Arrhythmia | 2002 |