Page last updated: 2024-10-30

losartan and Necrosis

losartan has been researched along with Necrosis in 11 studies

Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"Pathophysiologic levels of angiotensin II (AII) produce myocyte necrosis."7.69Angiotensin II (AII)-induced myocyte necrosis: role of the AII receptor. ( Henegar, JR; Janicki, JS; Kabour, A, 1994)
"Angiotensin II related cardiomyocyte necrosis and coronary vascular damage are angiotensin type 1 receptor mediated and completely preventable with the receptor antagonist losartan."7.69Prevention of angiotensin II induced myocyte necrosis and coronary vascular damage by lisinopril and losartan in the rat. ( Devineni, VR; Henegar, JR; Janicki, JS; Kabour, A, 1995)
"To produce arrhythmia, the left main coronary artery was occluded for 7 min, followed by 7 min of reperfusion and to produce necrosis, the the left main coronary artery was occluded for 30 min, followed by 120 min of reperfusion."5.31Effects of captopril and losartan on myocardial ischemia-reperfusion induced arrhythmias and necrosis in rats. ( Acet, A; Birincioglu, M; Ozer, MK; Sahna, E, 2002)
" Hindlimb ischemia was induced in wild-type (WT), Cx40(-/-), and losartan-treated Cx40(-/-) mice by using surgical procedures that either maintained (mild surgery) or compromised (severe surgery) perfusion of major collateral vessels supplying the distal limb."3.79Compromised regulation of tissue perfusion and arteriogenesis limit, in an AT1R-independent fashion, recovery of ischemic tissue in Cx40(-/-) mice. ( Angelov, SN; Burt, JM; Fang, JS; Simon, AM, 2013)
"We investigated the role of angiotensin II and endothelin-1 using the angiotensin AT1 receptor antagonist losartan and the endothelin ETA receptor antagonist atrasentan, in malignant hypertension and renal failure and damage induced by nitric oxide (NO) synthase inhibition in Harlan Sprague-Dawley (SD) rats."3.75Protective effects of angiotensin AT1 receptor blockade in malignant hypertension in the rat. ( Agharazii, M; Bélanger, S; Larivière, R; Lebel, M; Lemieux, P; Therrien, F, 2009)
"The therapeutic efficacy of angiotensin II receptor antagonist, losartan, was studied in patients with nonalcoholic steatohepatitis (NASH)."3.72Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis. ( Aso, K; Haneda, M; Hasegawa, T; Miyokawa, N; Nakamura, K; Okada, M; Okamoto, S; Tokusashi, Y; Yokohama, S; Yoneda, M, 2004)
"Pathophysiologic levels of angiotensin II (AII) produce myocyte necrosis."3.69Angiotensin II (AII)-induced myocyte necrosis: role of the AII receptor. ( Henegar, JR; Janicki, JS; Kabour, A, 1994)
"Angiotensin II related cardiomyocyte necrosis and coronary vascular damage are angiotensin type 1 receptor mediated and completely preventable with the receptor antagonist losartan."3.69Prevention of angiotensin II induced myocyte necrosis and coronary vascular damage by lisinopril and losartan in the rat. ( Devineni, VR; Henegar, JR; Janicki, JS; Kabour, A, 1995)
"To produce arrhythmia, the left main coronary artery was occluded for 7 min, followed by 7 min of reperfusion and to produce necrosis, the the left main coronary artery was occluded for 30 min, followed by 120 min of reperfusion."1.31Effects of captopril and losartan on myocardial ischemia-reperfusion induced arrhythmias and necrosis in rats. ( Acet, A; Birincioglu, M; Ozer, MK; Sahna, E, 2002)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (27.27)18.2507
2000's4 (36.36)29.6817
2010's4 (36.36)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Peña, C1
Hernández-Fonseca, JP1
Pedreañez, A1
Viera, N1
Mosquera, J1
Therrien, F1
Lemieux, P1
Bélanger, S1
Agharazii, M1
Lebel, M1
Larivière, R1
Oztürk, CN1
Tezel, E1
Yalçın, O1
Parlakpinar, H1
Ozer, MK2
Acet, A2
Fang, JS1
Angelov, SN1
Simon, AM1
Burt, JM1
Yokohama, S1
Yoneda, M1
Haneda, M1
Okamoto, S1
Okada, M1
Aso, K1
Hasegawa, T1
Tokusashi, Y1
Miyokawa, N1
Nakamura, K1
Kabour, A2
Henegar, JR2
Janicki, JS2
Lambert, C1
Massillon, Y1
Meloche, S1
Devineni, VR1
Lazareth, I1
Sahna, E1
Birincioglu, M1

Reviews

1 review available for losartan and Necrosis

ArticleYear
[Management of Raynaud's phenomenon].
    Annales de dermatologie et de venereologie, 2001, Volume: 128, Issue:4

    Topics: Adult; Age Distribution; Calcium Channel Blockers; Female; Humans; Iloprost; Losartan; Male; Middle

2001

Other Studies

10 other studies available for losartan and Necrosis

ArticleYear
Renal oxidative stress and renal CD8(+) T-cell infiltration in mercuric chloride-induced nephropathy in rats: role of angiotensin II.
    Journal of immunotoxicology, 2016, Volume: 13, Issue:3

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; A

2016
Protective effects of angiotensin AT1 receptor blockade in malignant hypertension in the rat.
    European journal of pharmacology, 2009, Apr-01, Volume: 607, Issue:1-3

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Atrasenta

2009
Evaluation of the effects of losartan on a random pattern skin flap model in rats.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2011, Volume: 17, Issue:2

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Dermatologic Surgical Procedures; Ischemia; Losart

2011
Effects of captopril and angiotensin II receptor blockers (AT1, AT2) on myocardial ischemia-reperfusion induced infarct size.
    Cytokine, 2011, Volume: 56, Issue:3

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arteries; Blood

2011
Compromised regulation of tissue perfusion and arteriogenesis limit, in an AT1R-independent fashion, recovery of ischemic tissue in Cx40(-/-) mice.
    American journal of physiology. Heart and circulatory physiology, 2013, Mar-15, Volume: 304, Issue:6

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Connexins; Gap Junction alpha-5 Protein; Hindlimb;

2013
Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis.
    Hepatology (Baltimore, Md.), 2004, Volume: 40, Issue:5

    Topics: Adult; Angiotensin Receptor Antagonists; Biomarkers; Fatty Liver; Female; Ferritins; Hepatitis; Huma

2004
Angiotensin II (AII)-induced myocyte necrosis: role of the AII receptor.
    Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:4

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Heart; Imidazoles; Lo

1994
Upregulation of cardiac angiotensin II AT1 receptors in congenital cardiomyopathic hamsters.
    Circulation research, 1995, Volume: 77, Issue:5

    Topics: Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Cardiomy

1995
Prevention of angiotensin II induced myocyte necrosis and coronary vascular damage by lisinopril and losartan in the rat.
    Cardiovascular research, 1995, Volume: 29, Issue:4

    Topics: Angiotensin I; Angiotensin II; Animals; Biphenyl Compounds; Coronary Vessels; Dose-Response Relation

1995
Effects of captopril and losartan on myocardial ischemia-reperfusion induced arrhythmias and necrosis in rats.
    Pharmacological research, 2002, Volume: 45, Issue:4

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Arrhythmia

2002