Page last updated: 2024-11-13

zilascorb

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

zilascorb: RN given refers to unlabeled parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	54682464
CHEMBL ID	2221292
SCHEMBL ID	62540
MeSH ID	M0192335

Synonyms (18)

Synonym
tumor necrosisfactor-alpha (tnf-.a.) & sodium 5,6-benzylidene-l-ascorbate
sba & tnf-.a.
(4's,5r)-3,4-dihydroxy-5-(2'-phenyl-[1',3']dioxolan-4'-yl)-5h-furan-2-one
(2r)-3,4-dihydroxy-2-[(4s)-2-phenyl-1,3-dioxolan-4-yl]-2h-furan-5-one
zilascorb
l-ascorbic acid, 5,6-o-(phenylmethylene)-
sodium-5,6-o-benzylidene ascorbate
5,6-o-benzylidene-l-ascorbic acid
20664-60-2
t544m6z94a ,
unii-t544m6z94a
SCHEMBL62540
SWTGJCNCBUCXSS-ISUZDFFFSA-N
CHEMBL2221292
l-ascorbic acid, 5,6-o-benzylidene-
DTXSID50942865
5,6-o-benzylidenehex-1-enofuranos-3-ulosato(2-)
Q27289686

Research Excerpts

Overview

Zilascorb(2H) is a benzaldehyde derivative giving rise to strong protein synthesis inhibition.

Excerpt	Reference	Relevance
"Zilascorb(2H) is a benzaldehyde derivative giving rise to strong protein synthesis inhibition. "	( Zilascorb(2H), a low-toxicity protein synthesis inhibitor that exhibits signs of anticancer activity in malignant melanoma. Aamdal, S; Gullaksen, N; Ingvar, C; Mette, E; Osmundsen, K; Semb, KA, 1998)	3.19

Bioavailability

Excerpt	Reference	Relevance
" Zilascorb(2H) in tablet formulation had a bioavailability of 32%, was quickly absorbed and slowly eliminated."	( Zilascorb(2H), a new reversible protein synthesis inhibitor: clinical study of an oral preparation. Aamdal, S; Bibow, K; Fodstad, O; Klem, B; Osmundsen, K; Semb, KA, 1997)	2.65

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	6 (85.71)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (14.29)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	2 (5.41%)	5.53%
Reviews	2 (5.41%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	33 (89.19%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	1.98	1	0	dihydrogen
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	1.98	1	0	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	5.32	7	2	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent

Condition	Relationship Strength	Studies	Trials
Cancer of Colon [description not available]	2.05	1	0
Colonic Neoplasms Tumors or cancer of the COLON.	2.05	1	0
Fibrosarcoma A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)	1.98	1	0
Malignant Melanoma [description not available]	8.78	2	1
Cancer of Ovary [description not available]	1.98	1	0
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	8.78	2	1
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	1.98	1	0
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	1.98	1	0
B16 Melanoma [description not available]	1.98	1	0
Benign Neoplasms [description not available]	3.38	1	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.38	1	1

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