mexiprostil

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

mexiprostil: RN given refers to (11alpha,13E,15R,16R)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	6436041
CHEMBL ID	2107118
SCHEMBL ID	564156
MeSH ID	M0110085

Synonyms (20)

Synonym
mdl-646
dl-646
mexiprostil
methyl 7-[(1r,2r,3r)-3-hydroxy-2-[(e,3r)-3-hydroxy-4-methoxy-4-methyloct-1-enyl]-5-oxocyclopentyl]heptanoate
CHEMBL2107118
88980-20-5
unii-l5u1x99q9z
mexiprostilum [latin]
mexiprostilum
mexiprostilo [spanish]
l5u1x99q9z ,
methyl (13e,15r)-11alpha,15-dihydroxy-4-methoxy-4-methyl-5-oxo-13-prostenoat
mexiprostilo
methyl (1r,2r,3r)-3-hydroxy-2-((e)-(3r)-3-hydroxy-4-methoxy-4-methyloctyl)-5-oxocyclopentaneheptanoate
mexiprostil [inn]
mexiprostil [mart.]
methyl (1r,2r,3r)-3-hydroxy-2-((e)-(3r)-3-hydroxy-4(rs)-methoxy-4-methyloctyl)-5-oxocyclopentaneheptanoate
SCHEMBL564156
Q27282746
DTXSID901021628

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
"Nephrotoxicity is the most troublesome side effect of cyclosporin A (CSA) therapy."	( Lack of effect of verapamil and MDL 646, a cytoprotective PGE1 analogue on cyclosporin A nephrotoxicity in vitro. Hall, TJ; Heckel, C, 1990)	0.28

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	11 (91.67)	18.7374
1990's	1 (8.33)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	4 (30.77%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (69.23%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
histamine [no description available]	1.96	1	0	aralkylamino compound; imidazoles	human metabolite; mouse metabolite; neurotransmitter
verapamil Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.	1.97	1	0	aromatic ether; nitrile; polyether; tertiary amino compound
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	1.96	1	0	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.37	2	0	prostaglandins E	human metabolite; mouse metabolite; oxytocic
alprostadil [no description available]	6.14	12	3	prostaglandins E	anticoagulant; human metabolite; platelet aggregation inhibitor; vasodilator agent
pentagastrin Pentagastrin: A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.	4.6	3	2	organic molecular entity

Condition	Relationship Strength	Studies
Gastric Ulcer [description not available]	1.96	1
Stomach Ulcer Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	1.96	1
Abortion, Tubal [description not available]	1.96	1
Abortion, Spontaneous Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.	1.96	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	1.96	1
Gastric Diseases [description not available]	1.96	1
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	1.96	1
Kidney Diseases Pathological processes of the KIDNEY or its component tissues.	1.97	1

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