acetylcysteine has been researched along with Necrosis in 126 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (10.32) | 18.7374 |
| 1990's | 13 (10.32) | 18.2507 |
| 2000's | 53 (42.06) | 29.6817 |
| 2010's | 45 (35.71) | 24.3611 |
| 2020's | 2 (1.59) | 2.80 |
| Authors | Studies |
|---|---|
| Ezhilarasan, D; Gayatri Devi, R | 1 |
| Ezhilarasan, D; Raghunandhakumar, S | 1 |
| Borozan, S; Čolović, M; Djuric, D; Dragutinović, V; Krstić, D; Labudović-Borović, M; Mitrović, D; Šćepanović, L; Stojanović, M; Todorović, D | 1 |
| Fuentes-Calvo, I; López-Hernández, FJ; López-Novoa, JM; Martínez-Salgado, C; Morales, AI; Prieto, M; Prieto-García, L; Sancho-Martínez, SM | 1 |
| McClain, SA; Singer, AJ; Towery, H | 1 |
| Aldridge, K; Bowden, A; Dosanjh, D; Foronjy, R; Grudzinska, FS; Lewis, KE; Lugg, ST; Mahida, RY; Naidu, B; Parekh, D; Sapey, E; Scott, A; Thickett, DR | 1 |
| Chen, A; Guo, Q; Jia, Y; Jiang, S; Jin, H; Li, M; Shao, J; Tan, S; Wang, F; Wang, L; Zhang, F; Zhang, Z; Zheng, S | 1 |
| Chang, YL; Chen, CH; Chen, CJ; Chen, WY; Chian, CY; Ho, YC; Huang-Liu, R; Kuan, YH; Lee, CY; Lee, SS; Lin, ML; Su, CH; Tsai, PK; Yang, ML | 1 |
| Hoekstra, LT; Riestiano, B; Saputro, I; Zarasade, L | 1 |
| Chao, X; Ding, WX; Du, K; Jaeschke, AH; Jaeschke, H; Ramachandran, A; Weemhoff, JL; Woolbright, BL | 1 |
| Aoyama, E; Fujita, H; Inoue, K; Kobuchi, H; Nakanishi, T; Ogino, T; Ohmoto, N; Oka, T; Sasaki, J; Yamamoto, M | 1 |
| Abe, I; Chanvorachote, P; Cheun-Arom, T; Chuanasa, T; Saito, N; Sirimangkalakitti, N; Suwanborirux, K | 1 |
| Hseu, YC; Hsu, LS; Hunag, JE; Kao, SH; Lee, MJ; Sheu, GT; Wang, CJ; Yeh, CW | 1 |
| Dorko, K; Forster, J; Jaeschke, H; Kumer, SC; McGill, MR; Schmitt, TM; Xie, Y | 1 |
| Han, BR; Kim, SH; Park, WH; Shin, HR; You, BR | 1 |
| Azarpira, N; Bazyari, M; Heidari, R; Jamshidzadeh, A; Najibi, A; Niknahad, H | 1 |
| Brandi, ML; Fontani, F; Iantomasi, T; Marcucci, G; Vincenzini, MT | 1 |
| Li, CJ; Pang, CY; Sun, LY | 1 |
| Bae, UJ; Koh, HW; Park, BH; Zhou, L | 1 |
| Balszuweit, F; Kehe, K; Menacher, G; Popp, T; Schmidt, A; Steinritz, D; Thiermann, H; Worek, F | 1 |
| Coen, M; Foster, J; Holmes, E; Kavanagh, TJ; Kyriakides, M; Maitre, L; Mohar, I; Nelson, SD; Stamper, BD; Wilson, ID | 1 |
| Chung, IF; Fann, MJ; Jiang, JH; Kao, LS; Wu, PC; Yang, TC | 1 |
| Jing, L; Ren, L; Sun, Z; Wang, J; Wei, J; Yang, M; Zhang, J; Zhang, L; Zhou, X | 1 |
| Chen, Y; Li, Y; Su, W; Wang, T; Ying, Z; Zhang, H; Zhang, J; Zhang, L; Zhou, L | 1 |
| Chen, M; Feng, J; Lan, J; Li, J; Liang, W; Song, M; Zhang, W; Zheng, D | 1 |
| Lóopez-Marure, R; Massó, FA; Montaño, LF; Páez, A; Rodríguez, E; Sánchez, CA; Varela, E; Zapata, E | 1 |
| Patel, R; Studzinski, GP; Wang, X | 1 |
| Cho, YH; Choi, JY; Chung, HW; Kang, SJ; Kim, BM; Kim, YJ; Lee, YJ; Woo, HD | 1 |
| Cai, YQ; Liu, CW; Zhang, SP; Zhou, YJ | 1 |
| Altan, H; Arslan, C; Bozkurt, AK; Koksal, C; Konukoglu, D; Ustundag, N | 1 |
| Chen, YW; Huang, CF; Liu, SH; Tsai, KS; Yang, CY; Yen, CC | 1 |
| Paquet, P; Piérard, GE | 1 |
| Nickoloff, BJ; Qin, JZ; Xin, H | 1 |
| Bouchier-Hayes, DJ; Lee, MJ; Moloney, MA; O'Donnell, DH | 1 |
| Bora, N; Gadadhar, S; Karande, AA | 1 |
| Bergmann, M; Fassl, A; Gdynia, G; George, J; Kees, T; Keith, M; Kopitz, J; Roth, W; Schirmacher, P; Weber, AN; Wiestler, OD; Zentgraf, HW | 1 |
| Abdallah, Y; Erdogan, A; Gündüz, D; Iraqi, W; Kasseckert, SA; Ladilov, Y; Neuhof, C; Piper, HM; Reusch, HP; Said, M; Schlüter, KD; Shahzad, T; Tillmanns, H | 1 |
| Chen, D; Li, J; Liu, Z; Wang, H; Wang, L | 1 |
| Avigan, D; Kharbanda, S; Kufe, D; Rosenblatt, J; Stone, R; Wu, Z; Yin, L | 1 |
| Bächle, AC; Harder, Y; Menger, MD; Mörsdorf, P; Ong, MF; Rezaeian, F | 1 |
| Chiou, LL; Dong, CY; Huang, GT; Lee, HS; Li, FC; Lin, CJ; Lo, SY; Lo, W; Sun, TL; Wang, SS | 1 |
| Chakravarthi, S; Haleagrahara, N; Julian, V | 1 |
| Chen, ZQ; Fu, SB; Huang, Z; Li, JH; Liu, JY; Ren, FB; Yue, W; Zhan, Q | 1 |
| Morimoto, R; Obinata, A | 1 |
| Chu, HW; Kosmider, B; Mason, RJ; Messier, EM | 1 |
| Arthur, PG; Grounds, MD; Radley-Crabb, HG; Terrill, JR | 1 |
| Abe, N; Murata, Y; Nakamura, Y; Okuhira, M; Tsutsui, C | 1 |
| Braz, LG; Castiglia, YM; Fabris, VE; Mansano, AM; Silva, LM; Vianna, PT | 1 |
| Antus, C; Engelmann, P; Gallyas, F; Lorand, T; Priber, JK; Racz, B; Radnai, B; Sumegi, B; Tucsek, Z; Turi, Z; Veres, B | 1 |
| de Senzi Moraes Pinto, R; Ferretti, R; Marques, MJ; Minatel, E; Moraes, LH; Neto, HS | 1 |
| Borman, H; Deniz, M; Haberal, M; Seyhan, T | 1 |
| Carbonel, AA; Montero, EF; Silva, SM; Simões, MJ; Taha, MO | 1 |
| Gauthier, ER; Guérin, PJ | 1 |
| Hinson, JA; James, LP; Lamps, LW; McCullough, SS | 1 |
| Broaddus, WC; Dent, P; Fisher, PB; Gopalkrishnan, RV; Grant, S; Lebedeva, IV; Lister, A; McKinstry, R; Mitchell, C; Qiao, L; Ramakrishnan, V; Sarkar, D; Sigmon, C; Su, ZZ; Yacoub, A | 1 |
| Bernhard, D; Bonn, GK; Huck, CW; Kind, M; Pfister, G; Salvenmoser, W; Wick, G | 1 |
| Borutaite, V; Brown, GC | 1 |
| Jung, MJ; Kweon, MH; Sung, HC | 1 |
| Kang, JJ; Kim, EK; Kim, SS; Koh, HJ; Kwon, OW; Lee, JH; Lee, SC; Shin, SH; Song, J | 1 |
| Agarwal, A; Claffey, KP; Klueh, U; Muñoz-Nájar, U; Shih, SC | 1 |
| Hirsh, M; Iancu, TC; Manov, I | 1 |
| Arriaza, E; Cara, C; Di Paola, M; Escribano, O; Fernández-Moreno, MD; Fueyo, JA; Guijarro, LG; Lorusso, M; Menor, C; Olleros, T; Román, ID | 1 |
| Almazan, G; Chemtob, S; Fragoso, G; Khorchid, A; Liu, HN; Martínez-Bermúdez, AK; Mushynski, WE | 1 |
| Andrades, M; Dal-Pizzol, F; Martins, MR; Menna-Barreto, S; Moreira, JC; Quevedo, J; Reinke, A; Ritter, C; Rocha, J | 1 |
| Kimoto-Kinoshita, S; Nishida, S; Tomura, TT | 1 |
| Csordas, A; Galfi, P; Jakus, J; Molnar, T; Neogrady, S | 1 |
| Bockmühl, U; Fuchs, J; Gross, J; Jahnke, V; Kietzmann, T; Machulik, A | 1 |
| Dambach, DM; Durham, SK; Laskin, DL; Laskin, JD | 1 |
| Albano, E; Badger, TM; Butura, A; Ingelman-Sundberg, M; Korourian, S; Petersen, DR; Prior, RL; Ronis, MJ; Sampey, BP; Shankar, K | 1 |
| Ayim, A; Brell, B; Hammerschmidt, S; Hippenstiel, S; Hocke, AC; N'Guessan, PD; Rosseau, S; Schmeck, B; Suttorp, N | 1 |
| Bognar, Z; Debreceni, B; Gallyas, F; Hanto, K; Sumegi, B; Tapodi, A; Varbiro, G; Wittmann, I | 1 |
| Arkadopoulos, N; Farantos, C; Kairi, E; Kostopanagiotou, G; Paphiti, A; Smyrniotis, V; Theodoraki, K; Theodoropoulos, T | 1 |
| Athersuch, TJ; Keun, H; Nicholson, JK; Tang, H | 1 |
| Khandelwal, S; Pathak, N | 1 |
| Johnson, VJ; Kim, J; Kim, SH; Sharma, RP | 1 |
| Aller, P; Amrán, D; de Blas, E; Fernández, C; Ramos, AM; Sancho, P; Susin, SA; Yuste, VJ | 1 |
| Abdalla, DS; Alves, VA; Carrilho, FJ; de Lima, VM; de Oliveira, CP; de Oliveira, MG; Laurindo, FR; Lopasso, FP; Simplicio, FI; Yuahasi, K | 1 |
| Fedak, PW; Fujii, H; Li, SH; Szmitko, PE; Verma, S | 1 |
| Chan, CP; Chang, MC; Chen, LI; Jeng, JH; Lee, PH; Lin, BR; Tsai, YL; Wang, YJ; Wang, YL | 1 |
| Aladag, M; Ara, C; Ciralik, H; Demirel, U; Firat, S; Harputluoglu, MM; Hilmioglu, F; Karincaoglu, M; Temel, I | 1 |
| Duong, HQ; Han, SI; Joo, YM; Kang, HS; Kim, CH; Kim, YJ; Lee, SY; Lim, SC; Moon, JY; Park, HG; Park, MJ; Yoo, MA; Youk, HS | 1 |
| Borges, FT; Dalboni, MA; Garofalo, AS; Pavão dos Santos, OF | 1 |
| Richmond, A; Su, Y; Yang, J | 1 |
| Clouzeau-Girard, H; Combe, C; Desmoulière, A; Guyot, C; Moronvalle-Halley, V | 1 |
| Jóźwiak, Z; Kania, K; Zych, A | 1 |
| Bağriaçik, EÜ; Karasu, C; Stefek, M; Uslu, K; Yurtçu, E | 1 |
| De Felici, M; Farini, D; Klinger, FG; Lobascio, AM; Scaldaferri, ML | 1 |
| Egashira, N; Itoh, Y; Kawashiri, T; Matsuo, M; Oishi, R; Yano, T | 1 |
| Sens, DA; Shavali, S | 1 |
| Amano, O; Fujii, H; Nakamura, Y; Sakagami, H; Shimetani, A; Takahashi, K | 1 |
| Critchley, JA; Prescott, LF | 1 |
| Lake, BG | 1 |
| Isom, GE; Khairy, L; Kildsig, DO | 1 |
| Nagasawa, HT; Zera, RT | 1 |
| Castro, JA; de Castro, CR; Valles, EG | 1 |
| Kalafatis, N; Macrides, TA; Naylor, LM; Shihata, A; Wright, PF | 1 |
| Oberhauser, EW; Rodrigo, RA; Rosenblut, G; Thielemann, LE; Videla, LA | 1 |
| Becks, LL; Dabrowska, MI; Hinshaw, DB; Lelli, JL; Levee, MG | 1 |
| Davis, R; DiMari, J; Megyesi, J; Price, P; Safirstein, R; Udvarhelyi, N | 1 |
| Abdul-Cader, Z; Al-Ali, AK; Al-Mustafa, ZH; Qaw, FS | 1 |
| Bernauer, U; Birner, G; Dekant, W; Werner, M | 1 |
| Ariceta, J; Ferrer, JV; Gomis, T; Guerrero, D; Herrera, J; Larrea, MM; Lera, JM | 1 |
| Ariceta, J; Balén, E; Ferrer, JV; Gomis, T; Guerrero, D; Larrea, MM; Lera, JM | 1 |
| Cabot, MC; Maurer, BJ; Metelitsa, LS; Reynolds, CP; Seeger, RC | 1 |
| Arrigo, AP; Diaz-Latoud, C; Gonin, S; Imbo, A; Manero, F; Richard, MJ; Ursini, MV | 1 |
| Colburn, NH; Collins, K; Davis, MA; Flaws, JA; Young, M | 1 |
| Defraigne, JO; Detry, O; Franssen, C; Limet, R; Meurisse, M; Pincemail, J | 1 |
| Hegde, BM; Raghuveer, CV; Rai, YS; Tripathi, Y | 1 |
| Chen, Q; Gole, M; Gow, AJ; Ischiropoulos, H; Lee, VM; Themistocleous, M | 1 |
| Fioravanti, A; Gambelunghe, C; Lepri, E; Micheletti, A; Pedini, M; Rufini, S | 1 |
| Aller, P; de Blas, E; Fernández, C; Galán, A; Troyano, A; Vilaboa, NE | 1 |
| Morisco, C; Sadoshima, J; Seta, K; Vatner, SF; Yamamoto, S | 1 |
| Gil, DP; Patiño, P; Rojas, M; Rugeles, MT | 1 |
| Bachelet, M; Polla, BS; Richard, MJ; Saunier, B; Souil, E; Thomas, G | 1 |
| Bachelet, M; François, D; Pinot, F; Polla, BS; Polla, RI; Richard, MJ; Vayssier-Taussat, M | 1 |
| Acar, HV; Cankir, Z; Cermik, H; Cinan, U; Danaci, M; Küçükardali, Y; Nalbant, S; Ozkan, S; Top, C | 1 |
| Austin, FD; Carloss, H | 1 |
| Prescott, LF | 1 |
| Best, L; Krenzelok, EP; Manoguerra, AS | 1 |
| Alexander, GJ; Bray, GP; Harrison, PM; Keays, R; Williams, R | 1 |
| Gabbe, SG; Landon, MB; Ludmir, J; Main, DM | 1 |
| Davis, M | 1 |
| Ishmael, J; Lock, EA | 1 |
| Corcoran, GB; Mitchell, JR; Racz, WJ; Smith, CV | 1 |
| Maldonado, AL; Mitchell, MC; Speeg, KV | 1 |
| Hashimoto, M; Jollow, DJ; Mitchell, JR; Potter, WZ; Thorgeirsson, SS | 1 |
2 review(s) available for acetylcysteine and Necrosis
| Article | Year |
|---|---|
The treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Antidotes; Aspartate Aminotransferases; Biotransformation; Chemical and Drug Induced Liver Injury; Cysteamine; Glutathione; Humans; Liver; Methionine; Necrosis; Sulfhydryl Compounds | 1983 |
Protective agents for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Cimetidine; Cysteamine; Glucuronates; Glutathione; Humans; Inactivation, Metabolic; Lipid Peroxides; Liver; Methionine; Necrosis; Propylthiouracil | 1986 |
124 other study(ies) available for acetylcysteine and Necrosis
| Article | Year |
|---|---|
Concurrent administration of farnesol protects acetaminophen-induced acute hepatic necrosis in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Farnesol; Glutathione; Liver; Mice; Necrosis; NF-kappa B; Transaminases | 2023 |
Boldine treatment protects acetaminophen-induced liver inflammation and acute hepatic necrosis in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Aporphines; Chemical and Drug Induced Liver Injury; Cytokines; Gene Expression Regulation; Liver; Male; Mice; Necrosis | 2021 |
Subchronic methionine load induces oxidative stress and provokes biochemical and histological changes in the rat liver tissue.
Topics: Acetylcysteine; Animals; Glutathione; Hepatocytes; Liver; Macrophages; Male; Malondialdehyde; Methionine; Necrosis; Oxidative Stress; Oxidoreductases; Rats; Rats, Wistar | 2018 |
N-acetylcysteine transforms necrosis into apoptosis and affords tailored protection from cisplatin cytotoxicity.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Line; Cell Survival; Cisplatin; Free Radical Scavengers; Humans; Jurkat Cells; Kidney Diseases; Lipid Peroxidation; Male; Necrosis; Rats; Rats, Wistar | 2018 |
Effect of tadalafil on reduction of necrosis in the ischemic zone in a rat comb burn model.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Disease Models, Animal; Disease Progression; Free Radical Scavengers; Ischemia; Naproxen; Necrosis; Random Allocation; Rats; Rats, Sprague-Dawley; Skin; Tadalafil; Vasodilator Agents | 2018 |
Pro-inflammatory effects of e-cigarette vapour condensate on human alveolar macrophages.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Cell Survival; Chemokine CCL2; Complex Mixtures; Electronic Nicotine Delivery Systems; Gases; Humans; Inflammation; Interleukin-6; Interleukin-8; Macrophages, Alveolar; Matrix Metalloproteinase 9; Necrosis; Nicotine; Phagocytosis; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Reactive Oxygen Species; THP-1 Cells; Tumor Necrosis Factor-alpha; Vaping | 2018 |
Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells.
Topics: Acetylcysteine; Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Hepatic Stellate Cells; Liver Cirrhosis; Male; Mice; Mice, Inbred ICR; Mitochondria; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Necrosis; Phosphorylation; Random Allocation; Reactive Oxygen Species; Receptor-Interacting Protein Serine-Threonine Kinases; RNA Interference; RNA, Small Interfering; Sesquiterpenes | 2018 |
Cadmium nitrate-induced neuronal apoptosis is protected by N-acetyl-l-cysteine via reducing reactive oxygen species generation and mitochondria dysfunction.
Topics: Acetylcysteine; Animals; Apoptosis; Cadmium Compounds; Caspases; Cell Death; Cell Line, Tumor; Cell Survival; Membrane Potential, Mitochondrial; Mice; Mitochondria; Necrosis; Neurons; Nitrates; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction | 2018 |
The effect of oral N-acetylcystein on prevention of extensive tissue destruction in electrical burn injury.
Topics: Acetylcysteine; Animals; Antioxidants; Burns, Electric; Creatine Kinase; Disease Models, Animal; Male; Necrosis; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Rhabdomyolysis; Skin; Wound Healing | 2018 |
Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Apoptosis; Caspase 3; Chemical and Drug Induced Liver Injury; Hepatocytes; Male; Mice, Inbred C57BL; Necrosis; Organophosphorus Compounds; Piperidines; Receptor-Interacting Protein Serine-Threonine Kinases | 2019 |
Necrotic and apoptotic cells serve as nuclei for calcification on osteoblastic differentiation of human mesenchymal stem cells in vitro.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Amino Acid Chloromethyl Ketones; Antioxidants; Apoptosis; Calcification, Physiologic; Caspase 3; Caspase Inhibitors; Cell Differentiation; Cell Line; Cell Lineage; Chromatin Assembly and Disassembly; Enzyme Activation; Humans; In Vitro Techniques; Mesenchymal Stem Cells; Necrosis; Osteoblasts; Reactive Oxygen Species | 2014 |
Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.
Topics: Acetylcysteine; Alkaloids; Antineoplastic Agents; Apoptosis; Humans; Hydroquinones; Lung Neoplasms; Molecular Structure; Necrosis; Structure-Activity Relationship; Tetrahydroisoquinolines; Tumor Suppressor Protein p53 | 2013 |
Shikonin time-dependently induced necrosis or apoptosis in gastric cancer cells via generation of reactive oxygen species.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Flow Cytometry; Free Radical Scavengers; Humans; Membrane Potential, Mitochondrial; Mitochondria; Naphthoquinones; Necrosis; Phosphorylation; Reactive Oxygen Species; Stomach Neoplasms; Time Factors | 2014 |
Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; Cell Death; Enzyme Activation; Female; Glutathione; Hepatocytes; Humans; JNK Mitogen-Activated Protein Kinases; Male; Middle Aged; Mitochondria, Liver; Mitochondrial Diseases; Necrosis; Primary Cell Culture; Proteins; Subcellular Fractions; Young Adult | 2014 |
Auranofin induces apoptosis and necrosis in HeLa cells via oxidative stress and glutathione depletion.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Auranofin; Buthionine Sulfoximine; Caspase Inhibitors; Cell Proliferation; Glutathione; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Necrosis; Oligopeptides; Oxidative Stress; Singlet Oxygen | 2015 |
Carbonyl traps as potential protective agents against methimazole-induced liver injury.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carnosine; Chemical and Drug Induced Liver Injury; Male; Metformin; Methimazole; Mice; Necrosis; Oxidative Stress; Protective Agents | 2015 |
Glutathione, N-acetylcysteine and lipoic acid down-regulate starvation-induced apoptosis, RANKL/OPG ratio and sclerostin in osteocytes: involvement of JNK and ERK1/2 signalling.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Animals; Antioxidants; Apoptosis; Bone Diseases; Bone Remodeling; Cell Line; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Glutathione; Glycoproteins; Hydrogen Peroxide; Intercellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; Mice; Necrosis; Osteocytes; Osteoprotegerin; Oxidation-Reduction; Phosphorylation; RANK Ligand; Thioctic Acid | 2015 |
Synergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis.
Topics: Acetylcysteine; Apoptosis; Apoptosis Inducing Factor; Ascorbic Acid; bcl-2-Associated X Protein; Cell Proliferation; Cells, Cultured; Cytochromes c; Drug Synergism; Dynamins; GTP Phosphohydrolases; Histones; Humans; Hydrogen Peroxide; Mesenchymal Stem Cells; Microtubule-Associated Proteins; Mitochondria; Mitochondrial Proteins; Necrosis; Oxidative Stress; Protective Agents; Proto-Oncogene Proteins c-bcl-2 | 2015 |
Aggravation of post-ischemic liver injury by overexpression of insulin-like growth factor binding protein 3.
Topics: Acetylcysteine; Adenoviridae; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Free Radical Scavengers; Gene Expression Regulation; Genetic Vectors; Hep G2 Cells; Humans; Hypothermia, Induced; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Ischemic Preconditioning; Liver; Male; Mice; Mice, Inbred C57BL; Necrosis; Neutrophil Infiltration; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Transgenes | 2015 |
Protective effects of the thiol compounds GSH and NAC against sulfur mustard toxicity in a human keratinocyte cell line.
Topics: Acetylcysteine; Antidotes; Apoptosis; Cell Line; Chemical Warfare Agents; Cytoprotection; Dose-Response Relationship, Drug; Glutathione; Humans; Inflammation Mediators; Interleukin-6; Interleukin-8; Keratinocytes; Mustard Gas; Necrosis; Sulfhydryl Compounds; Time Factors | 2016 |
Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Biomarkers; Biotransformation; Chemical and Drug Induced Liver Injury; Energy Metabolism; Eosinophilia; Glutathione; Isomerism; Liver; Magnetic Resonance Imaging; Male; Metabolomics; Mice, Inbred C57BL; Necrosis; Oxidative Stress; Specific Pathogen-Free Organisms; Tissue Distribution | 2016 |
Cell death caused by the synergistic effects of zinc and dopamine is mediated by a stress sensor gene Gadd45b - implication in the pathogenesis of Parkinson's disease.
Topics: Acetylcysteine; Animals; Antigens, Differentiation; Apoptosis; Cell Cycle Proteins; Cell Death; Dopamine; Drug Synergism; Free Radical Scavengers; Gene Knockdown Techniques; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C57BL; Necrosis; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; PC12 Cells; Rats; Zinc | 2016 |
Endosulfan inducing apoptosis and necroptosis through activation RIPK signaling pathway in human umbilical vascular endothelial cells.
Topics: Acetylcysteine; Apoptosis; Cell Survival; Cells, Cultured; Endosulfan; Endothelial Cells; Humans; Insecticides; Interleukin-33; MAP Kinase Kinase Kinases; Necrosis; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction | 2017 |
N-acetylcysteine attenuates intrauterine growth retardation-induced hepatic damage in suckling piglets by improving glutathione synthesis and cellular homeostasis.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Animals, Suckling; Apoptosis; Aspartate Aminotransferases; Fetal Growth Retardation; Gene Expression; Genes, bcl-2; Glutathione; Homeostasis; Liver; Liver Diseases; Male; Malondialdehyde; Necrosis; Oxidation-Reduction; Sus scrofa | 2018 |
The Opening of ATP-Sensitive K+ Channels Protects H9c2 Cardiac Cells Against the High Glucose-Induced Injury and Inflammation by Inhibiting the ROS-TLR4-Necroptosis Pathway.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Line; Decanoic Acids; Diazoxide; Gene Expression Regulation; Glucose; Glyburide; Hydroxy Acids; Imidazoles; Indoles; Membrane Potential, Mitochondrial; Myocytes, Cardiac; Necrosis; Oxidative Stress; Pinacidil; Potassium Channels; Rats; Reactive Oxygen Species; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction; Sulfonamides; Toll-Like Receptor 4 | 2017 |
Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Atorvastatin; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Membrane; Cell Proliferation; DNA Replication; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Membrane Potential, Mitochondrial; Necrosis; Oxidative Stress; Pyrroles; Reactive Oxygen Species; Simvastatin | 2008 |
hKSR-2, a vitamin D-regulated gene, inhibits apoptosis in arabinocytosine-treated HL60 leukemia cells.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Antioxidants; Apoptosis; Cytarabine; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Necrosis; Oligonucleotides, Antisense; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; RNA, Small Interfering; Vitamin D | 2008 |
Quercetin prevents necrotic cell death induced by co-exposure to benzo(a)pyrene and UVA radiation.
Topics: Acetylcysteine; Antioxidants; Benzo(a)pyrene; Cell Death; Cell Line, Tumor; Cell Survival; DNA Damage; Dose-Response Relationship, Drug; Epithelial Cells; Humans; L-Lactate Dehydrogenase; Necrosis; Quercetin; Reactive Oxygen Species; Sodium Azide; Ultraviolet Rays | 2008 |
The protection of selenium on ROS mediated-apoptosis by mitochondria dysfunction in cadmium-induced LLC-PK(1) cells.
Topics: Acetylcysteine; Animals; Apoptosis; bcl-2-Associated X Protein; Cadmium Chloride; Cell Survival; Cytochromes c; Enzyme Activation; LLC-PK1 Cells; Membrane Potential, Mitochondrial; Mitochondria; Necrosis; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sodium Selenite; Swine | 2009 |
Serine protease inhibitor aprotinin ameliorates renal injury in a rat model of ischemia-perfusion injury.
Topics: Acetylcysteine; Animals; Aprotinin; Glutathione; Inflammation; Kidney; Kidney Tubules; Malondialdehyde; Necrosis; Nephrectomy; Rats; Rats, Wistar; Reperfusion Injury; Serine Proteinase Inhibitors | 2009 |
Inorganic mercury causes pancreatic beta-cell death via the oxidative stress-induced apoptotic and necrotic pathways.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Blotting, Western; Cell Death; Cell Line; Cell Separation; Cricetinae; DNA; Flow Cytometry; Insulin; Insulin-Secreting Cells; L-Lactate Dehydrogenase; Mercuric Chloride; Mice; Mitochondrial Membranes; Necrosis; Oxidative Stress; Reactive Oxygen Species; Signal Transduction | 2010 |
New insights in toxic epidermal necrolysis (Lyell's syndrome): clinical considerations, pathobiology and targeted treatments revisited.
Topics: Acetylcysteine; Apoptosis; Drug Eruptions; Epidermis; Erythema Multiforme; Humans; Immunoglobulins, Intravenous; Keratinocytes; Lymphocyte Activation; Necrosis; Skin; Stevens-Johnson Syndrome; Tumor Necrosis Factor-alpha | 2010 |
3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines.
Topics: Acetylcysteine; Adenosine Triphosphate; Apoptosis; Cell Line, Tumor; Glutathione; Humans; Melanoma; Membrane Potential, Mitochondrial; Necrosis; Pyruvates; Skin Neoplasms; Superoxides | 2010 |
Contrast-induced nephrotoxicity: possible synergistic effect of stress hyperglycemia.
Topics: Acetylcysteine; Analysis of Variance; Animals; Apoptosis; Contrast Media; Dogs; Hyperglycemia; Kidney Diseases; Kidney Tubules; Necrosis; Osmolar Concentration; Oxidative Stress; Taurine | 2010 |
Signaling different pathways of cell death: Abrin induced programmed necrosis in U266B1 cells.
Topics: Abrin; Acetylcysteine; B-Lymphocytes; Caspase Inhibitors; Caspases; Cell Death; Cell Line; Humans; Jurkat Cells; Lysosomes; Membrane Potential, Mitochondrial; Necrosis; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; T-Lymphocytes | 2010 |
Danger signaling protein HMGB1 induces a distinct form of cell death accompanied by formation of giant mitochondria.
Topics: Acetylcysteine; Animals; Apoptosis; Astrocytes; Blotting, Western; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Electrophoresis, Gel, Two-Dimensional; Female; Fluorescent Antibody Technique; Free Radical Scavengers; Glioblastoma; HMGB1 Protein; Humans; JNK Mitogen-Activated Protein Kinases; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Mitochondria; Mitochondrial Proteins; Necrosis; Proteome; Reactive Oxygen Species; Signal Transduction; Tumor Cells, Cultured | 2010 |
Interplay between Ca2+ cycling and mitochondrial permeability transition pores promotes reperfusion-induced injury of cardiac myocytes.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Calcium; Cyclosporine; Fluoresceins; Male; Membrane Potential, Mitochondrial; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Myocytes, Cardiac; Necrosis; Rats; Rats, Wistar; Reactive Oxygen Species; Ruthenium Compounds; Ryanodine; Thapsigargin; Tiopronin | 2011 |
Simultaneous effects of lead and cadmium on primary cultures of rat proximal tubular cells: interaction of apoptosis and oxidative stress.
Topics: Acetates; Acetylcysteine; Adenosine Triphosphatases; Animals; Apoptosis; Cadmium; Calcium; Cell Survival; Cells, Cultured; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Lead; Lipid Peroxidation; Malondialdehyde; Membrane Potential, Mitochondrial; Necrosis; Organometallic Compounds; Oxidative Stress; Rats; Reactive Oxygen Species | 2011 |
MUC1-C oncoprotein suppresses reactive oxygen species-induced terminal differentiation of acute myelogenous leukemia cells.
Topics: Acetylcysteine; Amino Acid Sequence; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Leukemia, Myeloid, Acute; Mucin-1; Necrosis; Oligopeptides; Oxidation-Reduction; Oxidative Stress; Phenotype; Protein Structure, Tertiary; Reactive Oxygen Species | 2011 |
N-acetylcysteine attenuates leukocytic inflammation and microvascular perfusion failure in critically ischemic random pattern flaps.
Topics: Acetylcysteine; Animals; Apoptosis; Arterioles; Capillaries; Cell Adhesion; Dermatologic Surgical Procedures; Inflammation; Ischemia; Leukocyte Rolling; Leukocytes; Mice; Mice, Inbred C57BL; Microcirculation; Microvessels; Necrosis; Regional Blood Flow; Surgical Flaps; Vasodilation | 2011 |
Apical membrane rupture and backward bile flooding in acetaminophen-induced hepatocyte necrosis.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Bile Canaliculi; Cell Membrane; Liver; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Microscopy, Fluorescence, Multiphoton; Necrosis | 2011 |
N-acetylcysteine offers cardioprotection by decreasing cardiac lipid hydroperoxides and 8-isoprostane level in isoproterenol-induced cardiotoxicity in rats.
Topics: Acetylcysteine; Animals; Body Weight; Cardiotonic Agents; Creatine Kinase, MB Form; Dinoprost; Drug Therapy, Combination; Edema; Free Radical Scavengers; Glutathione; Heart; Isoproterenol; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Myocardium; Necrosis; Organ Size; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2011 |
Calcium overload induces C6 rat glioma cell apoptosis in sonodynamic therapy.
Topics: Acetylcysteine; Animals; Apoptosis; Calcium; Caspase 3; Cytochromes c; Egtazic Acid; Fluorometry; Glioma; Hematoporphyrins; Immunoblotting; Intracellular Membranes; Necrosis; Photosensitizing Agents; Rats; Reactive Oxygen Species; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tumor Cells, Cultured; Ultrasonic Therapy | 2011 |
Overexpression of hematopoietically expressed homeoprotein induces nonapoptotic cell death in mouse prechondrogenic ATDC5 cells.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Cartilage; Cell Death; Cell Differentiation; Cell Line; Cell Nucleus; Chondrocytes; Chondrogenesis; Cysteine Proteinase Inhibitors; Drug Evaluation, Preclinical; Free Radical Scavengers; Green Fluorescent Proteins; Heart Function Tests; Homeodomain Proteins; Mice; Molecular Targeted Therapy; Necrosis; Reactive Oxygen Species; Time Factors; Transcription Factors; Transfection; Up-Regulation | 2011 |
Human alveolar epithelial cell injury induced by cigarette smoke.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Apoptosis; Benzimidazoles; Chromans; Epithelial Cells; Humans; In Situ Nick-End Labeling; Lung Diseases; Microscopy, Fluorescence; Necrosis; NF-E2-Related Factor 2; Oxidative Stress; Phenotype; Propidium; Pulmonary Alveoli; Smoking | 2011 |
N-Acetylcysteine treatment of dystrophic mdx mice results in protein thiol modifications and inhibition of exercise induced myofibre necrosis.
Topics: Acetylcysteine; Animals; Antioxidants; Glutathione; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Animal; Necrosis; Oxidative Stress; Physical Conditioning, Animal; Protein Carbonylation; Proteins; Sulfhydryl Compounds | 2012 |
Cytotoxicity of benzyl isothiocyanate in normal renal proximal tubular cells and its modulation by glutathione.
Topics: Acetylcysteine; Animals; Cell Line; Cell Survival; Glutathione; Isothiocyanates; Kidney Tubules, Proximal; Necrosis; Oxidative Stress; Swine | 2012 |
Prevention of renal ischemia/reperfusion injury in rats using acetylcysteine after anesthesia with isoflurane.
Topics: Acetylcysteine; Anesthetics, Inhalation; Animals; Creatinine; Isoflurane; Kidney; Kidney Tubules; Male; Necrosis; Nephrectomy; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury | 2012 |
Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation.
Topics: Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Hep G2 Cells; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinase 9; Necrosis; Phenanthrenes; Poly(ADP-ribose) Polymerase Inhibitors; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA Interference; Signal Transduction | 2012 |
N-acetylcysteine treatment reduces TNF-α levels and myonecrosis in diaphragm muscle of mdx mice.
Topics: Acetylcysteine; Animals; Antioxidants; Diaphragm; Dystrophin; Inflammation; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle, Skeletal; Necrosis; Tumor Necrosis Factor-alpha | 2013 |
An effective antioxidant drug on prevention of the necrosis of zone of stasis: N-acetylcysteine.
Topics: Acetylcysteine; Animals; Antioxidants; Burns; Disease Models, Animal; Male; Necrosis; Rats; Rats, Sprague-Dawley | 2013 |
Proliferative activity in ischemia/reperfusion injury in hepatectomized mice: effect of N-acetylcysteine.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Cell Proliferation; Cytoprotection; Disease Models, Animal; Hepatectomy; Immunohistochemistry; Liver; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Necrosis; Proliferating Cell Nuclear Antigen; Reperfusion Injury; Time Factors | 2012 |
Induction of cellular necrosis by the glutathione peroxidase mimetic ebselen.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Antioxidants; Apoptosis; Azoles; Caspases; Cell Death; Cycloheximide; Cysteine Proteinase Inhibitors; Glutathione Peroxidase; Hybridomas; Isoindoles; Mice; Necrosis; Organoselenium Compounds | 2003 |
Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chemokines; Drug Interactions; Immunoenzyme Techniques; Injections, Intraperitoneal; Liver; Liver Diseases; Male; Mice; Mice, Inbred Strains; Necrosis; Nitric Oxide; Reactive Nitrogen Species; Up-Regulation | 2003 |
Melanoma differentiation-associated 7 (interleukin 24) inhibits growth and enhances radiosensitivity of glioma cells in vitro and in vivo.
Topics: Acetylcysteine; Adenoviridae; Animals; Astrocytes; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Brain Neoplasms; Cell Division; Cell Line; Cell Line, Tumor; Cell Survival; Cells, Cultured; DNA Fragmentation; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Down-Regulation; Gene Transfer Techniques; Genes, Tumor Suppressor; Glioblastoma; Glioma; Glutathione Transferase; Humans; Interleukins; Necrosis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Tetrazolium Salts; Thiazoles; Time Factors | 2003 |
Disruption of vascular endothelial homeostasis by tobacco smoke: impact on atherosclerosis.
Topics: Acetylcysteine; Arteriosclerosis; Endothelium, Vascular; Homeostasis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Models, Biological; Necrosis; Smoking | 2003 |
Nitric oxide induces apoptosis via hydrogen peroxide, but necrosis via energy and thiol depletion.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Caspases; Cell Death; Cell Line; Enzyme Activation; Glutathione; Glycolysis; Hydrogen Peroxide; Macrophages; Mice; Mitochondria; Mitogen-Activated Protein Kinases; Necrosis; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Polyamines; Reactive Oxygen Species; S-Nitrosoglutathione; Sulfhydryl Compounds; Time Factors | 2003 |
Cytoprotective effects of heme oxygenase-1 induction by 3-O-caffeoyl-1-methylquinic acid.
Topics: Acetylcysteine; Animals; Antioxidants; Cattle; Cell Line; Cryoprotective Agents; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Induction; Ferritins; Flow Cytometry; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hydroxybenzoates; Molecular Structure; Necrosis; Protoporphyrins; Quinic Acid; Reactive Oxygen Species; RNA, Messenger; tert-Butylhydroperoxide; Time Factors; Up-Regulation | 2004 |
Zn2+-induced cell death is mediated by the induction of intracellular ROS in ARPE-19 cells.
Topics: Acetylcysteine; Apoptosis; Blotting, Western; Cell Line; Cell Survival; Chlorides; Fluorescein-5-isothiocyanate; Humans; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Necrosis; p38 Mitogen-Activated Protein Kinases; Pigment Epithelium of Eye; Reactive Oxygen Species; Zinc Compounds | 2004 |
N-acetyl-cysteine promotes angiostatin production and vascular collapse in an orthotopic model of breast cancer.
Topics: Acetylcysteine; Angiostatins; Animals; Antioxidants; Apoptosis; Breast Neoplasms; Cell Division; Cell Line, Tumor; Cell Survival; Chickens; Disease Models, Animal; DNA, Complementary; Endothelial Cells; Free Radical Scavengers; Green Fluorescent Proteins; Humans; In Situ Nick-End Labeling; Luminescent Proteins; Lymphatic Metastasis; Mammary Neoplasms, Animal; Mice; Mice, Nude; Microcirculation; Microscopy, Fluorescence; Models, Biological; Necrosis; Neoplasm Metastasis; Neoplasm Transplantation; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Vascular Endothelial Growth Factor A | 2004 |
N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis.
Topics: Acetaminophen; Acetylcysteine; Antioxidants; Apoptosis; Calcium; Cations, Divalent; Cell Line, Tumor; Cell Nucleus; Flow Cytometry; Glutathione; Hepatoblastoma; Humans; Liver Neoplasms; Microscopy, Electron; Necrosis; Oxidation-Reduction; Oxidative Stress; Phosphatidylserines | 2004 |
Azathioprine acts upon rat hepatocyte mitochondria and stress-activated protein kinases leading to necrosis: protective role of N-acetyl-L-cysteine.
Topics: Acetylcysteine; Animals; Apoptosis; Azathioprine; Caspase 3; Caspases; Cell Survival; Cytochromes c; DNA; DNA Fragmentation; Glutathione; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Male; Mitochondria, Liver; Mitogen-Activated Protein Kinase 3; Necrosis; Oxygen Consumption; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Stress, Physiological; Superoxides; Tetrazolium Salts; Thiazoles; Thymidine; Tritium | 2004 |
Developmental differences in HO-induced oligodendrocyte cell death: role of glutathione, mitogen-activated protein kinases and caspase 3.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Cell Death; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glutathione; Hydrogen Peroxide; Mitogen-Activated Protein Kinases; Necrosis; Oligodendroglia; Oxidants; Oxidative Stress; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Stem Cells | 2004 |
Protective effect of N-acetylcysteine and deferoxamine on carbon tetrachloride-induced acute hepatic failure in rats.
Topics: Acetylcysteine; Animals; Antioxidants; Carbon Tetrachloride; Deferoxamine; Hydrocarbons; Inflammation; Liver; Liver Failure, Acute; Male; Models, Animal; Necrosis; Oxidative Stress; Rats; Rats, Wistar | 2004 |
Diethyldithiocarbamate can induce two different type of death: apoptosis and necrosis mediating the differential MAP kinase activation and redox regulation in HL60 cells.
Topics: Acetylcysteine; Apoptosis; Blotting, Western; Cell Death; Cell Line, Tumor; Cell Survival; Chelating Agents; Ditiocarb; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; HL-60 Cells; Humans; Hypoxia; Intracellular Membranes; Ions; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potentials; Metals; Mitochondria; Necrosis; Oxidation-Reduction; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Superoxide Dismutase; Time Factors | 2004 |
Divergent effects of resveratrol, a polyphenolic phytostilbene, on free radical levels and type of cell death induced by the histone deacetylase inhibitors butyrate and trichostatin A.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Butyrates; Cell Death; Cell Line, Tumor; Enzyme Inhibitors; Female; Free Radicals; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Intestinal Mucosa; Kinetics; Mammary Neoplasms, Animal; Mice; Necrosis; Resveratrol; Stilbenes | 2005 |
Apoptosis, necrosis and hypoxia inducible factor-1 in human head and neck squamous cell carcinoma cultures.
Topics: Acetylcysteine; Apoptosis; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Cell Shape; Cobalt; Deferoxamine; DNA-Binding Proteins; Flow Cytometry; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Necrosis; Nuclear Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription Factors | 2005 |
Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Blotting, Western; Chemical and Drug Induced Liver Injury; Chemokine CCL2; Chemokines; Gene Expression; Glutathione; Humans; Inflammation Mediators; Injections, Intraperitoneal; Interleukin-1; Interleukin-10; Interleukin-4; Liver; Macrophage Inflammatory Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Necrosis; NF-kappa B p50 Subunit; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Time Factors; Transcription Factors; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2006 |
Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition.
Topics: Acetylcysteine; Aldehydes; Animals; Antioxidants; Cattle; Central Nervous System Depressants; Cytochrome P-450 CYP2E1; Cytokines; Cytosol; Enteral Nutrition; Ethanol; Glutathione; Immune System; Immunohistochemistry; Inflammation; Kupffer Cells; Lipid Peroxidation; Lipopolysaccharide Receptors; Lipopolysaccharides; Liver; Lymphotoxin-alpha; Male; Malondialdehyde; Necrosis; Oxidants; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha | 2005 |
Streptococcus pneumoniae R6x induced p38 MAPK and JNK-mediated caspase-dependent apoptosis in human endothelial cells.
Topics: Acetylcysteine; Annexin A5; Antioxidants; Apoptosis; Bacterial Proteins; Blotting, Western; Caspase 6; Caspase 9; Caspases; Cell Death; Cells, Cultured; Cyclic AMP; Cytosol; DNA Fragmentation; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Deletion; Humans; Hydrogen Peroxide; L-Lactate Dehydrogenase; Lung; Microscopy, Fluorescence; Mitochondria; Necrosis; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Propidium; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Streptococcus pneumoniae; Streptolysins; Sulfhydryl Compounds; Time Factors; Umbilical Veins | 2005 |
Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose)polymerase-1 inhibition in oxidative stress.
Topics: Acetylcysteine; Blotting, Western; Cell Line; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Liver; Membrane Potentials; Microscopy, Fluorescence; Mitochondria; Models, Biological; Necrosis; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Time Factors | 2005 |
Attenuation of ischemic injury by N-acetylcysteine preconditioning of the liver.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Cyclic AMP; Glutathione Transferase; Ischemic Preconditioning; Liver; Male; Necrosis; Platelet Aggregation; Rats; Rats, Wistar; Reperfusion Injury; Time Factors | 2005 |
Quantitative urinalysis of the mercapturic acid conjugates of allyl formate using high-resolution NMR spectroscopy.
Topics: Acetylcysteine; Animals; Biomarkers; Dose-Response Relationship, Drug; Formic Acid Esters; Glutathione; Injections, Intraperitoneal; Liver; Magnetic Resonance Spectroscopy; Male; Necrosis; Rats; Rats, Sprague-Dawley; Time Factors | 2006 |
Oxidative stress and apoptotic changes in murine splenocytes exposed to cadmium.
Topics: Acetylcysteine; Animals; Apoptosis; Cadmium; Caspase 3; Caspases; Cell Survival; Cells, Cultured; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Combinations; Environmental Pollutants; G1 Phase; Male; Membrane Potentials; Mice; Mice, Inbred BALB C; Mitochondrial Membranes; Necrosis; Oxidative Stress; Pyrrolidines; Spleen; Thiocarbamates | 2006 |
Extracellular signal-regulated kinase-signaling-dependent G2/M arrest and cell death in murine macrophages by cadmium.
Topics: Acetylcysteine; Animals; Cadmium; Cadmium Chloride; Caspase 3; Caspases; Cell Cycle; Cell Death; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; DNA; Extracellular Signal-Regulated MAP Kinases; G2 Phase; Macrophages; Mice; Mice, Inbred BALB C; Necrosis; Phosphorylation; Reactive Oxygen Species; Time Factors | 2005 |
Regulation of apoptosis/necrosis execution in cadmium-treated human promonocytic cells under different forms of oxidative stress.
Topics: Acetylcysteine; Adenosine Triphosphate; Antimetabolites, Antineoplastic; Apoptosis; Benzamides; Buthionine Sulfoximine; Cadmium; Caspase 3; Caspase 9; Caspases; Drug Interactions; Glutathione; Humans; Hydrogen Peroxide; Membrane Potentials; Mitochondria; Monocytes; Necrosis; Oxidants; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Transfection; U937 Cells | 2006 |
Oral administration of S-nitroso-N-acetylcysteine prevents the onset of non alcoholic fatty liver disease in rats.
Topics: Acetylcysteine; Administration, Oral; Animals; Disease Models, Animal; Fatty Liver; Lipid Peroxidation; Liver; Male; Necrosis; Nitrates; Rats; Rats, Wistar; Transaminases | 2006 |
C-reactive protein alters antioxidant defenses and promotes apoptosis in endothelial progenitor cells.
Topics: Acetylcysteine; Antibodies; Apoptosis; C-Reactive Protein; Cells, Cultured; Cytoprotection; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Glutathione Peroxidase; Humans; Necrosis; Osmolar Concentration; Oxidoreductases; Reactive Oxygen Species; RNA Interference; Stem Cells; Superoxide Dismutase; Telomerase; Transfection | 2006 |
Induction of necrosis and apoptosis to KB cancer cells by sanguinarine is associated with reactive oxygen species production and mitochondrial membrane depolarization.
Topics: Acetylcysteine; Alkaloids; Annexin A5; Anticarcinogenic Agents; Antioxidants; Apoptosis; Benzophenanthridines; Catalase; Cell Adhesion; Cell Cycle; Cell Proliferation; Collagen; DNA Fragmentation; Fibronectins; Flow Cytometry; Humans; Isoquinolines; KB Cells; Membrane Potentials; Mitochondrial Membranes; Necrosis; Reactive Oxygen Species; Thiourea; Tumor Stem Cell Assay | 2007 |
Protective effects of Gingko biloba on thioacetamide-induced fulminant hepatic failure in rats.
Topics: Acetylcysteine; Alanine Transaminase; Ammonia; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs, Chinese Herbal; Free Radical Scavengers; Ginkgo biloba; Hepatic Encephalopathy; Liver; Male; Necrosis; Oxidative Stress; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Severity of Illness Index; Thioacetamide; Thiobarbituric Acid Reactive Substances | 2006 |
Protein kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to apoptosis by regulating superoxide dismutases and suppressing reactive oxygen species production in A549 lung cancer cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Caspase 9; Catalase; Cell Line, Tumor; Cell Survival; Endodeoxyribonucleases; Enzyme Activation; Enzyme Induction; Enzyme Stability; Extracellular Signal-Regulated MAP Kinases; Glucose; HMGB1 Protein; Humans; Lung Neoplasms; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Necrosis; Protein Kinase C; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Time Factors | 2007 |
Reactive oxygen species independent cytotoxicity induced by radiocontrast agents in tubular cells (LLC-PK1 and MDCK).
Topics: Acetylcysteine; Animals; Antioxidants; Cell Hypoxia; Cell Line; Cell Line, Tumor; Cell Survival; Contrast Media; Dogs; Kidney; L-Lactate Dehydrogenase; Lung Neoplasms; Necrosis; Radioisotopes; Reactive Oxygen Species; Swine | 2007 |
Antioxidants tiron and N-acetyl-L-cysteine differentially mediate apoptosis in melanoma cells via a reactive oxygen species-independent NF-kappaB pathway.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Antioxidants; Apoptosis; Cell Line, Tumor; Humans; Melanoma; Membrane Potentials; Mitochondria; Necrosis; NF-kappa B; Reactive Oxygen Species | 2007 |
Specific activation of the different fibrogenic cells in rat cultured liver slices mimicking in vivo situations.
Topics: Acetaminophen; Acetylcysteine; Animal Use Alternatives; Animals; Antioxidants; Bile Ducts, Intrahepatic; Cell Survival; Disease Models, Animal; Drug Antagonism; Epidermal Growth Factor; Estradiol; Fibroblasts; Hepatocytes; Kupffer Cells; Liver; Liver Cirrhosis; Male; Necrosis; Organ Culture Techniques; Portal System; Rats; Rats, Wistar; Thioacetamide | 2007 |
Involvement of reactive oxygen species in aclarubicin-induced death of human trisomic and diabetic fibroblasts.
Topics: Acetylcysteine; Aclarubicin; Antibiotics, Antineoplastic; Antioxidants; Apoptosis; Calcium; Cell Line; Diabetes Mellitus, Type 2; Down Syndrome; Fibroblasts; Humans; Membrane Potential, Mitochondrial; Necrosis; Pyrrolidines; Reactive Oxygen Species; Thiocarbamates | 2007 |
Stobadine inhibits doxorubicin-induced apoptosis through a caspase-9 dependent pathway in P815 mastocytoma cells.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Carbolines; Caspase 9; Caspase Inhibitors; Doxorubicin; Mastocytoma; Mice; Necrosis | 2007 |
Analysis of programmed cell death in mouse fetal oocytes.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Autophagy; Caspase Inhibitors; Cell Culture Techniques; Cells, Cultured; Cysteine Proteinase Inhibitors; DNA Fragmentation; Female; Fetus; Glycoproteins; Immunosuppressive Agents; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; Meiotic Prophase I; Mice; Mice, Inbred Strains; Microscopy, Electron, Transmission; Necrosis; Oligopeptides; Oocytes; Ovary; Sirolimus; Stem Cell Factor | 2007 |
Involvement of both tumor necrosis factor-alpha-induced necrosis and p53-mediated caspase-dependent apoptosis in nephrotoxicity of cisplatin.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Caspase Inhibitors; Caspases; Cell Line; Cisplatin; Cysteine Proteinase Inhibitors; Enzyme Activation; Free Radical Scavengers; Kidney Tubules; Necrosis; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Rats; Reactive Oxygen Species; Swine; Toluene; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2007 |
Synergistic neurotoxic effects of arsenic and dopamine in human dopaminergic neuroblastoma SH-SY5Y cells.
Topics: Acetylcysteine; Anticarcinogenic Agents; Antioxidants; Arsenites; Cell Line, Tumor; Cell Survival; Dopamine; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Drug Synergism; Humans; Isothiocyanates; Necrosis; Neuroblastoma; Neurons; Parkinson Disease; Sulfoxides; Thiocyanates | 2008 |
Glutathione can efficiently prevent direct current-induced cytotoxicity.
Topics: Acetylcysteine; Antioxidants; Cell Survival; Cells, Cultured; Cytoprotection; Dental Pulp Cavity; Electricity; Glutathione; Humans; Iontophoresis; Microscopy, Electron, Transmission; Necrosis; Neutrophils; Periapical Periodontitis; Root Canal Irrigants; Root Canal Preparation | 2008 |
Investigations into the mechanism of coumarin-induced hepatotoxicity in the rat.
Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Coumarins; Kinetics; Liver; Liver Diseases; Male; Microsomes, Liver; Naphthalenes; Necrosis; Rats; Rats, Inbred Strains; Sulfhydryl Compounds | 1984 |
Reversal of acetaminophen intoxication with an N-acetylcysteine-liposome preparation.
Topics: Acetaminophen; Acetylcysteine; Animals; Lethal Dose 50; Liposomes; Liver; Male; Mice; Necrosis | 1983 |
N-Acetyl-DL-penicillamine and acetaminophen toxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Male; Mice; Necrosis; Penicillamine | 1980 |
N-acetyl cysteine is an early but also a late preventive agent against carbon tetrachloride-induced liver necrosis.
Topics: Acetylcysteine; Animals; Carbon Tetrachloride; Lipid Peroxidation; Liver; Male; Microsomes, Liver; Necrosis; Rats; Rats, Sprague-Dawley | 1994 |
Hepatoprotective effects of the shark bile salt 5beta-scymnol on acetaminophen-induced liver damage in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestanols; Injections, Intraperitoneal; L-Lactate Dehydrogenase; Liver; Liver Diseases; Male; Mice; Necrosis | 1996 |
N-acetyl-L-cysteine abolishes the bromoethylamine-induced choline incorporation into renal papillary tissue.
Topics: Acetylcysteine; Animals; Choline; Ethylamines; Female; Free Radical Scavengers; Kidney Medulla; Lysophosphatidylcholines; Membranes; Necrosis; Phosphatidylcholines; Rats; Rats, Sprague-Dawley; Regeneration; Sphingomyelins | 1995 |
Sulfur mustard induces apoptosis and necrosis in endothelial cells.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Apoptosis; Cattle; Cell Adhesion; Cells, Cultured; Chemical Warfare Agents; Cytoskeleton; Dose-Response Relationship, Drug; Endothelium, Vascular; GTP-Binding Proteins; Microtubules; Mustard Gas; Necrosis | 1996 |
N-acetyl cysteine ameliorates ischemic renal failure.
Topics: Acetylcysteine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Genes, fos; Genes, jun; Ischemia; JNK Mitogen-Activated Protein Kinases; Kidney; Kidney Tubules, Proximal; Male; Mitogen-Activated Protein Kinases; Necrosis; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Renal Insufficiency; Reperfusion; RNA, Messenger; Transcription, Genetic | 1997 |
Cimetidine enhances the hepatoprotective action of N-acetylcysteine in mice treated with toxic doses of paracetamol.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Cimetidine; Free Radical Scavengers; Glutathione; Histamine H2 Antagonists; Liver; Liver Diseases; Male; Mice; Microsomes, Liver; Necrosis; Survival Rate | 1997 |
Biotransformation, excretion and nephrotoxicity of haloalkene-derived cysteine S-conjugates.
Topics: Acetylation; Acetylcysteine; Animals; Biotransformation; Butadienes; Cysteine; Female; gamma-Glutamyltransferase; Kidney; Liver; Male; Necrosis; Rats; Rats, Wistar; Sex Factors | 1997 |
Somatostatine does not decrease intestinal necrosis in an ischemia-reperfusion experimental model.
Topics: Acetylcysteine; Amylases; Animals; Biomarkers; Glutathione; Intestine, Small; Ischemia; Malondialdehyde; Myocardium; Necrosis; Peroxidase; Rats; Rats, Wistar; Reperfusion; Somatostatin | 1998 |
Allopurinol and N-acetylcysteine avoid 60% of intestinal necrosis in an ischemia-reperfusion experimental model.
Topics: Acetylcysteine; Allopurinol; Animals; Glutathione; Intestine, Small; Ischemia; Lung; Malondialdehyde; Myocardium; Necrosis; Rats; Rats, Wistar; Reperfusion; Reperfusion Injury | 1998 |
Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)- retinamide in neuroblastoma cell lines.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Caspase Inhibitors; Ceramides; DNA Fragmentation; DNA, Neoplasm; Drug Interactions; Fenretinide; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Necrosis; Reactive Oxygen Species; Retinoblastoma; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
p53/T-antigen complex disruption in T-antigen transformed NIH3T3 fibroblasts exposed to oxidative stress: correlation with the appearance of a Fas/APO-1/CD95 dependent, caspase independent, necrotic pathway.
Topics: 3T3 Cells; Acetylcysteine; Animals; Antibodies; Antigens, Polyomavirus Transforming; Antioxidants; Apoptosis; Cell Survival; Cell Transformation, Neoplastic; fas Receptor; Mice; Necrosis; Oxidative Stress; Reactive Oxygen Species; Simian virus 40; Tumor Suppressor Protein p53; Vitamin K | 1999 |
Effect of ceramide on intracellular glutathione determines apoptotic or necrotic cell death of JB6 tumor cells.
Topics: Acetylcysteine; Animals; Apoptosis; Drug Resistance; Glutathione; Mice; Necrosis; Propidium; Reactive Oxygen Species; Skin Neoplasms; Sphingosine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
Ischemia-reperfusion injury of rabbit kidney: comparative effects of desferrioxamine and N-acetylcysteine as antioxidants.
Topics: Acetylcysteine; Animals; Antioxidants; Aspartate Aminotransferases; Deferoxamine; Glutathione; Ischemia; Kidney; Kidney Cortex; L-Lactate Dehydrogenase; Microcirculation; Necrosis; Rabbits; Renal Circulation; Reperfusion Injury; Vitamin E | 2000 |
Effect of N-acetylcysteine and sodium nitrite on myocardial reperfusion injury.
Topics: Acetylcysteine; Animals; Blood Pressure; Dogs; Drug Synergism; Free Radicals; Male; Myocardial Reperfusion Injury; Necrosis; Sodium Nitrite | 1999 |
Two distinct mechanisms of nitric oxide-mediated neuronal cell death show thiol dependency.
Topics: Acetylcysteine; Animals; Cell Death; Cell Differentiation; Cell Line; Cell Survival; Cyclic GMP; Hydrazines; Molsidomine; Necrosis; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants; Sulfhydryl Compounds | 2000 |
N-acetylcysteine increases apoptosis induced by H(2)O(2) and mo-antiFas triggering in a 3DO hybridoma cell line.
Topics: Acetylcysteine; Animals; Antibodies, Monoclonal; Antioxidants; Apoptosis; Chromatography, High Pressure Liquid; Fas Ligand Protein; fas Receptor; Flow Cytometry; Glutathione; Hybridomas; Hydrogen Peroxide; Immunoglobulin G; Indicators and Reagents; Kinetics; Membrane Glycoproteins; Mice; Necrosis; Neutrophils; Oxidation-Reduction; Propidium; Time Factors; Tumor Cells, Cultured | 2000 |
Modulation of the stress response during apoptosis and necrosis induction in cadmium-treated U-937 human promonocytic cells.
Topics: Acetylcysteine; Apoptosis; bcl-2-Associated X Protein; Cadmium Chloride; Chaperonin 60; DNA-Binding Proteins; Dose-Response Relationship, Drug; Glutathione; Heat Shock Transcription Factors; Hot Temperature; HSP70 Heat-Shock Proteins; Humans; Methionine Sulfoximine; Monocytes; Necrosis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured | 2001 |
Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in cardiac myocytes.
Topics: Acetylcysteine; Adenoviridae; Alkaloids; Animals; Animals, Newborn; Annexin A5; Antioxidants; Apoptosis; Benzophenanthridines; Caspases; Cytosol; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Genetic Vectors; Glutathione; Hydrogen Peroxide; Immunoblotting; In Situ Nick-End Labeling; Injections, Intravenous; Microscopy, Fluorescence; Myocardium; Necrosis; Phenanthridines; Protein Isoforms; Protein Kinase C; Rats; Rats, Wistar; Reactive Oxygen Species; Staurosporine; Subcellular Fractions; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
Differential modulation of apoptosis and necrosis by antioxidants in immunosuppressed human lymphocytes.
Topics: Acetylcysteine; Adult; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Antioxidants; Apoptosis; Ascorbic Acid; Cyclosporine; Dexamethasone; Glucocorticoids; Humans; Immunosuppressive Agents; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Lectins, C-Type; Lymphocyte Activation; Lymphocytes; Male; Necrosis; Phytohemagglutinins; Superoxides | 2002 |
Hyperthermia assists survival of astrocytes from oxidative-mediated necrotic cell death.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Astrocytes; Cell Death; Cell Survival; Cells, Cultured; Glutathione; Hot Temperature; HSP70 Heat-Shock Proteins; Hyperthermia, Induced; Necrosis; Oxidative Stress; Rats; Smoke | 2002 |
Toxicity of cadmium in tobacco smoke: protection by antioxidants and chelating resins.
Topics: Acetylcysteine; Adenosine Triphosphate; Anions; Antioxidants; Cadmium; Cadmium Chloride; Cation Exchange Resins; Cell Death; Cells, Cultured; Chelating Agents; Dose-Response Relationship, Drug; Flow Cytometry; Free Radical Scavengers; Glutathione; HSP70 Heat-Shock Proteins; Humans; Microscopy, Immunoelectron; Monocytes; Necrosis; Reactive Oxygen Species; Resins, Synthetic; Smoking; Superoxides; Time Factors | 2002 |
Comparison of the therapeutic efficacy of 4-methylpyrazole and N-acetylcysteine on acetaminophen (paracetamol) hepatotoxicity in rats.
Topics: Acetaminophen; Acetylcysteine; Alcohol Dehydrogenase; Analgesics, Non-Narcotic; Animals; Antidotes; Drug Therapy, Combination; Fomepizole; Liver; Male; Necrosis; Pyrazoles; Rats; Rats, Wistar; Transaminases | 2002 |
Management of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Humans; Liver; Necrosis | 1979 |
Paracetamol poisoning. Prevention of liver damage.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Necrosis | 1979 |
Acetaminophen toxity.
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Necrosis; Sulfhydryl Compounds | 1977 |
Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Aspartate Aminotransferases; Drug Evaluation; Female; Hepatic Encephalopathy; Humans; Infusions, Intravenous; Liver; Male; Necrosis; Prognosis; Prothrombin Time; Retrospective Studies; Time Factors | 1990 |
Maternal acetaminophen overdose at 15 weeks of gestation.
Topics: Acetaminophen; Acetylcysteine; Adult; Female; Fetus; Humans; Liver; Necrosis; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Second; Time Factors; Ventilators, Mechanical | 1986 |
Nephrotoxicity of hexachlorobutadiene and its glutathione-derived conjugates.
Topics: Acetylcysteine; Animals; Butadienes; Cysteine; Female; Glutathione; Kidney Diseases; Kidney Medulla; Kidney Tubules, Proximal; Male; Necrosis; Rats; Sex Factors; Urea | 1986 |
Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Necrosis; Rats; Rats, Inbred F344; Time Factors | 1985 |
Additive protection of cimetidine and N-acetylcysteine treatment against acetaminophen-induced hepatic necrosis in the rat.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Cimetidine; Dose-Response Relationship, Drug; Drug Synergism; Glutathione; Imines; Liver; Male; Necrosis; Rats; Rats, Inbred F344 | 1985 |
Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Animals; Cricetinae; Depression, Chemical; Glutathione; Liver; Mass Spectrometry; Methylcholanthrene; Mice; Necrosis; Phenobarbital; Piperonyl Butoxide; Rats; Species Specificity; Stimulation, Chemical; Tritium | 1974 |