UDP-glucuronosyltransferase 1A1

A UDP-glucuronosyltransferase 1A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22309]

Synonyms

UGT1A1;
EC 2.4.1.17;
Bilirubin-specific UDPGT isozyme 1;
hUG-BR1;
UDP-glucuronosyltransferase 1-1;
UDPGT 1-1;
UGT1*1;
UGT1-01;
UGT1.1;
UDP-glucuronosyltransferase 1A isoform 1

Research

Bioassay Publications (12)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (8.33)	29.6817
2010's	8 (66.67)	24.3611
2020's	3 (25.00)	2.80

Compounds (52)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
coumarin	Homo sapiens (human)	IC50	300.0000	1	5
bupropion	Homo sapiens (human)	IC50	228.0000	1	5
carvedilol	Homo sapiens (human)	IC50	19.5000	2	2
chlorzoxazone	Homo sapiens (human)	IC50	300.0000	1	5
diclofenac	Homo sapiens (human)	IC50	131.0000	1	3
diclofenac	Homo sapiens (human)	Ki	52.0000	1	1
furafylline	Homo sapiens (human)	IC50	300.0000	1	6
ketoconazole	Homo sapiens (human)	IC50	20.0000	2	2
midazolam	Homo sapiens (human)	IC50	75.5000	1	4
niflumic acid	Homo sapiens (human)	IC50	33.0000	2	2
omeprazole	Homo sapiens (human)	IC50	228.2000	1	5
phenacetin	Homo sapiens (human)	IC50	300.0000	1	7
probenecid	Homo sapiens (human)	Ki	221.0000	1	1
riluzole	Homo sapiens (human)	IC50	170.0000	2	2
sulfaphenazole	Homo sapiens (human)	IC50	300.0000	1	6
tolbutamide	Homo sapiens (human)	IC50	296.2000	1	5
thyroxine	Homo sapiens (human)	IC50	5.2500	2	2
ethinyl estradiol	Homo sapiens (human)	IC50	32.5000	2	2
2,6-dihydroxyanthraquinone	Homo sapiens (human)	IC50	3.8000	2	2
1-naphthol	Homo sapiens (human)	IC50	260.0000	2	2
chlormethiazole	Homo sapiens (human)	IC50	300.0000	1	5
alpha-naphthoflavone	Homo sapiens (human)	IC50	115.4000	1	5
hydroxyphenytoin	Homo sapiens (human)	IC50	115.0000	2	2
paclitaxel	Homo sapiens (human)	IC50	139.7800	1	5
oleandomycin	Homo sapiens (human)	IC50	154.0000	1	7
sn 38	Homo sapiens (human)	IC50	360.0000	1	1
(S)-Mephenytoin	Homo sapiens (human)	IC50	300.0000	1	5
atazanavir	Homo sapiens (human)	IC50	0.3750	3	4
scutellarin	Homo sapiens (human)	Ki	96.6000	1	1
ritonavir	Homo sapiens (human)	IC50	2.3500	2	2
quinidine	Homo sapiens (human)	IC50	273.2000	1	5
farnesol	Homo sapiens (human)	IC50	43.5000	2	2
hymecromone	Homo sapiens (human)	IC50	100.0000	2	2
baicalein	Homo sapiens (human)	IC50	5.7000	2	2
scutellarein	Homo sapiens (human)	Ki	41.3000	1	1
daidzein	Homo sapiens (human)	IC50	63.6500	2	2
irilone	Homo sapiens (human)	Ki	11.3000	2	2
cyclosporine	Homo sapiens (human)	IC50	211.8333	1	6
licochalcone a	Homo sapiens (human)	IC50	0.9700	1	1
raltegravir	Homo sapiens (human)	IC50	180.0000	2	2
dolutegravir	Homo sapiens (human)	IC50	100.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ezogabine	Homo sapiens (human)	EC50	3.9000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
acetaminophen	Homo sapiens (human)	Km	9,400.0000	1	1
edaravone	Homo sapiens (human)	KmH	284.8000	1	1
troglitazone	Homo sapiens (human)	Km	58.0000	1	1
ethinyl estradiol	Homo sapiens (human)	Km	14.5000	1	2
etoposide	Homo sapiens (human)	Km	503.0000	1	1
sn 38	Homo sapiens (human)	Km	24.5000	2	2
ezogabine	Homo sapiens (human)	Km	460.0000	1	1
c 1311	Homo sapiens (human)	Km	28.9000	1	1
ezetimibe	Homo sapiens (human)	Km	64.0000	1	1
scutellarin	Homo sapiens (human)	Km	174.0000	1	1
mycophenolic acid	Homo sapiens (human)	Km	185.0000	1	1
alpha-hydroxytamoxifen	Homo sapiens (human)	Km	133.5000	1	2
scutellarein	Homo sapiens (human)	Km	5.2700	2	2
irilone	Homo sapiens (human)	Km	28.7500	2	2
nalorphine	Homo sapiens (human)	Km	2,075.0000	1	1
naltrexone	Homo sapiens (human)	Km	1,310.0000	1	1
morphine-3-glucuronide	Homo sapiens (human)	Km	18,700.0000	1	1
dolutegravir	Homo sapiens (human)	Km	21.0000	1	1

Enables

This protein enables 7 target(s):

Target	Category	Definition
retinoic acid binding	molecular function	Binding to retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. [GOC:hjd]
enzyme inhibitor activity	molecular function	Binds to and stops, prevents or reduces the activity of an enzyme. [GOC:ai, GOC:ebc]
steroid binding	molecular function	Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732]
glucuronosyltransferase activity	molecular function	Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. [RHEA:21032]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]
protein heterodimerization activity	molecular function	Binding to a nonidentical protein to form a heterodimer. [GOC:ai]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
perinuclear region of cytoplasm	cellular component	Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
endoplasmic reticulum chaperone complex	cellular component	A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1. [PMID:12475965]
cytochrome complex	cellular component	A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. [GOC:mah]

Involved In

This protein is involved in 20 target(s):

Target	Category	Definition
liver development	biological process	The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. [GOC:add, ISBN:068340007X]
bilirubin conjugation	biological process	The chemical reactions and pathways resulting in the formation of bilirubin monoglucuronide or bilirubin diglucuronide, water-soluble derivatives of bilirubin. [DOI:10.1016/0305-0491(80)90243-6]
xenobiotic metabolic process	biological process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
acute-phase response	biological process	An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals. [ISBN:0198506732]
response to nutrient	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. [GOC:go_curators]
steroid metabolic process	biological process	The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684]
estrogen metabolic process	biological process	The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. [ISBN:0198506732]
animal organ regeneration	biological process	The regrowth of a lost or destroyed animal organ. [GOC:mah]
response to lipopolysaccharide	biological process	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, ISBN:0721601464]
retinoic acid metabolic process	biological process	The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
response to starvation	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. [GOC:go_curators]
negative regulation of steroid metabolic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. [GOC:go_curators]
flavone metabolic process	biological process	The chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone). [PMID:18567791]
cellular glucuronidation	biological process	The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor. [GOC:BHF]
flavonoid glucuronidation	biological process	The modification of a flavonoid by the conjugation of glucuronic acid. The resultant flavonoid glucuronosides are often much more water-soluble than the precursor. [GOC:BHF, PMID:20056724]
xenobiotic glucuronidation	biological process	The modification of a xenobiotic substance by the conjugation of glucuronic acid. The resultant glucuronosides are often much more water-soluble than the xenobiotic precursor, enabling efficient excretion. [GOC:BHF, PMID:20056724]
biphenyl catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs). [PMID:16310831, PMID:16339959]
cellular response to ethanol	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. [GOC:mah]
cellular response to glucocorticoid stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [GOC:mah]
cellular response to estradiol stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah]