bisphenol a

Research Excerpts

Overview

Bisphenol A (BPA) is a toxic endocrine disrupting chemical that is released into the environment through modern manufacturing practices. One of the significant external routes of daily BPA exposure is diet. It is widely used in the production of polycarbonate plastics and epoxy resins.

Excerpt	Reference	Relevance
"Bisphenol A (BPA) is a chemical compound commonly used in the production of plastics for daily lives and industry. "	( Comparative toxicities of BPA, BPS, BPF, and TMBPF in the nematode Caenorhabditis elegans and mammalian fibroblast cells. Curry, S; Han, SM; Heo, JD; Hwang, KH; Hyun, M; Kim, HJ; Leeuwenburgh, C; McElroy, T; Rathor, L; Wohlgemuth, S; Xiao, R, 2021)	2.06
"Bisphenol A (BPA) is a known endocrine disruptor and has been gradually replaced in industrial applications by other bisphenols, such as bisphenol S (BPS). "	( Hyperactivity of basolateral amygdala mediates behavioral deficits in mice following exposure to bisphenol A and its analogue alternative. Hu, F; Li, Z; Liang, W; Wang, H; Zhang, L; Zhou, Y, 2022)	2.38
"Bisphenol A (or BPA) is a toxic endocrine disrupting chemical that is released into the environment through modern manufacturing practices. "	( The hazardous threat of Bisphenol A: Toxicity, detection and remediation. Balakumaran, PA; Binod, P; Kumar, D; Kumar, Y; Madhavan, A; Reshmy, R; Sim, SJ; Sindhu, R; Sirohi, R; Tarafdar, A, 2022)	2.47
"Bisphenol A (BPA) is an artificial chemical, and one of the significant external routes of daily BPA exposure is diet. "	( Comparison of daily bisphenol A intake based on dietary and urinary levels in breastfeeding women. Çiftçi, S; Samur, G; Yalçın, SS, 2021)	2.39
"Bisphenol A (BPA) is an artificial chemical widely used in the production of polycarbonate plastics and epoxy resins. "	( Potential role of green tea extract and epigallocatechin gallate in preventing bisphenol A-induced metabolic disorders in rats: Biochemical and molecular evidence. Hosseinzadeh, H; Imenshahidi, M; Mohajeri, SA; Mohsenzadeh, MS; Razavi, BM; Tabatabaee Yazdi, SA, 2021)	2.29
"Bisphenol A (BPA) is an endocrine disrupting chemical that promotes obesity. "	( Bisphenol A induces miR-708-5p through an ER stress-mediated mechanism altering neuronatin and neuropeptide Y expression in hypothalamic neuronal models. Belsham, DD; Lieu, CV; McIlwraith, EK, 2022)	3.61
"Bisphenol A (BPA) is an endocrine disruptor extensively used in the production of polycarbonate plastics and epoxy resins and a component of liquid and food containers. "	( Impact of bisphenol A (BPA) on cells and tissues at the human materno-fetal interface. Manzan-Martins, C; Paulesu, L, 2021)	2.47
"Bisphenol A (BPA) is a substance used in the manufacture of plastics which shows multidirectional adverse effects on living organisms. "	( The Influence of Bisphenol A (BPA) on the Occurrence of Selected Active Substances in Neuregulin 1 (NRG1)-Positive Enteric Neurons in the Porcine Large Intestine. Całka, J; Gonkowski, S; Makowska, K; Szymańska, K, 2021)	2.4
"Bisphenol A (BPA) is an estrogen-like compound, and an environmental hormone, that is commonly used in daily life. "	( Bisphenol A induced apoptosis via oxidative stress generation involved Nrf2/HO-1 pathway and mitochondrial dependent pathways in human retinal pigment epithelium (ARPE-19) cells. Chang, CC; Chen, CJ; Chen, CM; Chen, SP; Chen, WY; Chiang, YW; Kuan, YH; Su, CH; Sun, HY, 2022)	3.61
"Bisphenol A (BPA) is a well-known plasticizer that widely distributed in the aquatic environment. "	( Bisphenol A regulates apolipoprotein A1 expression through estrogen receptors and DNA methlylation and leads to cholesterol disorder in rare minnow testis. Li, B; Wei, W; Yang, H; Zhang, M; Zhang, Y; Zhu, Z, 2021)	3.51
"Bisphenol A (BPA) is a widespread endocrine disruptor affecting many organs and systems. "	( Bisphenol A Induces Accelerated Cell Aging in Murine Endothelium. Bosch, RJ; Cook, A; Delgado-Marín, M; Mínguez-Moratinos, M; Moreno-Gómez-Toledano, R; Ramírez-Carracedo, R; Reventún, P; Sánchez-Esteban, S; Saura, M, 2021)	3.51
"Bisphenol A (BPA) is an environmental contaminant widely suspected to be a neurological toxicant. "	( Bisphenol a Induces Autophagy Defects and AIF-Dependent Apoptosis via HO-1 and AMPK to Degenerate N2a Neurons. Hsieh, CF; Lee, CT; Wang, JY, 2021)	3.51
"Bisphenol A (BPA) is a typical environmental endocrine disruptor that exhibits estrogen-mimicking, hormone-like properties and can cause the collapse of bone homeostasis by an imbalance between osteoblasts and osteoclasts. "	( Effects of Bisphenol A and Its Alternatives, Bisphenol F and Tetramethyl Bisphenol F on Osteoclast Differentiation. Choi, J; Heo, JD; Kim, HM; Lee, SM; Soung, NK, 2021)	2.45
"Bisphenol A (BPA) is a well-known endocrine-disrupting chemical related to the carcinogenesis of estrogen-responsive organs. "	( Effects of bisphenol A on the proliferation, migration, and tumor growth of colon cancer cells: In vitro and in vivo evaluation with mechanistic insights related to ERK and 5-HT3. Cho, JS; Jun, JH; Kwak, YL; Oh, JE; Shim, JK, 2021)	2.45
"Bisphenol A (BPA) is a well-known plasticizer, which is widely distributed in the aquatic environment. "	( Bisphenol A disturbs hepatic apolipoprotein A1 expression and cholesterol metabolism in rare minnow Gobiocypris rarus. Ju, J; Wei, W; Yang, H; Zhang, M; Zhang, Y; Zhu, Z, 2022)	3.61
"Bisphenol A (BPA) is a common endocrine disruptor and a high-fat diet (HFD) also affects fertility. "	( Combinational exposure to Bisphenol A and a high-fat diet causes trans-generational Malfunction of the female reproductive system in mice. Ding, Y; Gao, R; Huang, R; Laurent, I; Li, J; Liao, M; Lin, X; Ma, L; Xiao, X; Zhang, Y, 2022)	2.46
"Bisphenol A (BPA) is a phenolic compound that is widely used to synthesize plastics as a monomer or additive [...]."	( New Evidence of Renal and Cardiovascular Alterations Promoted by Bisphenol A. Arenas, MI; Bosch, RJ; Moreno-Gómez-Toledano, R; Saura, M; Vélez-Vélez, E, 2021)	2.3
"Bisphenol A (BPA) is a well-known endocrine disruptor, widely used in various consumer products and ubiquitously found in air, water, food, dust, and sewage leachates. "	( Bisphenol A Analogues Suppress Spheroid Attachment on Human Endometrial Epithelial Cells through Modulation of Steroid Hormone Receptors Signaling Pathway. Fan, H; Fernando, SR; Jiang, L; Kodithuwakku, SP; Lee, KF; Ng, EHY; Wang, Z; Wong, CKC; Yeung, WSB, 2021)	3.51
"Bisphenol A (BPA) is a chemical agent which can exert detrimental effects on the male reproductive system, especially the prostate gland. "	( Protective effect of the association of curcumin with piperine on prostatic lesions: New perspectives on BPA-induced carcinogenesis. Campos, SGP; Facina, CH; Góes, RM; Ruiz, TFR; Taboga, SR; Vilamaior, PSL, 2021)	2.06
"Bisphenol A (BPA) is an industrial ubiquitous compound, frequently used to produce synthetic polymers and epoxy resins. "	( Perinatal Exposure to Bisphenol A and Developmental Programming of the Cardiovascular Changes in the Offspring. Al-Huseini, I; Das, S; Sirasanagandla, SR; Sofin, RGS, 2022)	2.48
"Bisphenol A (BPA) is a representative endocrine disrupting compound used in a vast array of consumer products, and are being frequently substituted by its analogues, bisphenol S (BPS) and bisphenol F (BPF). "	( Urinary bisphenol concentrations and its association with metabolic disorders in the US and Korean populations. Choi, JY; Huh, DA; Lee, J; Moon, KW, 2022)	2.16
"Bisphenol A (BPA) is a product in the manufacture of Bis-GMA, which is commonly used in dentistry, and is known to have a number of adverse effects."	( Knowledge, attitude and practice on exposure to Bisphenol A among dental surgeons in Southern India. Kumar, HA; Murali, PS; Ravi, MS; Shashidhar, K; Shersha, S; Soans, CR, 2021)	2.32
"Bisphenol A (BPA) is a widely used chemical in plastics but its proven harmful effects has led to the replacement and production of its analogs that might also induce hazard as well as associated risks. "	( Computational risk assessment framework for the hazard analysis of bisphenols and quinone metabolites. Pandit, S; Parthasarathi, R; Singh, P, 2022)	2.16
"Bisphenol A (BPA) is an environmental risk factor for autism spectrum disorder (ASD). "	( Autism-Related Transcription Factors Underlying the Sex-Specific Effects of Prenatal Bisphenol A Exposure on Transcriptome-Interactome Profiles in the Offspring Prefrontal Cortex. Hu, VW; Jindatip, D; Kanlayaprasit, S; Kikkawa, T; Osumi, N; Panjabud, P; Sarachana, T; Thongkorn, S, 2021)	2.29
"Bisphenol A (BPA) is an endocrine-disrupting chemical widely used in plastic products that may have an adverse effect on several physiologic functions in children. "	( The Impact of Bisphenol A on Thyroid Function in Neonates and Children: A Systematic Review of the Literature. Charmandari, E; Koutaki, D; Paltoglou, G; Vourdoumpa, A, 2021)	2.42
"Bisphenol A (BPA) is an environmentally prevalent endocrine disrupting chemical that can impact human health and may be an environmental risk factor for neurodevelopmental disorders. "	( Bisphenol a affects neurodevelopmental gene expression, cognitive function, and neuromuscular synaptic morphology in Drosophila melanogaster. Alfareh, A; Anderson, J; Davis, A; Johnson, E; Lee, W; Miller-Schulze, JP; Mulligan, K; Newman, J; Rodriguez, L; Tinsley, B; Tupikova, A; Visger, C; Welch, C; Widman, E, 2022)	3.61
"Bisphenol A (BPA) BPA is an endocrine-disrupting chemical that has a wide range of uses. "	( Comparative evaluation of the effects of bisphenol derivatives on oxidative stress parameters in HepG2 cells. Bacanli, M; Basaran, N; Erkekoglu, P; Kocer-Gumusel, B; Ozkemahli, G; Ozyurt, AB; Ozyurt, B; Yirun, A, 2023)	2.35
"Bisphenol A (BPA) is a ubiquitous environmental pollutant that can specifically induce estrogen receptor β (ERβ) expression, and the latter plays a crucial role during wound healing. "	( Dual effects of bisphenol A on wound healing, involvement of estrogen receptor β. Li, T; Li, Z; Wen, X; Xu, X; Zhu, M, 2022)	2.51
"Bisphenol A (BPA) is a chemical substance commonly used in the manufacture of plastic products. "	( Evaluation of the Toxicity of Bisphenol A in Reproduction and Its Effect on Fertility and Embryonic Development in the Zebrafish ( Ayala-Soldado, N; Lora-Benítez, AJ; Molina-López, AM; Mora-Medina, R; Moyano-Salvago, MDR; Reis, LPG, 2022)	2.45
"Bisphenol A (BPA) is a synthetic organic compound that is mainly used in the production of polymer materials polycarbonate and epoxy resin. "	( A critical review of presence, removal and potential impacts of endocrine disruptors bisphenol A. Hou, J; Xing, J; Zhang, M; Zhang, S, 2022)	2.39
"Bisphenol A (BPA) is an estrogenic EDC used in food containers, adhesives, dye powders, and dental fillers."	( Bisphenol A reveals its obesogenic effects through disrupting glucose tolerance, oxidant-antioxidant balance, and modulating inflammatory cytokines and fibroblast growth factor in zebrafish. Ak, E; Alturfan, AA; Beler, M; Cansız, D; Dandin, E; Emekli-Alturfan, E; Ünal, İ; Üstündağ, ÜV, 2022)	2.89
"Bisphenol A is a monomeric organic compound belonging to phenols. "	( Plastic – (not) fantastic? Impact of bisphenol A on functioning of mammalian oocytes and embryos Ajduk, A; Gronek, Z; Płocienniak, A; Sadkowska, M; Stodulska, A, 2021)	2.34
"Bisphenol A (BPA) is a substance commonly used in the production of plastics. "	( Concentrations of bisphenol a (BPA) in fresh pork loin meat under standard stock-farming conditions and after oral exposure - A preliminary study. Bodziach, K; Calka, J; Gonkowski, S; Makowska, K; Staniszewska, M, 2022)	2.5
"Bisphenol a (BPA) is a high production volume chemical that is frequently used to manufacture epoxy resins and polycarbonate plastics. "	( Characteristics of Bisphenol Cardiotoxicity: Impaired Excitability, Contractility, and Relaxation. Cooper, BL; Posnack, NG, 2022)	2.16
"Bisphenol A (BPA) is a pollutant, classified as an endocrine-disrupting chemical compound with estrogenic properties, their exposure in the early stages of neonatal life leads to an increase in the size and weight of breast tumors and induces cellular changes in the tumoral immune microenvironment where cytokines play a key role."	( The Endocrine Disruptor Compound Bisphenol-A (BPA) Regulates the Intra-Tumoral Immune Microenvironment and Increases Lung Metastasis in an Experimental Model of Breast Cancer. Garay-Canales, CA; Morales-Montor, J; Moreno-Mendoza, NA; Nava-Castro, KE; Palacios-Arreola, MI; Perez-Torres, A; Segovia-Mendoza, M, 2022)	1.44
"Bisphenol A (BPA) is a common environmental contaminant, whose exposure is associated with the progression of various kidney diseases. "	( Ferritinophagy is involved in Bisphenol A-induced ferroptosis of renal tubular epithelial cells through the activation of the AMPK-mTOR-ULK1 pathway. Bao, L; Duan, S; Feng, L; Fu, Y; Hu, X; Qiu, M; Wu, K; Zhang, N; Zhao, C; Zhao, Y, 2022)	2.45
"Bisphenol A (BPA) is an endocrine disrupting compound that can interfere with endocrine hormone functioning and thereby influence prostate development."	( Impact of chronic exposure of rats to bisphenol A from perinatal period to adulthood on intraprostatic levels of 5α-reductase isozymes, aromatase, and genes implicated in prostate cancer development. Castro, B; Del Moral, RG; Martínez-Rodríguez, S; Ortega, E; Ríos-Pelegrina, R; Sánchez, P; Torres, JM, 2022)	1.71
"Bisphenol A (BPA) is a widely used endocrine disruptor, which has attracted much attention due to its harmful effects on male reproduction. "	( BPA disrupted the testis testosterone levels by interfering ER enrichments within StAR 5' flanking region in rare minnow Gobiocypris rarus. Fu, S; Li, K; Liu, J; Wang, M; Wang, Z; Zhu, L, 2022)	2.16
"Bisphenol A (BPA) is a worldwide used endocrine disrupting chemical that can migration from food containers and packaging, resulting in bioaccumulation of BPA in humans and causing adverse health effects. "	( Tailoring diameters of carbon nanofibers with optimal mesopores to remarkably promote hemin adsorption toward ultrasensitive detection of bisphenol A. Chen, Y; Lei, Y; Li, J; Lu, H; Wang, X; Zhang, Y; Zhang, Z, 2022)	2.37
"Bisphenol A (BPA) is an organic substance widely used in the plastics industry. "	( Hair Sample Analysis as a Method of Monitoring Exposure to Bisphenol A in Dogs. Alonso, E; Aparicio, I; Gonkowski, S; Makowska, K; Martín, J; Rychlik, A; Santos, JL, 2022)	2.41
"Bisphenol A (BPA) is a chemical of major concern due to its endocrine disrupting function, high production volume, and persistence in the aquatic environment. "	( The toxicokinetics of bisphenol A and its metabolites in fish elucidated by a PBTK model. Bado-Nilles, A; Beaudouin, R; Daniele, G; Giroud, B; Mit, C; Vulliet, E, 2022)	2.48
"Bisphenol A (BPA) is an endocrine disruptor, that can cause immune dysfunction. "	( Cineole alleviates the BPA-inhibited NETs formation by regulating the p38 pathway-mediated programmed cell death. Chen, L; Jiang, Z; Qi, M; Tao, D; Wang, T; Xu, S, 2022)	2.16
"Bisphenol A (BPA) is an endocrine disrupting chemical which poses great concern because of its high proportionate industrial production, omnipresent human exposure and budding toxic consequences in human. "	( Molecular dissection of cellular response of pancreatic islet cells to Bisphenol-A (BPA): A comprehensive review. Banerjee, M; Banerjee, O; Kundu, S; Maji, BK; Mukherjee, S; Pal, S; Saha, I; Singh, S; Syamal, AK, 2022)	2.16
"Bisphenol A (BPA) is an endocrine disrupting chemical known to promote adipose tissue mass in vivo and adipogenesis in vitro. "	( Sex-specific extracellular matrix remodeling during early adipogenic differentiation by gestational bisphenol A exposure. Dong, K; Pu, Y; Ticiani, E; Veiga-Lopez, A; Waye, AA; Zhang, H, 2022)	2.38
"Bisphenol A (BPA) is a synthetic estrogen compound, which widely exists in the environment, interferes with mammalian endocrine and affects the function of reproductive system of males. "	( [Effects of bisphenol A exposure on proteins tyrosine phosphorylation in mammalian sperm]. He, JY; He, Q; Hu, QM; Li, MY; Li, SS; Yang, YX, 2022)	2.54
"Bisphenol A (BPA) is a component used in the production of polycarbonate plastics (PC) and epoxy resins, which are currently widely used in food and beverage packaging. "	( Influence of Temperature on the Quantity of Bisphenol A in Bottled Drinking Water. Ciślak, M; Ginter-Kramarczyk, D; Kruszelnicka, I; Zając-Woźnialis, A; Zembrzuska, J, 2022)	2.43
"Bisphenol A (BPA) is an environmental endocrine disruptor. "	( Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats. Bai, W; Cai, D; Chen, J; Jiang, X; Jin, Y; Li, H; Li, X; Li, Z; Liu, B; Liu, R; Sun, J; Teerds, K, 2022)	2.55
"Bisphenol A (BPA) is a compound used in the manufacture of a wide variety of everyday materials that, when released into the environment, causes multiple detrimental effects on humans and other organisms. "	( Bisphenol A in the environment and recent advances in biodegradation by fungi. Ahuactzin-Pérez, M; Cortés-Espinosa, DV; Fernández, FJ; Torres-García, JL, 2022)	3.61
"Bisphenol A (BPA) is an endocrine-disrupting chemical that is used widely in industry; people are exposed to BPA and its products daily."	( Low concentrations of bisphenol A promote the activation of the mitochondrial apoptotic pathway on Beta-TC-6 cells via the generation of intracellular reactive oxygen species and mitochondrial superoxide. Anastasiou, IA; Angelopoulou, A; Eleftheriadou, I; Gorgoulis, V; Karamouzis, MV; Katsaouni, A; Mourouzis, I; Pantos, C; Sarantis, P; Tentolouris, A; Tentolouris, N, 2022)	1.76
"Bisphenol A (BPA) is a synthetic compound utilized in industry for the production of various plastics. "	( Endocrine Disruptor Bisphenol a Affects the Neurochemical Profile of Nerve Fibers in the Aortic Arch Wall in the Domestic Pig. Gonkowski, S; Könyves, L; Rytel, L, 2022)	2.49
"Bisphenol A (BPA) is a polymer used in the production of polycarbonate plastics and epoxy resins. "	( Prenatal bisphenol A exposure in relation to behavioral outcomes in girls aged 4-5 and modification by socio-demographic factors in The Infant Development and Environment Study (TIDES). Barrett, ES; Bush, NR; Collett, BR; Evans, SF; Ibroci, E; Nguyen, RHN; Reichenberg, A; Sathyanarayana, S; Swan, SH; Thurston, SW, 2022)	2.58
"Bisphenol A (BPA) is a renowned plasticizer, and a key component of various plastics, resins, and food packaging materials. "	( Facile hydrothermal synthesis of manganese sulfide nanoelectrocatalyst for high sensitive detection of Bisphenol A in food and eco-samples. Annalakshmi, M; Balamurugan, TST; Chen, SM; He, JL; Kumaravel, S, 2022)	2.38
"Bisphenol A (BPA) is an industrial chemical, which has raised human health and environmental concerns due to its endocrine-disrupting properties. "	( Physiologically Based Toxicokinetic Modeling of Bisphenols in Zebrafish ( Andersson, PL; Chelcea, I; Hamers, T; Koekkoek, J; Legradi, J; Örn, S; Vogs, C, 2022)	2.16
"Bisphenol A (BPA) is a high-production-volume industrial chemical. "	( Bisphenol A Promotes the Progression of Colon Cancer Through Dual-Targeting of NADPH Oxidase and Mitochondrial Electron-Transport Chain to Produce ROS and Activating HIF-1α/VEGF/PI3K/AKT Axis. Cui, B; Guo, J; Liu, Y; Song, C; Xia, T; Zhang, B; Zhao, Q, 2022)	3.61
"Bisphenol A (BPA) is a plastic monomer that can leach into food and cause adverse health effects with long-term exposure. "	( A paper-analytical device for detecting bisphenol-A in foods. Liu, W; Lu, Y; Wang, Q; Wang, R, 2022)	2.16
"Bisphenol A (BPA) is a synthetic chemical used as a monomer in polycarbonate plastics and epoxy resins."	( Human body burden of bisphenol A: a case study of lactating mothers in Florianopolis, Brazil. Adenrele, AO; de Moraes, ACR; de Siqueira, CD; Filippin-Monteiro, FB, 2023)	1.95
"Bisphenol A (BPA) is a major environmental pollutant and food contaminant with endocrine-disrupting effects on human and animal health. "	( Perinatal exposure to environmental endocrine disruptor bisphenol A aggravates the onset of non-alcoholic fatty liver disease (NAFLD) in weanling F1 offspring of obese rats. Dabeer, S; Raisuddin, S, 2023)	2.6
"Bisphenol A (BPA) is a synthetic chemical used for the manufacturing of plastics, epoxy resin, and many personal care products. "	( The effects of prenatal bisphenol A exposure on brain volume of children and young mice. Dewey, D; Dunn, JF; Grohs, M; Hamilton, M; Huo, Y; Kurrasch, D; Landman, B; Lebel, C; Liu, J; Long, M; Martin, J; Ostertag, C; Pollock, T; Reynolds, JE; Zheng, J, 2022)	2.47
"Bisphenol A (BPA) is a widely known endocrine disruptor (ED) found in many children's products such as toys, feeding utensils, and teething rings. "	( Unravelling sex-specific BPA toxicokinetics in children using a pediatric PBPK model. Andrušaitytė, S; Casas, M; Chatzi, L; Deepika, D; Domingo, JL; Grazuleviciene, R; Kumar, V; Quentin, J; Sakhi, AK; Schuhmacher, M; Sharma, RP; Slama, R; Thomsen, C; Urquiza, J; Vafeiadi, M; Vrijheid, M; Waiblinger, D; Wright, J; Yang, TC, 2022)	2.16
"Bisphenol A (BPA) is a ubiquitous environmental toxin with deleterious endocrine-disrupting effects. "	( Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use. Abu, IF; Al-Huseini, I; Das, S; Juliana, N; Moqadass, M; Sakr, H; Sirasanagandla, SR, 2022)	2.44
"Bisphenol A (BPA) is a plasticizer that is used to harden plastics and polycarbonates."	( Effects of single or combined exposure to bisphenol A and mono(2-ethylhexyl)phthalate on oxidant/antioxidant status, endoplasmic reticulum stress, and apoptosis in HepG2 cell line. Ercan, A; Erkekoglu, P; Kocer-Gumusel, B; Ozkemahli, G; Yersal, N; Zeybek, ND, 2023)	1.9
"Bisphenol A is a common environmental factor and endocrine disruptor that exerts a negative impact on male reproductive ability. "	( Bisphenol A induces testicular oxidative stress in mice leading to ferroptosis. Chi, LK; Guo, CR; Jiang, HB; Li, L; Wang, MY; Yao, XQ; Zeng, WW; Zhao, Y; Zhu, XD, )	3.02
"Bisphenol A (BPA) is a widely used endocrine disrupter that causes male reproductive dysfunction in humans and rodents. "	( Dietary zinc deficient condition increases the Bisphenol A toxicity in diabetic rat testes. Jena, G; Sahu, C, 2022)	2.42
"Bisphenol A (BPA) is an endocrine disruptor widely existing in plastics and resins, which can accumulate in animals and human bodies, posing a potential threat to the physiological and biochemical reactions of human beings or other organisms. "	( Potential toxicity of bisphenol A to α-chymotrypsin and the corresponding mechanisms of their binding. Chu, S; Guo, S; He, F; Li, X; Li, Y; Liu, R; Sun, N; Zhao, Q; Zong, W, 2023)	2.67
"Bisphenol A (BPA) is an endocrine-disrupting chemical widely present in many consumer goods that poses a significant threat to our health upon exposure. "	( Bisphenol A-Induced Endocrine Dysfunction and its Associated Metabolic Disorders. Calivarathan, L; Maniradhan, M, 2023)	3.8
"Bisphenol A (BPA) is a xenoestrogen that has been shown to disrupt the endocrine system and cause reproductive toxicity."	( Bisphenol A: Potential Factor of Miscarriage in Women in the Context of the Phenomenon of Neutrophil Extracellular Traps. Cechowska-Pasko, M; Charkiewicz, AE; Czerniecki, J; Garley, M; Jabłońska, E; Miltyk, W; Omeljaniuk, WJ; Ratajczak-Wrona, W, 2022)	2.89
"Bisphenol A (BPA) is a xenoestrogen, synthesized to produce polymers such as polycarbonates and epoxy resins."	( Lycopene protects against Bisphenol A induced toxicity on the submandibular salivary glands via the upregulation of PPAR-γ and modulation of Wnt/β-catenin signaling. El-Sayed, NM; Mosaad, SM; Selim, MA, 2022)	1.74
"Bisphenol A (BPA) is a common environmental endocrine disruptor. "	( Association of urinary bisphenol A concentrations with in vitro fertilisation outcomes: a systematic review and meta-analysis protocol. Cao, XL; Xu, CM; Xu, NX; Zhou, XY, 2022)	2.47
"Bisphenol A (BPA) is a toxic endocrine disruptor detected in various environments. "	( Mechanism of visible light enhances microbial degradation of Bisphenol A. Yang, F; Zhao, F, 2023)	2.59
"Bisphenol A (BPA) is an endocrine disruptor that is present in freshwater and marine environments. "	( Bisphenol A alters sexual dimorphism and gene expression in marine medaka Oryzias melastigma. Horie, Y; Kanazawa, N; Nomura, M; Okamura, H; Yamamoto, M, 2023)	3.8
"Bisphenol A (BPA) is a harmful endocrine disruptor, sensitive and rapid quantification of BPA is highly desirable. "	( An ultrasensitive electrochemical biosensor for bisphenol A based on aptamer-modified MrGO@AuNPs and ssDNA-functionalized AuNP@MBs synergistic amplification. Cui, J; Hu, L; Jia, J; Wang, Y, 2023)	2.61
"Bisphenol A (BPA) is an endocrine-disrupting chemical widely used in the plastics industry, including food container, toys, and medical equipment. "	( Effects of bisphenol A on human umbilical arteries. Azevedo, R; Marcelino, H; Oliveira, N; Verde, I, 2023)	2.74
"Bisphenol A (BPA) is a substance commonly used in dental materials with noxious properties. "	( Evaluation of the bisphenol released in the saliva after residual adhesive removal in orthodontic patients by using ultrasonic scaling and rotary system: A single-center randomized clinical trial. Aghanejad, A; Hamidi, AA; Mirzakouchaki, B; Rafighi, A; Seifi, S; Shahrbaf, S, 2023)	2.35
"Bisphenol A (BPA) is an endocrine disruptor found in polycarbonate plastics and exposure in humans is nearly ubiquitous and it has widespread effects on cognitive, emotional, and reproductive behaviors in both humans and animal models. "	( Brief postnatal exposure to bisphenol A affects apoptosis and gene expression in the medial prefrontal cortex and social behavior in rats with sex specificity. Brinks, AS; Doshi, AD; Drzewiecki, CM; Juraska, JM; Koh, JY; Sellinger, EP, 2023)	2.65
"Bisphenol A (BPA) is a well-known endocrine-disrupting compound that causes several toxic effects on human and aquatic organisms. "	( Risk assessment of bisphenol analogues towards mortality, heart rate and stress-mediated gene expression in cladocerans Moina micrura. Abidin, AAZ; Aris, AZ; Kim, KW; Kim, SD; Razak, MR; Yusof, ZNB; Yusoff, FM, 2023)	2.68
"Bisphenol A (BPA) is a ubiquitous chemical compound constantly being released into the environment, making it one of the most persistent endocrine-disrupting chemical (EDC) in nature. "	( Effects of BPA substitutes on the prenatal and cardiovascular systems. Abrantes-Soares, F; Cairrao, E; Lorigo, M, 2022)	2.16
"Bisphenol A (BPA) is a rapid spreading organic pollutant that widely used in many industries especially as a plasticizer in polycarbonate plastic and epoxy resins. "	( Transcriptome analysis and cytochrome P450 monooxygenase reveal the molecular mechanism of Bisphenol A degradation by Pseudomonas putida strain YC-AE1. Abo-Kadoum, MA; Atta, OM; Eltoukhy, A; Jia, Y; Lamraoui, I; Nahurira, R; Wang, J; Yan, Y, 2022)	2.38
"Bisphenol A (BPA) is an endocrine disruptor widely distributed in the environment due to its common use in the plastics industry. "	( Changes in the Enteric Neurons Containing Selected Active Substances in the Porcine Descending Colon after the Administration of Bisphenol A (BPA). Gonkowski, S; Makowska, K, 2022)	2.37
"Bisphenol A (BPA) is an omnipresent environmental pollutant. "	( Susceptibility of male reproductive system to bisphenol A, an endocrine disruptor: Updates from epidemiological and experimental evidence. Bijalwan, V; Das, S; Sarkar, K; Singh, DP; Yadav, S; Yadav, SK, 2023)	2.61
"Bisphenol A (BPA) is a chemical product that is widely used as a plastic precursor. "	( Renoprotective effect of N-acetylcystein and vitamin E in bisphenol A-induced rat nephrotoxicity; Modulators of Nrf2/ NF-κB and ROS signaling pathway. Abdallah, Z; Abdelrazik, E; Farrag, EA; Hassan, HM; Magdy, A, 2022)	2.41
"Bisphenol A (BPA) is an endocrine-disrupting chemical inducing several damages such as neurotoxicity, immunotoxicity, and metabolic disorders. "	( Bisphenol A exacerbates anxiety-like behavior and neuroinflammation in prefrontal cortex of adult obese mice. Annunziata, C; Comella, F; Del Piano, F; Ferrante, MC; Grumetto, L; Lama, A; Mattace Raso, G; Meli, R; Melini, S; Opallo, N; Pirozzi, C, 2023)	3.8
"Bisphenol A is an endocrine disruptor used in the composition of food containers. "	( [Bisphenol A and breast cancer: State of knowledge and meta-analysis]. Albert, C; Bonneau, C; Fauconnier, MB; Maumy, L; Rouzier, R; Tondreau, A, 2023)	3.26
"Bisphenol A (BPA) is a widely used synthetic industrial compound frequently detected in food. "	( Hazard characterization of bisphenol A (BPA) based on rodent models - Multilevel meta-analysis and dose-response analysis for reproductive toxicity. Bakar Siddique, MA; Brunton, NP; Cummins, E; Harrison, SM; Monahan, FJ; Nag, R; Wang, X, 2023)	2.65
"Bisphenol A (BPA) is a common environmental chemical with a range of potential adverse health effects. "	( Acute exposure to low-dose bisphenol A delays cardiac repolarization in female canine heart - Implication for proarrhythmic toxicity in large animals. Ma, J; Niklewski, PJ; Wang, HS, 2023)	2.65
"Bisphenol A (BPA) is an estrogenic endocrine disruptor that induces metabolic disorders. "	( Untargeted Lipidomics Revealed the Protective Effects of Cyanidin-3- Bai, W; Cai, D; Jiang, X; Jin, Y; Li, X; Liu, B; Liu, R; Sun, J; Tian, L; Zhang, Q; Zhang, W, 2023)	2.35
"Bisphenol A (BPA) is an endocrine disruptor commonly used in the production of plastics. "	( Effects of the long-term influence of bisphenol A and bisphenol S on the population of nitrergic neurons in the enteric nervous system of the mouse stomach. Całka, J; Gonkowski, S; Makowska, K, 2023)	2.62
"Bisphenol A (BPA) is a widely produced chemical worldwide found in numerous everyday products. "	( Application of High-Performance Liquid Chromatography Combined with Fluorescence Detector and Dispersive Liquid-Liquid Microextraction to Quantification of Selected Bisphenols in Human Amniotic Fluid Samples. Szubartowski, S; Tuzimski, T, 2022)	2.16
"Bisphenol A (BPA) is an endocrine disruptor, widely employed, and detected in many consumer products and food items. "	( New Insights into How Melatonin Ameliorates Bisphenol A-Induced Colon Damage: Inhibition of NADPH Oxidase. Han, D; Shi, X; Xu, S; Yao, Y; Zhu, W, 2023)	2.61
"Bisphenol A (BPA) is an endocrine disruptor with a wide distribution in the environment that is used in the manufacturing of plastic products."	( Immunomodulatory effect of dopamine in human keratinocytes and macrophages under chronical bisphenol-A exposure conditions. Bessone, ML; Canellada, AM; Castro, M; Macchi, R; Mangone, FM; Parrado, AC; Rey-Roldán, EB; Salaverry, LS, 2023)	1.63
"Bisphenol A (BPA) is a ubiquitous endocrine disruptor that poses adverse human health risks. "	( Biotransformation of bisphenol A in vivo and in vitro by laccase-producing Trametes hirsuta La-7: Kinetics, products, and mechanisms. Li, S; Liu, J; Sun, K; Waigi, MG; Wang, X; Zhu, R, 2023)	2.67
"Bisphenol A (BPA) is a widely produced chemical, mostly used in the production of polycarbonate plastics, and can act as an endocrine disruptor. "	( Negative effects of endocrine disruptor bisphenol A on ovarian granulosa cells and the protective role of folic acid. Celar Sturm, D; Virant-Klun, I, 2023)	2.62
"Bisphenol A (BPA) is an endocrine disruptor (ED), widely used as a comonomer or an additive in the plastics industry. "	( Negative effects of endocrine disruptor bisphenol A on ovarian granulosa cells and the protective role of folic acid. Celar Sturm, D; Virant-Klun, I, 2023)	2.62
"Bisphenol A (BPA) is a widely used plasticizer agent and a well-known ubiquitous endocrine disruptor, which is frequently associated with a series of reproductive, developmental, and transgenerational effects over wildlife, livestocks, and humans. "	( Toxicological impacts and likely protein targets of bisphenol a in Paramecium caudatum. Fonseca, AL; Senra, MVX, 2023)	2.6
"Bisphenol A (BPA) is an endocrine disrupting chemical and poses a grave threat to the human health. "	( Selective fluorescent probe for sensitive determination of bisphenol A based on molecularly imprinted polymers decorated carbon dots derived from citric acid and ethylenediamine. Huang, S; Liu, H; Liu, Y; Nie, L; Niu, J; Yuan, S; Zhang, Y; Zhou, Q, 2023)	2.6
"Bisphenol A (BPA) is a phenolic compound used in plastics elaboration for food protection or packaging. "	( Low Dose of BPA Induces Liver Injury through Oxidative Stress, Inflammation and Apoptosis in Long-Evans Lactating Rats and Its Perinatal Effect on Female PND6 Offspring. Lichtensteiger, W; Linillos-Pradillo, B; Paredes, SD; Rancan, L; Schlumpf, M; Tresguerres, JÁF; Vara, E, 2023)	2.35
"Bisphenol A (BPA) is a serious environmental endocrine disruptor, and its exposure can cause liver tissue damage."	( ROS mediated pyroptosis-M1 polarization crosstalk participates in inflammation of chicken liver induced by bisphenol A and selenium deficiency. Li, X; Liu, X; Shi, X; Sun, X; Wang, Y; Xu, S; Xu, T; Zhang, W; Zhang, Y, 2023)	1.84
"Bisphenol A (BPA) is an endocrine-disrupting chemical that acts as inflammatory promoter and tumoral facilitator in mammary tissue."	( Bisphenol A disruption promotes mammary tumor microenvironment via phenotypic cell polarization and inflammatory response. Cabral, ÁS; Calmon, MF; Castro, NFC; Colleta, SJ; Dos Santos, DD; Gil, CD; Girol, AP; Leonel, ECR; Rahal, P; Ruiz, TFR; Taboga, SR; Vilamaior, PSL, 2023)	3.07
"Bisphenol A (BPA) is a common environmental endocrine disruptor which mimic the effect of estrogen. "	( Increased levels of IL-17 and autoantibodies following Bisphenol A exposure were associated with activation of PI3K/AKT/mTOR pathway and abnormal autophagy in MRL/lpr mice. Dong, Y; Gao, L; Jia, L; Liu, D; Sun, Q, 2023)	2.6
"Bisphenol A (BPA) is an endocrine disruptor that has adverse effects on lipid metabolism. "	( Bisphenol A has a sex-dependent disruptive effect on hepatic lipid metabolism in zebrafish. Cao, Q; Long, X; Wang, J; Yang, H; Zhang, Y; Zhu, Z, 2023)	3.8
"Bisphenol A (BPA) is a common environmental endocrine disruptor, and overexposure is a threat to male reproduction. "	( Cuscuta chinensis flavonoids reducing oxidative stress of the improve sperm damage in bisphenol A exposed mice offspring. Bao, Y; Jiao, Y; Liu, Y; Shi, W; Wang, X; Zhao, Q; Zhu, Y, 2023)	2.58
"Bisphenol A (BPA) is an industrial chemical that is widely used in various industrial applications. "	( Detection of bisphenol A in thermal paper receipts and assessment of human exposure: A case study from Sharjah, United Arab Emirates. Alawadhi, N; Nazer, K; Semerjian, L, 2023)	2.72
"Bisphenol A (BPA) is a harmful endocrine disrupting compound that alters not only classical cellular mechanisms but also epigenetic mechanisms. "	( Granulosa cells undergo BPA-induced apoptosis in a miR-21-independent manner. Favetta, LA; LaMarre, J; Sabry, R; Williams, M, 2023)	2.35
"Bisphenol A (BPA) is a weak estrogenic endocrine disruptor known to cause adverse reproductive outcomes in women."	( Distinct metabolic signatures in blood plasma of bisphenol A-exposed women with polycystic ovarian syndrome. Bhat, SK; Joshi, MB; Kabekkodu, SP; Prabhu, NB; Rai, PS; Satyamoorthy, K; Vasishta, S, 2023)	1.89
"Bisphenol A (BPA) is a chemical with large-scale applications in the manufacturing of industrial products. "	( Risk assessment of bisphenol A (BPA) in Irish meat and meat products. Brunton, NP; Cummins, E; Harrison, SM; Monahan, FJ; Nag, R; Siddique, MAB; Wang, X, 2023)	2.68
"Bisphenol A (BPA) is a micro-pollutant found in various environmental matrices at concentrations as low as ng/L. "	( Realistic concentrations of Bisphenol-A trigger a neurotoxic response in the brain of zebrafish: Oxidative stress, behavioral impairment, acetylcholinesterase inhibition, and gene expression disruption. Dublán-García, O; Elizalde-Velázquez, GA; Galar-Martínez, M; García-Medina, S; Gómez-Oliván, LM; Heredia-García, G; Islas-Flores, H, 2023)	2.35
"Bisphenol A (BPA) is a high-production-volume chemical with numerous industrial and consumer applications. "	( The State of Research and Weight of Evidence on the Epigenetic Effects of Bisphenol A. Besaratinia, A, 2023)	2.58
"Bisphenol A (BPA) is a plasticizer that is widely used in the manufacturing of polycarbonate plastics (PC) and epoxy resins for use in a broad range of consumer products, including materials in contact with food and beverages, as well as medical devices, toys and dental sealants [...]."	( Special Issue "Molecular Mechanisms of Bisphenol A Toxicity and Effects of Environmental Levels on Health". Coppola, L; La Rocca, C, 2023)	2.62
"Bisphenol A (BPA) is a known endocrine disruptor found in many consumer products that humans come into contact with on a daily basis. "	( A review on immunomodulatory effects of BPA analogues. Franko, N; Kodila, A; Sollner Dolenc, M, 2023)	2.35
"Bisphenol A (BPA) is an endocrine disruptor found in different plastic and resin products."	( The impacts of exposure to bisphenol A in the adult female prostate Meriones unguiculatus. Amaro, GM; Bedolo, CM; Campos, SGP; Leonel, ECR; Ruiz, TFR; Taboga, SR; Vilamaior, PSL, 2023)	1.93
"Bisphenol A (BPA) is a synthetic chemical to which humans are exposed through a variety of environmental sources. "	( Systematic review of the potential carcinogenicity of bisphenol A in humans. Fan, T; Goodman, JE; Hixon, ML; Olgun, NS; Piatos, P; Prueitt, RL; Zhou, J, 2023)	2.6
"Bisphenol A (BPA) is a chemical partially soluble in water and exists in a solid state. "	( Alterations induced by Bisphenol A on cellular organelles and potential relevance on human health. Adiga, D; Chakrabarty, S; Kabekkodu, SP; Khan, NG; Rai, PS; Tungekar, B, 2023)	2.66
"Bisphenol A (BPA) is a plasticiser used in the manufacturing of many products and its effects on human health remain controversial. "	( The effects of trans fat diet intake on metabolic parameters and pancreatic tissue in offspring of prenatal bisphenol A exposed rats. Abdul Aziz, M; Abulehia, H; Mohd Nor, NS; Sheikh Abdul Kadir, SH; Zulkifli, S, 2023)	2.57
"Bisphenol A (BPA) is a ubiquitous synthetic compound used as a monomer in the production of polycarbonate plastics and epoxy resins. "	( Transcriptome-Wide Analysis of Low-Concentration Exposure to Bisphenol A, S, and F in Prostate Cancer Cells. Cortés-Ramírez, SA; Cruz-Burgos, M; González-Covarrubias, V; González-Ramírez, I; Losada-García, A; Maldonado-Lagunas, V; Morales-Pacheco, M; Ostrosky-Wegman, P; Rodríguez-Dorantes, M; Rodríguez-Martínez, G; Salazar, AM; Sordo, M; Vazquez-Santillan, K, 2023)	2.59
"Bisphenol A (BPA) is an endocrine disrupting chemical with estrogenic activity that has been associated with increasing rates of breast cancer."	( Bisphenol A increases the size of primary mammary tumors and promotes metastasis in a murine model of breast cancer. Castillo-Sanchez, R; Cortes-Reynosa, P; Gomez, R; Perez Salazar, E; Torres-Alamilla, P, 2023)	3.07
"Bisphenol A (BPA) is an endocrine disrupting chemical and broadly used in plastics. "	( Electrochemical sensor for sensitive detection of bisphenol A based on molecularly imprinted TiO Li, T; Liu, C; Liu, YH; Wang, XH; Zhang, X, 2023)	2.61
"Bisphenol A (BPA) is a monomer to produce polycarbonate plastics and can be released into the environment through human activities, leading to its accumulation in animals, plants and humans through direct contact or environmental exposure. "	( Important roles of Hif1a in maternal or adult BPA exposure induced pancreatic injuries. Gong, Z; Li, Y; Liu, H; Zhou, Y, 2023)	2.35
"Bisphenol A (BPA) is an endocrine-disrupting chemical substance responsible for the composition of polycarbonate plastics and epoxy resins. "	( Prenatal exposure to bisphenol A and neonatal health outcomes: A systematic review. Guo, J; Liu, K; Su, Y; Yang, J, 2023)	2.67
"Bisphenol A (BPA) is a proven EDC capable of mimicking or blocking receptors and altering hormone concentrations and metabolism."	( The Effects of Bisphenol A on Human Male Infertility: A Review of Current Epidemiological Studies. Cairrao, E; Lorigo, M; Mariana, M; Presunto, M, 2023)	1.98
"Bisphenol A (BPA) is an endocrine-disrupting chemical, widely used to produce polycarbonate plastic. "	( Carnosic acid and rosemary extract reversed the lipid accumulation induced by bisphenol A in the 3T3-L1 preadipocytes and C57BL/6J mice via SIRT1/FoxO1 pathway. Huang, HC; Hung, HC; Lai, CN; Liao, CH; Liao, YH; Liu, PT; Lu, SM; Tsai, CW, 2023)	2.58
"Bisphenol A (BPA) is a ubiquitous environmental xenobiotic impacting millions of people worldwide. "	( Environmental-relevant bisphenol A exposure promotes ovarian cancer stemness by regulating microRNA biogenesis. Ip, CKM; Lam, SSN; Shi, Z; Wong, AST; Wong, CKC, 2023)	2.66
"Bisphenol A (BPA) is an endocrine-disrupting compound, and the binding mechanism of BPA with carrier proteins has drawn widespread attention. "	( Impacts of Halogen Substitutions on Bisphenol A Compounds Interaction with Human Serum Albumin: Exploring from Spectroscopic Techniques and Computer Simulations. Cai, R; Chen, C; Chi, B; Dai, L; Ding, P; Gao, L; Zhang, H, 2023)	2.63
"Bisphenol A (BPA) is a chemical used in the production of certain plastics and resins. "	( Benzene ring bisphenol A substitutes potently inhibit human, rat, and mouse gonadal 3β-hydroxysteroid dehydrogenases: Structure-activity relationship and in silico docking analysis. Chen, Y; Ge, RS; Ren, Z; Sang, J; Wang, H; Wang, Y; Yu, Y; Zhang, M; Zhu, Y, 2023)	2.72
"Bisphenol A (BPA) is an endocrine-disrupting chemical commonly used in manufacturing plastic products. "	( Environment-wide association study to identify exposure pathways of bisphenol A in Korean children and adolescents: Korean National Environmental Health Survey (KoNEHS) 2018-2020. Ryoo, JH; Shin, S, 2023)	2.59
"Bisphenol A (BPA) is a widely used plastic monomer that potentially interferes with ovarian neuroendocrine, endocrine, and autocrine/paracrine factors, causing reproductive dysfunction. "	( Reproductive toxicity of bisphenol A, at environmentally relevant concentrations, on ovarian redox balance, maturational response, and intra-oocyte signalling events in Labeo bata. Das, S; Ghosh, S; Maitra, S; Mukherjee, U, 2024)	3.19
"Bisphenol A (BPA) is an endocrine disruptor used in food contact materials, by the application of polycarbonate plastics and epoxy resins. "	( Methodological approaches for the assessment of bisphenol A exposure. Carvalho, C; Casal, S; Correia, D; Costa, SA; Cunha, S; Lopes, C; Magalhães, V; Severo, M; Torres, D; Vilela, S, 2023)	2.61
"Bisphenol A (BPA) is an endocrine-disrupting chemical commonly utilized in the manufacture of plastics, which may cause damage to brain tissue. "	( Potential neuroprotective effect of nanomicellar curcumin on learning and memory functions following subacute exposure to bisphenol A in adult male rats. Fallahnezhad, S; Ghorbani-Taherdehi, F; Gorji-Valokola, M; Kafashzadeh, M; Nadim, A; Sahebkar, A, 2023)	2.56
"Bisphenol A (BPA) is a known endocrine disruptor mimicking natural estrogens with the potential to affect human health, especially during prenatal and postnatal exposure at or below current acceptable daily intake levels. "	( IVIVE-PBPK based new approach methodology for addressing early life toxicity induced by Bisphenol A. Chen, J; Deepika, D; Kumar, V; Li, X; Ni, M; Xiong, W; Zhang, L, 2024)	3.11
"Bisphenol A (BPA) is an endocrine disruptor. "	( Bisphenol A exposure exacerbates tracheal inflammatory injury in selenium-deficient chickens by regulating the miR-155/TRAF3/ROS pathway. Chen, S; Li, S; Li, X; Lin, H; Peng, L; Wan, C; Xu, S, 2023)	3.8
"Bisphenol A (BPA) is a widespread environmental pollutant linked to detrimental effects on human health and reduced life expectancy following chronic exposure. "	( Mitigating the impact of bisphenol A exposure on mortality: Is diet the key? A cohort study based on NHANES. Chen, S; Chen, YM; Huang, BX; Huang, RZ; Huang, SY; Huang, ZH; Jian, YY; Lan, QY; Liu, ZY; Lu, XT; Lv, LL; Wu, T; Wusiman, M; Zhu, HL, 2023)	2.66
"Bisphenol A (BPA) is an industrial chemical used extensively in plastics and resins. "	( An Overview to Molecularly Imprinted Electrochemical Sensors for the Detection of Bisphenol A. Fu, L; Karimi-Maleh, H; Lin, CT; Pan, Y; Shi, M; Shi, P; Wu, M; Ye, C; Zhao, N; Zhu, Y, 2023)	2.58
"Bisphenol A (BPA) is a ubiquitous environmental pollutant that can have harmful effects on human and animal immune systems by inducing oxidative stress. "	( BPA and low-Se exacerbate apoptosis and autophagy in the chicken bursa of Fabricius by regulating the ROS/AKT/FOXO1 pathway. Lin, H; Sun, W; Xu, S; Xu, T; Yin, Y, 2024)	2.89
"Bisphenol A (BPA) is a widely used industrial chemical with neurotoxic effects."	( An Examination of the Relationship Between Exposure to Bisphenol A and Attention-Deficit/Hyperactivity Disorder in Children and Adolescents. Baykal, S; Nalbantoğlu, A, )	1.1
"Bisphenol A (BPA) is a common endocrine disruptor widely used in the production of electronic, sports, and medical equipment, as well as consumer products like milk bottles, dental sealants, and thermal paper. "	( Transcriptomic Integration Analyses Uncover Common Bisphenol A Effects Across Species and Tissues Primarily Mediated by Disruption of JUN/FOS, EGFR, ER, PPARG, and P53 Pathways. Faiola, F; Lu, Y; Yang, R; Yin, N, 2023)	2.6
"Bisphenol A (BPA) functions as a detrimental substance that disrupts the endocrine system in animals while also impeding the growth and development of plants. "	( Ethylene and ROS mediate root growth inhibition induced by the endocrine disruptor bisphenol A (BPA). Bahmani, R; Hwang, S; Kim, D; Modareszadeh, M, 2023)	2.58
"Bisphenol A (BPA) is an artificial xenoestrogen widely used in consumer products containing polycarbonate plastics and epoxy resins. "	( Bisphenol A inhibits autophagosome-lysosome fusion and lipid droplet degradation. Chen, Y; Huang, H; Huang, S; Li, D; Liu, R; Song, D; Wang, B; Xu, C, 2019)	3.4
"Bisphenol A is an endocrine disruptor associated with hormone synthesis and reproduction alterations. "	( BPA interferes with StAR-mediated mitochondrial cholesterol transport to induce germline dysfunctions. Allard, P; Chen, Y; Ferreira, D; Gibbs, K; Hussain, A; Panter, B, 2019)	1.96
"Bisphenol A (BPA) is a non-persistent endocrine-disrupting chemical with nearly ubiquitous, involuntary exposure. "	( Association between peri-conceptional bisphenol A exposure in women and men and time to pregnancy-The HOPE study. Cox, KJ; Ju, S; Porucznik, CA; Stanford, JB; Yeum, D; Zhang, Y, 2019)	2.23
"Bisphenol A (BPA) is a ubiquitous substance found in a wide array of consumer products and healthcare consumables, and at low doses in drinking water. "	( Bisphenol A: A Concise Review of Literature and a Discussion of Health and Regulatory Implications. Mokbel, K; Wazir, U, )	3.02
"Bisphenol A (BPA) is an endocrine disrupting chemical used worldwide over the last 30 years in many consumer products."	( Assessment of Bisphenol A Levels in Preschool Children: Results of a Human Biomonitoring Study in Ankara, Turkey Aktaş, A; Battal, D; Çok, İ; İkidağ, ÖT, 2020)	1.64
"Bisphenol A (BPA) is an environmental contaminant that exhibits estrogen-like activity; it impairs reproductive organs, sperm production, spermatogenesis and fertility."	( Effects of co-administered melatonin, fructose and bisphenol A (BPA) on rat epididymis and sperm characteristics. Akarca-Dizakar, SÖ; Coşkun Akçay, N; Erdoğan, D; Eşmekaya, MA; Ömeroğlu, S; Peker, T; Türkoğlu, I, 2020)	1.53
"Bisphenol A (BPA) is a chemical monomer widely used in the production of hard plastics for food containers and personal items. "	( Neurochemical and behavioral analysis by acute exposure to bisphenol A in zebrafish larvae model. Ahn, S; Bae, MA; Chae, JS; Hwang, KS; Jung, MH; Kan, H; Kim, GR; Kim, SK; Kim, SS; Lee, HY; Lee, KR; Shin, DS; Song, JS; Yang, JY, 2020)	2.24
"Bisphenol A (BPA) is an environmental pollutant that has been associated with adverse health effects including skeletal muscle insulin resistance, a major contributor to the pathogenesis of type 2 diabetes (T2D). "	( The effects of acute BPA exposure on skeletal muscle mitochondrial function and glucose metabolism. Aguer, C; Ahmed, F; Caron, A; Chehadé, L; Garneau, L, 2020)	2
"Bisphenol A (BPA) is an endocrine disruptor that affects fetal growth in experimental studies. "	( Associations of Trimester-Specific Exposure to Bisphenols with Size at Birth: A Chinese Prenatal Cohort Study. Braun, JM; Buka, SL; Cai, Z; Hu, J; Huo, W; Jiang, M; Li, H; Li, J; Li, Y; Liu, S; Peng, Y; Shi, K; Wu, C; Xia, W; Xu, S; Zhang, B; Zhang, W; Zhang, Y; Zhao, H; Zheng, T; Zhou, A; Zhou, Y; Zhu, Y, 2019)	1.96
"Bisphenol A (BPA) is a ubiquitously distributed endocrine disrupting chemical (EDC). "	( Bisphenol A triggers axonal injury and myelin degeneration with concomitant neurobehavioral toxicity in C57BL/6J male mice. Akhter, J; Banerjee, BD; Goswami, P; Gupta, S; Jahan, S; Khan, J; Parvez, S; Raisuddin, S; Salhotra, S; Sharma, S, 2019)	3.4
"Bisphenol A (BPA) is a widespread environmental endocrine disruptor that has multiple effects on reproductive organ development. "	( Cuscuta chinensis flavonoids alleviate bisphenol A-induced apoptosis of testicular cells in male mice offspring. Bao, Y; Han, C; Li, S; Shi, W; Wei, Y, 2019)	2.23
"Bisphenol A (BPA) is a major constituent of plastic products, including epoxy resin containers, mobile phones, dental sealants, as well as electronic and medical equipment. "	( Memory Function, Neurological, and Immunological Biomarkers in Allergic Asthmatic Mice Intratracheally Exposed to Bisphenol A. Koike, E; Takano, H; Win-Shwe, TT; Yanagisawa, R, 2019)	2.17
"Bisphenol A (BPA) is a compound used in the polymerization of plastic polycarbonates. "	( Perinatal exposure to bisphenol A (BPA) impairs neuroendocrine mechanisms regulating food intake and kisspetin system in adult male rats. Evidences of metabolic disruptor hypothesis. Andreoli, MF; Bosquiazzo, VL; Canesini, G; Kass, L; Luque, EH; Ramos, JG; Rossetti, MF; Stoker, C, 2020)	2.32
"Bisphenol A (BPA) is a substance ubiquitously present in the environment, and its toxicity on reproductive function has been well characterised in animal models. "	( Urinary bisphenol A concentration is correlated with poorer oocyte retrieval and embryo implantation outcomes in patients with tubal factor infertility undergoing in vitro fertilisation. Jin, F; Kang, Q; Le, F; Mao, Y; Shen, J; Xu, X; Yang, X; Yuan, M, 2020)	2.44
"Bisphenol A (BPA) is a synthetic phenol extensively used in the manufacturing of polycarbonated plastics."	( Bisphenol A modified DNA: A possible immunogenic stimulus for anti-DNA autoantibodies in systemic lupus erythematosus. Al-Rashdi, FH; Alhomaidan, HT; Almatrafi, S; Rasheed, N; Rasheed, Z, )	2.3
"Bisphenol A (BPA) is a plasticizer with endocrine disrupting properties particularly relevant for children health. "	( Juvenile Toxicity Rodent Model to Study Toxicological Effects of Bisphenol A (BPA) at Dose Levels Derived From Italian Children Biomonitoring Study. Busani, L; Carli, F; Deodati, A; Di Virgilio, A; La Rocca, C; Maranghi, F; Martinelli, A; Narciso, L; Tait, S; Tassinari, R, 2020)	2.24
"Bisphenol A (BPA) is an ideal plasticizing factor used in manufacturing of plastics and epoxy resins."	( Role of copeptin as a novel biomarker of bisphenol A toxic effects on cardiac tissues: biochemical, histological, immunohistological, and genotoxic study. Amin, DM, 2019)	1.5
"Bisphenol A (BPA) is an endocrine disruptor to which animals and humans are highly exposed. "	( Environmental Pollution as a Risk Factor in Testicular Tumour Development: Focus on the Interaction between Bisphenol A and the Associated Immune Response. Girón-Pérez, MI; Méndez-García, LA; Morales Montor, J; Nava-Castro, KE; Navidad-Murrieta, MS; Ramírez-Nieto, R; Segovia-Mendoza, M, 2019)	2.17
"Bisphenol A (BPA) is a potential food contaminant arising from its use in plastics and represents a well-known xenoestrogen, acting as an endocrine disruptor."	( Combinatory estrogenic effects of bisphenol A in mixtures with alternariol and zearalenone in human endometrial cells. Aichinger, G; Marko, D; Pantazi, F, 2020)	1.56
"Bisphenol A (BPA) is a harmful environmental contaminant acting as an endocrine disruptor in animals, but it also affects growth and development in plants. "	( The mechanism of root growth inhibition by the endocrine disruptor bisphenol A (BPA). Bahmani, R; Hwang, S; Kim, D; Modareszadeh, M; Park, JH; Thompson, AJ; Yoo, HH, 2020)	2.24
"Bisphenol A (BPA) is an estrogenic endocrine disrupting chemical to which humans are frequently exposed during routine daily life. "	( Hepatoprotective effects of curcumin and taurine against bisphenol A-induced liver injury in rats. Aslanturk, A; Uzunhisarcikli, M, 2019)	2.2
"Bisphenol A (BPA) is a contaminant in virtually all Americans. "	( Fetal bisphenol A and ethinylestradiol exposure alters male rat urogenital tract morphology at birth: Confirmation of prior low-dose findings in CLARITY-BPA. Ellersieck, MR; Ricke, EA; Ricke, WA; Stahlhut, RW; Taylor, JA; Timms, BG; Uchtmann, KS; Vom Saal, FS, 2020)	2.48
"Bisphenol A (BPA) is a ubiquitous component in the manufacturing of plastic. "	( Bisphenol A Activates an Innate Viral Immune Response Pathway. Goldblum, R; Midoro-Horiuti, T; Sowers, ML; Tang, H; Tian, B; Zhang, K, 2020)	3.44
"Bisphenol A (BPA) is an abundant contaminant found in aquatic environments. "	( Assessment of the Effects of Bisphenol A on Dopamine Synthesis and Blood Vessels in the Goldfish Brain. He, Q; Lin, F; Liu, X; Wang, Q; Xiao, S; Yang, H; Zhao, H; Zheng, L, 2019)	2.25
"Bisphenol A (BPA) is a high production volume chemical with a broad application spectrum. "	( A tiered high-throughput screening approach for evaluation of estrogen and androgen receptor modulation by environmentally relevant bisphenol A substitutes. Arning, J; Eilebrecht, E; Kaßner, F; Keminer, O; Kohler, M; Teigeler, M; Wenzel, A; Windshügel, B, 2020)	2.2
"Bisphenol A (BPA) is a well-known endocrine disruptor and it is widely used mainly in the plastics industry. "	( The effects of different bisphenol derivatives on oxidative stress, DNA damage and DNA repair in RWPE-1 cells: A comparative study. Beal, D; Erkekoglu, P; Fayyad-Kazan, H; Kocer Gumusel, B; Kose, O; Rachidi, W, 2020)	2
"Bisphenol A (BPA) is an environmental pollutant with adverse effects on different ecosystems. "	( Biodegradation of bisphenol A by the immobilized laccase on some synthesized and modified forms of zeolite Y. Amin, M; Faramarzi, MA; Jahandar, H; Taghizadeh, T; Talebian-Kiakalaieh, A; Tarighi, S, 2020)	2.33
"Bisphenol A (BPA) is a well-known ubiquitous chemical found in polycarbonate, polysulfone and epoxy resins, used in mass production for many consumer products. "	( Simultaneous determination of bisphenol A and its chlorinated derivatives in human plasma: Development, validation and application of a UHPLC-MS/MS method. Albouy-Llaty, M; Ayraud-Thevenot, S; Belmouaz, M; Binson, G; Cambien, G; Dupuis, A; Migeot, V; Rabouan, S; Venisse, N, 2020)	2.29
"Bisphenol A (BPA) is a well-known endocrine disruptor that imposees adverse effects on male fertility via interacting with germ cells of testis. "	( Alleviating impact of hydroethanolic Murraya koenigii leaves extract on bisphenol A instigated testicular lethality and apoptosis in mice. Aniqa, A; Kaur, S; Sadwal, S; Singh, G, 2020)	2.23
"Bisphenol A (BPA) is a xenoestrogen that is prevalent in the environment of industrialized nations due its use in the production of many plastic household items. "	( Bisphenol A (BPA) induces progesterone receptor expression in an estrogen receptor α-dependent manner in perinatal brain. Fahrenkopf, A; Wagner, CK, )	3.02
"Bisphenol A is an important organic chemical as an intermediate, final and inert ingredient in manufacturing of many important products like polycarbonate plastics, epoxy resins, flame retardants, food-drink packaging coating, and other. "	( Biodegradation of endocrine disruptor Bisphenol A by Pseudomonas putida strain YC-AE1 isolated from polluted soil, Guangdong, China. Abo-Kadoum, MA; Eltoukhy, A; Jia, Y; Khokhar, I; Nahurira, R; Wang, J; Yan, Y, 2020)	2.27
"Bisphenol A (BPA) is a toxic environmental pollutant commonly found in wastewater. "	( Bentonite-supported nano zero-valent iron composite as a green catalyst for bisphenol A degradation: Preparation, performance, and mechanism of action. Bao, T; Chen, ZJ; Damtie, MM; Frost, RL; Hosseinzadeh, A; Jin, J; Liu, Y; Ni, BJ; Phong Vo, HN; Wang, XF; Wei, W; Wu, K; Ye, JS; Yu, ZM, 2020)	2.23
"Bisphenol A (BPA) is a well-known for endocrine-disrupting chemical (EDC) and is one of the highest amounts of chemicals produced worldwide. "	( The mixture effects of bisphenol derivatives on estrogen receptor and androgen receptor. Choi, J; Iida, M; Kojima, H; Lee, Y; Park, C; Park, J; Sim, S; Song, H, 2020)	2
"Bisphenol A (BPA) is an emerging organic pollutant, widely distributed in environment. "	( Dopamine alleviates bisphenol A-induced phytotoxicity by enhancing antioxidant and detoxification potential in cucumber. Ahammed, GJ; Chen, S; Liu, A; Mao, Q; Ren, J; Wang, X; Wang, Y; Wu, M; Yan, Y, 2020)	2.32
"Bisphenol A (BPA), is a common contaminant in diverse environmental compartments and its endocrine disruptive effect on living organisms has been widely reported. "	( Discrepant dose responses of bisphenol A on oxidative stress and DNA methylation in grass carp ovary cells. Fan, X; Hou, T; Jia, J; Tang, K; Wang, Z; Wei, X, 2020)	2.29
"Bisphenol A (BPA) is a substance used in the production of plastics which has a negative impact on many internal organs. "	( Bisphenol A (BPA)-Induced Changes in the Number of Serotonin-Positive Cells in the Mucosal Layer of Porcine Small Intestine-the Preliminary Studies. Gonkowski, S, 2020)	3.44
"Bisphenol A (BPA) is an emerging pollutant of global concern. "	( Effects of Bisphenol A on Alarcón-Hernández, E; Cervantes-Camacho, I; Guerrero-Estévez, SM; López, MF; López-López, E, 2020)	2.39
"Bisphenol A (BPA) is a manmade chemical that is only found in the environment due to anthropogenic activities. "	( Spatial and Temporal Distribution of BPA in the Canadian Freshwater Environment. Garron, C; Lalonde, B, 2020)	2
"Bisphenol A (BPA) is a well-known endocrine disruptor used to manufacture polycarbonate plastics and epoxy resins. "	( Prenatal bisphenol A exposure contributes to Tau pathology: Potential roles of CDK5/GSK3β/PP2A axis in BPA-induced neurotoxicity. Gao, R; Gao, Y; Jiang, L; Wang, J; Wang, Y; Xiao, H; Xie, X; Xue, J; Yu, J; Zhang, L, 2020)	2.42
"Bisphenol A (BPA) is an industrial synthetic chemical used in the production of polycarbonate plastics and epoxy resins. "	( Bisphenol A induces focal adhesions assembly and activation of FAK, Src and ERK2 via GPER in MDA-MB-231 breast cancer cells. Candanedo-Gonzales, F; Castillo-Sanchez, R; Cortes-Reynosa, P; Gomez, R; Martinez-Baeza, E; Ramirez-Ricardo, J; Salazar, EP, 2020)	3.44
"Bisphenol A is a typical endocrine disrupting chemicals (EDCs) and produce various toxic effects on animals due to its potential endocrine disruption, oxidative damage effect, mutagenic effect and hypomethylation. "	( Acute BPA exposure-induced oxidative stress, depressed immune genes expression and damage of hepatopancreas in red swamp crayfish Procambarus clarkii. Mi, K; Wei, W; Xue, W; Yang, H; Zhang, Y, 2020)	2
"Bisphenol A (BPA) is a synthetic xenoestrogen diffused worldwide. "	( Bisphenol A induces DNA damage in cells exerting immune surveillance functions at peripheral and central level. Ciaglia, E; D'Auria, R; Di Pietro, P; Meccariello, R; Nori, SL; Puca, AA; Russo, RD; Santoro, A; Vecchione, C; Viggiano, A, 2020)	3.44
"Bisphenol A (BPA) is a xenobiotic that causes oxidative stress in various organs in living organisms. "	( Melatonin Ameliorates BPA Induced Oxidative Stress in Human Red Blood Cells: An Abdullah, SM; Rashid, H, 2020)	2
"Bisphenol A (BPA) is a synthetic compound widely used for the production of polycarbonate plasticware and epoxy resins. "	( Maternal Dietary Exposure to Low-Dose Bisphenol A Affects Metabolic and Signaling Pathways in the Brain of Rat Fetuses. Barberio, L; Bertoli, S; Gagliardi, S; Leone, A; Mandalà, M; Pallottini, V; Segatto, M; Tonini, C, 2020)	2.27
"Bisphenol A (BPA) is an industrial raw material widely used in water bottles, medical devices and food packaging, and is now ubiquitous in the environment. "	( Bisphenol A regulates cytochrome P450 1B1 through miR-27b-3p and induces carp lymphocyte oxidative stress leading to apoptosis. Cui, Y; Li, S; Liu, Q; Wang, W; Xu, S; Zhang, Y, 2020)	3.44
"Bisphenol A (BPA) is a ubiquitous environmental contaminant that is known to be associated with the risk of arterial hypertension. "	( MicroRNA expression in response to bisphenol A is associated with high blood pressure. Cho, YH; Hong, YC; Kim, JH, 2020)	2.28
"Bisphenol A (BPA) is a widespread pollutant threatening the ecosystem and human health. "	( Biodegradation of Bisphenol A by Aung, MM; Eltoukhy, A; Hlaing, TS; Jia, Y; Lamraoui, I; Li, X; Nwe, MT; Wang, J; Yan, Y, 2020)	2.33
"Bisphenol A (BPA) is a monomer used in the production of polycarbonate, a polymer commonly found in plastics, epoxy resins and thermal papers. "	( BPA toxicity during development of zebrafish embryo. Machado, MRF; Santos, WGD; Scopel, CFV; Sousa, C, )	1.57
"Bisphenol A (BPA) is an industrial chemical used in the production of various plastic materials. "	( Luteolin-Supplemented diets ameliorates Bisphenol A-Induced toxicity in Drosophila melanogaster. Abolaji, AO; Adedara, AO; Adesanoye, OA; Faloye, TR; Olaoye, HO, 2020)	2.27
"Bisphenol A (BPA) is an environmental chemical that induces neurotoxic effects for human. "	( Bisphenol-A exposure induced neurotoxicity and associated with synapse and cytoskeleton in Neuro-2a cells. An, Z; Chen, L; Ge, Y; Hu, D; Hua, L; Li, J; Ning, H; Tian, T; Yin, Z, 2020)	2
"Bisphenol A (BisPH-A) is a latent danger that threatens our health, which we frequently exposure in our modern life (e.g. "	( Resveratrol diminishes bisphenol A-induced oxidative stress through TRPM2 channel in the mouse kidney cortical collecting duct cells. Çiğ, B; Yildizhan, K, 2020)	2.31
"Bisphenol A (BPA) is a recognized xenoestrogen, in that it possesses oestrogenic and anti-androgenic properties. "	( The Impact of Prenatal Exposure to Bisphenol A on Male Reproductive Function. Hart, RJ, 2020)	2.28
"Bisphenol A (BPA) is a ubiquitous endocrine disrupting chemical and obesogen. "	( Bisphenol A Induces Agrp Gene Expression in Hypothalamic Neurons through a Mechanism Involving ATF3. Belsham, DD; Loganathan, N; McIlwraith, EK, 2021)	3.51
"Bisphenol A (BPA) is a high production volume chemical that has wide industrial applications, especially as a color developer in thermal papers. "	( Evaluation of bisphenol A levels in Nigerian thermal receipts and estimation of daily dermal exposure. Adedire, CO; Adeyemi, JA; Barbosa, F; Gallimberti, M; Olise, CC; Rocha, BA, 2020)	2.36
"Bisphenol A (BPA) is a widespread environmental endocrine disrupting chemical. "	( Urinary bisphenol A concentrations and in vitro fertilization outcomes among women from a fertility clinic. Jurewicz, J; Kaleta, D; Klimowska, A; Krasiński, R; Radwan, M; Radwan, P; Wielgomas, B, 2020)	2.44
"Bisphenol A (BPA) is an oestrogenic endocrine disruptor widely used in the production of certain plastics, e.g., polycarbonate, hard and clear plastics, and epoxy resins that act as protective coating for food and beverage cans. "	( Role of Antioxidants in Alleviating Bisphenol A Toxicity. Amjad, S; Pang, MG; Rahman, MS, 2020)	2.28
"Bisphenol A (BPA) is an environmental endocrine disruptor and a risk factor for prostate cancer. "	( Potential role of CFTR in bisphenol A-induced malignant transformation of prostate cells via mitochondrial apoptosis. He, Y; Liu, J; Ou, C; Tan, C; Xiang, X; Zhu, X, 2020)	2.3
"Bisphenol A (BPA) is a widely studied and well-recognised endocrine-disrupting chemical, and one of the current issues is its safe replacement by various analogues. "	( Impacts of bisphenol A analogues on zebrafish post-embryonic brain. Charlier, TD; Coumailleau, P; Pellegrini, E; Trempont, S, 2020)	2.39
"Bisphenol A is an oil-derived, large market volume chemical with a wide spectrum of applications in plastics, adhesives and thermal papers. "	( Biomass-derived chemical substitutes for bisphenol A: recent advancements in catalytic synthesis. Barbaro, P; Liguori, F; Moreno-Marrodan, C, 2020)	2.27
"Bisphenol A (BPA) is a well-known endocrine disruptor that affects male fertility. "	( Chronic exposure of BPA impairs male germ cell proliferation and induces lower sperm quality in male mice. Liu, F; Liu, X; Wang, Z, 2021)	2.06
"Bisphenol A (BPA) is an organic synthetic compound serving as a monomer to produce polycarbonate plastic, widely used in the packaging for food and drinks, medical devices, thermal paper, and dental materials. "	( Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease. Beguinot, F; Cimmino, I; Fiory, F; Formisano, P; Miele, C; Oriente, F; Perruolo, G, 2020)	2.31
"Bisphenol A (BPA) is a major public health concern because of its high-volume industrial production, ubiquitous exposure to humans, and potential toxic effects on multiple organs and systems in humans. "	( Association Between Bisphenol A Exposure and Risk of All-Cause and Cause-Specific Mortality in US Adults. Bao, W; Dai, SY; Lehmler, HJ; Liu, B; Rong, S; Trasande, L, 2020)	2.32
"Bisphenol A (BPA) is a well-known xenobiotic endocrine disrupting chemical, with estrogenic activity and many other potential biological effects. "	( A transcriptomics-based analysis of toxicity mechanisms of zebrafish embryos and larvae following parental Bisphenol A exposure. Cai, Z; Huang, W; Liu, C; Wang, X; Wu, K; Xiao, J; Zheng, S, 2020)	2.21
"Bisphenol A (BPA) is a widespread chemical agent which can exert detrimental effects on the male reproductive system. "	( Bisphenol A-Induced Epigenetic Changes and Its Effects on the Male Reproductive System. Alviggi, C; Alviggi, E; Bagnulo, F; Buonfantino, C; Carbone, L; Cariati, F; Carotenuto, C; Conforti, A; Peluso, SR; Strina, I, 2020)	3.44
"Bisphenol A (BPA) is an organic synthetic compound that is ubiquitously present in daily life. "	( What is the Impact of Bisphenol A on Sperm Function and Related Signaling Pathways: A Mini-review? Luo, T; Xu, W; Yuan, Y; Zhou, Y, 2020)	2.32
"Bisphenol A (BPA) is an endocrine-disrupting chemical. "	( Effects of bisphenol A at the safe reference dose on abdominal fat deposition in aged hens. Ding, C; Fan, W; Gao, X; Gao, Z; Li, M; Liu, S; Miao, Y; Shi, X; Song, S; Tan, L, 2020)	2.39
"Bisphenol A (BPA) is an endocrine-disruptor compound that exhibits estrogenic activity. "	( Bisphenol A, an endocrine-disruptor compund, that modulates the immune response to infections. Araiza, VHDR; Castro, KEN; Cruz, SM; de Leon, CTG; Mendoza, MS; Morales Montor, J; Rueda, KC, 2021)	3.51
"Bisphenol A (BPA) is a well-known endocrine disruptor with several effects on mammalian systems and has been linked to diseases, such as cancer. "	( Effects of bisphenol A and S on blood coagulation: Berto-Junior, C; Chagas, AP; Cinelli, LP; Costa, BBD; da Silva, LL; Miranda-Alves, L; Moreira, TA; Peixoto, BP, 2021)	2.45
"Bisphenol A (BPA) is an industrial chemical that has been identified by some jurisdictions as an environmental concern. "	( Bisphenol A in the Canadian environment: A multimedia analysis. Backus, SM; Dove, A; Dubé-Roberge, K; Garron, C; Gewurtz, SB; King, M; Lalonde, B; Letcher, RJ; Martin, PA; McDaniel, TV; McGoldrick, DJ; Pelletier, M; Power, M; Small, J; Smyth, SA; Tardif, G; Teslic, S; Tessier, J, 2021)	3.51
"Bisphenol A (BPA) is a synthetic ubiquitous environmental toxicant present in many industrial and consumer products. "	( Bisphenol A in Africa: A review of environmental and biological levels. Adelani, IB; De Campos, OC; Olawole, TD; Rotimi, OA; Rotimi, SO, 2021)	3.51
"Bisphenol A (BPA) is a well-known endocrine disruptor that has elicited great concern because of its potential toxic effects in organisms. "	( The comparative toxicities of BPA, BPB, BPS, BPF, and BPAF on the reproductive neuroendocrine system of zebrafish embryos and its mechanisms. Chen, H; Liu, S; Luo, S; Qiu, W; Wang, KJ; Wang, X; Xiong, Y; Xu, B; Zheng, C, 2021)	2.06
"Bisphenol A (BPA) is a well-known endocrine-disrupting chemical which can cause potential health risks and interfere with thyroid hormones through multiple avenues. "	( Bisphenol A and thyroid hormones: Bibliometric analysis of scientific publications. Li, W; Wang, L; Yuan, N; Zhang, X, 2020)	3.44
"Bisphenol A (BPA) is a widely used endocrine disrupter. "	( The effect of environmental Bisphenol A exposure on breast cancer associated with obesity. Engin, A; Engin, AB, 2021)	2.36
"Bisphenol A (BPA) is a substance extensively used in daily life, mainly in plastic materials. "	( [Large-scale contamination by Bisphenol A: are we aware of the risk and forms of exposure?] Bittencourt, SS; Daronch, OT; Gil, I; Ingenchki, V; Lima, MM; Maluf, EMCP, 2020)	2.29
"Bisphenol A (BPA) is an endocrine disruptor compound (EDC) widely used in the manufacture of polycarbonates, and it has affinity for the estrogen receptor (ER)."	( The chemical environmental pollutants BPA and BPS induce alterations of the proteomic profile of different phenotypes of human breast cancer cells: A proposed interactome. Ambrosio, J; García-Becerra, R; Gómez de León, CT; Morales-Montor, J; Nava-Castro, KE; Segovia-Mendoza, M, 2020)	1.28
"Bisphenol A (BPA) is an endocrine disrupting chemical. "	( A comprehensive study on bisphenol A degradation by newly isolated strains Acinetobacter sp. K1MN and Pseudomonas sp. BG12. Chodór, M; Jałowiecki, Ł; Noszczyńska, M; Piotrowska-Seget, Z, 2021)	2.37
"Bisphenol A (BPA) is an industrial plasticizer widely found in consumer products, and exposure to BPA during early development has been associated with the prevalence of various cardiometabolic diseases including obesity, metabolic syndrome, type 2 diabetes, and cardiovascular diseases. "	( Systems toxicogenomics of prenatal low-dose BPA exposure on liver metabolic pathways, gut microbiota, and metabolic health in mice. Blencowe, M; Bline, A; Cely, I; Diamante, G; Ding, J; Lang, J; Lusis, AJ; Singh, M; Yang, X; Zamora, Z, 2021)	2.06
"Bisphenol A (BPA) is a well-known endocrine disruptor that has obesogenic properties. "	( Effects on the liver lipidome of rat offspring prenatally exposed to bisphenol A. Eguchi, A; Iwata, H; Kannan, K; Kim, EY; Li, L; Nguyen, HT, 2021)	2.3
"Bisphenol A (BPA) is an endocrine disruptor that negatively affects spermatogenesis, a process where Sertoli cells play a central role. "	( Bisphenol A Deranges the Endocannabinoid System of Primary Sertoli Cells with an Impact on Inhibin B Production. Cecconi, S; D'Andrea, G; Dainese, E; Dufrusine, B; Fezza, F; Iorio, R; Lizzi, AR; Luzi, C; Maccarrone, M; Piccoli, A; Rossi, G, 2020)	3.44
"Bisphenol A (BPA) is a chemical of concern in the food industry. "	( Determination of Free Bisphenol A in Commercially Packaged Ready-to-Consume Carbonated/Non-Carbonated and Non-Alcoholic Beverages with Immunoaffinity Column Purification and UPLC with Fluorescence Detector, First Action 2019.07. Chen, L; Liu, J; Toth, D; Yang, J; Yu, J, 2021)	2.38
"Bisphenol A (BPA) is a contaminant whose presence in aquatic environments is increasing. "	( The heart of the adult goldfish Carassius auratus as a target of Bisphenol A: a multifaceted analysis. Amelio, D; Cerra, MC; Filice, M; Garofalo, F; Gattuso, A; Imbrogno, S; Leo, S; Mazza, R, 2021)	2.3
"Bisphenol A (BPA) is an endocrine-disrupting compound that impairs testosterone synthesis in male mammals. "	( Bisphenol A attenuates testosterone production in Leydig cells via the inhibition of NR1D1 signaling. Chen, H; Gao, L; Jin, Y; Li, C; Liu, W; Ma, T; Pang, Z; Wang, A; Wang, C; Wang, X; Wu, M; Xiao, Y; Yang, L; Yao, Q; Zhang, L; Zhao, H; Zhao, L, 2021)	3.51
"Bisphenol A (BPA) is a ubiquitous environmental chemical that has been linked to behavioral differences in children and shown to impact critical neurodevelopmental processes in animal models. "	( Exposure to bisphenol A differentially impacts neurodevelopment and behavior in Drosophila melanogaster from distinct genetic backgrounds. Casiquin, J; Ceballos, A; Danziger, K; Ghenta, K; Hindi, Z; Ivory, I; Leodones, K; Mulligan, K; Murphy, L; Newman, J; Nguyen, U; Nzenkue, K; Palacios, Y; Penn, A; Sen, Y; Stein, J; Tinsley, B; Triplehorn, M; Welch, C; Widman, E, 2021)	2.44
"Bisphenol A (BPA) is a high-production-volume industrial chemical that facilitates the development of breast cancer. "	( Bisphenol A promotes breast cancer cell proliferation by driving miR-381-3p-PTTG1-dependent cell cycle progression. Chen, C; Chen, M; Deng, P; Gao, P; Li, Y; Liang, Y; Liu, M; Luo, Y; Ma, Q; Pi, H; Tan, M; Tian, L; Wang, L; Xi, Y; Xie, J; Yu, Z; Zeng, Y; Zhang, L; Zhou, W; Zhou, Z, 2021)	3.51
"Bisphenol A (BPA) is an industrial product, widely used in human consumed types of equipment that can be transmitted orally, by inhalation or through dermal absorption and is detectable in many body fluids including cord blood. "	( High fetal bisphenol A exposure enhances IL22 secretion: A proinflammatory cytokine. Babayigit, A; Bahceciler, NN; Dalkan, C; Uncu, M; Yetkin, O; Yuruker, O, 2023)	2.74
"Bisphenol A (BPA) is a widespread endocrine-disrupting chemical with estrogen like effects, which could interfere with the human reproductive system by disrupting the normal function of granulosa cells (GCs) leading to abnormal ovarian function. "	( Bisphenol A promotes autophagy in ovarian granulosa cells by inducing AMPK/mTOR/ULK1 signalling pathway. Hua, R; Li, P; Lin, M; Ma, J; Quan, S; Xu, X; Yu, Z; Zhou, Y, 2021)	3.51
"Bisphenol A (BPA) is an endocrine-disrupting chemical used in polycarbonate and epoxy resins. "	( Bisphenol A stabilizes Nrf2 via Ca Imaoka, S; Kobayashi, Y; Oguro, A; Sakuma, R; Sugitani, A, 2021)	3.51
"Bisphenol A (BPA) is a xeno-oestrogenic compound that adversely affects the spermatogenesis process by inducing oxidative stress, which ultimately leads to male infertility."	( Selenium attenuates bisphenol A incurred damage and apoptosis in mice testes by regulating mitogen-activated protein kinase signalling. Aniqa, A; Kaur, S; Sadwal, S; Saluja, M, 2021)	1.67
"Bisphenol A (BPA) is an ubiquitous synthetic chemical exerting numerous adverse effects. "	( Bisphenol A disturbs metabolism of primary rat adipocytes without affecting adipokine secretion. Okulicz, M; Szkudelska, K; Szkudelski, T, 2021)	3.51
"Bisphenol A (BPA) is a chemical used in the manufacturing of plastics to which human exposure is ubiquitous. "	( Transcriptomic pathway and benchmark dose analysis of Bisphenol A, Bisphenol S, Bisphenol F, and 3,3',5,5'-Tetrabromobisphenol A in H9 human embryonic stem cells. Atlas, E; Chepelev, N; Gagné, R; Hobbs, CA; Kuo, B; Maynor, T; Peshdary, V; Recio, L; Shepard, K; Williams, A; Yauk, C, 2021)	2.31
"Bisphenol A (BPA) is a typical endocrine disruptor that causes problems in waters all around the world. "	( Enhanced Phytoremediation of Bisphenol A in Polluted Lake Water by Seedlings of Jiang, J; Zhang, G; Zhao, C, 2021)	2.36
"Bisphenol A (BPA) is a monomer that is widely used in the manufacturing of polycarbonate plastics (including storage plastics and baby bottles) and is considered to be one of the most widely used synthetic compounds in the manufacturing industry. "	( The Putative Adverse Effects of Bisphenol A on Autoimmune Diseases. Alexander, M; Amital, H; Coplan, L; Kurnick, A; Sharif, K; Shoenfeld, Y; Watad, A, 2022)	2.45
"Bisphenol A (BPA) is an endocrine disruptor (ED) frequently used in food packaging. "	( Effects of a Plastic-Free Lifestyle on Urinary Bisphenol A Levels in School-Aged Children of Southern Italy: A Pilot Study. Campanozzi, A; Carotenuto, M; Cibelli, G; Messina, G; Mollica, MP; Monda, M; Monda, V; Polito, R; Salerno, M; Scarinci, A; Sessa, F; Valenzano, A, 2021)	2.32
"Bisphenol A (BPA) is a well-recognized endocrine disruptor and is globally used in the manufacture of many plastic items. "	( Gamma aminobutyric acid signaling disturbances and altered astrocytic morphology associated with Bisphenol A induced cognitive impairments in rat offspring. Kazi, SAF; Memon, S; Nizamani, GS; Singha, SP, 2021)	2.28
"Bisphenol A (BpA) is a chemical predominantly used in manufacturing and is being replaced by other analogs due to its potential toxicity."	( Quantitative analysis of bisphenol analogue mixtures by terahertz spectroscopy using machine learning method. Fan, S; Huang, J; Liu, X; Shan, L; Sun, Y; Zhu, Z, 2021)	1.65
"Bisphenol A (BPA) is a chemical endocrine disruptor to which humans are often exposed in daily life. "	( Anti-anxiety and antidepressant-like effects of astragaloside IV and saponins extracted from Astragalus spinosus against the bisphenol A-induced motor and cognitive impairments in a postnatal rat model of schizophrenia. Abd Elkader, HAE; Abdou, HM; Essawy, AE; Khamiss, OA, 2021)	2.27
"Bisphenol A (BPA) is a xenoestrogen chemical commonly used to manufacture polycarbonate plastics and epoxy resin and might affect various human organs. "	( Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells. An, MJ; Kim, CH; Kim, J; Kim, JW; Kim, JY; Kim, MJ; Lee, HM; Park, J; Shin, GS, 2021)	3.51
"Bisphenol A (BPA) is a widely used raw material that can be detected both in the environment and in the human body. "	( Bisphenol A induces ovarian cancer cell proliferation and metastasis through estrogen receptor-α pathways. Fu, L; Gao, H; Jin, TW; Liu, S; Sang, C; Song, Y; Wang, Z; Zhang, S; Zhao, Y; Zou, X, 2021)	3.51
"Bisphenol A (BPA) is a non-persistent chemical with endocrine disrupting abilities used in a variety of consumer products. "	( Prenatal exposure to bisphenol A and autistic- and ADHD-related symptoms in children aged 2 and5 years from the Odense Child Cohort. Andersson, AM; Bilenberg, N; Frederiksen, H; Hansen, JB; Jensen, RC; Jensen, TK; Kyhl, HB; Timmermann, CAG, 2021)	2.38
"Bisphenol A is a well-known chemical substance triggering reprotoxic and endocrine disruptor effects. "	( Lifetime dietary exposure to bisphenol A in the general population and during pregnancy: Foetal exposure and health risk assessment. Le Bizec, B; Picard-Hagen, N; Pruvost-Couvreur, M; Rivière, G, 2021)	2.36
"Bisphenol A (BPA) is a known endocrine disruptor and free BPA will interact with estrogen. "	( Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study Çiftçi, S; Samur, G; Yalçın, SS, 2021)	3.51
"Bisphenol A is a phenolic plasticizer used in the production of various plastic products. "	( Determination and occurrence of bisphenol A and thirteen structural analogs in soil. He, Y; Hu, A; Li, Y; Lu, Z; Xu, J; Xu, Y, 2021)	2.35
"Bisphenol A is an endocrine interfering compound, produced and used on a large scale worldwide. "	( Production of Pleurotus sajor-caju crude enzyme broth and its applicability for the removal of bisphenol A. Arbigaus, A; Bonatti-Chaves, M; Furigo Júnior, A; Furlan, SA; Gern, RMM; Melo, MP; Rampinelli, JR; Silveira, MLLD; Wagner, TM; Wisbeck, E, 2021)	2.28
"Bisphenol A (BPA) is a ubiquitous contaminant with endocrine-disrupting effects in mammals. "	( An overview of the literature on emerging pollutants: Chlorinated derivatives of Bisphenol A (Cl Dupuis, A; Haddad, S; Migeot, V; Plattard, N; Venisse, N, 2021)	2.29
"Bisphenol A (BPA) is a ubiquitous industrial chemical found in everyday plastic products and materials. "	( BPA and BPA alternatives BPS, BPAF, and TMBPF, induce cytotoxicity and apoptosis in rat and human stem cells. Chin, A; Harnett, KG; Schuh, SM, 2021)	2.06
"Bisphenol A (BPA) is an endocrine disrupting chemical able to promote hormone-responsive tumors. "	( Effects of high-dose bisphenol A on the mouse oral mucosa: A possible link with oral cancers. Almeida, TFA; Alves Diniz, IM; Aparecida Silva, T; Campolina-Silva, GH; de Lourdes Cardeal, Z; Fernandes de Oliveira, AL; Garlet, GP; Gomes, JM; Leopoldino, AM; Macari, S; Mayra da Silva, J; Menezes, HC; Oliveira, CA; Oliveira, SR, 2021)	2.38
"Bisphenol A (BPA) is a ubiquitous environmental toxin worldwide. "	( Drivers of owning more BPA. Adegoke, EO; Pang, MG; Rahman, MS, 2021)	2.06
"Bisphenol A (BPA) is an endocrine-disrupting chemical used in the production of plastics, and is linked to developmental, reproductive, and metabolic disorders including obesity. "	( BPA, BPAF and TMBPF Alter Adipogenesis and Fat Accumulation in Human Mesenchymal Stem Cells, with Implications for Obesity. Cohen, IC; Cohenour, ER; Harnett, KG; Schuh, SM, 2021)	2.06
"Bisphenol A (BPA) is a high-production-volume monomer for the manufacture of a wide variety of polycarbonate plastics and resins. "	( In vivo and in vitro transcriptomics meta-analyses reveal that BPA may affect TGF-beta signaling regardless of the toxicology system employed. Faiola, F; Lu, Y; Yang, R; Yin, N, 2021)	2.06
"Bisphenol A (BPA) is a widely used chemical with toxic effects on the liver. "	( A Quantitative Study on the Protective Effects of Resveratrol against Bisphenol A-induced Hepatotoxicity in Rats: A Stereological Study. Bordbar, H; Fazelian-Dehkordi, K; Nadimi, E; Soleymani, F; Yahyavi, SS, 2021)	2.3
"Bisphenol A (BPA) is an endocrine-disrupting chemical utilized in the manufacture of food packaging, dental materials, medical devices, children's toys, and baby products. "	( Combined effect of fulvestrant and low dose BPA: comparative implications on EMT, apoptosis, and TGF-β1 signaling in HepG2 cells. Öz, E; Tüylü Küçükkılınç, T, 2022)	2.16
"Bisphenol A (BPA) is a widely distributed environmental endocrine disruptor. "	( Coenzyme Q10 ameliorates BPA-induced apoptosis by regulating autophagy-related lysosomal pathways. Li, X; Liu, F; Liu, Y; Song, D; Tao, W; Yang, S; Yao, Y; Zhao, A, 2021)	2.06
"Bisphenol A (BPA) is a widespread environmental contaminant, found in human fluids and tissues. "	( Bisphenol a Interferes with Uterine Artery Features and Impairs Rat Feto-Placental Growth. Barberio, L; Canesi, L; Grasselli, E; Mandalà, M; Paulesu, L, 2021)	3.51
"Bisphenol A (BPA) is an organic chemical compound widely used for manufacturing plastics. "	( Prenatal Exposure to BPA: The Effects on Hepatic Lipid Metabolism in Male and Female Rat Fetuses. Barberio, L; Bertoli, S; Cigliano, L; Leone, A; Mandalà, M; Mazzoli, A; Pallottini, V; Segatto, M; Tonini, C, 2021)	2.06
"Bisphenol A (BPA) is a synthetic phenol extensively used in the manufacture of polycarbonate plastics and epoxy resins and a component of liquid and food storages. "	( Placental Glucose Transporters and Response to Bisphenol A in Pregnancies from of Normal and Overweight Mothers. Ermini, L; Ietta, F; Masturzo, B; Moretti, L; Nuzzo, AM; Paulesu, L; Rolfo, A; Romagnoli, R, 2021)	2.32
"Bisphenol A is an extremely high-volume chemical widely used in polycarbonate plastics, the linings of food and beverage tins, and shopping receipts. "	( What Does CLARITY-BPA Mean for Canadians? Rogers, LD, 2021)	2.06
"Bisphenol A (BPA) is an endocrine-disrupting chemical used commonly in the manufacture of plastic bottles, beverage cans, consumer products, and medical devices. "	( Role of cerium oxide nanoparticles in improving oxidative stress and developmental delays in Drosophila melanogaster as an in-vivo model for bisphenol a toxicity. Christopher, RV; Dan, P; Jana, N; Mahendran, TS; Meenakshisundaram, A; Sarkar, A; Sheik Mohideen, S; Sundararajan, V; Venkatasubbu, D, 2021)	2.27
"Bisphenol A (BPA) is a high-production volume chemical used to manufacture consumer and medical-grade plastic products. "	( Bisphenol S and Bisphenol F Are Less Disruptive to Cardiac Electrophysiology, as Compared With Bisphenol A. Ciccarelli, N; Cooper, B; Guerrelli, D; Jaimes, R; Posnack, NG; Prudencio, TM; Reilly, M; Sheng, J; Swift, LM, 2021)	2.28
"Bisphenol A (BPA) is a known endocrine disruptor compound that is widely applied as a monomer base in polycarbonate plastics and as a binding agent in several epoxy resins. "	( Urinary bisphenol levels in plastic industry workers. Azzouz, M; Bader, G; Benmbarek, K; Benmohammed, K; Cunha, SC; Fernandes, JO; Rebai, I, 2021)	2.06
"Bisphenol A (BPA) is a chemical commonly used in the industrial sectors, hence humans are exposed to the compound repetitively. "	( Chronic exposure to low doses of bisphenol A alters hydromineral responses in rats. Arguelles, J; Nuñez, P; Perillan, C, 2021)	2.35
"Bisphenol A (BPA) is a compound that is especially widespread in most commonly used objects due to its multiple uses in the plastic industry. "	( Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03-16 Study. Arenas, MI; Bosch, RJ; Bover, J; Coll, E; Moreno-Gómez-Toledano, R; Quiroga, B; Vélez-Vélez, E, 2021)	3.51
"Bisphenol A (BPA) is an endocrine disruptor that it is present in numerous products of daily use. "	( Bisphenol-A exposure and risk of breast and prostate cancer in the Spanish European Prospective Investigation into Cancer and Nutrition study. Agudo, A; Amiano, P; Arrebola, JP; Chirlaque, MD; Colorado, S; Delfrade, J; Guevara, M; Jimenez, A; Olea, N; Rodríguez-Barranco, M; Salamanca-Fernández, E; Sánchez, MJ; Vela, F, 2021)	2.06
"Bisphenol A (BPA) is a well-known endocrine-disrupting chemical that is widely used in a variety of products, including plastics, medical equipment and receipts. "	( Cardiac toxicity from bisphenol A exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Chon, SH; Hyun, SA; Ka, M; Kim, KK; Kim, YJ; Ko, MY; Lee, CY; Seo, JW, 2021)	2.38
"Bisphenol A (BPA) is an industrial chemical mostly used in the manufacture of plastics, resins and thermal paper. "	( Human-Biomonitoring derived exposure and Daily Intakes of Bisphenol A and their associations with neurodevelopmental outcomes among children of the Polish Mother and Child Cohort Study. Andysz, A; Bose-O'Reilly, S; Bury, D; Garí, M; Hanke, W; Jankowska, A; Kasper-Sonnenberg, M; Koch, HM; Moos, R; Nowak, D; Polanska, K, 2021)	2.31
"Bisphenol A (BPA) is an estrogenic endocrine-disrupting chemical (EDC) that has a range of potential adverse health effects. "	( Progesterone Protects Against Bisphenol A-Induced Arrhythmias in Female Rat Cardiac Myocytes via Rapid Signaling. Hong, K; Ma, J; Wang, HS, 2017)	2.19
"Bisphenol A (BPA) is an industrial chemical found in thermal receipts and food and beverage containers. "	( Bisphenol A Exposure, Ovarian Follicle Numbers, and Female Sex Steroid Hormone Levels: Results From a CLARITY-BPA Study. Brehm, E; Flaws, JA; Gao, L; Patel, S; Rattan, S; Ziv-Gal, A, 2017)	3.34
"Bisphenol A (BPA) is a high production volume chemical that is used in plastics and epoxy coatings. "	( Derivation of an oral Maximum Allowable Dose Level for Bisphenol A. Goodman, JE; Hixon, ML; Pacheco Shubin, S; Peterson, MK, 2017)	2.15
"Bisphenol A (BPA) is an estrogenic chemical used in the production of polycarbonate plastics and epoxy resins. "	( Bisphenol A Induces Oxidative Stress in Bone Marrow Cells, Lymphocytes, and Reproductive Organs of Holtzman Rats. Tiwari, D; Vanage, G, )	3.02
"Bisphenol A (BPA) is a widely used chemical that has been extensively studied as an endocrine-disrupting chemical (EDC). "	( In vitro and in vivo estrogenic activity of BPA, BPF and BPS in zebrafish-specific assays. Aït-Aïssa, S; Balaguer, P; Brion, F; Cravedi, JP; Le Fol, V; Porcher, JM; Sonavane, M; Zalko, D, 2017)	1.9
"Bisphenol A (BPA) is an endocrine disrupting chemical used in a wide range of consumer products including photoactive dyes used in thermal paper. "	( Handling of thermal paper: Implications for dermal exposure to bisphenol A and its alternatives. Bernier, MR; Vandenberg, LN, 2017)	2.14
"Bisphenol A (BPA) is a synthetic chemical primarily used to produce polycarbonate plastics and epoxy resins. "	( Accelerated biodegradation of BPA in water-sediment microcosms with Bacillus sp. GZB and the associated bacterial community structure. An, T; Li, G; Peng, P; Xiong, J, 2017)	1.9
"Bisphenol A (BPA) is an endocrine disruptor with an oestrogenic activity that is widely produced for the manufacture of polycarbonate plastic, epoxy resin, and thermal paper. "	( Is bisphenol A an environmental obesogen? Faure, S; Legeay, S, 2017)	2.52
"Bisphenol A (BPA) is a synthetic endocrine-disrupting chemical of high prevalence in the environment, which may affect the function of the hypothalamic-pituitary-testis (HPT) axis in adult rats. "	( Delayed onset of puberty in male offspring from bisphenol A-treated dams is followed by the modulation of gene expression in the hypothalamic-pituitary-testis axis in adulthood. Cavallin, MD; de Campos, P; Oliveira, CA; Oliveira, IM; Romano, MA; Romano, RM, 2017)	2.15
"Bisphenol A (BPA) is an endocrine-disrupting chemical that may contribute to development of obesity and metabolic disorders. "	( Effects of Low-Dose Developmental Bisphenol A Exposure on Metabolic Parameters and Gene Expression in Male and Female Fischer 344 Rat Offspring. Bladin, E; Dunder, L; Lejonklou, MH; Lind, L; Lind, PM; Pettersson, V; Rönn, M; Waldén, TB, 2017)	2.18
"Bisphenol A (BPA) is an artificial environmental endocrine disrupting chemical and commonly used as a monomer of polycarbonate plastics and epoxy resins. "	( Protective effect of crocin on BPA-induced liver toxicity in rats through inhibition of oxidative stress and downregulation of MAPK and MAPKAP signaling pathway and miRNA-122 expression. Abnous, K; Birner-Gruenberger, R; Hosseinzadeh, H; Mehri, S; Vahdati Hassani, F, 2017)	1.9
"Bisphenol A (BPA) is a well-known endocrine disrupting chemical (EDC) that is used to manufacture plastic consumer products. "	( Bisphenol A disrupts steroidogenesis and induces a sex hormone imbalance through c-Jun phosphorylation in Leydig cells. Chang, AA; Hu, MC; Lan, HC; Lin, IW; Wu, KY; Yang, ZJ, 2017)	3.34
"Bisphenol A (BPA) is a well-known endocrine-disrupting chemical, and it is one of the highest volume chemicals produced worldwide. "	( Bisphenol A induces COX-2 through the mitogen-activated protein kinase pathway and is associated with levels of inflammation-related markers in elderly populations. Bui, PTC; Choi, K; Gye, MC; Hong, YC; Kim, JH; Lee, YJ; Park, J; Song, H, 2017)	3.34
"Bisphenol A (BPA) is a well-known global environmental toxicant and a ubiquitous oestrogenic chemical."	( Bisphenol A induced oxidative stress and apoptosis in mice testes: Modulation by selenium. Bansal, MP; Kaur, S; Saluja, M, 2018)	2.64
"Bisphenol A (BPA) is an emerging environmental endocrine disruptor that has toxic effects on plants growth. "	( Stomatal and non-stomatal factors regulated the photosynthesis of soybean seedlings in the present of exogenous bisphenol A. Huang, X; Jiao, L; Wang, L; Zhou, Q, 2017)	2.11
"Bisphenol A is a chemical with hazardous health effects that is largely used in the manufacture of extensively used products including adhesives, plastics, powder paints, thermal paper and paper coatings, and epoxy resin, and is reported to exist in nature in an accumulative manner. "	( Removal of bisphenol A by electrochemical carbon-nanotube filter: Influential factors and degradation pathway. Bakr, AR; Rahaman, MS, 2017)	2.29
"Bisphenol A (BPA) is an endocrine disruptor frequently detected in human biofluids. "	( Prolonged Exposure to Bisphenol A from Single Dermal Contact Events. Liu, J; Martin, JW, 2017)	2.21
"Bisphenol A (BPA) is a component of polycarbonate plastics to which humans are regularly exposed at low levels, and an endocrine disruptor with effects on several hormonal systems. "	( Low-dose developmental exposure to bisphenol A induces sex-specific effects in bone of Fischer 344 rat offspring. Dunder, L; Larsson, S; Lejonklou, MH; Lind, PM; Lind, T; Melhus, H; Rasmusson, A, 2017)	2.17
"Bisphenol A is a chemical compound related to adverse maternal and neonatal outcomes. "	( Bisphenol A and adverse pregnancy outcomes: a systematic review of the literature. Christopoulos-Timogiannakis, E; Daskalakis, G; Kotrogianni, P; Koutaki, D; Papantoniou, N; Pergialiotis, V, 2018)	3.37
"Bisphenol A (BPA) is an environmental contaminant widely used in the plastic industry. "	( The possible molecular mechanisms of bisphenol A action on porcine early embryonic development. Ahn, YD; Cui, XS; Guo, J; Kim, NH; Niu, YJ; Shin, KT; Zhao, MH, 2017)	2.17
"Bisphenol A (BPA) is a chemical compound used for polycarbonate plastics, food containers, epoxy resins coating metallic cans for food and beverage conservation."	( Bisphenol A and Metabolic Diseases: Challenges for Occupational Medicine. Caporossi, L; Papaleo, B, 2017)	2.62
"Bisphenol A (BPA) is a synthetic non-steroidal oestrogen used in the production of plastics. "	( Bisphenol A Exposure Impairs Epididymal Development during the Peripubertal Period of Rats: Inflammatory Profile and Tissue Changes. de Lion Siervo, GEM; de Oliveira Mendes, L; Fattori, V; Fernandes, GSA; Luchetta, NR; Ogo, FM; Scarano, WR; Staurengo-Ferrari, L; Verri, WA; Vieira, HR, 2018)	3.37
"Bisphenol A (BPA) is an endocrine disruptor used in a variety of consumer products. "	( Bisphenol A decreases progesterone synthesis by disrupting cholesterol homeostasis in rat granulosa cells. Andric, N; Fa, S; Jasnic, J; Pogrmic-Majkic, K; Samardzija, D; Stanic, B, 2018)	3.37
"Bisphenol A (BPA) is a widely distributed estrogen-mimetic molecule, with well-established effects on the dopaminergic system. "	( Bisphenol A glucuronidation in patients with Parkinson's disease. Amboni, M; Barone, P; Landolfi, A; Savanelli, MC; Troisi, J; Vitale, C, 2017)	3.34
"Bisphenol A (BPA) is an endocrine disruptor with multiple purported metabolic effects. "	( Bisphenol A urinary level, its correlates, and association with cardiometabolic risks in Lebanese urban adults. Abiad, M; Ismail, H; Khoueiry-Zgheib, N; Koleilat, L; Mouneimne, Y; Nakhoul, N; Nasrallah, M; Nasreddine, L; Tamim, H, 2017)	3.34
"Bisphenol A (BPA) is an endocrine disrupting chemical used in the production of polycarbonate plastics and resins. "	( Effects of maternal or paternal bisphenol A exposure on offspring behavior. Allardice, HA; Harris, EP; Rissman, EF; Schenk, AK, 2018)	2.21
"Bisphenol A (BPA) is a commonly used plasticizer. "	( The effects of in utero bisphenol A exposure on ovarian follicle numbers and steroidogenesis in the F1 and F2 generations of mice. Flaws, JA; Gao, L; Mahalingam, S; Ther, L; Wang, W; Ziv-Gal, A, 2017)	2.2
"Bisphenol A (BPA) is an endocrine disrupting chemical widely used in the manufacture of polycarbonate plastic and epoxy resin to produce a multitude of consumer products, food and drink containers, and medical devices. "	( Bisphenol A in Reproduction: Epigenetic Effects. Chianese, R; Fasano, S; Guida, M; Meccariello, R; Pierantoni, R; Richards, S; Scafuro, M; Troisi, J, 2018)	3.37
"Bisphenol A (BPA) is an environmental endocrine-disrupting substance with oestrogenic activity."	( Short-term exposure to bisphenol A affects water and salt intakes differently in male and ovariectomised female rats. Arguelles, J; Nuñez, P; Perillan, C, 2018)	1.51
"Bisphenol A (BPA) is an environmental endocrine disruptor."	( Bisphenol A promotes hyperuricemia via activating xanthine oxidase. Gao, R; He, JC; Hu, J; Li, J; Li, Q; Luo, T; Ma, L; Peng, C; Qing, H; Wang, Y; Wang, Z; Wu, C; Xiang, X; Xiao, X; Yang, S; Yang, Y; Zhang, L; Zou, L, 2018)	2.64
"Bisphenol A (BPA) is a phenolic compound being constituent of numerous everyday-used products. "	( Short-term in vitro effects of bisphenol A activity on phenotype and function of peripheral blood immune system cells. Grubczak, K; Kretowska, A; Moniuszko, M; Poplawska, I; Zbucka-Kretowska, M, 2017)	2.18
"Bisphenol A (BPA) is a well-known endocrine disrupting compound. "	( Bisphenol A and reproductive hormones and cortisol in peripubertal boys: The INMA-Granada cohort. Arrebola, JP; Calvente, I; Dávila-Arias, C; Fernández, MF; Hauser, R; Mínguez-Alarcón, L; Mustieles, V; Ocón-Hernandez, O; Olea, N; Pérez-Lobato, R; Rubio, S; Vela-Soria, F, 2018)	3.37
"Bisphenol A (BPA) is a chemical found in plastics that resembles oestrogen in organisms. "	( Effects of bisphenol A treatment during pregnancy on kidney development in mice: a stereological and histopathological study. Alonso-Magdalena, P; Arguelles, J; Fernandez, T; García-Arévalo, M; Nadal, A; Nuñez, P; Perillan, C, 2018)	2.31
"Bisphenol A (BPA) is an endocrine disrupter which has adverse effects on male reproduction. "	( Adult exposure to bisphenol A in rare minnow Gobiocypris rarus reduces sperm quality with disruption of testicular aquaporins. Guan, Y; Liu, Y; Wang, Z; Yuan, C; Zhang, T; Zhang, Y, 2018)	2.26
"Bisphenol A (BPA) is a pervasive environmental toxicant with known reproductive effects on sperm parameters and hormone levels. "	( Urinary bisphenol A concentrations are associated with reproductive parameters in young men. Adoamnei, E; Fernández, MF; Jørgensen, N; Mendiola, J; Olea, N; Swan, SH; Torres-Cantero, AM; Vela-Soria, F, 2018)	2.36
"Bisphenol A (BPA) is an endocrine disrupter that acts in an estrogen-like manner. "	( A prospective cohort study of the association between bisphenol A exposure and the serum levels of liver enzymes in children. Ha, EH; Han, H; Hong, YS; Lee, HA; Lee, S; Oh, SY; Park, B; Park, BH; Park, H, 2018)	2.17
"Bisphenol A (BPA) is a ubiquitous man-made endocrine disrupting compound (EDC). "	( Transgenerational Effects of Bisphenol A on Gene Expression and DNA Methylation of Imprinted Genes in Brain. Adli, M; Drobná, Z; Flaws, JA; Harris, EP; Henriksen, AD; Lambeth, PS; Montiel, C; Rissman, EF; Shang, S; Wolstenholme, JT; Zhou, C, 2018)	2.21
"Bisphenol A (BPA) is an endocrine disruptor that is widely used in the manufacture of polycarbonate plastics, epoxy resins and dental sealants. "	( Bisphenol A-induced ultrastructural changes in the testes of common marmoset. Dhumal, RV; Dighe, VD; Singh, D; Vanage, GR; Vijaykumar, T, 2017)	3.34
"Bisphenol A (BPA) is a ubiquitous environmental toxin, structurally related with p-cresol, that accumulates in CKD."	( Bisphenol A is an exogenous toxin that promotes mitochondrial injury and death in tubular cells. Abaigar, P; Bosch-Panadero, E; Camarero, V; Civantos, E; Egido, J; González-Parra, E; Mas, S; Ortiz, A; Ruiz-Priego, A, 2018)	2.64
"Bisphenol A (BPA) is an industrial material used for many plastic products and is considered an endocrine disruptor. "	( Low-dose bisphenol A activates the ERK signaling pathway and attenuates steroidogenic gene expression in human placental cells. Chang, AA; Cheng, YC; Chu, PW; Huang, HH; Lan, HC; Wu, GJ; Yang, ZJ, 2018)	2.34
"Bisphenol A (BPA) is an extremely common polymer that is used in typical everyday products throughout the world, especially in food and beverage containers. "	( Bisphenol A Causes Liver Damage and Selectively Alters the Neurochemical Coding of Intrahepatic Parasympathetic Nerves in Juvenile Porcine Models under Physiological Conditions. Dzika, E; Konrad, P; Kruminis-Kaszkiel, E; Rytel, L; Thoene, M; Wojtkiewicz, J; Włodarczyk, A, 2017)	3.34
"Bisphenol A (BPA) is a widely used compound in the food packaging industry. "	( Bisphenol A exposure induces increased microglia and microglial related factors in the murine embryonic dorsal telencephalon and hypothalamus. Goto, S; Ikeda, Y; Komada, M; Miyazawa, K; Takahashi, M, 2018)	3.37
"Bisphenol A (BPA) is an endocrine-disrupting chemical. "	( Relationship between bisphenol A exposure and attention-deficit/ hyperactivity disorder: A case-control study for primary school children in Guangzhou, China. Cha, C; Fan, R; Kuang, H; Li, G; Li, Y; Luo, Z; Pang, Q; Zhang, H, 2018)	2.24
"Bisphenol A (BPA) is a widespread environmental pollutant, reportedly harmful to living organisms. "	( Disruption of actin filaments in Zea mays by bisphenol A depends on their crosstalk with microtubules. Adamakis, IS; Arseni, EM; Eleftheriou, EP; Panteris, E; Stavropoulou, K, 2018)	2.18
"Bisphenol A (BPA) is a ubiquitous chemical suspected to possess oestrogenic hormonal activities. "	( The impact of antenatal Bisphenol A exposure on male reproductive function at 20-22 years of age. Dickinson, JE; Doherty, DA; Handelsman, DJ; Hart, RJ; Keelan, JA; McLachlan, R; Minaee, NS; Newnham, JP; Norman, RJ; Pennell, CE; Thorstensen, EB, 2018)	2.23
"Bisphenol A (BPA) is a component of polycarbonate plastics, epoxy resins and polystyrene found in many common products. "	( Neonatal exposure to bisphenol A alters the hypothalamic-pituitary-thyroid axis in female rats. Arocena, P; Bourguignon, NS; Fernandez, MO; Libertun, C; Lux-Lantos, V; Rosa, M, 2018)	2.24
"Bisphenol A is an endocrine disrupting chemical associated with type 2 diabetes mellitus (T2DM), cardiovascular disease and liver enzyme abnormalities."	( Role of bisphenol A as environmental factor in the promotion of non-alcoholic fatty liver disease: in vitro and clinical study. Dallio, M; Di Sarno, R; Diano, N; Errico, S; Federico, A; Gionti, L; Gravina, AG; Loguercio, C; Masarone, M; Nicolucci, C; Persico, M; Stiuso, P; Tuccillo, C, 2018)	2.36
"Bisphenol A (BPA) is a well-known endocrine disruptor compound reported to have prostate toxicity. "	( Oral exposure of low-dose bisphenol A promotes proliferation of dorsolateral prostate and induces epithelial-mesenchymal transition in aged rats. Huang, DY; Li, L; Pan, Q; Su, X; Sun, ZY; Wu, JH; Wu, SS; Zheng, CC, 2018)	2.22
"Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) that might be harmful to human health. "	( Differential Burns, KA; Coons, LA; Houtman, R; Korach, KS; Li, Y; Pelch, KE; Perera, L; Teng, CT; Tyler Ramsey, J; van Beuningen, R, 2018)	1.92
"Bisphenol A (BPA) is an emerging contaminant widely used in various industrial products. "	( Bisphenol risk in fish exposed to a contamination gradient: Triggering of spatial avoidance. Araújo, CVM; França, FM; Neto, MB; Paiva, TCB; Pompêo, MLM; Silva, DCVR; Silva, FT, 2018)	1.92
"Bisphenol A (BPA) is a known environmental endocrine-disrupting chemical that is widely used in plastics manufacturing. "	( Short-term induction of vitellogenesis in the immature male yellowfin seabream ( Acanthopagrus latus) exposed to bisphenol A and 17 β-estradiol. Matroodi, S; Negintaji, A; Safahieh, A; Zolgharnein, H, 2018)	2.13
"Bisphenol A (BPA) is a base chemical used extensively in numerous consumer products, and human exposure to BPA is ubiquitous. "	( Perinatal Bisphenol A Exposure Increases Atherosclerosis in Adult Male PXR-Humanized Mice. Park, SH; Sui, Y; Wang, F; Zhou, C, 2018)	2.33
"Bisphenol A (BPA) is a widely used environmental pollutant in the production of plastics but causes hepatotoxicity in mammals. "	( Healing potential of Adiantum capillus-veneris L. plant extract on bisphenol A-induced hepatic toxicity in male albino rats. Iqbal, HH; Kanwal, Q; Munir, B; Qadir, A, 2018)	2.16
"Bisphenol A (BPA) is a monomer found in polycarbonate-made containers that can induce functional alterations, including impaired oocyte meiotic division and reduced molecule transfer in GJIC."	( Bisphenol A alters oocyte maturation by prematurely closing gap junctions in the cumulus cell-oocyte complex. Acuña-Hernández, DG; Arreola-Mendoza, L; García-Zepeda, SP; Hernández-Ochoa, I; Olivares-Reyes, JA; Parra-Forero, LY; Santacruz-Márquez, R, 2018)	2.64
"Bisphenol A (BPA) is a widely used additive in the plastic industry and has been reported to have genotoxicity. "	( Mass spectrometry investigation of DNA adduct formation from bisphenol A quinone metabolite and MCF-7 cell DNA. Cai, Z; Wei, J; Xiang, L; Zhao, H, 2018)	2.16
"Bisphenol A (BPA) is an ubiquitous environmental toxin that is also found in dialyzers. "	( Influence of dialysis membrane composition on plasma bisphenol A levels during online hemodiafiltration. Abaigar, P; Bosch-Panadero, E; Camarero, V; Civantos, E; Egido, J; González-Parra, E; Mahillo, I; Mas, S; Ortiz, A; Ruiz-Priego, A; Sanchez-Ospina, D, 2018)	2.17
"Bisphenol A (BPA) is a chemical used in numerous industrial applications. "	( Cytotoxicity of seven bisphenol analogues compared to bisphenol A and relationships with membrane affinity data. Barbato, F; Capuozzo, A; Grumetto, L; Irace, C; Russo, G; Santamaria, R, 2018)	2.24
"Bisphenol A (BPA) is an organic compound from the phenolic group commonly used for the production of plastics. "	( Bisphenol A-Induced changes in the enteric nervous system of the porcine duodenum. Gonkowski, S; Szymanska, K, 2018)	3.37
"Bisphenol A (BPA) is a ubiquitous industrial chemical that has been identified as an endocrine disrupting compound (EDC). "	( Effects of continuous bisphenol A exposure from early gestation on 90 day old rat testes function and sperm molecular profiles: A CLARITY-BPA consortium study. Anderson, LM; Boekelheide, K; Camacho, L; Dere, E; Hall, SJ; Huse, SM; Lewis, SM; Madnick, SJ; McDonnell-Clark, E; Spade, DJ; Vanlandingham, MM, 2018)	2.24
"Bisphenol A (BPA) is a ubiquitous plasticizer which is absorbed by ingestion and dermal contact; propyl paraben (PPB) inhibits the microbiome and extends the shelf life of many personal care products, whereas triclosan (TCS) is commonly found in antiseptics, disinfectants, or additives. "	( Toxic Effects of Bisphenol A, Propyl Paraben, and Triclosan on Caenorhabditis elegans. García-Espiñeira, MC; Olivero-Verbel, J; Tejeda-Benítez, LP, 2018)	2.26
"Bisphenol A (BPA) is a synthetic chemical widely used in the industry, which may potentially evoke negative effects on human health, especially on reproductive processes and fetal development. "	( Evaluation of Bisphenol A influence on endocannabinoid system in pregnant women. Ciborowski, M; Czerniecki, J; Kretowski, A; Lazarek, U; Maslyk, M; Miltyk, W; Parfieniuk, E; Wolczynski, S; Zbucka-Kretowska, M; Zbucki, R, 2018)	2.28
"Bisphenol A (BPA) is a well-known and widely used endocrine disrupter, but data on its association with childhood reproductive development are limited."	( Association between bisphenol a exposure and idiopathic central precocious puberty (ICPP) among school-aged girls in Shanghai, China. Chen, Y; Ding, G; Huang, H; Shen, L; Tian, Y; Wang, X; Wang, Y; Zhou, Z, 2018)	2.25
"Bisphenol A (BPA) is an emerging pollutant of environmental concern, classified as "moderately toxic" and "toxic", causing adverse effects on aquatic biota. "	( The effects of Bisphenol A on the seagrass Cymodocea nodosa: Leaf elongation impairment and cytoskeleton disturbance. Adamakis, IS; Malea, P; Panteris, E, 2018)	2.28
"Bisphenol A (BPA) is an endocrine disruptor that is ubiquitous in the environment. "	( Impacts of exogenous pollutant bisphenol A on characteristics of soybeans. Huang, X; Li, X; Shen, F; Wang, L; Zhou, Q, 2018)	2.21
"Bisphenol A (BPA) is an endocrine disruptor compound that is continuously released into the environment and is barely degraded in wastewater treatment plants. "	( A highly reusable MANAE-agarose-immobilized Pleurotus ostreatus laccase for degradation of bisphenol A. Bracht, A; Brugnari, T; Bubna, GA; Castoldi, R; Contato, AG; Corrêa, RCG; de Freitas, EN; de Souza, CGM; Peralta, RM; Pereira, MG; Polizeli, MLTM, 2018)	2.14
"Bisphenol A (BPA) is a xenoestrogen, which is commonly used as a monomer of polycarbonate plastics food containers and epoxy resins. "	( Co-exposure to endocrine disruptors: effect of bisphenol A and soy extract on glucose homeostasis and related metabolic disorders in male mice. Ahangarpour, A; Jafarirad, S; Malehi, AS; Mohaghegh, SM; Veissi, M, 2018)	2.18
"Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) that has been demonstrated to induce alterations in reproductive organs while melatonin (ML), an antioxidant, present in plants and animals, is capable of protecting against EDC-induced alterations. "	( Melatonin ameliorates bisphenol A-induced perturbations of the prostate gland of adult Wistar rats. Aina, OO; Ajani, SO; Lanipekun, DO; Oke, BO; Ola-Davies, EO; Olukole, SG; Oyeyemi, MO, 2018)	2.24
"Bisphenol A (BPA) is an endocrine disruptor and also a suggested obesogen and metabolism-disrupting chemical. "	( Low-dose developmental bisphenol A exposure alters fatty acid metabolism in Fischer 344 rat offspring. Dunder, L; Halin Lejonklou, M; Lind, L; Lind, PM; Risérus, U, 2018)	2.23
"Bisphenol A (BPA) is an important industrial raw material that is widely applied in daily products. "	( Bisphenol A concentrations in human urine, human intakes across six continents, and annual trends of average intakes in adult and child populations worldwide: A thorough literature review. Dang, Z; Huang, RP; Lin, Z; Liu, ZH; Wu, PX; Yin, H; Zhu, NW, 2018)	3.37
"Bisphenol A (BPA) is an endocrine-disrupting chemical, and activates the aryl hydrocarbon receptor (AhR) and the estrogen receptor, leading to the induction of drug metabolizing enzymes. "	( Bisphenol A induces Nrf2-dependent drug-metabolizing enzymes through nitrosylation of Keap1. Imaoka, S; Nakamura, M; Oguro, A; Yamanaka, H, 2018)	3.37
"Bisphenol A (BPA) is an organic monomer used to make common consumer goods such as plastic containers, sports equipment, and cosmetics which are heavily produced worldwide. "	( A microfluidic electrochemical aptasensor for enrichment and detection of bisphenol A. Bae, NH; Gwak, H; Hyun, KA; Jung, HI; Kashefi-Kheyrabadi, L; Kim, J; Lee, SJ, 2018)	2.15
"Bisphenol A (BPA) is a well-known endocrine disruptor with several effects on reproduction, development, and cancer incidence, and it is highly used in the plastic industry. "	( Unraveling molecular targets of bisphenol A and S in the thyroid gland. Berto-Júnior, C; de Carvalho, DP; Ferreira, ACF; Graceli, JB; Miranda-Alves, L; Romeiro, NC; Santos-Silva, AP; Soares, P, 2018)	2.21
"Bisphenol A (BPA) is an environmental endocrine disruptor. "	( Differential responses of GC‑1 spermatogonia cells to high and low doses of bisphenol A. Duan, F; Li, R; Li, Y; Pan, H; Zhou, X, 2018)	2.15
"Bisphenol A (BPA) is an endocrine disruptor implicated in male urogenital malformations."	( Endocrine disruptor bisphenol A is implicated in urinary voiding dysfunction in male mice. Leverson, GE; Nguyen, JL; Nicholson, TM; Ricke, WA; Taylor, JA; Vom Saal, FS; Wood, RW, 2018)	1.53
"Bisphenol A (BPA) is an organic substance, which is commonly used in the production of plastic. "	( Nitric oxide as an active substance in the enteric neurons of the porcine digestive tract in physiological conditions and under intoxication with bisphenol A (BPA). Calka, J; Gonkowski, S; Szymanska, K, 2018)	2.12
"Bisphenol A (BPA) is a synthetic, organic compound frequently present in consumer plastics, including plastic-lined cans, water bottles, toys, and teeth sutures. "	( Alterations in human neutrophil function caused by bisphenol A. Balistrieri, A; Corriden, R; Hobohm, L; Meier, A; Srivastava, T, 2018)	2.18
"Bisphenol A (BPA) is an endocrine disruptor that is widely produced as a by-product in the plastics industry. "	( Potential hazards of bisphenol A exposure to semen quality and sperm DNA integrity among infertile men. Abdel-Gaber, RM; Gaber, HD; Mostafa, NAM; Omran, GA; Salah, EA, 2018)	2.24
"Bisphenol A (BPA) is a typical endocrine disrupting chemical with extensive applications, and has been correlated with various hazardous health effects, including obesity and other metabolic-related diseases. "	( Non-cytotoxic nanomolar concentrations of bisphenol A induce human mesenchymal stem cell adipogenesis and osteogenesis. Dong, H; Faiola, F; Liu, S; Yao, X; Yin, N, 2018)	2.19
"Bisphenol A (BPA) is an environmental endocrine disruptor and is found in many consumer products. "	( Bisphenol A and pubertal height growth in school-aged children. Jin, L; Li, DK; Liang, H; Miao, M; Tu, X; Wang, Z; Yuan, W; Zhou, Z, 2019)	3.4
"Bisphenol A (BPA) is a high-production chemical used in a variety of applications worldwide. "	( CLARITY-BPA academic laboratory studies identify consistent low-dose Bisphenol A effects on multiple organ systems. Belcher, SM; Patisaul, HB; Prins, GS; Vandenberg, LN, 2019)	2.19
"Bisphenol A (BPA) is a widely spreading environmental endocrine disruptor . "	( Advances in BPA-induced Oxidative Stress and Related Effects and Mechanisms in Liver, 1991-2017. Liu, R; Zhang, X, 2020)	2
"Bisphenol A (BPA) is an organic pollutant derived from plastic degradation that has numerous and variable adverse effects on human health and wildlife. "	( Bisphenol A affects neural development of the ascidian Ciona robusta. Mercurio, S; Messinetti, S; Pennati, R, 2019)	3.4
"Bisphenol A (BPA) is an environmental toxin widely used in manufacturing industries. "	( Sensitive neurotoxicity assessment of bisphenol A using double immunocytochemistry of DCX and MAP2. Chang, SC; Cho, JH; Kim, AH; Lee, J; Lee, S; Lee, WJ; Lee, Y, 2018)	2.19
"Bisphenol A (BPA) is a common ingredient in plastic wares and epoxy resins that are essential for our daily life. "	( Microbial Community Enhances Biodegradation of Bisphenol A Through Selection of Sphingomonadaceae. Choi, D; Oh, S, 2019)	2.21
"Bisphenol A (BPA) is a small molecular weight endocrine disrupting chemical (EDC) that is used in the production of plastics with deleterious effects on various body systems while gallic acid (GA) is a known antioxidant capable of ameliorating EDC-induced perturbations. "	( Gallic acid protects against bisphenol A-induced alterations in the cardio-renal system of Wistar rats through the antioxidant defense mechanism. Ola-Davies, OE; Olukole, SG, 2018)	2.21
"Bisphenol A (BPA) is a high-production volume industrial chemical found in many consumer products. "	( Urinary Bisphenol A Levels and Male Fertility. Dziewirska, E; Hanke, W; Jurewicz, J; Kałużny, P; Klimowska, A; Radwan, M; Radwan, P; Wielgomas, B, 2018)	2.36
"Bisphenol A (BPA), which is an applied endocrine disrupting chemical in industry for producing epoxy resins and polycarbonate plastics and naringin, is an active flavanone glycoside of grapefruit and many citrus fruits. "	( Protective effect of naringin against BPA-induced cardiotoxicity through prevention of oxidative stress in male Wistar rats. Alboghobeish, S; Alizadeh, S; Kalantari, H; Khodayar, MJ; Khorsandi, L; Mahdavinia, M; Samimi, A; Zeidooni, L, 2020)	2
"Bisphenol A (BPA) is an endocrine disrupting compound that is a pervasive environmental contaminant. "	( Prenatal Bisphenol A Exposure Alters Epithelial Cell Composition in the Rhesus Macaque Fetal Oviduct. Hung, PH; Hunt, PA; Van Winkle, LS; VandeVoort, CA; Williams, CJ, 2019)	2.37
"Bisphenol A (BPA) is an endocrine disrupting chemical used on a wide range in industry. "	( Inhibition of L-type calcium channels by Bisphenol A in rat aorta smooth muscle. Cairrao, E; Feiteiro, J; Glória, S; Mariana, M, 2018)	2.19
"Bisphenol A (BPA) is an environmental endocrine disruptor and has been shown to be positively associated with increased risk of preeclampsia in human studies."	( Bisphenol A exposure alters placentation and causes preeclampsia-like features in pregnant mice involved in reprogramming of DNA methylation of WNT2. Feng, L; Li, X; Tang, Y; Xiong, Y; Ye, Y, 2019)	2.68
"Bisphenol A (BPA) is a widespread environmental chemical that has been associated with adverse endocrine and neurodevelopmental effects, some of which may be mediated by microbiota."	( Host Developmental Toxicity of BPA and BPA Alternatives Is Inversely Related to Microbiota Disruption in Zebrafish. Brinkman, NE; Catron, TR; Gaballah, S; Keely, SP; Kvasnicka, A; Lamendella, R; Phelps, D; Tal, T; Wheaton, E; Wood, CE; Wright, JR; Zurlinden, TJ, 2019)	1.24
"Bisphenol A (BPA) is a common additive in food packaging materials, and many methods have been discovered to limit BPA for the sake of food safety. "	( Investigation of diazo-derivatization of bisphenol A and its applicability for quantitation in food safety inspections using high-performance liquid chromatography. Li, Y; Liu, Z; Sun, L; Wang, L; Yang, H; Zheng, X, 2019)	2.22
"Bisphenol AF (BPAF) is a fluorinated analog of bisphenol A (BPA), and it is a more potent estrogen receptor (ER) agonist. "	( Endocrine activities and adipogenic effects of bisphenol AF and its main metabolite. Carino, A; Distrutti, E; Finel, M; Fiorucci, S; Marchianò, S; Mašič, LP; Skledar, DG; Tomašič, T; Troberg, J; Trontelj, J; Zega, A, 2019)	2.21
"Bisphenol A (BPA) is an emerging contaminant, regularly detected in aquatic ecosystems, considered as an endocrine disrupting compound (EDC). "	( Ecotoxicological risk assessment due to the presence of bisphenol A and caffeine in surface waters in the Sinos River Basin - Rio Grande do Sul - Brazil. Antunes, MV; Fleck, JD; Kael, IM; Linden, R; Peteffi, GP; Rosa, DC, )	1.82
"Bisphenol A (BPA) is a widespread compound associated with the manufacture of many consumer products. "	( Protective effects of selenium and nano-selenium on bisphenol-induced reproductive toxicity in male rats. Abdel-Halim, BR; Ahmed, W; Ibrahim, MA; Khalaf, AA; Moselhy, WA, 2019)	1.96
"Bisphenol A (BPA) is an endocrine-disrupting chemical used in the manufacture of many products used daily. "	( Effects of BPA on expression of apoptotic genes and migration of ovine trophectoderm (oTr1) cells during the peri-implantation period of pregnancy. Bazer, FW; Elmetwally, MA; Halawa, AA; Lenis, YY; Tang, W; Wu, G, 2019)	1.96
"Bisphenol A (BPA) is an endocrine disruptor which has been shown to be a harmful compound for living organisms. "	( Bisphenol A as an environmental pollutant with dual genotoxic and DNA-protective effects. Durovcova, I; Galova, E; Puskar, M; Sevcovicova, A; Spackova, J, 2018)	3.37
"Bisphenol A (BPA) is an endocrine disrupting compound commonly found in natural waters at concentrations that are considered harmful for aquatic life. "	( Impact of bisphenol A influent concentration and reaction time on MnO Balgooyen, S; Campagnola, G; Ginder-Vogel, M; Remucal, CK, 2019)	2.36
"Bisphenol A (BPA) is a synthetic chemical resin used worldwide to produce plastic products. "	( Dental Sealants Part 4: Bisphenol A: What dentists should know. Beretta, M; Colombo, S; Ferrazzano, GF; Paglia, L, 2018)	2.23
"Bisphenol A (BPA) is an estrogenic endocrine disruptor which disturbs a normal animal development. "	( Development of bisphenol A (BPA)-sensing indicator Arabidopsis thaliana which synthesizes anthocyanin in response to BPA in leaves. Bahmani, R; Hwang, S; Kim, D; Ko, JH, 2019)	2.31
"Bisphenol A (BPA) is a toxic compound emitting to the environment mainly by polycarbonate production facilities. "	( Cometabolic degradation of bisphenol A by pure culture of Ralstonia eutropha and metabolic pathway analysis. Babatabar, S; Shojaosadati, SA; Yakhchali, B; Zamir, SM; Zarch, AB, 2019)	2.25
"Bisphenol A (BPA) is an important chemical that widely used in our life. "	( Toxicological effects of bisphenol A exposure-induced cancer cells migration via activating directly integrin β1. Ji, P; Jia, B; Li, Z; Shan, S; Shi, T, 2019)	2.26
"Bisphenol A (BPA) is a non-persistent chemical with endocrine disrupting abilities widely used in a variety of consumer products. "	( Prenatal bisphenol A exposure is associated with language development but not with ADHD-related behavior in toddlers from the Odense Child Cohort. Andersen, HR; Andersson, AM; Bilenberg, N; Bleses, D; Frederiksen, H; Grandjean, P; Jensen, TK; Juul, A; Kyhl, HB; Mustieles, V; Schoeters, G; Trecca, F, 2019)	2.37
"Bisphenol A (BPA) is a high-production-volume chemical with endocrine disrupting properties commonly used as color developer in thermal paper. "	( Determination of bisphenol A and bisphenol S concentrations and assessment of estrogen- and anti-androgen-like activities in thermal paper receipts from Brazil, France, and Spain. Barouki, R; Fernández, MF; Freire, C; Jiménez-Díaz, I; Molina-Molina, JM; Mustieles, V; Olea, N; Peinado, FM; Piccoli, C; Rodriguez-Carrillo, A, 2019)	2.3
"Bisphenol A (BPA) is an abundant endocrine-disrupting compound that is found in the aquatic environment and has adverse effects on fish reproduction; however, the exact pathway of these impacts is unclear. "	( Toxic effects of bisphenol A on goldfish gonad development and the possible pathway of BPA disturbance in female and male fish reproduction. Li, Y; Liu, X; Wang, Q; Wang, Y; Xiao, S; Yan, M; Yang, H; Yang, M; Yang, Y; Yu, Y; Zhao, H; Zheng, L; Zhou, L, 2019)	2.3
"Bisphenol A (BPA) is a widely used chemical that has been detected in follicular fluid and associated with adverse reproductive effects. "	( Supraphysiological Concentrations of Bisphenol A Alter the Expression of Extracellular Vesicle-Enriched miRNAs From Human Primary Granulosa Cells. Adir, M; Baccarelli, AA; Bollati, V; Hauser, R; Israel, A; Machtinger, R; Mansour, A; Racowsky, C; Rodosthenous, RS, 2019)	2.23
"Bisphenol A (BPA) is a synthetic compound broadly used in medical devices as well as in packaging of food and drinks. "	( Determination of bisphenol A in red wine using a double vortex-ultrasound-assisted microextraction assay: Role of the interfacial properties. Ambrosone, L; Cinelli, G; Cuomo, F; Lopez, F; Venditti, F, 2019)	2.3
"Bisphenol A (BPA) is a plasticizer used widely in many industrial products and is now well established as an endocrine-disrupting chemical (EDC). "	( A mini review of bisphenol A (BPA) effects on cancer-related cellular signaling pathways. Ambrosino, C; Hoshyar, R; Mansouri, B; Nomiri, S; Tyler, CR, 2019)	2.3
"Bisphenol A (BPA) is a synthetic chemical with known deleterious effects on biota. "	( Genome sequence of a spore-laccase forming, BPA-degrading Bacillus sp. GZB isolated from an electronic-waste recycling site reveals insights into BPA degradation pathways. An, T; Das, R; Li, G; Liang, Z; Mai, B, 2019)	1.96
"Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) that is widely used in the manufacturing of plastics and inner linings of food cans. "	( Maternal bisphenol A exposure disrupts spermatogenesis in adult rat offspring. Campos, P; Chiamolera, MI; Da Conceição, RR; Giannocco, G; Oliveira, IM; Romano, MA; Romano, RM; Sena de Souza, J; Silva, MRD, 2019)	2.37
"Bisphenol A (BPA) is a key endocrine-disrupting chemical (EDC) in the manufacturing industry. "	( The apoptotic effects of bisphenol A exposure on the rat ovary: an experimental study. Abalı, R; Bilgi, A; Bilgi, PT; Boran, AB; Şahin, M; Tunçdemir, M, 2019)	2.26
"Bisphenol A (BPA) is an endocrine disruptor widely used to manufacture consumer goods. "	( The effects of perinatal bisphenol A exposure on thyroid hormone homeostasis and glucose metabolism in the prefrontal cortex and hippocampus of rats. Fan, S; Guo, Y; Kato, N; Pan, BX; Tan, R; Xu, X; Zhang, J; Zhang, W, 2019)	2.26
"Bisphenol A (BPA) is a chemical with endocrine- and metabolism-disrupting properties which can be measured in a majority of the population."	( Developmental exposure to a very low dose of bisphenol A induces persistent islet insulin hypersecretion in Fischer 344 rat offspring. Bergsten, P; Dunder, L; Lejonklou, MH; Lind, PM; Manukyan, L, 2019)	1.49
"Bisphenol A (BPA) is an endocrine disruptor whose ubiquitous presence in the environment has been related with impairment of male reproduction. "	( Male exposure to bisphenol a impairs spermatogenesis and triggers histone hyperacetylation in zebrafish testes. Fernández-Díez, C; González-Rojo, S; Herráez, MP; Lombó, M, 2019)	2.3
"Bisphenol A (BPA) is an endocrine disruptor that can lead to adverse effects in human health."	( Bisphenol A exposure and risk of thyroid nodules in Chinese women: A case-control study. Feng, Y; Li, L; Li, Y; Liang, J; Song, H; Wang, W; Wang, Y; Ying, Y; Zhang, C, 2019)	2.68
"Bisphenol A (BPA) is an environmentally ubiquitous chemical widely used in industry and is known to have adverse effects on organisms. "	( Metabolism disruption analysis of zebrafish larvae in response to BPA and BPA analogs based on RNA-Seq technique. Dong, P; Liu, S; Qiu, W; Wong, M; Yang, F; Yang, M; Zheng, C, 2019)	1.96
"Bisphenol A (BPA) is a high production volume chemical and because of its use in many consumer products, exposure is ubiquitous. "	( Association between gestational urinary bisphenol a concentrations and adiposity in young children: The MIREC study. Arbuckle, TE; Braun, JM; Dodds, L; Fraser, WD; Lanphear, BP; Li, N; Massarelli, I; Muckle, G, 2019)	2.22
"Bisphenol A (BPA) is a chemical found in environmental xenoestrogen. "	( Histopathological and biochemical studies on the effect of curcumin and taurine against bisphenol A toxicity in male rats. Apaydin, FG; Aslanturk, A; Bas, H; Kalender, S; Kalender, Y; Uzunhisarcikli, M, 2019)	2.18
"Bisphenol A (BPA) is a synthetic plasticizer that is commonly used in the production of polycarbonate plastics and epoxy resins. "	( The Endocrine Disruptor Bisphenol A (BPA) Exerts a Wide Range of Effects in Carcinogenesis and Response to Therapy. Abdel-Rahman, WM; Hafezi, SA, 2019)	2.26
"Bisphenol A (BPA) is an endocrine disrupter commonly used in the manufacturing of plastics based on polycarbonate, polyvinyl chloride and resins."	( Low doses of Bisphenol A have pro-inflammatory and pro-oxidant effects, stimulate lipid peroxidation and increase the cardiotoxicity of Doxorubicin in cardiomyoblasts. Botti, G; Coppola, C; Iaffaioli, RV; Maurea, N; Mita, DG; Piscopo, G; Quagliariello, V, 2019)	1.6
"Bisphenol A (BPA) is a very versatile industrial chemical. "	( Embryonic stem cell- and transcriptomics-based in vitro analyses reveal that bisphenols A, F and S have similar and very complex potential developmental toxicities. Cheng, Z; Dong, H; Faiola, F; Hu, B; Liang, S; Liang, X; Liu, S; Yang, R; Yin, N, 2019)	1.96
"Bisphenol A (BPA) is a semi-persistent environmental endocrine disrupter and widely present in aqueous environments. "	( Photo-assisted electrochemical detection of bisphenol A in water samples by renewable {001}-exposed TiO Liu, C; Pei, DN; Si, Y; Yu, HQ; Zhang, AY, 2019)	2.22
"Bisphenol A (BPA) is a commonly used chemical in consumer products. "	( Photocatalysis and catalytic wet air oxidation: Degradation and toxicity of bisphenol A containing wastewaters. Azalim, S; Brahmi, R; Heponiemi, A; Huovinen, M; Keiski, RL; Lassi, U; Loikkanen, J; Ojala, S; Pirilä, M; Rathnayake, B; Saouabe, M; Vähäkangas, K, 2020)	2.23
"Bisphenol A (BPA) is an environmental pollutant used as a plasticizer in the manufacture of many plastic products, such as packaging, containers, and water and beverage bottles. "	( Inhibitory effect of Bisphenol A on in vitro feline uterine contractions. Kabakci, R; Macun, HC; Polat, IM; Yildirim, E, 2019)	2.28
"Bisphenol A (BPA) is a chemical of high production volume that is used widely in many industries and is known as a xenooestrogen and anti-thyroid hormone endocrine disrupter. "	( Bisphenol A attenuates thyroxine-induced apoptosis in ovarian granulosa cells of pigs. Shi, F; Song, D; Wei, Q; Wu, G, 2019)	3.4
"Bisphenol A was found to be a promoter specifically to proliferate the human UL cells by activating the transcription and translation of GPR30-EGFR and MAPK/ERK/c-fos signaling pathway members."	( Bisphenol A promotes the proliferation of leiomyoma cells by GPR30-EGFR signaling pathway. Ding, B; Li, Z; Lu, Q; Shen, Y; Xu, J, 2019)	3.4
"Bisphenol A (BPA) is a representative endocrine disrupting chemical (EDC) that has estrogenic effects in aquatic animals. "	( Acute toxicity of bisphenol A and its structural analogues and transcriptional modulation of the ecdysone-mediated pathway in the brackish water flea Diaphanosoma celebensis. Cho, H; In, S; Kim, RO; Lee, YM; Yoo, JW; Yoon, HW, 2019)	2.29
"Bisphenol A (BPA) is an important endocrine disrupting chemical. "	( Widespread Occurrence of Bisphenol A in Daily Clothes and Its High Exposure Risk in Humans. Gong, X; Liu, Y; Sun, H; Wang, L; Zhang, T; Zhang, Y, 2019)	2.26
"Bisphenol A (BPA) is an endocrine disruptor of estrogenic nature. "	( Neonatal Bisphenol A Exposure Affects the IgM Humoral Immune Response to 4T1 Breast Carcinoma Cells in Mice. Hernández Avila, R; Morales-Montor, J; Nava-Castro, KE; Ostoa-Saloma, P; Palacios-Arreola, MI, 2019)	2.37
"Bisphenol A (BPA) is a ubiquitous endocrine-disrupting chemical. "	( Transgenerational Bisphenol A Causes Deficits in Social Recognition and Alters Postsynaptic Density Genes in Mice. Drobná, Z; Flaws, JA; Goldsby, JA; Henriksen, AD; Irvin, JW; Rissman, EF; Stevenson, R; Wolstenholme, JT, 2019)	2.29
"Bisphenol A (BPA) is an endocrine disruptor (ED) possibly linked to adverse reproductive and neurodevelopmental effects that is used as an additive in food and beverage containers. "	( Fetal exposure to bisphenol A: Presence of bisphenol A in urine of pregnant women assisted in a hospital in the City of Buenos Aires. Year 2013. Aliperti, V; Aragone, S; Cambiaso, O; Cruz, M; Ferloni, A; Figar, S; Giménez, MI; Kandel Gambarte, P; Méndez, ML; Moix, CF; Otaño, L; Pereiro, N; Saulino, JC; Uicich, R; Vázquez, ML; Vidal, FA; Wahren, CG, 2019)	2.29
"Bisphenol A (BPA) is a kind of environmental endocrine disruptors (EEDs) that interfere embryo implantation. "	( The effect of bisphenol a exposure onto endothelial and decidualized stromal cells on regulation of the invasion ability of trophoblastic spheroids in in vitro co-culture model. Che, D; Gao, J; Jiang, J; Li, C; Li, P; Pang, J; Song, T; Yang, Y, 2019)	2.32
"Bisphenol A (BPA) is a well-known endocrine disruptor. "	( Expression of serine proteases in neutrophils from women and men: Regulation by endocrine disruptor bisphenol A. Czerniecki, J; Dabrowska, D; Garley, M; Grubczak, K; Iwaniuk, A; Jablonska, E; Moniuszko, M; Nowak, K; Ratajczak-Wrona, W; Wilk, S; Wolczynski, S, 2019)	2.17
"Bisphenol A (BPA) is a well-characterized endocrine disrupting chemical (EDC) used in plastics, epoxy resins and other products. "	( Perinatal bisphenol A (BPA) exposure alters brain oxytocin receptor (OTR) expression in a sex- and region- specific manner: A CLARITY-BPA consortium follow-up study. Fuchs, J; Patisaul, HB; Witchey, SK, 2019)	2.36
"Bisphenol A (BpA) is a chemical that is extensively used in common plastic products, such as food and drink containers. "	( Surface plasmon resonance biosensor for the ultrasensitive detection of bisphenol A. Erika, G; Jiří, H; Xue, CS, 2019)	2.19
"Bisphenol A (BPA) is an environmental endocrine disrupting chemical widely used in the production of consumer products, such as polycarbonate plastics, epoxies, and thermal receipt paper. "	( Bisphenol A co-exposure effects: a key factor in understanding BPA's complex mechanism and health outcomes. Gassman, NR; Sonavane, M, 2019)	3.4
"Bisphenol A (BPA) is a known endocrine disruptor that poses concerning environmental and human-health related issues and ecological risks. "	( Mitigation of bisphenol A using an array of laccase-based robust bio-catalytic cues - A review. Barceló, D; Bilal, M; Iqbal, HMN, 2019)	2.32
"Bisphenol A (BPA) is an abundant environmental contaminant and studies have shown the presence of BPA in the urine of over 90% of population tested in Canada and USA. "	( Transgenerational effects of BPA on female reproduction. Carnevali, O; Consales, C; Habibi, HR; Pacchierotti, F; Santangeli, S, 2019)	1.96
"Bisphenol A (BPA) is an endocrine disrupting chemical widely used in the world. "	( Testicular toxicity of orally administrated bisphenol A in rats and protective role of taurine and curcumin. Apaydin, FG; Kalender, S; Kalender, Y, 2019)	2.22
"Bisphenol A (BPA) is an endocrine-disrupting chemical widely used in the production of polycarbonate plastics and epoxy resins, which has been previously linked to diabetes among non-Hispanic populations. "	( Exposure to bisphenol A and diabetes risk in Mexican women. Cebrián, ME; Gamboa-Loira, B; Gómez-Ruiz, H; Hernández-Garciadiego, L; López-Carrillo, L; Mérida-Ortega, Á; Murphy, L, 2019)	2.34
"Bisphenol A (BPA) is an endocrine disruptor compound with estrogenic activity, possessing affinity for both nuclear (ERα and ERβ) and membrane estrogen receptors. "	( Sex-associated protective effect of early bisphenol-A exposure during enteric infection with Trichinella spiralis in mice. Morales-Montor, J; Nava-Castro, KE; Pérez-Torres, A; Río-Araiza, VHD; Segovia-Mendoza, M; Solleiro-Villavicencio, H, 2019)	1.96
"Bisphenol A (BPA) is an industrial component commonly used in synthesis of polycarbonate plastics, epoxy resin and other polymer materials. "	( The adverse health effects of bisphenol A and related toxicity mechanisms. Chen, X; Du, X; Liu, H; Ma, Y; Marwa, PW; Petlulu, P; Wang, R; Wang, Y; Wu, J; Yuan, L; Zhang, H, 2019)	2.25
"Bisphenol A (BPA) is an environmental chemical that has adverse effects on health, probably causing childhood obesity. "	( The Association between Bisphenol A Exposure and Obesity in Children-A Systematic Review with Meta-Analysis. Kim, KY; Kim, Y; Lee, E, 2019)	2.26
"Bisphenol A (BPA) is an endocrine disruptor. "	( Canned food intake and urinary bisphenol a concentrations: a randomized crossover intervention study. Chiu, CC; Kao, TH; Lai, TC; Liang, SS; Peng, CY; Tsai, EM; Wang, TN, 2019)	2.24
"Bisphenol A (BPA) is a well-known endocrine-disrupting chemical (EDC) that has received particular attention because of its widespread distribution in humans. "	( Melatonin ameliorates bisphenol A-induced DNA damage in the germ cells of adult male rats. Chen, CH; Chen, Y; Duan, WX; He, MD; Liu, C; Wang, Y; Wu, HJ; Xu, SC; Yu, ZP; Zhang, L; Zhou, Z, 2013)	2.15
"Bisphenol A (BPA) is a chemical in widespread use that is under scientific discussion due to its endocrine activity. "	( Functional UDP-glucuronyltransferase 2B15 polymorphism and bisphenol A concentrations in blood: results from physiologically based kinetic modelling. Gundert-Remy, U; Mielke, H; Partosch, F, 2013)	2.08
"Bisphenol A (BPA) is an estrogenizing endocrine disruptor compound of concern. "	( Lifelong exposure to bisphenol a alters cardiac structure/function, protein expression, and DNA methylation in adult mice. Chalifour, LE; Patel, BB; Raad, M; Sebag, IA, 2013)	2.15
"Bisphenol A (BPA) is a well-known endocrine disruptor used to manufacture polycarbonate plastics and epoxy resins. "	( Effects of low doses of bisphenol A on the metabolome of perinatally exposed CD-1 mice. Cabaton, NJ; Canlet, C; Cravedi, JP; Gautier, R; Molina, J; Rubin, BS; Sonnenschein, C; Soto, AM; Tremblay-Franco, M; Wadia, PR; Zalko, D, 2013)	2.14
"Bisphenol A (BPA) is an environmental estrogenic endocrine disruptor that may have adverse health impacts on a range of tissue/systems. "	( Low-dose bisphenol A and estrogen increase ventricular arrhythmias following ischemia-reperfusion in female rat hearts. Chen, Y; Hong, K; Rubinstein, J; Song, W; Wang, HS; Yan, S, 2013)	2.25
"Bisphenol A (BPA) is a ubiquitous compound that is emerging as a possible toxicant during embryonic development. "	( Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. Abramowitz, J; Berglund, K; Birnbaumer, L; Busciglio, J; Gao, Y; Guo, JU; Hanna, M; Kittur, J; Liedtke, WB; Torres, MD; Yeo, M, 2013)	3.28
"Bisphenol A analogs are a class of chemicals known as diphenylmethanes, which contain two benzene rings separated by one central carbon atom, usually with a para-hydroxy group on both benzene rings. "	( Bioactivation of bisphenol A and its analogs (BPF, BPAF, BPZ and DMBPA) in human liver microsomes. Knez, Ž; Kotnik, P; Mašič, LP; Schmidt, J; Trontelj, J, 2013)	2.17
"Bisphenol A (BPA) is a high volume production chemical used in polycarbonate plastics, epoxy resins, thermal paper receipts, and other household products. "	( Sex specific impact of perinatal bisphenol A (BPA) exposure over a range of orally administered doses on rat hypothalamic sexual differentiation. Jones, B; Mabrey, N; McCaffrey, KA; Patisaul, HB; Swan, SH; Weiss, B, 2013)	2.11
"Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) whose migration from food packaging is recognized worldwide. "	( Bisphenol A migration from plastic materials: direct insight of ecotoxicity in Daphnia magna. Domingues, V; Ferreira, IM; Gameiro, P; Mansilha, C; Pinho, C; Rocha, S; Silva, P, 2013)	3.28
"Bisphenol A (BPA), is a well-known endocrine disruptor compound (EDC) that affects the normal development and function of the female and male reproductive system, however the mechanisms of action remain unclear. "	( Bisphenol A affects androgen receptor function via multiple mechanisms. Austin, CP; Goodwin, B; Huang, R; Jetten, AM; Merrick, BA; Norris, J; Shockley, K; Teng, C; Tice, RR; Xia, M, 2013)	3.28
"Bisphenol A (BPA) is a component of polycarbonate plastics and epoxy resins used in many commercial products including coatings and liners of food containers. "	( Bisphenol A: Update on newly developed data and how they address NTP's 2008 finding of "Some Concern". Allaben, W; Kind, J; Shelnutt, S, 2013)	3.28
"Bisphenol A (BPA) is a chemical agent used in the production of epoxy resins and polycarbonate plastic products, including water bottles, and as a coating for dental sealants, food/beverage containers, and canned food linings. "	( A new approach for regulating bisphenol A for the protection of the public's health. Barraza, L, 2013)	2.12
"Bisphenol A (BPA) is a high volume production chemical used in the manufacture of polycarbonate plastics and epoxy resins. "	( Relationship between urinary bisphenol A levels and prediabetes among subjects free of diabetes. Sabanayagam, C; Shankar, A; Teppala, S, 2013)	2.12
"Bisphenol A (BPA) is an estrogenic compound commonly used in manufacture of various consumer products. "	( Aberrant DNA methylation at Igf2-H19 imprinting control region in spermatozoa upon neonatal exposure to bisphenol A and its association with post implantation loss. D'souza, C; Doshi, T; Vanage, G, 2013)	2.05
"Bisphenol A (BPA) is a widespread endocrine-disrupting chemical used as the building block for polycarbonate plastics. "	( Perinatal bisphenol A exposure and adult glucose homeostasis: identifying critical windows of exposure. Huan, F; Li, Y; Liu, J; Qian, W; Wang, J; Xiao, H; Yu, P; Zhao, J, 2013)	2.23
"Bisphenol A (BPA) is an important monomer in the manufacture of polycarbonate plastics, food cans, and other daily used chemicals. "	( Bacteria-mediated bisphenol A degradation. Chen, L; Yin, K; Zhang, W, 2013)	2.17
"Bisphenol A (BPA) is a synthetic estrogen-like chemical mimetic widely used in the manufacture of polycarbonate plastics and epoxy resins found in numerous consumer products including food packaging, medical devices, and dental sealants. "	( Oral homeostasis disruption by medical plasticizer component bisphenol A in adult male rats. Artur, Y; Bergès, R; Boudalia, S; Canivenc-Lavier, MC; Decocq, L; Folia, M; Ménétrier, F; Pasquis, B; Schneider, C, 2013)	2.07
"Bisphenol A (BPA) is an estrogenic endocrine disruptor widely used in the production of plastics. "	( Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol A exposure. Champagne, FA; Franks, B; Gudsnuk, K; Kundakovic, M; Madrid, J; Miller, RL; Perera, FP, 2013)	2.06
"Bisphenol A (BPA) is an environmental estrogen associated with risk of several kinds of tumour."	( Interactive effect of bisphenol A (BPA) exposure with -22G/C polymorphism in LOX gene on the risk of osteosarcoma. Jia, J; Liu, Y; Shao, ZW; Tian, Q; Yang, SH, 2013)	1.43
"Bisphenol A (BPA) is an endocrine disruptor agent which exerts a wide variety of metabolic effects."	( Investigation of serum bisphenol A, vitamin D, and parathyroid hormone levels in patients with obstructive sleep apnea syndrome. Bilgic, HK; Erden, ES; Erem, C; Genc, S; Gokce, C; Motor, S; Oktar, S; Sungur, S; Ulutas, KT; Ustun, I, 2014)	1.43
"Bisphenol A (BPA) is a high volume production chemical that has been detected in 93% of the United States population. "	( Maternal bisphenol a exposure during pregnancy and its association with adipokines in Mexican-American children. Calafat, AM; Davé, V; Eskenazi, B; Harley, K; Holland, N; McFadden, J; Volberg, V, 2013)	2.25
"Bisphenol A (BPA) is a widely used monomer of polycarbonate plastics and epoxide resin that has been implicated in asthma pathogenesis when exposure occurs to the developing fetus. "	( Perinatal bisphenol A exposures increase production of pro-inflammatory mediators in bone marrow-derived mast cells of adult mice. Dolinoy, DC; Mancuso, P; O'Brien, E, )	1.98
"Bisphenol A (BPA) is an endocrine disruptor that inhibits growth of mouse ovarian follicles and disrupts steroidogenesis at a dose of 438μM. "	( Bisphenol A inhibits cultured mouse ovarian follicle growth partially via the aryl hydrocarbon receptor signaling pathway. Craig, ZR; Flaws, JA; Wang, W; Ziv-Gal, A, 2013)	3.28
"Bisphenol A (BPA) is a structural analogue of estrogen that binds to estrogen receptors."	( Are typical human serum BPA concentrations measurable and sufficient to be estrogenic in the general population? Doerge, DR; Fisher, JW; Hanson-Drury, S; Teeguarden, J, 2013)	1.11
"Bisphenol A (BPA) is a ubiquitous contaminant in environment and human body. "	( Bisphenol A affects axonal growth, musculature and motor behavior in developing zebrafish. Bai, C; Chen, Y; Dong, Q; Huang, C; Jiang, H; Li, W; Wang, X; Wang, Y; Xiao, Q; Yang, D, 2013)	3.28
"Bisphenol A (BPA) is a ubiquitous environmental endocrine disrupting compound (EDC); public health concerns have been fueled by findings that maternal BPA exposure can change sex differences in the brain and in some behaviors. "	( Does preconception paternal exposure to a physiologically relevant level of bisphenol A alter spatial memory in an adult rat? Ding, S; Fan, Y; He, D; Jin, X; Liu, J; Manyande, A; Tian, C; Xu, S; Yang, H; Ye, X; Ying, C; Zhao, N, 2013)	2.06
"Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) widely used in common consumer products containing polycarbonate plastics and epoxy resins. "	( Mouse strain does not influence the overall effects of bisphenol a-induced toxicity in adult antral follicles. Flaws, JA; Neese, SL; Peretz, J, 2013)	2.08
"Bisphenol A (BPA) is a ubiquitous environmental contaminant in food products and aquatic ecosystems. "	( Cd-doped ZnO quantum dots-based immunoassay for the quantitative determination of bisphenol A. Zhang, J; Zhang, K; Zhao, SQ; Zhou, JQ, 2014)	2.07
"Bisphenol A (BPA) is an estrogenic endocrine disruptor used for producing polycarbonate plastics and epoxy resins. "	( Perinatal exposure to low-dose bisphenol A impairs spatial learning and memory in male rats. Cui, H; Kawaguchi, S; Kohara, Y; Kuwahara, R; Yamashita, K, 2013)	2.12
"Bisphenol A (BPA) is a man-made endocrine disrupting compound used to manufacture polycarbonate plastics. "	( Transgenerational effects of prenatal bisphenol A on social recognition. Goldsby, JA; Rissman, EF; Wolstenholme, JT, 2013)	2.1
"Bisphenol A (BPA) is a widespread environmental contaminant detected in urine of 93 % of investigated US population. "	( Bisphenol A differently inhibits CaV3.1, Ca V3.2 and Ca V3.3 calcium channels. L'ubica, L; Mária, K; Michaela, P; Silvia, H, 2014)	3.29
"Bisphenol A (BPA) is a well-known environmental toxic substance, which exerts unfavorable effects through endocrine disruptor (ER)-dependent and ER-independent mechanisms to threaten ecological systems seriously. "	( Effect of BPA on the germination, root development, seedling growth and leaf differentiation under different light conditions in Arabidopsis thaliana. Chen, W; Liao, HM; Liu, JX; Liu, YS; Pan, WJ; Wua, QP; Xiong, C; Zheng, L, 2013)	1.83
"Bisphenol A (BPA) is a widely used plastics constituent that has been associated with endocrine, immune and metabolic effects. "	( Bisphenol A modulates the metabolic regulator oestrogen-related receptor-α in T-cells. Cipelli, R; Galloway, T; Harries, L; Melzer, D; Okuda, K; Yoshihara, S, 2014)	3.29
"Bisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. "	( Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats. Anselmo-Franci, JA; Barbisan, LF; Brandt, JZ; Fávaro, WJ; Felisbino, SL; Grassi, TF; Scarano, WR; Silveira, LT, 2014)	2.08
"Bisphenol A (BPA) is a high-production-volume chemical that is widely used in polycarbonate plastics and epoxy food-can coatings. "	( A survey of bisphenol A and other bisphenol analogues in foodstuffs from nine cities in China. Kannan, K; Liao, C, 2014)	2.22
"Bisphenol A (BPA) is a common endocrine disruptor found as an environmental and food contaminant. "	( A multi-generational study on low-dose BPA exposure in Wistar rats: effects on maternal behavior, flavor intake and development. Abdennebi-Najar, L; Berges, R; Boudalia, S; Canivenc-Lavier, MC; Chabanet, C; Decocq, L; Folia, M; Pasquis, B, )	1.57
"Bisphenol A (BPA) is an endocrine disruptor with potentially harmful effects on humans. "	( LINE-1 hypomethylation in spermatozoa is associated with Bisphenol A exposure. Li, DK; Li, R; Li, T; Li, Y; Miao, M; Yuan, W; Zhang, O; Zhou, X; Zhou, Z, 2014)	2.09
"Bisphenol A (BPA) is an estrogen-mimicking endocrine disruptor. "	( Perinatal exposure to low-dose bisphenol A affects the neuroendocrine stress response in rats. Alexis, MN; Kitraki, E; Mitsiou, DJ; Panagiotidou, E; Zerva, S, 2014)	2.13
"Bisphenol A (BPA) is an estrogenic endocrine disruptor used for producing polycarbonate plastics and epoxy resins. "	( Bisphenol A does not affect memory performance in adult male rats. Jojima, T; Kawaguchi, S; Kohara, Y; Kuwahara, R; Yamashita, K, 2014)	3.29
"Bisphenol A (BPA) is a chemical widely used in the synthesis pathway of polycarbonates for the production of many daily used products. "	( Self-assembly and chemical modifications of bisphenol a on Cu(111): interplay between ordering and thermally activated stepwise deprotonation. Allegretti, F; Barth, JV; Diller, K; Fischer, S; Klappenberger, F; Lloyd, JA; Oh, SC; Papageorgiou, AC; Reichert, J; Seitsonen, AP, 2014)	2.11
"Bisphenol A (BPA) is an environmental endocrine-disrupting chemicals that is widely used in common consumer products. "	( Development and validation of an LC-MS/MS method for simultaneous quantitative analysis of free and conjugated bisphenol A in human urine. Battal, D; Cok, I; Tunctan, B; Unlusayin, I, 2014)	2.06
"Bisphenol A (BPA) is a commonly used phenolic environmental estrogen. "	( [Effects of bisphenol A on the female reproductive organs and their mechanisms]. Dou, ZH; He, Z; Li, ZX; Pan, XY; Wan, Y; Wang, XN; Wang, ZC; Yan, PP, 2013)	2.21
"Bisphenol A (BPA) is a widespread estrogenic compound. "	( Neuroendocrine and behavioral effects of maternal exposure to oral bisphenol A in female mice. Franceschini, I; Hardin-Pouzet, H; Keller, M; Martini, M; Mhaouty-Kodja, S; Naulé, L; Parmentier, C; Picot, M, 2014)	2.08
"Bisphenol A (BPA) is a widely used material known to cause adverse effects in humans and other mammals. "	( Metabolomic analysis reveals metabolic changes caused by bisphenol A in rats. Chen, M; Chen, X; Dong, C; Han, X; Hu, Y; Mao, Z; Qiao, S; Tang, R; Wang, S; Wang, X; Wang, Y; Wu, D; Xia, Y; Xu, B; Zhou, K; Zhou, Z, 2014)	2.09
"Bisphenol A (BPA) is a high production volume chemical with hormone-like properties that has been implicated as a potential carcinogen. "	( Dose-dependent incidence of hepatic tumors in adult mice following perinatal exposure to bisphenol A. Anderson, OS; Bergin, IL; Dingman, MA; Dolinoy, DC; Gyekis, JP; Vandenbergh, DJ; Weinhouse, C; Yang, J, 2014)	2.07
"Bisphenol A (BPA) is a high production volume industrial chemical to which there is widespread human oral exposure. "	( Toxicity evaluation of bisphenol A administered by gavage to Sprague Dawley rats from gestation day 6 through postnatal day 90. Bryant, MS; Camacho, L; Chidambaram, M; Davis, KJ; Delclos, KB; Felton, RP; Gamboa da Costa, G; Juliar, BE; Latendresse, JR; Lewis, SM; Olson, GR; Patton, RE; Thorn, BT; Trbojevich, R; Vanlandingham, MM; Woodling, KA, 2014)	2.16
"Bisphenol A (BPA) is a synthetic, endocrine-disrupting compound. "	( Determination of free Bisphenol A (BPA) concentrations in breast milk of U.S. women using a sensitive LC/MS/MS method. Anderton, DL; Arcaro, KF; Browne, EP; Kramer, L; O'Keefe, PW; Reckhow, DA; Zimmers, SM, 2014)	2.16
"Bisphenol A (BPA) is a well-known EDC commonly found in plastic products including food and water containers, baby bottles, and metal can linings."	( Influence of bottle-feeding on serum bisphenol a levels in infants. Kim, HS; Lee, KH; Nam, HK; Oh, YJ; Rhie, YJ, 2014)	1.4
"Bisphenol A (BPA) is a chemical with widespread human exposure suspected of causing low-dose effects. "	( Are structural analogues to bisphenol a safe alternatives? Alice van Vugt-Lussenburg, BM; Dybdahl, M; Pedersen, M; Rosenmai, AK; Taxvig, C; Vinggaard, AM; Wedebye, EB, 2014)	2.14
"Bisphenol A (BPA) is a known reproductive toxicant in rodents. "	( In utero bisphenol A exposure disrupts germ cell nest breakdown and reduces fertility with age in the mouse. Flaws, JA; Hafner, KS; Wang, W, 2014)	2.26
"Bisphenol A (BPA) is an organic compound to which human populations are ubiquitously exposed. "	( High intake of dietary sugar enhances bisphenol A (BPA) disruption and reveals ribosome-mediated pathways of toxicity. Branco, AT; Lemos, B, 2014)	2.12
"Bisphenol A (BPA) is a well-known endocrine disruptor with adverse oestrogen-like effects eliciting adverse effects in humans and wildlife. "	( Efficiency of advanced oxidation processes in lowering bisphenol A toxicity and oestrogenic activity in aqueous samples. Pintar, A; Plahuta, M; Tišler, T; Toman, MJ, 2014)	2.09
"Bisphenol A (BPA) is a chemical compound used in massive amounts in the production of synthetic polymers and thermal paper. "	( Bisphenol A--sources, toxicity and biotransformation. Michałowicz, J, 2014)	3.29
"Bisphenol A (BPA) is an industrial chemical, particularly used to harden plastics. "	( Urinary bisphenol a levels in girls with idiopathic central precocious puberty. Akçurin, S; Aşçı, A; Bircan, I; Durmaz, E; Erkekoğlu, P; Gümüşel, BK, 2014)	2.28
"Bisphenol A (BPA) is a kind of a controversial endocrine disruptor, and is ubiquitous in environment. "	( Degradation of bisphenol A in water by the heterogeneous photo-Fenton. Guo, Q; Jiang, C; Xu, Z; Zhuo, Q, )	1.93
"Bisphenol A (BPA) is a synthetic compound used in numerous chemicals, such as polycarbonate plastics and epoxy resins, and it can be released into aquatic environment and poses risk on aquatic organisms. "	( Metabolomic analysis revealed that female mussel Mytilus galloprovincialis was sensitive to bisphenol A exposures. Ji, C; Wei, L; Wu, H; Zhao, J, 2014)	2.07
"Bisphenol A (BPA) is a ubiquitous industrial chemical found in a variety of plastic containers intended for food storage and in the epoxy resin linings of metal food and beverage cans, where it is used to prevent corrosion, food contamination, and spoilage. "	( Bisphenol A, obesity, and type 2 diabetes mellitus: genuine concern or unnecessary preoccupation? Evans-Molina, C; Mirmira, P, 2014)	3.29
"Bisphenol A (BPA) is an endocrine disruptor that displays estrogenic activity. "	( Estrogen-related receptor γ is an in vivo receptor of bisphenol A. Balaguer, P; Bernard, L; Boulahtouf, A; Bourguet, W; Brunet, F; Gibert, Y; Laudet, V; Prud'homme, SM; Samarut, E; Tohmé, M, 2014)	2.09
"Bisphenol A (BPA) is a base chemical used extensively in many consumer products. "	( Bisphenol A increases atherosclerosis in pregnane X receptor-humanized ApoE deficient mice. Gonzalez, FJ; Helsley, RN; Morris, AJ; Park, SH; Sui, Y; Sunkara, M; Zhou, C, 2014)	3.29
"Bisphenol A (BPA) is a known endocrine disruptor and one of the most serious environmental contaminants, often present at low levels in various water sources. "	( A portable optic fiber aptasensor for sensitive, specific and rapid detection of bisphenol-A in water samples. Gu, AZ; He, M; Long, F; Shi, HC; Yildirim, N, 2014)	1.85
"Bisphenol A (BPA) is a widely used industrial chemical in the manufacturing of polycarbonate plastic bottles, food and beverage can linings, thermal receipts, and dental sealants. "	( Quantitative determination of free and total bisphenol A in human urine using labeled BPA glucuronide and isotope dilution mass spectrometry. Foster, WG; Kosarac, I; Kubwabo, C; Lalonde, K, 2014)	2.1
"Bisphenol A (BPA) is a commonly used monomer in various products including bottled water. "	( Exposure assessment of endocrine disruptors in bottled drinking water of Lebanon. Dhaini, HR; Nassif, RM, 2014)	1.85
"Bisphenol A (BPA) is a widespread environmental contaminant, and humans are routinely exposed to BPA. "	( Altered social interactions in male juvenile cynomolgus monkeys prenatally exposed to bisphenol A. Ihara, T; Kawasaki, K; Koyama, T; Kuroda, Y; Nakagami, A; Negishi, T; Nishida, Y; Tashiro, T; Yoshikawa, Y, )	1.8
"Bisphenol A (BPA) is a high production volume monomer used for making a wide variety of polycarbonate plastics and resins. "	( Bisphenol A and the female reproductive tract: an overview of recent laboratory evidence and epidemiological studies. Caserta, D; Di Segni, N; Giovanale, V; Mallozzi, M; Mantovani, A; Marci, R; Moscarini, M, 2014)	3.29
"Bisphenol A (BPA) is an environmental endocrine disruptor which has been detected in human bodies. "	( Gene expression profiling analysis of bisphenol A-induced perturbation in biological processes in ER-negative HEK293 cells. Cao, T; Gu, L; Jiang, C; Li, M; Yin, R; Zhang, X, 2014)	2.12
"Bisphenol A (BPA) is a xenoestrogen commonly used in consumer products and the plastic industry."	( Lifetime-dependent effects of bisphenol A on asthma development in an experimental mouse model. Averbeck, M; Lehmann, I; Petzold, S; Polte, T; Simon, JC, 2014)	1.41
"Bisphenol A (BPA) is a widespread endocrine disrupting chemical (EDC) strongly suspected to have adverse health effects. "	( Estrogen and bisphenol A affect male rat enamel formation and promote ameloblast proliferation. Babajko, S; Berdal, A; Canivenc Lavier, MC; Jedeon, K; Loiodice, S; Marciano, C; Vinel, A, 2014)	2.21
"Bisphenol A (BPA) is a ubiquitous endocrine disrupting chemical in our daily life, and its health effect in response to prenatal exposure is still controversial. "	( Visualized gene network reveals the novel target transcripts Sox2 and Pax6 of neuronal development in trans-placental exposure to bisphenol A. Chao, HR; Chen, KH; Cheng, AL; Chou, WC; Chuang, CY; Mao, IF; Yang, CW, 2014)	2.05
"Bisphenol A (BPA) is a synthetic compound used in the production of many polycarbonate plastics and epoxy resins. "	( Bisphenol-A: epigenetic reprogramming and effects on reproduction and behavior. Baker, SL; Bielajew, C; Konkle, AT; Mileva, G, 2014)	1.85
"Bisphenol A (BPA) is an endocrine disruptor that may have adverse effects on human health. "	( Inhibition of the functional interplay between endoplasmic reticulum (ER) oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A. Hashimoto, S; Hidaka, Y; Hikima, T; Imai, D; Imaoka, S; Inaba, K; Ito, L; Kadokura, H; Kanemura, S; Masui, S; Okumura, M; Shiba, K; Yamaguchi, H; Yutani, K, 2014)	2.04
"Bisphenol A (BPA) is a ubiquitous plasticizing agent used in the manufacturing of polycarbonate plastics and epoxy resins. "	( Impact of bisphenol a on the cardiovascular system - epidemiological and experimental evidence and molecular mechanisms. Gao, X; Wang, HS, 2014)	2.25
"Bisphenol A (BPA) is a suspected endocrine disruptor highly prevalent in our environment since it is used as monomer of polycarbonate plastics and epoxy resins. "	( Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice. Beuzelin, D; Chetivaux, M; Ducheix, S; Guillou, H; Huc, L; Lasserre, F; Marmugi, A; Martin, P; Mselli-Lakhal, L; Pineau, T; Polizzi, A, 2014)	2.11
"Bisphenol A (BPA) is an endocrine disruptor compound widespread in terrestrial and aquatic systems of urbanized and industrialized regions. "	( Decontamination activity of ryegrass exudates towards bisphenol A in the absence and presence of dissolved natural organic matter. Baum, C; Eckhardt, KU; Gattullo, CE; Kiersch, K; Leinweber, P; Loffredo, E, 2015)	2.11
"Bisphenol A (BPA) is a widely utilized endocrine disruptor capable of mimicking endogenous hormones, employed in the manufacture of numerous consumer products, thereby interfering with physiological cellular functions. "	( Bisphenol A disrupts transcription and decreases viability in aging vascular endothelial cells. Brito, L; Delgado, M; Ferreira, RB; Monteiro, S; Neves, E; Pereira, HS; Ribeiro-Varandas, E; Viegas, W, 2014)	3.29
"Bisphenol A (BPA) is a weakly estrogenic compound that has been detected in a wide variety of food products and biological matrices (saliva, blood, urine, etc). "	( Placental concentrations of bisphenol A and birth weight from births in the Southeastern U.S. Adair, D; Guida, M; Mikelson, C; Richards, S; Symes, S; Troisi, J; Zullo, F, 2014)	2.14
"Bisphenol A (BPA) is an environmental chemical that has been shown to alter estrogen, androgen, and thyroid hormone signaling pathways."	( Prenatal bisphenol A exposure and maternally reported behavior in boys and girls. Barrett, ES; Calafat, AM; Evans, SF; Kobrosly, RW; Stahlhut, R; Swan, SH; Thurston, SW; Weiss, B; Yolton, K, 2014)	1.54
"Bisphenol A (BPA) is a ubiquitous chemical in the environment and potentially harmful to plants. "	( Effects of bisphenol A on mineral nutrition in soybean seedling roots. Huang, X; Nie, L; Wang, L; Wang, Q; Wang, S; Zhou, Q, 2015)	2.25
"Bisphenol A (BPA) is an environmental endocrine disrupter. "	( Bisphenol A exposure enhances atherosclerosis in WHHL rabbits. Dong, S; Fan, J; Fang, C; Li, S; Niimi, M; Ning, B; Satoh, K; Shiomi, M; Waqar, AB; Ye, T, 2014)	3.29
"Bisphenol A (BPA) is an endocrine disrupting environmental contaminant used in a wide variety of products, and BPA metabolites are found in almost everyone's urine, suggesting widespread exposure from multiple sources. "	( Holding thermal receipt paper and eating food after using hand sanitizer results in high serum bioactive and urine total levels of bisphenol A (BPA). Ellersieck, MR; Hormann, AM; Moyer, CL; Nagel, SC; Stahlhut, RW; Taylor, JA; Toutain, PL; Vom Saal, FS; Welshons, WV, 2014)	2.05
"Bisphenol A (BPA) is a compound released from plastics and other consumer products used in everyday life. "	( Liver DNA methylation analysis in adult female C57BL/6JxFVB mice following perinatal exposure to bisphenol A. Dollé, ME; Hodemaekers, HM; Issa, JP; Jelinek, J; Kamstra, JH; Legler, J; Lute, C; Pennings, JL; Steegenga, WT; van der Ven, LT; van Esterik, JC; Vitins, AP, 2015)	2.08
"Bisphenol A (BPA) is an environmental estrogen used in the manufacture of polycarbonate plastics and epoxy resins used to make food and beverage packaging. "	( Urinary bisphenol A and age at menarche among adolescent girls: evidence from NHANES 2003-2010. Ellison, GL; Ghazarian, AA; Joseph Su, L; McGuinn, LA, 2015)	2.29
"Bisphenol A (BPA) is a widely used environmental endocrine disruptor. "	( Mitochondrion-mediated apoptosis is involved in reproductive damage caused by BPA in male rats. Chen, S; Hu, Y; Li, Q; Luo, C; Wang, P, 2014)	1.85
"Bisphenol A (BPA) is a widely studied typical endocrine-disrupting chemical, and one of the major new issues is the safe replacement of this commonly used compound. "	( A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound. Benachi, A; Eladak, S; Grisin, T; Guerquin, MJ; Habert, R; Livera, G; Moison, D; N'Tumba-Byn, T; Pozzi-Gaudin, S; Rouiller-Fabre, V, 2015)	2.18
"Bisphenol A (BPA) is a chemical used in plastic bottles and inner coating of beverage cans, and its exposure is almost ubiquitous. "	( Exposure to bisphenol A from drinking canned beverages increases blood pressure: randomized crossover trial. Bae, S; Hong, YC, 2015)	2.24
"Bisphenol A (BPA) is an endocrine disruptor agent, exerting a wide variety of metabolic effects."	( Investigation of Bisphenol A as an endocrine disruptor, total thiol, malondialdehyde, and C-reactive protein levels in chronic obstructive pulmonary disease. Demirkose, M; Erden, ES; Gokce, C; Motor, S; Oktar, S; Okur, R; Sungur, S; Ustun, I; Yakar, Y; Yuksel, R, 2014)	1.46
"Bisphenol A (BPA) is a ubiquitous pollutant around the globe, but whether environmental concentrations have toxic effects remains controversial. "	( Temperature determines toxicity: bisphenol A reduces thermal tolerance in fish. Little, AG; Seebacher, F, 2015)	2.14
"Bisphenol A (BPA) is a widely used industrial chemical and also an environmental endocrine disruptor (EED), which serves as a monomer in the manufacture of polycarbonate plastics. "	( Bisphenol a exposure promotes the migration of NCM460 cells via estrogen receptor-mediated integrin β1/MMP-9 pathway. Jin, X; Li, Z; Shi, T; Zhang, Q; Zhao, C, 2016)	3.32
"Bisphenol A (BPA) is a commonly used material in daily life, and it is argued to cause oxidative stress in liver and ovarian tissue. "	( Influence of α-tocopherol and α-lipoic acid on bisphenol-A-induced oxidative damage in liver and ovarian tissue of rats. Avci, B; Bahadir, A; Bilgici, B; Tuncel, OK, 2016)	1.88
"Bisphenol A (BPA) is a well-known environmental endocrine-disrupting chemical. "	( The in vitro immune modulatory effect of bisphenol A on fish macrophages via estrogen receptor α and nuclear factor-κB signaling. Chen, B; Chen, J; Liu, S; Qiu, W; Wang, KJ; Wu, M; Yang, M, 2015)	2.13
"Bisphenol A (BPA) is a well-known plasticizer and xenoestrogen that is responsible for many acquired reproductive difficulties, especially in men. "	( Increase in the expression of inducible nitric oxide synthase on exposure to bisphenol A: a possible cause for decline in steroidogenesis in male mice. Agarwal, NK; Chouhan, S; Ghosh, A; Prakash, J; Singh, SP; Westfall, S; Yadav, SK, 2015)	2.09
"Bisphenol A (BPA) is a high production volume chemical and an endocrine disruptor. "	( Impact of gestational bisphenol A on oxidative stress and free fatty acids: Human association and interspecies animal testing studies. Dolinoy, DC; Kannan, K; Padmanabhan, V; Patisaul, HB; Pennathur, S; Veiga-Lopez, A; Zeng, L, 2015)	2.17
"Bisphenol A (BPA) is a nonpersistent compound that can alter the reproductive system of laboratory animals even at extremely low exposure levels."	( Bisphenol A: a threat to human health? Alam, I; Chandolia, A; Gupta, P; Srivastava, S, )	2.3
"Bisphenol A (BPA) is an artificial environmental endocrine disrupter. "	( Bisphenol A exposure induces metabolic disorders and enhances atherosclerosis in hyperlipidemic rabbits. Dong, S; Fan, J; Fang, C; Li, S; Niimi, M; Ning, B; Satoh, K; Shiomi, M; Waqar, AB; Ye, T, 2015)	3.3
"Bisphenol A (BPA) is an industrial chemical widely used in the production of polycarbonate and epoxy resins. "	( Determination of bisphenol A and related substitutes/analogues in human breast milk using gas chromatography-tandem mass spectrometry. Antignac, JP; Bichon, E; Boquien, CY; Boscher, C; Deceuninck, Y; Le Bizec, B; Legrand, A; Marchand, P, 2015)	2.2
"Bisphenol A (BPA) is a high-volume, synthetic compound found in epoxy resins and plastics used in food packaging. "	( Exposure assessment of adult intake of bisphenol A (BPA) with emphasis on canned food dietary exposures. Birnbaum, L; Christensen, K; Lorber, M; Paepke, O; Schecter, A; Shropshire, W, 2015)	2.13
"Bisphenol A (BPA) is a chemical widely used both in plastics production as a food and beverage container and in thermal papers as a color developer. "	( Levels of bisphenol-A in different paper products in Guangzhou, China, and assessment of human exposure via dermal contact. Chen, C; Fan, R; Hu, M; Li, J; Lin, ZY; Liu, X; Lv, Y; Wang, Y; Zeng, B; Zhou, Y; Zhuang, Q, 2015)	1.86
"Bisphenol A (BPA) is a biologically active industrial chemical used in production of consumer products. "	( Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts. Coskun, E; Dizdaroglu, M; Gassman, NR; Horton, JK; Jaruga, P; Stefanick, DF; Wilson, SH, 2015)	3.3
"Bisphenol A (BPA) is a synthetic chemical extensively used in many consumer products. "	( Improvement of bisphenol A quantitation from urine by LCMS. Franke, AA; Li, X, 2015)	2.21
"Bisphenol A (BPA) is a ubiquitous endocrine disrupting compound. "	( Bisphenol A exposure and behavioral problems among inner city children at 7-9 years of age. Calafat, AM; Herbstman, J; Hoepner, LA; Margolis, A; Perera, FP; Rauh, V; Roen, EL; Wang, S; Wang, Y, 2015)	3.3
"Bisphenol A (BPA) acts as an endocrine disruptor, affects animal reproductive success in vivo and affects sperm functions in vitro at environmentally relevant concentrations, leading to reduction in sperm motility and fertilizing ability in fish. "	( Bisphenol A reduces fertilizing ability and motility by compromising mitochondrial function of sperm. Azeez, PA; Kataria, JM; Kolluri, G; Mohan, J; Pandey, NK; Sastry, KV; Saxena, M; Shafeeque, CM; Sharma, B; Sharma, SK; Singh, R; Singh, RP, 2015)	3.3
"Bisphenol A (BPA) is an important industrial chemical for polycarbonate (PC) and epoxy resins in paper and plastic industries. "	( Building an aptamer/graphene oxide FRET biosensor for one-step detection of bisphenol A. Cai, Y; Qi, B; Wang, L; Xu, C; Xu, L; Zheng, L; Zhu, Y, 2015)	2.09
"Bisphenol A (BPA) is a suspected human endocrine disruptor which is widely used."	( Exposure to bisphenol-A and reproductive hormones among male adults. Chen, J; Gao, E; Li, DK; Liu, X; Miao, M; Sun, F; Wang, J; Yuan, W; Zhou, Z, 2015)	1.86
"Bisphenol A (BPA) is a well-known environmental estrogenic disruptor that causes adverse effects. "	( Bisphenol A exposure accelerated the aging process in the nematode Caenorhabditis elegans. He, M; Liu, D; Tan, L; Wang, S; Wang, Y, 2015)	3.3
"Bisphenol A (BPA) is an industrial compound with pervasive distribution in the environments of industrialized countries. "	( Acute Influences of Bisphenol A Exposure on Hypothalamic Release of Gonadotropin-Releasing Hormone and Kisspeptin in Female Rhesus Monkeys. Garcia, JP; Hedman, CJ; Keen, KL; Kenealy, BP; Kurian, JR; Terasawa, E, 2015)	2.18
"Bisphenol A (BPA) is an estrogenic chemical commonly found in a variety of habitats."	( Developmental exposure to bisphenol A (BPA) alters sexual differentiation in painted turtles (Chrysemys picta). Bhandari, RK; Deem, SL; Holliday, CM; Holliday, DK; Jandegian, CM; Nicks, D; Rosenfeld, CS; Selcer, KW; Tillitt, DE; Vélez-Rivera, V; Vom Saal, FS; Yang, Y, 2015)	1.44
"Bisphenol A (BPA) is an ubiquitous chemical, which is an endocrine disruptor. "	( Association of bisphenol A exposure with overweight in the elderly: a panel study. Bae, S; Choi, YH; Hong, YC; Kim, JH; Lee, MR; Park, C, 2015)	2.21
"Bisphenol A (BPA) is a xenobiotic endocrine-disrupting chemical. "	( Bisphenol A effects on gene expression in adipocytes from children: association with metabolic disorders. Calogero, RA; Cirillo, G; Crispi, S; Del Giudice, EM; Diano, N; Menale, C; Mita, DG; Mita, L; Papparella, A; Piccolo, MT, 2015)	3.3
"Bisphenol A (BPA) is an endocrine-disrupting chemical that is ubiquitous in the environment because of its broad industrial use. "	( Edible fungus degrade bisphenol A with no harmful effect on its fatty acid composition. Chen, X; Li, M; Zhang, C, 2015)	2.17
"Bisphenol A (BPA) is a kind of carcinogen, which can interfere with the body's endocrine system. "	( Detection of bisphenol A in food packaging based on fluorescent conjugated polymer PPESO3 and enzyme system. Huang, H; Li, Y; Liu, J; Su, X; Tong, J, 2015)	2.23
"Bisphenol A (BPA) is an environmental xenoestrogenic endocrine disruptor, utilized for production of consumer products, and exerts adverse effects on the developing nervous system. "	( Bisphenol-A Mediated Inhibition of Hippocampal Neurogenesis Attenuated by Curcumin via Canonical Wnt Pathway. Agarwal, S; Chaturvedi, RK; Tiwari, SK; Tripathi, A, 2016)	1.88
"Bisphenol A (BPA) is a chemical found in hard plastics and the coatings of food and drinks cans which can behave in a similar way to estrogen and other hormones in the human body. "	( Oleuropein and hydroxytyrosol protect from bisphenol A effects in livers and kidneys of lactating mother rats and their pups'. Bouallegui, Z; Ghorbel, H; Isoda, H; Mahmoudi, A; Marrekchi, R; Sayadi, S, )	1.84
"Bisphenol A (BPA) is an industrial contaminant and is reported to be a risk factor associated with the development of tumors. "	( Effects of bisphenol A on decreasing the percentage and promoting the growth of stem cell-like cells from SK-N-SH human neuroblastoma cells. Dong, KR; Ma, YY; Qi, SQ; Xiao, XM; Xu, T; Yang, L; Yang, SB; Zheng, JC; Zheng, S; Zhu, HT, 2015)	2.25
"Bisphenol A (BPA) is a widely used endocrine disruptor. "	( Long-term oral exposure to bisphenol A induces glucose intolerance and insulin resistance. Ahn, HY; Jang, HC; Jeong, IK; Jung Oh, T; Kim, HH; Moon, MK; Park, KS; Park, YJ, 2015)	2.16
"Bisphenol A (BPA) is a fairly ubiquitous compound which has a great concern to human health. "	( Thymoquinone attenuates toxicity and oxidative stress induced by bisphenol A in liver of male rats. Abdel-Wahab, WM, 2014)	2.08
"Bisphenol A (BPA) is a widely known endocrine disruptor with estrogenic, antiestrogenic or antiandrogenic properties. "	( Development and validation of LC-MS/MS method for quantification of bisphenol A and estrogens in human plasma and seminal fluid. Bicikova, M; Chlupacova, T; Hampl, R; Heracek, J; Hill, M; Sosvorova, L; Starka, L; Vitku, J, 2015)	2.1
"Bisphenol A is a known endocrine disrupting chemical and reproductive toxicant. "	( Bisphenol A exposure inhibits germ cell nest breakdown by reducing apoptosis in cultured neonatal mouse ovaries. Flaws, JA; Peretz, J; Wang, W; Zhou, C, 2015)	3.3
"Bisphenol A (BPA) is a widespread endocrine disrupter mainly used in food contact plastics. "	( Bisphenol A affects placental layers morphology and angiogenesis during early pregnancy phase in mice. Mantovani, A; Maranghi, F; Tait, S; Tassinari, R, 2015)	3.3
"Bisphenol A (BPA) is an industrial pollutant considered as one of the major endocrine-disrupting chemicals found in natural waters. "	( Treatment of aqueous bisphenol A using nano-sized zero-valent iron in the presence of hydrogen peroxide and persulfate oxidants. Arslan-Alaton, I; Dursun, D; Girit, B; Olmez-Hanci, T, 2015)	2.18
"Bisphenol A (BPA) is a chemical produced at high volumes and used widely in food and drink packaging. "	( Association between levels of serum bisphenol A, a potentially harmful chemical in plastic containers, and carotid artery intima-media thickness in adolescents and young adults. Chen, PC; Chien, KL; Lian, GW; Lin, CY; Shen, FY; Su, TC; Sung, FC, 2015)	2.13
"Bisphenol A (BPA) is a chemical used in numerous consumer products that is able to interfere with the mammalian endocrine system. "	( Effects of Wnt/β-catenin signaling on bisphenol A exposure in male mouse reproductive cells. Chen, X; Fang, Z; Liu, X; Song, X; Yang, X, 2015)	2.13
"Bisphenol A (BPA) is a ubiquitous environmental contaminant with endocrine disruption potential. "	( In situ H(+)-mediated formation of singlet oxygen from NaBiO3 for oxidative degradation of bisphenol A without light irradiation: Efficiency, kinetics, and mechanism. Ding, Y; Ruan, Y; Tang, H; Xia, X, 2015)	2.08
"Bisphenol A (BPA) is a ubiquitous endocrine-disrupting chemical in the environment that exerts potential harm to plants. "	( Effects of bisphenol A, an environmental endocrine disruptor, on the endogenous hormones of plants. Hua, W; Huang, X; Wang, L; Wang, Q; Wang, S; Zhou, M; Zhou, Q, 2015)	2.25
"Bisphenol A (BPA) is an industrial chemical produced in large volumes. "	( Bisphenol A and its structural analogues in household waste paper. Astrup, TF; Eriksson, E; Pedersen, GA; Pivnenko, K, 2015)	3.3
"Bisphenol A (BPA) is a high volume production chemical and has been identified as an endocrine disruptor, prompting concern that developmental exposure could impact brain development and behavior. "	( Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study. Adonay, ME; Aylor, DL; Camacho, L; Patisaul, HB; Rebuli, ME; Reif, DM, 2015)	2.13
"Bisphenol A (BPA) is an EDC that is widely used in food containers."	( Low-dose Bisphenol A Activates Cyp11a1 Gene Expression and Corticosterone Secretion in Adrenal Gland via the JNK Signaling Pathway. Lan, HC; Lin, IW; Lin, JH; Yang, ZJ, 2015)	1.56
"Bisphenol A (BPA) is a chemical used in the production of numerous consumer products resulting in potential daily human exposure to this chemical. "	( NIEHS/FDA CLARITY-BPA research program update. Bryant, M; Bucher, JR; Camacho, L; Chidambaram, M; Churchwell, MI; Delclos, KB; Favaro, C; Ferguson, SA; Flaws, J; Fostel, J; Gamboa da Costa, G; Heindel, JJ; Howard, PC; Lewis, SM; McLellen, M; Newbold, RR; Schug, TT; Twaddle, NC; Vanlandingham, M; Walker, NJ; Woodling, K; Zoeller, RT, 2015)	1.86
"Bisphenol A (BPA) is a ubiquitous endocrine disruptor exerting lifelong effects on gene expression in rodent prostate cancer (PCa) models. "	( Exposure of Human Prostaspheres to Bisphenol A Epigenetically Regulates SNORD Family Noncoding RNAs via Histone Modification. Chen, J; Cheong, A; Ho, SM; Hu, WY; Lam, HM; Leung, YK; Medvedovic, M; Prins, GS; Shi, GB; Zhang, X; Zhu, X, 2015)	2.14
"Bisphenol A (BPA) is a ubiquitous organic environmental contaminant with ED activity."	( Maternal Transfer of Bisphenol A During Nursing Causes Sperm Impairment in Male Offspring. Cardoso, TF; Corcini, CD; Fernandes, CG; Kalb, AC; Kalb, AL; Martínez, PE; Varela Junior, AS, 2016)	1.47
"Bisphenol A (BPA) is a synthetic industrial chemical commonly used in consumer products. "	( Bisphenol A and child and youth behaviour: Canadian Health Measures Survey 2007 to 2011. Findlay, LC; Kohen, DE, 2015)	3.3
"Bisphenol A (BPA) is a high production volume chemical intermediate used primarily in the production of polycarbonate plastics and epoxy resins. "	( Characterizing the effects of bisphenol A on sediment-dwelling benthic organisms. Caspers, N; Hentges, S; Klečka, G; Mihaich, E; Ortego, L; Staples, C; Woelz, J, 2016)	2.17
"Bisphenol A (BPA) is a high-production-volume chemical associated with a wide range of health outcomes in animal and human studies. "	( Bisphenol A, Bisphenol S, and 4-Hydro​xyphenyl 4-Isopro​oxyphenyl​sulfone (BPSIP) in Urine and Blood of Cashiers. Birnbaum, LS; Bucher, JR; Church, R; Churchwell, MI; Garantziotis, S; Herbert, B; Hunt, D; Jankowich, R; Kissling, GE; Scheri, RC; Schurman, SH; Taylor, KW; Thayer, KA, 2016)	3.32
"Bisphenol A (BPA) is an endocrine disruptor used in manufacturing of plastic devices, resulting in an ubiquitous presence in the environment linked to human infertility, obesity or cardiovascular diseases. "	( Transgenerational inheritance of heart disorders caused by paternal bisphenol A exposure. Fernández-Díez, C; González-Rojo, S; Herráez, MP; Lombó, M; Navarro, C; Robles, V, 2015)	2.1
"Bisphenol A (BPA) is an environmental compounds is known to possess endocrine disruption potentials. "	( Genome-wide microRNA expression profiling in placentas from pregnant women exposed to BPA. De Felice, B; De Stefano, N; Di Carlo, C; Di Spiezio Sardo, A; Ferbo, U; Guida, M; Manfellotto, F; Palumbo, A; Troisi, J; Zullo, F, 2015)	1.86
"Bisphenol A (BPA) is a plasticiser found in a number of household plastics, electronics, and food-packaging materials. "	( Bisphenol A exposure pathways in early childhood: Reviewing the need for improved risk assessment models. English, KR; Healy, BF; Jagals, P; Sly, PD, )	3.02
"Bisphenol A (BPA) is an environmental endocrine disrupter (EED). "	( Prenatal low-dose bisphenol A enhances behavioral responses induced by a predator odor. Aou, S; Fujimoto, T; Kubo, K; Nishikawa, Y, 2015)	2.19
"Bisphenol A (BPA) is an endocrine disruptor and potential reproductive toxicant, but results of epidemiologic studies have been mixed and have been criticized for inadequate exposure assessment that often relies on a single measurement."	( Exposure Classification and Temporal Variability in Urinary Bisphenol A Concentrations among Couples in Utah--The HOPE Study. Anderson, DJ; Bailey, NM; Brozek, EM; Cox, KJ; Porucznik, CA; Stanford, JB; Szczotka, KM; Wilkins, DG, 2016)	2.12
"Bisphenol A (BPA) is an endocrine and metabolic disruptor commonly employed as a color developer in thermal papers. "	( High Levels of Bisphenol A and Bisphenol S in Brazilian Thermal Paper Receipts and Estimation of Daily Exposure. Azevedo, LF; Barbosa, F; Campiglia, AD; Gallimberti, M; Rocha, BA, 2015)	2.21
"Bisphenol A (BPA) is a ubiquitous industrial chemical used in the production of a wide variety of items. "	( Effects of developmental exposure to bisphenol A on spatial navigational learning and memory in rats: A CLARITY-BPA study. Camacho, L; Ellersieck, MR; Ferguson, SA; Javurek, AB; Johnson, SA; Lewis, SM; Painter, MS; Rosenfeld, CS; Vanlandingham, MM; Welsh, TH, 2016)	2.15
"Bisphenol A (BPA) is a widely used plasticizer, which came into focus because of its genotoxic and sensitizing potential. "	( Bisphenol A suppresses Th1-type immune response in human peripheral blood mononuclear cells in vitro. Becker, K; Fuchs, D; Gostner, JM; Pease, JE; Raggl, E; Schennach, H; Überall, F, 2015)	3.3
"Bisphenol A (BPA) is an endocrine disruptor associated with poor pregnancy outcomes in human and rodents. "	( Effects of High-Butterfat Diet on Embryo Implantation in Female Rats Exposed to Bisphenol A. Cheong, A; Ho, SM; Kannan, K; Leung, YK; Martinez, AM; Thomas, MA; Xue, J; Ying, J, 2015)	2.09
"Bisphenol A (BPA) is an environmental endocrine disruptor that has been associated with cardiovascular outcomes in previous observational studies. "	( Association of Bisphenol A Exposure With Hypertension and Early Macrovascular Diseases in Chinese Adults: A Cross-Sectional Study. Bi, Y; Chen, Y; Lai, S; Li, M; Lu, J; Ning, G; Wang, T; Wang, W; Xu, M; Xu, Y, 2015)	2.21
"Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) that has been implicated as a potential carcinogen and epigenotoxicant. "	( Stat3 is a candidate epigenetic biomarker of perinatal Bisphenol A exposure associated with murine hepatic tumors with implications for human health. Bergin, IL; Dolinoy, DC; Harris, C; Weinhouse, C, 2015)	2.11
"Bisphenol A (BPA) is a well-known environmental, endocrine-disrupting chemical, and bisphenol S (BPS) has been considered a safer alternative for BPA-free products. "	( Actions of Bisphenol A and Bisphenol S on the Reproductive Neuroendocrine System During Early Development in Zebrafish. Farajzadeh, M; Pan, C; Qiu, W; Wayne, NL; Yang, M; Zhao, Y, 2016)	2.27
"Bisphenol A (BPA) is an endocrine disrupting environmental chemical. "	( Bisphenol A in Urine of Chinese Young Adults: Concentrations and Sources of Exposure. Gao, C; Jiang, L; Kannan, K; Li, YF; Liu, L; Ma, W; Ren, N; Zhu, N, 2016)	3.32
"Bisphenol A (BPA) is an endocrine disrupting chemical that elicits a variety of reproductive effects."	( BPA exposure during in vitro oocyte maturation results in dose-dependent alterations to embryo development rates, apoptosis rate, sex ratio and gene expression. Favetta, LA; Ferris, J; King, WA; MacLusky, N; Mahboubi, K, 2016)	1.16
"Bisphenol A (BPA) is a widely used industrial chemical and suspected endocrine disruptor to which humans are ubiquitously exposed. "	( Bisphenol A sulfonation is impaired in metabolic and liver disease. King, R; Kulkarni, SR; Slitt, AL; Yalcin, EB, 2016)	3.32
"Bisphenol A (BPA) is a well-known endocrine disruptor. "	( Ultrasensitive determination of bisphenol A and its chlorinated derivatives in urine using a high-throughput UPLC-MS/MS method. Bacle, A; Brunet, B; Dupuis, A; Grignon, C; Migeot, V; Rouillon, S; Thevenot, S; Venisse, N, 2016)	2.16
"Bisphenol A (BPA) is a chemical used extensively worldwide in the manufacture of plastic polymers. "	( Association of early life exposure to bisphenol A with obesity and cardiometabolic traits in childhood. Chalkiadaki, G; Chatzi, L; Dermitzaki, E; Fthenou, E; Karachaliou, M; Kogevinas, M; Myridakis, A; Roumeliotaki, T; Sarri, K; Stephanou, EG; Vafeiadi, M; Vassilaki, M, 2016)	2.15
"Bisphenol A (BPA) is a monomer found in plastic products used daily for the storage and consumption of food and beverages, such as plastic bottles, containers, and even toys. "	( [BISPHENOL A--AN INFAMOUS MOLECULE]. Gutman, A; Shoenfeld, Y, 2015)	2.77
"Bisphenol A (BPA) is a kind of environmental endocrine disruptors (EEDs) that interfere embryo implantation. "	( Effect of Bisphenol A on invasion ability of human trophoblastic cell line BeWo. Liu, T; Lu, J; Qu, XL; Wang, ZY; Zhang, M; Zhang, YZ, 2015)	2.26
"Bisphenol A (BPA) is a commonly used endocrine-disrupting chemical used as a component of polycarbonates plastics that has potential adverse effects on human health. "	( Impairment of object recognition memory by maternal bisphenol A exposure is associated with inhibition of Akt and ERK/CREB/BDNF pathway in the male offspring hippocampus. Han, H; Li, Z; Luo, G; Wang, C; Wang, J; Wang, S; Zhou, B, 2016)	2.13
"Bisphenol A (BPA) is an estrogenic environmental toxin widely used in the production of plastics and ubiquitous human exposure to this chemical has been proposed to be a potential risk to human health. "	( Exposure to bisphenol A (BPA) in Wistar rats reduces sperm quality with disruption of ERK signal pathway. Ding, L; Gao, ES; Hou, LF; Li, J; Mao, R; Ran, MM; Tao, J; Wang, JT; Yuan, W; Zhou, Q, 2016)	2.26
"Bisphenol A (BPA) is a widely used industrial plasticizer, which is ubiquitously present in the environment and organisms. "	( Neonatal bisphenol A exposure induces meiotic arrest and apoptosis of spermatogenic cells. Bu, P; Lan, S; Li, F; Wang, Y; Wu, H; Xie, M; Yuan, L, 2016)	2.29
"Bisphenol A (BPA) is a synthetic oestrogen that is extensively used in a wide range of daily used plastic products. "	( Effect of bisphenol A on morphology, apoptosis and proliferation in the resting mammary gland of the adult albino rat. Bayomy, NA; Elbakry, RH; Ibrahim, MA, 2016)	2.28
"Bisphenol A (BPA) is a known endocrine-disrupting compound (EDC) that has a structure similar to that of the hormone estrogen. "	( Ultrasensitive Bisphenol A Field-Effect Transistor Sensor Using an Aptamer-Modified Multichannel Carbon Nanofiber Transducer. Jang, J; Jun, J; Kim, SG; Lee, JS; Shin, DH, 2016)	2.23
"Bisphenol A (BPA) is an industrial synthetic chemical utilized in the production of numerous products including food and beverage containers. "	( Bisphenol A Induces Migration through a GPER-, FAK-, Src-, and ERK2-Dependent Pathway in MDA-MB-231 Breast Cancer Cells. Castillo Sanchez, R; Gomez, R; Perez Salazar, E, 2016)	3.32
"Bisphenol A (BPA), is an artificial estrogen initially produced for medical purposes but is today widely used in polycarbonate plastics and epoxy resins. "	( Altered heart proteome in fructose-fed Fisher 344 rats exposed to bisphenol A. Iggland, M; Karlsson, H; Lind, L; Lind, PM; Ljunggren, SA; Rönn, M, 2016)	2.11
"Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) produced in huge quantities in the manufacture of polycarbonate plastics and epoxy resins. "	( Effects of Bisphenol A on ion channels: Experimental evidence and molecular mechanisms. Alonso-Magdalena, P; Fuentes, E; Martinez-Pinna, J; Nadal, A; Quesada, I; Ripoll, C; Soriano, S, 2016)	2.27
"Bisphenol A (BPA) is an endocrine disrupting chemical used to synthesize polycarbonate plastics and epoxy resins. "	( Bisphenol A exposure and children's behavior: A systematic review. Dewey, D; Ejaredar, M; Lee, Y; Roberts, DJ; Sauve, R, 2017)	3.34
"Bisphenol A (BPA) is an endocrine disruptor found in food containers and plastic beverages and also in medical devices such as dialyzers. "	( Determination of bisphenol A in water and the medical devices used in hemodialysis treatment. Bacle, A; Bauwens, M; Belmouaz, M; Dupuis, A; Grignon, C; Migeot, V; Teychene, B; Thevenot, S; Venisse, N, 2016)	2.22
"Bisphenol A (BPA) is a high-volume industrial chemical used in the global production of polycarbonate plastics and epoxy resins, which are used in food and drink containers, such as tableware (plates and mugs). "	( Risk assessment based on urinary bisphenol A levels in the general Korean population. Hwang, IG; Hwang, MS; Jeong, DH; Kang, HS; Kho, YH; Ko, A; Lee, HS; Lee, JM; Lee, KS; Moon, G; Park, JH; Shin, MK; Suh, JH, 2016)	2.16
"Bisphenol A (BPA) is a widely studied typical endocrine-disrupting chemical. "	( Bisphenol A, an environmental estrogen-like toxic chemical, induces cardiac fibrosis by activating the ERK1/2 pathway. Fang, Z; Hou, L; Hu, Y; Ju, J; Li, J; Li, Q; Li, Z; Qin, W; Wu, X; Xu, C; Zhang, L; Zhang, Q; Zhang, Y; Zhou, T, 2016)	3.32
"Bisphenol A (BPA) is an important industrial raw material. "	( Analysis of effects of a new environmental pollutant, bisphenol A, on antioxidant systems in soybean roots at different growth stages. Huang, X; Li, X; Wang, L; Zhang, J; Zhou, L; Zhou, Q, 2016)	2.13
"Bisphenol A (BPA) is a ubiquitous, endocrine-disrupting environmental contaminant that increases risk of some adverse developmental effects. "	( Direct measurement of Bisphenol A (BPA), BPA glucuronide and BPA sulfate in a diverse and low-income population of pregnant women reveals high exposure, with potential implications for previous exposure estimates: a cross-sectional study. Friesen, M; Gerona, RR; Hunt, PA; Pan, J; Schwartz, JM; Taylor, JA; Woodruff, TJ; Zota, AR, 2016)	2.19
"Bisphenol A (BPA) is a well-known endocrine disrupting chemical (EDC), ubiquitous in the aquatic environment, which poses an ecotoxicological risk to the health of aquatic organisms. "	( Oxidative stress and immune disturbance after long-term exposure to bisphenol A in juvenile common carp (Cyprinus carpio). Chen, J; Chen, Z; Jiang, L; Li, Y; Qiu, W; Wu, M; Yang, M, 2016)	2.11
"Bisphenol A (BPA) is a well-known estrogenic endocrine disrupting chemical (EDC) ubiquitously present in various environmental media. "	( The potential immune modulatory effect of chronic bisphenol A exposure on gene regulation in male medaka (Oryzias latipes) liver. Liu, S; Pan, C; Qiu, W; Shen, Y; Wang, KJ; Wu, M; Yang, M, 2016)	2.13
"Bisphenol A (BPA) is a commercially important high production chemical widely used in epoxy resins and polycarbonate plastics, and is ubiquitous in the environment. "	( Bisphenol A causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio). Dempster, EL; Laing, LV; Mill, J; Paull, GC; Santos, EM; Trunkfield, LA; Trznadel, M; Uren Webster, TM; van Aerle, R; Viana, J; Wilson, RJ, 2016)	3.32
"Bisphenol A (BPA) is an abundantly used xenoestrogenic chemical which may cause various disorders in body."	( Induction Effect of Bisphenol A on Gene Expression Involving Hepatic Oxidative Stress in Rat. Aghapour, F; Kazemi, S; Moghadamnia, AA; Mousavi, SN; Rezaee, B; Sadeghi, F, 2016)	1.48
"Bisphenol A (BPA) is a synthetic estrogen-mimic chemical. "	( Bisphenol A accelerates capacitation-associated protein tyrosine phosphorylation of rat sperm by activating protein kinase A. Chu, C; Ni, Z; Ru, Y; Wan, X; Wang, S; Zhang, Y; Zhou, Y; Zhou, Z, 2016)	3.32
"Bisphenol A (BPA) is an endocrine disrupting chemical with ubiquitous human exposure. "	( Bisphenol A-Induced Ovotoxicity Involves DNA Damage Induction to Which the Ovary Mounts a Protective Response Indicated by Increased Expression of Proteins Involved in DNA Repair and Xenobiotic Biotransformation. Ganesan, S; Keating, AF, 2016)	3.32
"Bisphenol A(BPA) is a common chemical material use in food and beverage packaging."	( Preventive effects of procyanidin A2 on glucose homeostasis, pancreatic and duodenal homebox 1, and glucose transporter 2 gene expression disturbance induced by bisphenol A in male mice. Afshari, G; Ahangarpour, A; Hashemitabar, M; Khodadadi, A; Mard, SA, 2016)	1.35
"Bisphenol A (BPA) is a ubiquitous compound emerging as a possible toxicant during embryonic development. "	( Bisphenol A Represses Dopaminergic Neuron Differentiation from Human Embryonic Stem Cells through Downregulating the Expression of Insulin-like Growth Factor 1. Chen, A; Cui, Y; Fan, G; Hu, J; Huang, B; Jiang, C; Li, H; Liu, J; Ning, S; Qin, L; Zhang, Q, 2017)	3.34
"Bisphenol A (BPA) is an important industrial chemical, mainly used in the manufacture of polycarbonate plastic and epoxy resins. "	( Upregulation of human CYP2C9 expression by Bisphenol A via estrogen receptor alpha (ERα) and Med25. Englert, NA; Shi, Z; Wu, L; Xu, JY; Zhang, SY; Zhang, XJ, 2017)	2.16
"Bisphenol A (BPA) is a monomer used in plastics and plasticizers. "	( Effects of various LED light spectra on antioxidant and immune response in juvenile rock bream, Oplegnathus fasciatus exposed to bisphenol A. Choi, CY; Choi, JY; Choi, YJ; Kim, NN; Kim, TH; Oh, SY, 2016)	2.08
"Bisphenol A (BPA) is a ubiquitous compound used in polymer manufacturing for a wide array of applications; however, increasing evidence has shown that BPA causes significant endocrine disruption and this has raised public concerns over safety and exposure limits. "	( Experimental Data Extraction and in Silico Prediction of the Estrogenic Activity of Renewable Replacements for Bisphenol A. Harvey, BG; Hong, H; Ng, HW; Palmese, GR; Sadler, JM; Sakkiah, S; Stanzione, JF; Tong, W, 2016)	2.09
"Bisphenol A (BPA) is an important industrial chemical used as a plasticizer in polycarbonate and epoxy resins in the plastic and paper industries. "	( Recent advances and progress in the detection of bisphenol A. Kang, L; Li, H; Lu, C; Luo, R; Luo, X; Peng, X; Sun, F; Xiang, X, 2016)	2.13
"Bisphenol A (BPA) acts as an endocrine-disrupting compound even at a low concentration. "	( Screening of Toxic Effects of Bisphenol A and Products of Its Degradation: Zebrafish (Danio rerio) Embryo Test and Molecular Docking. Kurkowiak, J; Makarova, K; Siudem, P; Zawada, K, 2016)	2.17
"Bisphenol A (BPA) is an endocrine disruptor, and could induce germ cells apoptosis in the testis of mammals. "	( Bisphenol A induces spermatocyte apoptosis in rare minnow Gobiocypris rarus. Cheng, M; Wang, Z; Wu, L; Zhang, G; Zhang, Y, 2016)	3.32
"Bisphenol A (BPA) is an endocrine disrupting, high volume production chemical found in a variety of products. "	( Impact of Low Dose Oral Exposure to Bisphenol A (BPA) on the Neonatal Rat Hypothalamic and Hippocampal Transcriptome: A CLARITY-BPA Consortium Study. Arambula, SE; Belcher, SM; Patisaul, HB; Planchart, A; Turner, SD, 2016)	2.15
"Bisphenol A (BPA) is a chemical produced in large volumes for use in manufacturing of consumer products and industrial applications, and an endocrine disruptor known to affect several hormonal systems. "	( Low-dose developmental exposure to bisphenol A alters the femoral bone geometry in wistar rats. Boberg, J; Christiansen, S; Hass, U; Larsson, S; Lejonklou, MH; Lind, PM; Örberg, J; Shen, L, 2016)	2.15
"Bisphenol A (BPA) is a synthetic monomer used widely in many forms, from food containers to toys, medical products and many others."	( Correlation between antibodies to bisphenol A, its target enzyme protein disulfide isomerase and antibodies to neuron-specific antigens. Kharrazian, D; Vojdani, A, 2017)	1.46
"Bisphenol A (BPA) is an ubiquitous xenoestrogen widely employed in a variety of consumer products including plastic and metal food and beverage containers, dental sealants and fillings, medical equipment and thermal receipts."	( [Autism spectrum disorders and bisphenol A: Is serotonin the lacking link in the chain?] Dejean, C; Sarrouilhe, D, 2017)	1.46
"Bisphenol A is an environment-polluting industrial chemical able to interfere with the endocrine system. "	( Bisphenol A induces hypothalamic down-regulation of the the cannabinoid receptor 1 and anorexigenic effects in male mice. Ambrosino, C; Chianese, R; Chioccarelli, T; Cobellis, G; Fasano, S; Migliaccio, M; Pierantoni, R; Suglia, A, 2016)	3.32
"Bisphenol A (BPA) is a widely used chemical in the production of many polycarbonate plastics, epoxy resin linings for food and beverage containers and thermal papers. "	( Higher dermal exposure of cashiers to BPA and its association with DNA oxidative damage. Dai, Y; Fan, R; Li, Y; Lu, S; Lv, Y; Pang, Q; Rui, C; Wang, Y; Zhou, Y, 2017)	1.9
"Bisphenol A (BPA) is an estrogen-mimicking chemical that can be selectively detected in water using a chemical sensor based on molecularly imprinted polymers (MIPs). "	( Selectivity Enhancement in Molecularly Imprinted Polymers for Binding of Bisphenol A. Alenazi, NA; Lai, EP; Manthorpe, JM, 2016)	2.11
"Bisphenol A (BPA) is an environmental endocrine disruptor and is found in many consumer products. "	( Urine bisphenol A and pubertal development in boys. Chen, J; Li, D; Liang, H; Miao, M; Wang, Z; Wu, C; Yuan, W; Zhou, Z, 2017)	2.38
"Bisphenol A (BPA) is a ubiquitous environmental pollutant which is often associated with various health issues. "	( Possible influence of the environmental pollutant bisphenol A on the cardiometabolic risk factors. Ičin, T; Jakšić, V; Medić Stojanoska, M; Milić, N; Milošević, N; Sudji, J; Vuković, B, 2017)	2.15
"Bisphenol A (BPA) is an organic synthetic compound employed to produce plastics and epoxy resins. "	( Influence of Bisphenol A on Type 2 Diabetes Mellitus. Colao, A; de Angelis, C; Muscogiuri, G; Negri, M; Pivonello, C; Pivonello, R; Provvisiero, DP; Simeoli, C, 2016)	2.25
"Bisphenol A (BPA) is an endocrine disrupting chemical with ubiquitous environmental exposure. "	( Second trimester amniotic fluid bisphenol A concentration is associated with decreased birth weight in term infants. Aijaz, S; Blair, IA; Busch, CM; Ijaz, N; Manson, JM; Mesaros, CA; Pinney, SE; Snyder, NW; Xiao, R, 2017)	2.18
"Bisphenol A (BPA) is a known endocrine disruptor that is acutely toxic to the living organisms."	( Adsorptive removal of bisphenol A (BPA) from aqueous solution: A review. Anastopoulos, I; Bhatnagar, A, 2017)	1.49
"Bisphenol A (BPA) is an endocrine-disrupting compound used to manufacture plastics; it is present in linings of food cans, bottles, thermal receipts, and many other everyday items and is detectable in human urine and blood. "	( Multi- and Transgenerational Consequences of Bisphenol A on Sexually Dimorphic Cell Populations in Mouse Brain. Goldsby, JA; Rissman, EF; Wolstenholme, JT, 2017)	2.16
"Bisphenol A (BPA) is a synthetic chemical substance used as a starting ingredient in the manufacturing process of a number or orthodontic materials. "	( A systematic study of the release of bisphenol A by orthodontic materials and its biological effects. Adli, H; Azeroual, MF; Bahije, L; Benyahia, H; Halimi, A; Zaoui, F, 2016)	2.15
"Bisphenol analogues are a group of chemicals which are being widely applied in industrial and household products owing to regulations on bisphenol A (BPA) in many countries. "	( Simultaneously determination of bisphenol A and its alternatives in sediment by ultrasound-assisted and solid phase extractions followed by derivatization using GC-MS. Chen, M; Ma, X; Wang, Q; Wang, X; Xia, J; Zhu, L, 2017)	2.18
"Bisphenol A (BPA) is a key monomer in the production of plastics. "	( Inflammation, oxidative stress and apoptosis cascade implications in bisphenol A-induced liver fibrosis in male rats. Abdallah, FR; Atteia, HH; Elswefy, SE; Hasan, RA; Wahba, AS, 2016)	2.11
"Bisphenol A (BPA) is a widely present endocrine disruptor chemical found in many household items. "	( Bisphenol A (BPA) in the serum of pet dogs following short-term consumption of canned dog food and potential health consequences of exposure to BPA. Backus, RC; Bivens, NJ; Ellersieck, MR; Givan, SA; Javurek, AB; Johnson, SA; Kannan, K; Koestel, ZL; Rosenfeld, CS; Spollen, WG; Tsuruta, K; Wiedmeyer, CE; Xue, J, 2017)	3.34
"Bisphenol A (BPA) is an endocrine disrupting compound that may have adverse developmental, reproductive, neurological, and immune system effects. "	( Rapid and sensitive detection of bisphenol a from serum matrix. Chen, J; Cheng, C; Cui, H; Lin, X; Terry, P; Wu, J, 2017)	2.18
"Bisphenol A (BPA) is a well-known endocrine-disrupting chemical that is ubiquitously present in the environment. "	( Bioconcentration pattern and induced apoptosis of bisphenol A in zebrafish embryos at environmentally relevant concentrations. Chen, Z; Jiang, L; Lei, P; Pan, C; Wu, M; Yang, M, 2017)	2.15
"Bisphenol A (BPA) is an extensively used chemical with endocrine disrupting properties. "	( The Association between Exposure to Environmental Bisphenol A and Gonadotropic Hormone Levels among Men. Chen, J; Liang, H; Liu, X; Miao, M; Shi, H; Wang, J; Xu, W; Yuan, W; Zhu, J, 2017)	2.15
"Bisphenol A is an endocrine disrupting compound widely used in the production of polycarbonate plastics and epoxy resins. "	( Clastogenic effects of bisphenol A on human cultured lymphocytes. Cannarsa, E; Cervella, P; Santovito, A; Schleicherova, D, 2018)	2.23
"Bisphenol A (BPA) is an endocrine disrupting compound used in food and beverage plastic containers and has been shown to increase breast cancer cellular proliferation. "	( Bisphenol A Induces Sox2 in ER Krum, SA; Lillo, MA; Miranda-Carboni, GA; Nichols, C; Seagroves, TN, 2017)	3.34
"Bisphenol A (BPA) is an artificial environmental endocrine disrupting chemicals. "	( Curcumin attenuates BPA-induced insulin resistance in HepG2 cells through suppression of JNK/p38 pathways. Chen, Y; Geng, S; Huang, C; Jiang, Y; Li, X; Li, Y; Meng, Y; Wang, S; Wang, X; Wu, J; Wu, R; Xie, C; Yang, X; Zhong, C; Zhu, J; Zhu, M; Zhu, W, 2017)	1.9
"Bisphenol A (BPA) is an endocrine disrupting chemical and several biological effects have been reported. "	( Interaction between bisphenol derivatives and protein disulphide isomerase (PDI) and inhibition of PDI functions: requirement of chemical structure for binding to PDI. Hashimoto, S; Imaoka, S; Okada, K, 2008)	1.79
"Bisphenol A (BPA) is an industrial chemical with estrogenic activity. "	( Influence of bisphenol a on developing rat estrogen receptors and some cytokines in rats: a two-generational study. Gao, Z; Kou, Z; Liu, N; Miao, S; Su, C; Xu, G, 2008)	2.16
"Bisphenol A (BPA) is a well-known endocrine disrupter used widely. "	( Maternal and fetal exposure to bisphenol A in Korea. Hong, YC; Im, MW; Jang, DD; Jung, JY; Kim, E; Kim, HK; Lee, JH; Lee, KH; Lee, YJ; Leem, JH; Ma, JY; Min, CS; Nam, BH; Park, EY; Park, JH; Ryu, HY; Won, HS; Yoon, HS, 2008)	2.07
"Bisphenol A (BPA) is an estrogenic contaminant that has been quantified at higher levels in the follicular fluid of women with polycystic ovarian syndrome (PCOS) compared to healthy fertile controls. "	( Bisphenol A concentration-dependently increases human granulosa-lutein cell matrix metalloproteinase-9 (MMP-9) enzyme output. Dominguez, MA; Foster, WG; Neal, MS; Petre, MA, 2008)	3.23
"Bisphenol A (BPA) is a widespread estrogenic chemical used in the production of polycarbonate, and epoxy resins lining food and beverage cans and in dental sealants. "	( Effects of developmental exposure to bisphenol A on brain and behavior in mice. Gioiosa, L; Palanza, P; Parmigiani, S; vom Saal, FS, 2008)	2.06
"Bisphenol A (BPA) is an environmental chemical with physiological potencies that cause adverse effects, even at environmentally relevant exposures, on the basis of a number of studies in experimental rodents. "	( Alterations in male infant behaviors towards its mother by prenatal exposure to bisphenol A in cynomolgus monkeys (Macaca fascicularis) during early suckling period. Ihara, T; Imai, N; Kawasaki, K; Koyama, T; Kuroda, Y; Nakagami, A; Negishi, T; Nishida, Y; Yoshikawa, Y, 2009)	2.02
"Bisphenol A (BPA) is a component of polycarbonate and other plastics including resins that line food and beverage containers. "	( Bisphenol A: Perinatal exposure and body weight. Rubin, BS; Soto, AM, 2009)	3.24
"Bisphenol A (BPA) is an estrogenic contaminant of food and water associated with adverse developmental effects in laboratory animals. "	( Within-person variability in urinary bisphenol A concentrations: measurements from specimens after long-term frozen storage. Baird, DD; Hoppin, JA; Longnecker, MP; Nepomnaschy, PA; Weinberg, CR; Wilcox, AJ, 2009)	2.07
"Bisphenol A (BPA) is a component of polycarbonate plastics, epoxy resins, and polystyrene and is found in many products. "	( Neonatal exposure to bisphenol a alters reproductive parameters and gonadotropin releasing hormone signaling in female rats. Bianchi, M; Fernández, M; Libertun, C; Lux-Lantos, V, 2009)	2.11
"Bisphenol A is an industrial contaminant and is considered to be an endocrine disruptor; its estrogenic property has been reported in many studies. "	( Bisphenol A downregulates CYP19 transcription in JEG-3 cells. Huang, H; Leung, LK, 2009)	3.24
"Bisphenol A (BPA) is a ubiquitous environmental contaminant with endocrine disruption potential. "	( Oxidative removal of bisphenol A by manganese dioxide: efficacy, products, and pathways. Gant, J; Lin, K; Liu, W, 2009)	2.11
"Bisphenol A (BPA) is a high-production-volume chemical commonly used in the manufacture of polycarbonate plastic. "	( Polycarbonate bottle use and urinary bisphenol A concentrations. Bassett, LS; Calafat, AM; Carwile, JL; Chang, JY; Driscoll, DA; Luu, HT; Michels, KB; Ye, X; Yuan, C, 2009)	2.07
"Bisphenol A (BPA) is an environmental pollutant to disrupt endocrine system or cause cancer, thus the detection of BPA is very important. "	( Sensitivity and selectivity determination of BPA in real water samples using PAMAM dendrimer and CoTe quantum dots modified glassy carbon electrode. Ai, S; Chen, Q; Liu, X; Yin, H; Zhou, Y; Zhu, L; Zhu, X, 2010)	1.8
"Bisphenol A (BPA) is an endocrine disrupter that has been associated with impaired spermatogenesis."	( Neonatal exposure of male rats to Bisphenol A impairs fertility and expression of sertoli cell junctional proteins in the testis. Doshi, T; Salian, S; Vanage, G, 2009)	1.35
"Bisphenol A is a known endocrine disruptor in vertebrates that mimics the action of estrogens by interacting with hormone receptors. "	( Effects of bisphenol A in the ring-legged earwig, Euborellia annulipes. Grosjean, EM; Rankin, SM, 2010)	2.19
"Bisphenol A (BPA) is an endocrine disruptor for which health risk assessment has proven controversial. "	( Risk to all or none? A comparative analysis of controversies in the health risk assessment of Bisphenol A. Beronius, A; Håkansson, H; Hanberg, A; Rudén, C, 2010)	2.02
"Bisphenol A (BPA) is a synthetic chemical used in the manufacture of materials present in many common consumer products. "	( Urinary bisphenol A concentrations and ovarian response among women undergoing IVF. Calafat, AM; Ehrlich, S; Hauser, R; Mok-Lin, E; Petrozza, J; Williams, PL; Wright, DL; Ye, X, 2010)	2.24
"Bisphenol A (BPA) is a high production volume chemical widely used in food and drinks packaging. "	( Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06. Galloway, TS; Henley, WE; Lewis, C; Melzer, D; Rice, NE, 2010)	2.11
"Bisphenol A (BPA) is an endocrine disrupting chemical that is found in human urine throughout industrial societies around the globe. "	( Bisphenol a: how the most relevant exposure sources contribute to total consumer exposure. Hungerbühler, K; Scheringer, M; von Goetz, N; Wormuth, M, 2010)	3.25
"Bisphenol A (BPA) is a ubiquitous environmental contaminant with established endocrine disruptor properties. "	( Proteomic analysis in mammary glands of rat offspring exposed in utero to bisphenol A. Betancourt, AM; Lamartiniere, CA; Mobley, JA; Russo, J, 2010)	2.03
"Bisphenol A (BPA) is a monomer used in manufacturing a wide range of chemical products, including epoxy resins and polycarbonate. "	( Bisphenol A in combination with TNF-alpha selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity. Guo, H; Hirosawa, N; Ichihara, Y; Ishihara, O; Jiao, S; Kikuchi, H; Lin, Z; Ling, F; Liu, T; Narita, Y; Sakamoto, Y; Senju, S; Suzuki, M; Uemura, Y; Wang, D; Zhang, Q, 2010)	3.25
"Bisphenol A (BPA) is a widespread endocrine-disrupting chemical used as the base compound in the manufacture of polycarbonate plastics. "	( Bisphenol A exposure during pregnancy disrupts glucose homeostasis in mothers and adult male offspring. Alonso-Magdalena, P; Burks, D; Menes, L; Nadal, A; Quesada, I; Soriano, S; Vieira, E, 2010)	3.25
"Bisphenol A (BPA) is a high volume chemical used in a wide variety of products, including plastic bottles and canned goods. "	( Bisphenol A: invisible pollution. Groff, T, 2010)	3.25
"Bisphenol A (BPA) is a well-known plastic-derived pollutant that can bind to oestrogen receptors and is considered an endocrine-disrupting chemical. "	( Effects of perinatal administration of Bisphenol A on the neuronal nitric oxide synthase expressing system in the hypothalamus and limbic system of CD1 mice. Fissore, E; Gotti, S; Martini, M; Miceli, D; Palanza, P; Panzica, G; Viglietti-Panzica, C, 2010)	2.07
"Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. "	( Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats. Doerge, DR; Fisher, JW; Twaddle, NC; Vanlandingham, M, 2010)	2.13
"Bisphenol A (BPA) is a high-production volume industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. "	( Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys. Doerge, DR; Fisher, JW; Twaddle, NC; Woodling, KA, 2010)	2.13
"Bisphenol A (BPA) is an industrial chemical used to make polymers including some used in food contact applications. "	( Development of a method for the determination of bisphenol A at trace concentrations in human blood and urine and elucidation of factors influencing method accuracy and sensitivity. Chappelle, AH; Chuang, JC; Connolly, P; Dimond, S; Hentges, S; Markham, DA; Rao, N; Shiotsuka, RN; Waechter, JM; Wimber, M, )	1.83
"Bisphenol A (BPA) is a ubiquitous environmental chemical with reported endocrine-disrupting properties."	( In utero exposure to bisphenol A shifts the window of susceptibility for mammary carcinogenesis in the rat. Betancourt, AM; Desmond, RA; Eltoum, IA; Lamartiniere, CA; Russo, J, 2010)	2.12
"Bisphenol A (BPA) is a suspected endocrine disruptor in the environment. "	( Ubiquity of bisphenol A in the atmosphere. Fu, P; Kawamura, K, 2010)	2.18
"Bisphenol A (BPA) is an endocrine-disrupting chemical, widely used in industry and dentistry. "	( Prenatal and lactational exposure to low-doses of bisphenol A alters brain monoamine concentration in adult mice. Fushiki, S; Itoh, K; Nakamura, K; Sugimoto, T; Yoshimoto, K, 2010)	2.06
"Bisphenol A (BPA) is a high production volume chemical widely used in packaging for food and beverages. "	( Daily bisphenol A excretion and associations with sex hormone concentrations: results from the InCHIANTI adult population study. Bandinelli, S; Cipelli, R; Corsi, AM; Ferrucci, L; Galloway, T; Guralnik, J; McCormack, P; Melzer, D; Money, C, 2010)	2.28
"Bisphenol A (BPA) is a potential endocrine disruptor and testicular toxicant. "	( Mitochondrial signaling pathway is also involved in bisphenol A induced germ cell apoptosis in testes. Ji, YL; Liu, P; Wang, H; Wang, Q; Xu, DX; Zhang, C; Zhang, Y; Zhao, XF, 2010)	2.05
"Bisphenol A (BPA) is a chemical used extensively to manufacture commonly used plastics and epoxy resin liners for food and beverage cans. "	( Bisphenol a exposure: human risk and health policy. Erler, C; Novak, J, 2010)	3.25
"Bisphenol A (BPA) is a high production volume substance primarily used to produce polycarbonate plastic and epoxy resins. "	( Estimating potential risks to terrestrial invertebrates and plants exposed to bisphenol A in soil amended with activated sludge biosolids. Caspers, N; Friederich, U; Hall, T; Hentges, S; Klečka, G; Mihaich, E; Ortego, L; Staples, C, 2010)	2.03
"Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products, epoxy resin-based food can liners, and paper products. "	( Quantification of deuterated bisphenol A in serum, tissues, and excreta from adult Sprague-Dawley rats using liquid chromatography with tandem mass spectrometry. Churchwell, MI; Doerge, DR; Twaddle, NC; Vanlandingham, M, 2010)	2.09
"Bisphenol A (BPA) is a known ED that leaches from polycarbonate plastics, as such human exposure is common."	( Perinatal exposure of rats to Bisphenol A affects fertility of male offspring--an overview. Doshi, T; Salian, S; Vanage, G, 2011)	1.38
"Bisphenol A (BPA) is an endocrine disruptor (ED) that is abundant in the environment because of its extensive use in human-manufactured products. "	( Bisphenol A content in fish caught in two different sites of the Tyrrhenian Sea (Italy). Bencivenga, U; Bianco, M; Canciglia, P; Colonna, A; Diano, N; Lepore, M; Mita, DG; Mita, L; Monaco, G; Portaccio, M; Sica, V; Viggiano, E; Zollo, F, 2011)	3.25
"Bisphenol A (BPA) is an industrial chemical used primarily in polycarbonate plastic and epoxy resins."	( Lead and bisphenol A concentrations in the Canadian population. Bushnik, T; Haines, D; Levallois, P; Levesque, J; Van Oostdam, J; Viau, C, 2010)	1.5
"Bisphenol A (BPA) is a xenoestrogen that was first synthesized in 1891. "	( The role of Bisphenol A in shaping the brain, epigenome and behavior. Connelly, JJ; Rissman, EF; Wolstenholme, JT, 2011)	2.19
"Bisphenol A (BPA) is a chemical used for lining metal cans and in polycarbonate plastics, such as baby bottles. "	( Bisphenol A (BPA) in U.S. food. Birnbaum, L; Haffner, D; Harris, TR; Malik, N; Paepke, O; Schecter, A; Smith, S, 2010)	3.25
"Bisphenol A (BPA) is an estrogenic agonist compound that induces changes in diverse reproductive parameters in rats. "	( Administration of bisphenol A to dams during perinatal period modifies molecular and morphological reproductive parameters of the offspring. Baranda-Avila, N; Cerbón, M; García-Guzmán, M; Mendoza-Rodríguez, CA; Morimoto, S; Perrot-Applanat, M, 2011)	2.15
"Bisphenol A (BPA) is a highly prevalent constituent of plastics that has been associated with diabetes, cardiovascular disease, and an increased risk of miscarriages in humans. "	( Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities. Allard, P; Colaiácovo, MP, 2010)	3.25
"Bisphenol A (BPA) is an endocrine disruptor with estrogenic properties that can adversely affect meiotic spindle assemblies. "	( Serum unconjugated bisphenol A concentrations in women may adversely influence oocyte quality during in vitro fertilization. Bloom, MS; Fujimoto, VY; Kim, D; Lamb, JD; Taylor, JA; vom Saal, FS, 2011)	2.14
"Bisphenol A (BPA) is a widespread industrial compound used in the synthesis of polycarbonate plastics. "	( Endocrine disruptors and polycystic ovary syndrome (PCOS): elevated serum levels of bisphenol A in women with PCOS. Chatzigeorgiou, A; Diamanti-Kandarakis, E; Economou, F; Kandaraki, E; Koutsilieris, M; Livadas, S; Palimeri, S; Palioura, E; Panidis, D, 2011)	2.04
"Bisphenol A (BPA) is an endocrine-disrupting chemical, widely used in dentistry and various industries. "	( Prenatal and lactational exposure to low-doses of bisphenol A alters adult mice behavior. Dai, H; Fushiki, S; Han, L; Itoh, K; Kato, S; Nakamura, K; Sugimoto, T; Wang, X, 2012)	2.07
"Bisphenol A (BPA) is a monomer used mainly in the synthesis of polycarbonates and epoxy resins. "	( In vivo and ex vivo percutaneous absorption of [14C]-bisphenol A in rats: a possible extrapolation to human absorption? Beydon, D; Ferrari, E; Grandclaude, MC; Marquet, F; Payan, JP; Wathier, L, 2011)	2.06
"Bisphenol A (BPA) is a widely used chemical that has been shown to adversely affect health outcomes in experimental animal studies, particularly following fetal or early life exposure. "	( Bisphenol A and children's health. Braun, JM; Hauser, R, 2011)	3.25
"Bisphenol A is an endocrine disrupting compound, which is ubiquitous in the environment due to its wide use in plastic and resin production. "	( Fate of bisphenol A during treatment with the litter-decomposing fungi Stropharia rugosoannulata and Stropharia coronilla. Hatakka, A; Hofrichter, M; Kabiersch, G; Rajasärkkä, J; Steffen, K; Tuomela, M; Ullrich, R; Virta, M, 2011)	2.25
"Bisphenol A (BPA) is an estrogenic environmental toxin widely used in the production of plastics and ubiquitous human exposure to this chemical has been proposed to be a potential risk to public health. "	( Epigenetic perspective on the developmental effects of bisphenol A. Champagne, FA; Kundakovic, M, 2011)	2.06
"Bisphenol A (BPA) is an endocrine disruptor that has garnered much attention because of its presence in many consumer materials, which generates a significant risk for exposure."	( Quantitative determination of bisphenol A from human saliva using bulk derivatization and trap-and-elute liquid chromatography coupled to electrospray ionization mass spectrometry. Figard, BJ; Moore, H; Morgan, AA; Nguyen, HP; Schug, KA; Yang, SH, 2011)	1.38
"Bisphenol A (BPA) is a chemical with high production volume and wide applications in many industries. "	( In vitro fluorescence displacement investigation of thyroxine transport disruption by bisphenol A. Cao, J; Guo, LH; Wan, B; Wei, Y, 2011)	2.04
"Bisphenol A (BPA) is an industrial plasticizer that leaches from food containers during normal usage, leading to human exposure. "	( Bisphenol A increases mammary cancer risk in two distinct mouse models of breast cancer. Keri, RA; Weber Lozada, K, 2011)	3.25
"Bisphenol A (BPA) is a widely produced endocrine-disrupting chemical. "	( Comparison of serum bisphenol A concentrations in mice exposed to bisphenol A through the diet versus oral bolus exposure. Collet, SH; Ellersieck, MR; Jašarevic, E; Kannan, K; Liao, C; Mao, J; Rosenfeld, CS; Sieli, PT; Toutain, PL; Vom Saal, FS; Warzak, DA, 2011)	2.14
"Bisphenol A (BPA) is a synthetic industrial reactant used in the production of polycarbonate plastics, and genistein is a natural phytoestrogen abundant in the soybean. "	( Measurement of bisphenol A, bisphenol A ß-D-glucuronide, genistein, and genistein 4'-ß-D-glucuronide via SPE and HPLC-MS/MS. Buckley, B; Coughlin, JL; Winnik, B, 2011)	2.16
"Bisphenol A (BPA) is a chemical suspected of causing endocrine and metabolic disruption in animals and humans. "	( Urinary bisphenol A and obesity: NHANES 2003-2006. Carwile, JL; Michels, KB, 2011)	2.25
"Bisphenol A (BPA) is a high production-volume chemical used in the manufacture of a wide variety of consumer products. "	( Assessment of risk to humans of bisphenol A in marine and freshwater fish from Pearl River Delta, China. Giesy, JP; Huang, Y; Wei, X; Wong, CK; Wong, MH, 2011)	2.1
"Bisphenol A (BPA) is an industrial chemical used in the manufacture of polycarbonate plastics and epoxy resins. "	( Urinary bisphenol A concentrations and their implications for human exposure in several Asian countries. Alomirah, H; Cho, HS; Kannan, K; Li, YF; Liao, C; Minh, TB; Mohd, MA; Nakata, H; Ren, N; Zhang, Z, 2011)	2.25
"Bisphenol A (BPA) is a ubiquitous high volume industrial chemical that is an estrogen and an environmental endocrine disrupting chemical. "	( Assessment of bisphenol A released from reusable plastic, aluminium and stainless steel water bottles. Belcher, SM; Cooper, JE; Kendig, EL, 2011)	2.17
"Bisphenol A (BPA) is a widespread endocrine disrupting chemical that influences adult physiology and behavior after perinatal exposure. "	( Pubertal exposure to bisphenol A disrupts behavior in adult C57BL/6J mice. He, F; Song, Z; Tai, F; Wu, R; Yu, C; Zhang, X, 2011)	2.13
"Bisphenol A (BPA) is a 'weak' endocrine disruptor. "	( Human meiotic progression and recombination are affected by Bisphenol A exposure during in vitro human oocyte development. Brieño-Enríquez, MA; Cabero, L; Caldés, MG; Camats-Tarruella, N; García-Cruz, R; Martínez, F; Robles, P; Roig, I, 2011)	2.05
"Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. "	( Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague-Dawley rats. Brown, RP; Doerge, DR; Fisher, JW; Twaddle, NC; Vanlandingham, M, 2011)	2.16
"Bisphenol A (BPA) is an estrogenic endocrine disruptor commonly used in manufacture of polycarbonate plastics and epoxy resins. "	( Hypermethylation of estrogen receptor promoter region in adult testis of rats exposed neonatally to bisphenol A. Balasinor, N; Dighe, V; Doshi, T; Mehta, SS; Vanage, G, 2011)	2.03
"Bisphenol A (BPA) is an environmental endocrine disrupting chemical that binds to both ER receptor subtypes as well as to AR."	( Estrogenic environmental chemicals and drugs: mechanisms for effects on the developing male urogenital system. Richter, CA; Ruhlen, RL; Taylor, JA; vom Saal, FS, 2011)	1.09
"Bisphenol A (BPA) is a synthetic estrogen commonly used in polycarbonate plastic and resin-lined food and beverage containers. "	( Bisphenol A exposure is associated with in vivo estrogenic gene expression in adults. Bandinelli, S; Cipelli, R; Corsi, AM; Ferrucci, L; Galloway, T; Guralnik, J; Harries, L; Henley, W; McCormack, P; Melzer, D; Money, C; Young, A, 2011)	3.25
"Bisphenol A (BPA) is a monomer of polycarbonate plastic used to manufacture plastic baby bottles and lining of food cans. "	( Melatonin ameliorates bisphenol A-induced biochemical toxicity in testicular mitochondria of mouse. Ahmad, F; Anjum, S; Ansari, RA; Kaur, M; Rahman, S; Raisuddin, S; Rashid, H, 2011)	2.13
"Bisphenol A (BPA) is a widely used plasticizer that can contaminate food and the wider environment and lead to human exposure. "	( Simultaneous quantification of bisphenol A and its glucuronide metabolite (BPA-G) in plasma and urine: applicability to toxicokinetic investigations. Collet, SH; Corbel, T; Gayrard, V; Lacroix, MZ; Picard-Hagen, N; Puel, S; Toutain, PL; Viguié, C, 2011)	2.1
"Bisphenol A (BPA) is a potential endocrine disruptor. "	( Inhibition of human and rat testicular steroidogenic enzyme activities by bisphenol A. Chu, Y; Ge, RS; Hu, G; Ye, L; Zhao, B, 2011)	2.04
"Bisphenol A (BPA) is a widely used chemical in the manufacture of polycarbonate plastics and epoxy resins. "	( Relationship between urinary bisphenol A levels and diabetes mellitus. Shankar, A; Teppala, S, 2011)	2.1
"Bisphenol A (BPA) is a man-made compound used to make polycarbonate plastics and epoxy resins; public health concerns have been fueled by findings that BPA exposure can reduce sex differences in brain and some behaviors. "	( Gestational exposure to low dose bisphenol A alters social behavior in juvenile mice. Connelly, JJ; Edwards, M; Rissman, EF; Shetty, SR; Taylor, JA; Wolstenholme, JT, 2011)	2.09
"Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. "	( Pharmacokinetics of bisphenol A in neonatal and adult CD-1 mice: inter-species comparisons with Sprague-Dawley rats and rhesus monkeys. Doerge, DR; Fisher, JW; Twaddle, NC; Vanlandingham, M, 2011)	2.14
"Bisphenol A (BPA) is a synthetic compound used to produce plastics and epoxy resins. "	( Chronic oral exposure to bisphenol A results in a nonmonotonic dose response in mammary carcinogenesis and metastasis in MMTV-erbB2 mice. Desmond, R; Eltoum, I; Jenkins, S; Lamartiniere, CA; Wang, J, 2011)	2.12
"Bisphenol A (BPA) is a sealant and flux of plastic materials and has been determined to be an endocrine-disrupting chemical. "	( Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in Taiwan. Chen, JL; Chen, YC; Chou, WC; Chuang, CY; Lin, CF; Shih, FC, 2011)	2.15
"Bisphenol A (BPA) is a 'weak' endocrine disruptor. "	( Gene expression is altered after bisphenol A exposure in human fetal oocytes in vitro. Brieño-Enríquez, MA; Cabero, L; Garcia Caldés, M; Martínez, F; Reig-Viader, R; Roig, I; Toran, N, 2012)	2.1
"Bisphenol A (BPA) is a potential endocrine disruptor and testicular toxicant. "	( Bisphenol A impairs insulin signaling and glucose homeostasis and decreases steroidogenesis in rat testis: an in vivo and in silico study. D'Cruz, SC; Jayakanthan, M; Jubendradass, R; Mathur, PP; Rani, SJ, 2012)	3.26
"Bisphenol A (BPA) is an estrogenic environmental toxin widely used for the production of plastics. "	( Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocytes. Chao, HH; Feng, YM; Li, L; Pan, B; Shen, W; Sun, XF; Zhang, HQ; Zhang, LJ; Zhang, XF, 2012)	2.16
"Bisphenol A (BPA) is a base chemical used extensively in many consumer products. "	( Bisphenol A and its analogues activate human pregnane X receptor. Ai, N; Park, SH; Perkins, JT; Rios-Pilier, J; Sui, Y; Welsh, WJ; Zhou, C, 2012)	3.26
"Bisphenol A (BPA) is an endocrine-disrupting chemical, widely used in various industries and the field of dentistry. "	( Bisphenol A, an endocrine-disrupting chemical, and brain development. Fushiki, S; Itoh, K; Yaoi, T, 2012)	3.26
"Bisphenol A (BPA) is a well-known endocrine disruptor (ED) which represents a major toxicological and public health concern due to its widespread exposure to humans. "	( Clastogenic and mutagenic effects of bisphenol A: an endocrine disruptor. Bhartiya, U; Chilgunde, S; Joseph, L; Kamble, J; Kawle, D; Maru, G; Patil, P; Tiwari, D; Vanage, G, 2012)	2.09
"Bisphenol A (BPA) is an ubiquitous chemical contaminant that has recently been associated with adverse effects on human health. "	( Human excretion of bisphenol A: blood, urine, and sweat (BUS) study. Beesoon, S; Birkholz, D; Genuis, SJ; Lobo, RA, 2012)	2.15
"Bisphenol A (BPA) is an endocrine disruptor compound (EDC) of xenobiotic origin occurring in natural waters and wastewaters, especially in the most industrialized and urbanized areas. "	( Biodecontamination of water from bisphenol A using ligninolytic fungi and the modulation role of humic acids. Loffredo, E; Senesi, N; Traversa, A, 2012)	2.1
"Bisphenol A (BPA) is a common chemical used in the manufacture of polycarbonate plastics and epoxy resins, with >93% of US adults having detectable BPA levels in urine. "	( Urinary bisphenol A and hypertension in a multiethnic sample of US adults. Shankar, A; Teppala, S, 2012)	2.26
"Bisphenol A (BPA) is an endocrine disrupting agent that can alter the normal gonadal steroid-sensitive sexual differentiation of the brain and behavior. "	( Perinatal BPA exposure demasculinizes males in measures of affect but has no effect on water maze learning in adulthood. Jones, BA; Watson, NV, 2012)	1.82
"Bisphenol A is an industrial chemical widely used in plastic products with a consequent exposure to humans. "	( Exposure to bisphenol A is associated with low-grade albuminuria in Chinese adults. Bi, Y; Chen, Y; Huang, Y; Li, M; Lu, J; Ning, G; Qi, L; Wang, T; Wang, W; Xu, M; Xu, Y, 2012)	2.2
"Bisphenol A (BPA) is a xenoestrogen commonly used in food storage plastics. "	( Effects of bisphenol A administration to pregnant mice on serum Ca and intestinal Ca absorption. Ikeda, S; Kume, S; Otsuka, H; Sugimoto, M, 2012)	2.21
"Bisphenol A (BPA) is an important industrial chemical used as the monomer for polycarbonate plastic and in epoxy resins for use in food can liners. "	( Pharmacokinetics of bisphenol A in serum and adipose tissue following intravenous administration to adult female CD-1 mice. Doerge, DR; Fisher, JW; Twaddle, NC; Vanlandingham, M, 2012)	2.15
"Bisphenol A (BPA) is a synthetic chemical widely used in the production of polycarbonate plastic and epoxy resins found in numerous consumer products. "	( Urinary bisphenol A concentrations and implantation failure among women undergoing in vitro fertilization. Berry, KF; Calafat, AM; Ehrlich, S; Flaws, JA; Hauser, R; Missmer, SA; Petrozza, JC; Williams, PL; Wright, D; Ye, X, 2012)	2.26
"Bisphenol A (BPA) is an endocrine-disrupting chemical that leaches from polycarbonate plastics that consequently leads to low-dose human exposure. "	( Low concentrations of bisphenol A induce lipid accumulation mediated by the production of reactive oxygen species in the mitochondria of HepG2 cells. Guéraud, F; Héliès-Toussaint, C; Huc, L; Lemarié, A, 2012)	2.14
"Bisphenol A (BPA) is an estrogenic compound widely used in polycarbonate plastics. "	( Fetal bisphenol A exposure: concentration of conjugated and unconjugated bisphenol A in amniotic fluid in the second and third trimesters. Chen, M; Edlow, AG; Lu, C; McElrath, TF; Smith, NA, 2012)	2.3
"Bisphenol A (BPA) is an environmental endocrine disruptor widely present in the soil and sedimentary environment. "	( Goethite-mediated transformation of bisphenol A. Ding, J; Gan, J; Huang, X; Lin, K; Wang, H, 2012)	2.1
"Bisphenol A (BPA) is a common chemical used in the manufacture of polycarbonate plastics and epoxy resins, and > 93% of U.S. "	( Bisphenol A and peripheral arterial disease: results from the NHANES. Sabanayagam, C; Shankar, A; Teppala, S, 2012)	3.26
"Bisphenol A (BPA) is an estrogenic environmental toxin widely used for the production of plastics. "	( Bisphenol A exposure modifies DNA methylation of imprint genes in mouse fetal germ cells. Chen, B; Feng, YM; Feng, YN; Li, L; Liang, GJ; Shen, W; Zhang, LJ; Zhang, XF, 2012)	3.26
"Bisphenol A (BPA) is a plasticizer and an endocrine-disrupting chemical. "	( Gestational exposure to bisphenol a produces transgenerational changes in behaviors and gene expression. Connelly, JJ; Edwards, M; Gatewood, JD; Rissman, EF; Shetty, SR; Taylor, JA; Wolstenholme, JT, 2012)	2.13
"Bisphenol A (BPA) is an environmental estrogen that exhibits non-genotoxic carcinogenicity, causing concern globally. "	( Effects of bisphenol A on the proliferation and cell cycle of HBL-100 cells. Hao, W; Jiang, J; Shang, L; Wei, X; Wu, S, 2012)	2.21
"Bisphenol A (BPA) is an estrogenic chemical used to manufacture many commonly used plastic and epoxy resin-based products. "	( Bisphenol A inhibits follicle growth and induces atresia in cultured mouse antral follicles independently of the genomic estrogenic pathway. Craig, ZR; Flaws, JA; Peretz, J, 2012)	3.26
"Bisphenol A (BPA) is a chemical estrogen widely used in the food packaging industry, especially in baby bottles. "	( Effects of bisphenol A on the development of central immune organs of specific-pathogen-free chick embryos. Ding, Y; Liu, T; Luo, D; She, R; Tian, J; Xia, K; Yue, Z, 2014)	2.23
"Bisphenol A (BPA) is a polyphenol widely used in industry as an intermediate in the production of polycarbonate plastics and epoxy resins, which are applied to produce plastic food containers, inner surface coating of food and beverage cans. "	( Analysis of Bisphenol A in milk by using a multicommuted fluorimetric sensor. Fernández-de Córdova, ML; Molina-García, L; Ruiz-Medina, A, 2012)	2.2
"Bisphenol A (BPA) is a high-production volume chemical classified as an environmental estrogen and used primarily in the plastics industry. "	( The effects of maternal exposure to bisphenol A on allergic lung inflammation into adulthood. Bauer, SM; Chapman, TJ; Emo, J; Georas, SN; Lawrence, BP; Roy, A, 2012)	2.1
"Bisphenol A (BPA) is a high-volume production chemical that has been suspected to have adverse health effects. "	( Associations of bisphenol A exposure with heart rate variability and blood pressure. Bae, S; Hong, YC; Kim, JH; Lim, YH; Park, HY, 2012)	2.17
"Bisphenol A (BPA) is an intermediate used to produce epoxy resins and polycarbonate plastics. "	( Adult fathead minnow, Pimephales promelas, partial life-cycle reproductive and gonadal histopathology study with bisphenol A. Caspers, N; Dietrich, D; Dimond, S; Hall, AT; Hentges, S; Mihaich, E; Ortego, L; Rhodes, J; Staples, C; van der Hoeven, N; Wolf, J, 2012)	2.03
"Bisphenol A (BPA) is a contaminant with increasing exposure to it and exerts both toxic and estrogenic effects on mammalian cells."	( Bisphenol A induces hepatotoxicity through oxidative stress in rat model. AlOlayan, EM; Daghestani, MH; ElAmin, M; Elobeid, MA; Hassan, ZK; Omer, SA; Virk, P, 2012)	2.54
"Bisphenol A (BPA) is a synthetic phenolic compound to which the general public may be exposed via consumer products and environmental contamination. "	( Association between urinary concentrations of bisphenol A and type 2 diabetes in Korean adults: a population-based cross-sectional study. Kim, K; Park, H, 2013)	2.09
"Bisphenol A (BPA) is an industrial compound and a well known endocrine-disrupting chemical with estrogenic activity. "	( Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes. Balaguer, P; Boulahtouf, A; Bourguet, W; Cavailles, V; Delfosse, V; Grimaldi, M; Labesse, G; le Maire, A; Pons, JL, 2012)	2.03
"Bisphenol A (BPA) is a common industrial chemical that has been associated with a variety of biological disorders. "	( What every dentist should know about bisphenol A. Bashirelahi, N; Hack, GD; LaBauve, JR; Long, KN, )	1.85
"Bisphenol A (BPA) is a widely produced, endocrine disrupting compound that is pervasive in the environment. "	( Sex and dose-dependent effects of developmental exposure to bisphenol A on anxiety and spatial learning in deer mice (Peromyscus maniculatus bairdii) offspring. Ellersieck, MR; Geary, DC; Jašarević, E; Kannan, K; Liao, C; Roberts, RM; Rosenfeld, CS; Vandas, GM; Williams, SA, 2013)	2.07
"Bisphenol A (BPA) is a high production volume chemical used to make polycarbonate plastic and is found in many consumer products. "	( Consortium-based science: the NIEHS's multipronged, collaborative approach to assessing the health effects of bisphenol A. Birnbaum, LS; Bucher, JR; Collman, GW; Heindel, JJ; Johnson, AF; Schug, TT; Zeldin, DC, 2012)	2.03
"Bisphenol A [BPA] is a widely dispersed environmental chemical that is of much concern because the BPA monomer is a weak transcriptional activator of human estrogen receptor α [ERα] and ERβ in cell culture. "	( 3D models of MBP, a biologically active metabolite of bisphenol A, in human estrogen receptor α and estrogen receptor β. Baker, ME; Chandsawangbhuwana, C, 2012)	2.07
"Bisphenol A (BPA) is a well known endocrine disruptor. "	( Antioxidant responses and whole-organism changes in Daphnia magna acutely and chronically exposed to endocrine disruptor bisphenol A. Erjavec, B; Jemec, A; Pintar, A; Tišler, T, 2012)	2.03
"Bisphenol A (BPA) is a potential endocrine disruptor. "	( Inhibition of human and rat 11β-hydroxysteroid dehydrogenases activities by bisphenol A. Chu, Y; Ge, RS; Guo, J; Hu, G; Qiu, L; Wang, C; Xu, Y; Ye, L; Yuan, X; Zhu, W, 2012)	2.05
"Bisphenol A (BPA) is an environmental endocrine disruptor that seriously threatens ecological systems. "	( Effects of bisphenol A on growth and nitrogen nutrition of roots of soybean seedlings. Sun, H; Wang, L; Zhou, Q, 2013)	2.22
"Bisphenol A (BPA) is a representatively endocrine disruptor, which shows a highly toxic effect on life system. "	( Effects of bisphenol A on growth, photosynthesis and chlorophyll fluorescence in above-ground organs of soybean seedlings. Qiu, Z; Wang, L; Zhou, Q, 2013)	2.22
"Bisphenol A is a widespread industrial chemical which over the past decade has demonstrated its toxicity as an endocrine disruptor. "	( Reliable quantification of bisphenol A and its chlorinated derivatives in human breast milk using UPLC-MS/MS method. Albouy-Llaty, M; Cariot, A; Dupuis, A; Legube, B; Migeot, V; Rabouan, S, 2012)	2.12
"Bisphenol A (BPA) is an endocrine disrupting chemical to which humans are exposed. "	( Bisphenol A at concentrations found in human serum induces aneugenic effects in endothelial cells. Delgado, M; Ribeiro-Varandas, E; Sofia Pereira, H; Viegas, W, 2013)	3.28
"Bisphenol A (BPA) is an organic compound with two functional phenol groups, and used for manufacturing polycarbonate plastic and epoxy resins, as well as other applications."	( Effects of octylphenol and bisphenol A on the expression of calcium transport genes in the mouse duodenum and kidney during pregnancy. An, BS; Jeung, EB; Kim, S; Yang, H, 2013)	1.41
"Bisphenol A is a chemical that is present in a number of products and types of food packaging. "	( Urinary bisphenol A concentrations in pregnant women. Callan, AC; Eaglesham, G; Heffernan, A; Hinwood, AL; Mueller, J; Odland, JØ, 2013)	2.27
"Bisphenol A (BPA) is an endocrine disrupting chemical that is ubiquitous in wild and built environments. "	( Estrogen-like disruptive effects of dietary exposure to bisphenol A or 17α-ethinyl estradiol in CD1 mice. Belcher, SM; Buesing, DR; Christie, SM; Cookman, CJ; Gear, RB; Hugo, ER; Kasper, SN; Kendig, EL; Kendziorski, JA; Ungi, KR; Williams, K, )	1.82
"Bisphenol A is a monomer used in the production of polycarbonate plastics, epoxy resins, and flame retardants. "	( Computational study of the reactivity of bisphenol A-3,4-quinone with deoxyadenosine and glutathione. Kolšek, K; Mavri, J; Sollner Dolenc, M, 2013)	2.1
"Bisphenol A (BPA) is an endocrine-disrupting chemical that leads to low-dose human exposure due to its ability to leach from chemically derived products, as polycarbonate plastics and epoxy resin. "	( Bisphenol A interferes with thyroid specific gene expression. Ambrosino, C; Carchia, E; De Felice, M; Ganbaatar, E; Gentilcore, D; Mallardo, M; Porreca, I; Rizzo, F, 2013)	3.28
"Bisphenol A (BPA) is an important industrial chemical used as the monomer for polycarbonate plastic and in epoxy resins for food can liners. "	( Concurrent determination of bisphenol A pharmacokinetics in maternal and fetal rhesus monkeys. Callicott, RJ; Doerge, DR; Fisher, JW; Patterson, TA; Roegge, CS; Twaddle, NC, 2013)	2.13
"Bisphenol A (BPA) is a high production volume endocrine disrupting chemical that is widely used in many consumer products and prevalent in human biological fluids. "	( Neither direct nor developmental exposure to bisphenol A alters the severity of experimental inflammatory colitis in mice. Cao, W; Gaylo, A; Lawrence, BP; Roy, A; Saubermann, LJ, )	1.83
"Bisphenol A (BPA) is a widely used weak estrogenic environmental ED and it is debated whether BPA concentrations within the average internal exposure are toxic."	( Differential effects of bisphenol A and diethylstilbestrol on human, rat and mouse fetal leydig cell function. Benachi, A; Frydman, R; Habert, R; Lacroix, M; Lecureuil, C; Lesage, L; Livera, G; Moison, D; N'Tumba-Byn, T; Pozzi-Gaudin, S; Prud'homme, SM; Rouiller-Fabre, V, 2012)	1.41
"Bisphenol A (BPA) is an endocrine disruptor that in animal studies can bind to the thyroid hormone receptor and affect thyroid function. "	( Urinary bisphenol a concentration and thyroid function in Chinese adults. Bi, Y; Chen, Y; Dai, M; Lai, S; Li, M; Liu, Y; Lu, J; Ning, G; Tian, X; Wang, T; Wang, W; Xu, M; Xu, Y, 2013)	2.27
"Bisphenol A (BPA) is a chemical compound widely used in manufacturing plastic products. "	( Bisphenol A accelerates toxic amyloid formation of human islet amyloid polypeptide: a possible link between bisphenol A exposure and type 2 diabetes. Cheng, B; Gong, H; Huang, K; Li, C; Li, T; Sun, Y; Zhang, X; Zheng, L, 2013)	3.28
"Bisphenol A (BPA) is a chemical that is used in a variety of consumer products, and exposure to BPA is widespread among the general population. "	( Association between bisphenol A and abnormal free thyroxine level in men. Aekplakorn, W; Chailurkit, LO; Ongphiphadhanakul, B; Sriphrapradang, C, 2013)	2.16
"Bisphenol A (BPA) is an environmental contaminant that has been under investigation for its detrimental effect on the aquatic ecosystem. "	( Biodegradation of bisphenol A by Heliscus lugdunensis, a naturally occurring hyphomycete in freshwater environments. Navidonski, M; Omoike, A; Wacker, T, 2013)	2.17
"Bisphenol A is a widely used industrial chemical with many potential sources of human exposure. "	( Metabolism and kinetics of bisphenol a in humans at low doses following oral administration. Colnot, T; Csanády, GA; Dekant, W; Filser, JG; Völkel, W, 2002)	2.05
"Bisphenol A (BPA) is an environmental estrogen with potentially averse effects on public health. "	( Altered profiles of spontaneous novelty seeking, impulsive behavior, and response to D-amphetamine in rats perinatally exposed to bisphenol A. Adriani, W; Dessì-Fulgheri, F; Farabollini, F; Laviola, G; Seta, DD, 2003)	1.97
"Bisphenol A (BPA) is a weak xenoestrogen mass-produced with potential human exposure. "	( Disposition of a low dose of 14C-bisphenol A in male rats and its main biliary excretion as BPA glucuronide. Betsui, H; Kurebayashi, H; Ohno, Y, 2003)	2.04
"Bisphenol A (BPA) is a monomer with estrogenic activity that is used in the production of food packaging, dental sealants, polycarbonate plastic, and many other products. "	( Bisphenol A is released from used polycarbonate animal cages into water at room temperature. Howdeshell, KL; Judy, BM; Orazio, CE; Peterman, PH; Ruhlen, RL; Taylor, JA; Vom Saal, FS; Welshons, WV, 2003)	3.2
"Bisphenol A (BPA) is an estrogenic chemical that leaches from dental materials and plastic food and beverage containers."	( Sex reversal effects on Caiman latirostris exposed to environmentally relevant doses of the xenoestrogen bisphenol A. Larriera, A; Luque, EH; Muñoz-de-Toro, M; Ramos, JG; Rey, F; Rodriguez, H; Sirosky, P; Stoker, C, 2003)	1.25
"Bisphenol A (BPA) is a well-known endocrine disruptor. "	( Bisphenol A significantly enhances the neutrophilic differentiation of promyelocytic HL-60 cells. Adachi, R; Hirayama, A; Kasahara, T; Kusui, K; Suzuki, K; Watanabe, H, 2003)	3.2
"Bisphenol A (BPA), known to be a xenoestrogen, is widely used in industry and dentistry. "	( Bisphenol A induces apoptosis in central neural cells during early development of Xenopus laevis. Adati, N; Kurose, K; Nishimura, T; Oka, T; Sakuma, K; Shinkai, T, 2003)	3.2
"Bisphenol A (BPA) is a global environmental contaminant that has been implicated as a potential endocrine disruptor. "	( Effects of neonatal administration of 17beta-estradiol, beta-estradiol 3-benzoate, or bisphenol A on mouse and rat spermatogenesis. Toyama, Y; Yuasa, S, 2004)	1.99
"Bisphenol A (BPA) is an estrogenic EDC widely found in plastic products."	( Differences in serum bisphenol a concentrations in premenopausal normal women and women with endometrial hyperplasia. Hiroi, H; Ikezuki, Y; Momoeda, M; Okamura, A; Taketani, Y; Takeuchi, T; Tsutsumi, O; Yokota, H, 2004)	1.36
"Bisphenol A is a key industrial chemical used in the manufacture of polycarbonate plastics and other products. "	( Covert signal disruption: anti-ecdysteroidal activity of bisphenol A involves cross talk between signaling pathways. Hoy, H; Hwang, GS; LeBlanc, GA; Mu, X; Rider, CV, 2005)	2.02
"Bisphenol A (BPA) is an important monomer used in the manufacture of epoxy resins for internal food can linings. "	( Migration of bisphenol A from can coatings--effects of damage, storage conditions and heating. Cooper, I; Goodson, A; Robin, H; Summerfield, W, 2004)	2.14
"Bisphenol A (BPA) is a weakly estrogenic monomer used in the production of polycarbonate plastic and epoxy resins, both of which are used in food contact and other applications. "	( Evaluation of oral and intravenous route pharmacokinetics, plasma protein binding, and uterine tissue dose metrics of bisphenol A: a physiologically based pharmacokinetic approach. Barton, HA; Clewell, HJ; Covington, TR; Teeguarden, JG; Waechter, JM, 2005)	1.98
"Bisphenol A (BPA) is a known xenoestrogen with similar properties to 17beta-estradiol. "	( A dynamic simulation of bisphenol A dosimetry in neuroendocrine organs. Hutter, JC; Kim, CS; Luu, HM, 2004)	2.07
"Bisphenol A (BPA) is a monomer of polycarbonate plastics that has estrogenic activities and has been shown to be a substrate for multidrug resistant efflux mechanisms, specifically, P-glycoprotein. "	( Effect of bisphenol A on drug efflux in BeWo, a human trophoblast-like cell line. Audus, KL; Jin, H, 2005)	2.17
"Bisphenol A (BPA) is a weak xenestrogen (ADI = 50 microg kg(-1), US EPA) which is mass-produced, with potential for human exposure. "	( Disposition of low doses of 14C-bisphenol A in male, female, pregnant, fetal, and neonatal rats. Kurebayashi, H; Nagatsuka, S; Nemoto, H; Noguchi, H; Ohno, Y, 2005)	2.05
"Bisphenol A (BPA) is an estrogenic chemical that is widely used in the manufacture of plastics and epoxy resins. "	( The environmental estrogen bisphenol a inhibits estradiol-induced hippocampal synaptogenesis. Hajszan, T; Leranth, C; MacLusky, NJ, 2005)	2.07
"Bisphenol A (BPA) is a weak estrogen. "	( Quantitation of bisphenol A and bisphenol A glucuronide in biological samples by high performance liquid chromatography-tandem mass spectrometry. Bittner, N; Dekant, W; Völkel, W, 2005)	2.12
"Bisphenol A (BPA) is a toxic industrial chemical that affects the endocrine system even at low concentrations. "	( Development and validation of a capillary high-performance liquid chromatography/electrospray tandem mass spectrometric method for the quantification of bisphenol A in air samples. Barbieri, A; Sabatini, L; Violante, FS, 2005)	1.97
"Bisphenol A (BPA) is a common component of composites and dental sealants. "	( Exposure to bisphenol A from bis-glycidyl dimethacrylate-based dental sealants. Barr, DB; Barr, JR; Calafat, AM; Joskow, R; Needham, LL; Rubin, C, 2006)	2.16
"Bisphenol A (BPA) is an important chemical in the production of epoxy resins and polycarbonate plastics, and basic monomers which are used for a variety of applications. "	( Toxicokinetics of bisphenol A in pregnant DA/Han rats after single i.v. application. Degen, GH; Diel, P; Moors, S, 2006)	2.11
"Bisphenol A (BPA) is a typical endocrine disrupter. "	( Rapid Ca(2+) signaling induced by Bisphenol A in cultured rat hippocampal neurons. Kawato, S; Kimoto, T; Tanabe, N, )	1.85
"Bisphenol A (BPA) is a widely used plasticizer whose estrogenic properties may impact hormone-responsive disorders and fetal development. "	( A role for sulfation-desulfation in the uptake of bisphenol a into breast tumor cells. Barvian, KK; Bertozzi, CR; Bigsby, RM; Stowell, CL; Verdugo, DE; Widlanski, TS; Young, PC, 2006)	2.03
"Bisphenol A is a commonly known endocrine-disrupting compound detected in environmental water samples. "	( Photolysis and photocatalysis of bisphenol A: identification of degradation products by liquid chromatography with electrospray ionization/time-of-flight/mass spectrometry (LC/ESI/ToF/MS). Fernández-Alba, AR; Ferrer, I; Hernando, MD; Mezcua, M, 2006)	2.06
"Bisphenol A (BPA) is a highly biotoxic compound that kills many microorganisms at a low concentration (1,000 ppm). "	( Isolation of bisphenol A-tolerant/degrading Pseudomonas monteilii strain N-502. Inoue, A; Masuda, M; Ueno, S; Yamasaki, Y, 2007)	2.15
"Bisphenol A (BPA) is an environmental estrogen that stimulates proliferation of human breast cancer MCF-7 cells."	( Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells. Nakaya, M; Onda, H; Sasaki, K; Tachibana, H; Yamada, K; Yukiyoshi, A, 2007)	1.36
"Bisphenol A (BPA) is a monomer of plastic products widely used in daily life, and has weak estrogenic activity. "	( Bisphenol A induces permanent squamous change in mouse prostatic epithelium. Arima, K; Ishii, K; Kanai, M; Kanda, H; Ogura, Y; Sugimura, Y; Wang, Y, 2007)	3.23
"Bisphenol A (BPA) is a representative endocrine disruptor that may have adverse effects on human health. "	( Transmaternal exposure to bisphenol a modulates the development of oral tolerance. Mayumi, M; Ohshima, Y; Omata, N; Tokuriki, S; Yamada, A; Yasutomi, M, 2007)	2.08
"Bisphenol A (BPA) is a weakly estrogenic monomer used to produce polymers for food contact and other applications, so there is potential for oral exposure of humans to trace amounts via ingestion. "	( Development of a physiologically based pharmacokinetic model for bisphenol A in pregnant mice. Chan, MP; Hishikawa, J; Kawamoto, Y; Matsuyama, W; Morisawa, S; Nakayama, A; Wada, M, 2007)	2.02
"Bisphenol A (BPA) is a common ingredient in dental materials. "	( Microarray analysis of bisphenol A-induced changes in gene expression in human oral epithelial cells. Ito, K; Koshi, R; Masutani, S; Seki, K; Sugano, N; Yoshinuma, N, 2007)	2.09
"Bisphenol A functions as an inverse antagonist of estrogen-related receptor gamma to sustain the high basal constitutive activity of the latter and to reverse the deactivating inverse agonist activity of 4-hydroxytamoxifen."	( Receptor binding characteristics of the endocrine disruptor bisphenol A for the human nuclear estrogen-related receptor gamma. Chief and corroborative hydrogen bonds of the bisphenol A phenol-hydroxyl group with Arg316 and Glu275 residues. Isozaki, K; Liu, X; Matsushima, A; Okada, H; Shimohigashi, Y; Tokunaga, T, 2007)	1.3
"Bisphenol A (BPA) is a synthetic monomer widely used to polymerize polycarbonate plastics and resins. "	( Evaluation of aneugenic effects of bisphenol A in somatic and germ cells of the mouse. Adler, ID; Attia, S; Eichenlaub-Ritter, U; Pacchierotti, F; Ranaldi, R, 2008)	2.07
"Bisphenol A (BPA) is an environmental endocrine disrupter that is known to be transferred to the fetus via the placenta and to the neonate via milk. "	( Downregulation of peritoneal macrophage activity in mice exposed to bisphenol A during pregnancy and lactation. Back, SK; Kim, HJ; Pyo, MY; Yang, M, 2007)	2.02
"Bisphenol A (BPA) is a known endocrine disrupting chemical (EDC) that has been widely used for the production of polycarbonate plastics and epoxy resins. "	( Sorption behavior of bisphenol A on marine sediments. Li, X; Wang, Y; Xu, X, 2008)	2.11
"Bisphenol A (BPA) is an endocrine disruptor that can mimic the action of estrogens by interacting with hormone receptors and is, therefore, potentially able to influence reproductive functions in vertebrates. "	( The endocrine disruptor bisphenol A increases the expression of HSP70 and ecdysone receptor genes in the aquatic larvae of Chironomus riparius. Martínez-Guitarte, JL; Morcillo, G; Planelló, R, 2008)	2.1
"Bisphenol A (BPA) is an endocrine disruptor with weak estrogenic activity, used in epoxy resin and polycarbonate plastic. "	( Cutaneous penetration of bisphenol A in pig skin. Déchaud, H; Harthé, C; Kaddar, N; Mappus, E; Pugeat, M, 2008)	2.09
"Bisphenol A (BPA) is a widespread endocrine-disrupting chemical that can affect humans and animals."	( Exposure to Bisphenol A prenatally or in adulthood promotes T(H)2 cytokine production associated with reduction of CD4CD25 regulatory T cells. Sugane, K; Takamoto, M; Yan, H, 2008)	2.17
"Bisphenol A (BPA) is a monomer used in the manufacture of a multitude of chemical products, including epoxy resins and polycarbonate. "	( Normal reproductive organ development in CF-1 mice following prenatal exposure to bisphenol A. Breslin, WJ; Butala, JH; Cagen, SZ; Dimond, SS; Harris, LR; Jekat, FW; Joiner, RL; Shiotsuka, RN; Veenstra, GE; Waechter, JM, 1999)	1.97
"Bisphenol A (BPA) is a chemical used primarily as a monomer in the manufacture of numerous chemical products, such as epoxy resins and polycarbonate. "	( Normal reproductive organ development in Wistar rats exposed to bisphenol A in the drinking water. Breslin, WJ; Butala, JH; Cagen, SZ; Dimond, SS; Harris, LR; Jekat, FW; Joiner, RL; Shiotsuka, RN; Veenstra, GE; Waechter, JM, 1999)	1.98
"Bisphenol A (BPA) is an environmental estrogen with potentially aversive effects on public health. "	( Perinatal exposure to the estrogenic pollutant bisphenol A affects behavior in male and female rats. Dessì-Fulgherit, F; Farabollini, F; Porrini, S, 1999)	2
"Bisphenol A (BPA) is a monomer of plastics and epoxy resins that is widely used in dentistry and the food packaging industry."	( High concentrations of bisphenol A induce cell growth and prolactin secretion in an estrogen-responsive pituitary tumor cell line. Chun, TY; Gorski, J, 2000)	1.34
"Bisphenol A (BPA) is a weak estrogen agonist when tested using in vitro or in vivo bioassays."	( Effects of bisphenol A on energy balance and accumulation in brown adipose tissue in rats. Clemens, LG; Fang, J; Giesy, JP; Kannan, K; Nunez, AA, 2001)	1.42
"Bisphenol A (BPA) is a well-known endocrine-disrupting chemical found in the environment. "	( Metabolic activation of bisphenol A by rat liver S9 fraction. Makishima, M; Ohta, S; Suzuki, N; Yoshihara, S, 2001)	2.06
"Bisphenol A (BPA) is a common structural component in a wide variety of biomaterial monomers. "	( Bisphenol A and its biomaterial monomer derivatives alteration of in vitro cytochrome P450 metabolism in rat, minipig, and human. Cannon, JM; Kostoryz, E; Russo, KA; Smith, RE; Yourtee, DM, 2000)	3.19
"Bisphenol A (BPA) is an essential component of epoxy resins used in the lacquer lining of metal food cans, as a component of polycarbonates, and in dental sealants. "	( Evaluation of developmental toxicity in rats exposed to the environmental estrogen bisphenol A during pregnancy. Cha, SW; Chung, MK; Han, SS; Kim, JC; Koh, WS; Shin, HC, 2001)	1.98
"Bisphenol A (BPA) is an endocrine disruptor, and is used as a raw material for bisphenol A diglycidyl methacrylate and polycarbonate, that are used in the dental materials. "	( Content and release of bisphenol A from polycarbonate dental products. Furuta, H; Ishikawa, K; Nishimura, F; Sugiyama, K; Suzuki, K, 2000)	2.06
"Bisphenol A (BPA) is an estrogenic chemical that is highly employed in the manufacture of a wide range of consumer products."	( In utero exposure to low doses of bisphenol A lead to long-term deleterious effects in the vagina. Chahoud, I; Flick, B; Mayr, E; Paul, M; Schönfelder, G; Talsness, C, )	1.13
"Bisphenol A (BPA) is a monomer component of polycarbonate plastics and epoxy resins. "	( An evaluation of the possible carcinogenicity of bisphenol A to humans. Doull, J; Haighton, LA; Hlywka, JJ; Kroes, R; Lynch, BS; Munro, IC, 2002)	2.01
"Bisphenol A (BPA) is a weak estrogenic compound mass-produced with potential human exposure. "	( Disposition of a low dose of bisphenol a in male and female cynomolgus monkeys. Harada, R; Kurebayashi, H; Numata, H; Ohno, Y; Stewart, RK, 2002)	2.05

Effects

Bisphenol A (BPA) has been widely used in the manufacture of polycarbonate plastic, water bottles and food containers. It has been acknowledged as an estrogenic chemical able to interact with human estrogen receptors (ER) It has also been shown to disrupt thyroid hormone function.

Excerpt	Reference	Relevance
"Bisphenol A (BPA) has a number of adverse effects on the reproductive development of females. "	( Bisphenol A interferes with lncRNA Fhadlos2 and RUNX3 association in adolescent mouse ovary. Cheng, H; Li, H; Li, W; Wang, R; Wu, F; Xie, X; Zhang, Y; Zhu, Y, 2023)	3.8
"Bisphenol A (BPA) has caused serious pathologies in varying organs of humans and animals, especially reproductive organs. "	( Naringenin protects swine testis cells from bisphenol A-induced apoptosis via Keap1/Nrf2 signaling pathway. Chen, H; Chen, J; Li, L; Shi, X; Xu, S, 2022)	2.43
"Bisphenol A (BPA) has been shown to exhibit various toxic effects, including the induction of reproductive disorders. "	( Bisphenol A-sulfate conjugate disrupts AURKA transcription and cell cycle in BeWo cytotrophoblasts. Fujiki, J; Inoue, H; Iwano, H; Maeda, N; Tsunoda, S; Uchida, M; Yokota, H, 2022)	3.61
"Bisphenol A (BPA) has been linked to attention-deficit/hyperactivity disorder (ADHD) symptoms, but the neurotoxic effects of bisphenol substitutes such as bisphenol F (BPF) and S (BPS) have not been well investigated. "	( Association of bisphenol A, bisphenol F, and bisphenol S with ADHD symptoms in children. Hong, YC; Kim, BN; Kim, JI; Lee, YA; Lim, YH; Shin, CH, 2022)	2.52
"Bisphenol A (BPA) has emerged as a contaminant of concern because long-term exposure may affect the human endocrine system. "	( Magnetic Halloysite Nanotube-Based SERS Biosensor Enhanced with Au@Ag Core-Shell Nanotags for Bisphenol A Determination. Chen, P; Chen, R; Gao, Z; Han, D; He, D; Li, S; Peng, Y; Qin, K; Ren, S; Wang, Y, 2022)	2.38
"Bisphenol A (BPA) has been reported to have neurotoxic properties that may increase the risk of neurodegenerative diseases by inducing neuroinflammation. "	( Ergosterol isolated from cloud ear mushroom (Auricularia polytricha) attenuates bisphenol A-induced BV2 microglial cell inflammation. Baek, SJ; Chuchawankul, S; Moungkote, N; Nilkhet, S; Sarachana, T; Sillapachaiyaporn, C; Tencomnao, T; Ung, AT, 2022)	2.39
"Bisphenol A (BPA) has deleterious effects on bone metabolism; however, its underlying mechanism has not yet been comprehensively understood. "	( Bisphenol A inhibits osteogenic activity and causes bone resorption via the activation of retinoic acid-related orphan receptor α. Choi, YH; Kim, GY; Lee, CM; Maduranga Karunarathne, WAH; Park, SR, 2022)	3.61
"Bisphenol A (BPA) has been widely used in the manufacture of polymeric materials. "	( Aerobic degradation of bisphenol A by Pseudomonas sp. LM-1: characteristic and pathway. Gu, C; Liang, J; Liu, M; Rui, J; Shi, J; Yu, Y; Zhang, X, 2023)	2.66
"Bisphenol A (BPA) has been linked to susceptibility to autism spectrum disorder (ASD). "	( Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the offspring hippocampus. Hu, VW; Jindatip, D; Kanlayaprasit, S; Kasitipradit, K; Lertpeerapan, P; Panjabud, P; Sarachana, T; Thongkorn, S, 2023)	2.57
"Bisphenol A (BPA) has been widely restricted, leading to a significant increase in the production of bisphenol AF (BPAF), one of the most common bisphenol analogs use as a substitute for BPA. "	( Maternal BPAF exposure impaired synaptic development and caused behavior abnormality in offspring. Bai, S; Du, G; Fan, Y; Li, S; Lu, C; Ma, X; Ni, Y; Qi, C; Qin, Y; Wu, X; Xu, Q; Xu, Z, 2023)	2.35
"Bisphenol A (BPA) has been demonstrated to cause ovarian toxicity including disruption of steroidogenesis and inhibition of follicle growth. "	( Urinary bisphenol A and S are associated with diminished ovarian reserve in women from an infertility clinic in Northern China. Bai, Y; Jia, L; Zhai, L; Zhang, N; Zhao, Y, 2023)	2.79
"Bisphenol A (BPA) has attracted growing attention as a well-known environmental pollutant due to its high risk of male reproductive toxicity. "	( Induction of reproductive injury by bisphenol A and the protective effects of cyanidin-3-O-glucoside and protocatechuic acid in rats. Bai, W; Cai, D; Jiang, X; Jin, Y; Li, X; Liu, B; Liu, R; Sun, J; Tian, L; Wu, X, 2023)	2.63
"Bisphenol A (BPA) has been reported to injure the developing and adult brain. "	( Exposure to bisphenol A induces neurotoxicity associated with synaptic and cytoskeletal dysfunction in neuro-2a cells. Chen, L; Ge, Y; Hu, D; Hua, L; Li, R; Ma, Z; Ning, H; Ren, F; Wang, S; Wang, X; Yin, Z, 2023)	2.73
"Bisphenol A (BPA) has a number of adverse effects on the reproductive development of females. "	( Bisphenol A interferes with lncRNA Fhadlos2 and RUNX3 association in adolescent mouse ovary. Cheng, H; Li, H; Li, W; Wang, R; Wu, F; Xie, X; Zhang, Y; Zhu, Y, 2023)	3.8
"Bisphenol A (BPA) has been widely reported to exert endocrine disrupting effects, including the induction of adipogenesis in cultured preadipocytes and intact animals. "	( Bisphenols B, E, F, and S and 4-cumylphenol induce lipid accumulation in mouse adipocytes similarly to bisphenol A. Ramskov Tetzlaff, CN; Rosenmai, AK; Svingen, T; Taxvig, C; Vinggaard, AM, 2020)	2.22
"Bisphenol A (BPA) has been shown to affect normal fetal growth, but human evidence on its analogues (BPF and BPS) is limited."	( Prenatal exposure to bisphenol a and its analogues (bisphenol F and S) and ultrasound parameters of fetal growth. Deng, YL; Lu, WQ; Mei, SR; Yang, P; Zeng, Q; Zhou, B, 2020)	2.32
"Bisphenol A (BPA) has been described as an endocrine disruptor and consequently banned from the food industry in several countries."	( Bisphenol A and S impaired ovine granulosa cell steroidogenesis. Binet, A; Desmarchais, A; Elis, S; Jaubert, M; Maillard, V; Papillier, P; Téteau, O, 2020)	2.72
"Bisphenol A (BPA) has been frequently found in surface waters worldwide, and its estrogenic effects in humans are well documented. "	( Nationwide distribution and potential risk of bisphenol analogues in Indian waters. Kumar, NJI; Lalwani, D; Lam, PKS; Ruan, Y; Taniyasu, S; Wang, X; Yamashita, N; Yamazaki, E, 2020)	2.26
"Many bisphenol A (BPA) analogs have been commercially used recently, such as 2,2-bis(4-hydroxyphenyl)butane (BPB), 4,4'-ethylidenebisphenol, 4,4'-methylenediphenol (BPF), 4,4'-(1,4-phenylenediisopropylidene)bisphenol (BPP), 4,4'-dihydroxydiphenyl sulfone (BPS), 4,4'-cyclohexylidenebisphenol (BPZ), 4,4'-(hexafluoroisopropylidene)diphenol (BPAF), 4,4'-(1-phenylethylidene)bisphenol (BPAP), and 2,2-bis(4-hydroxy-3,5-dimethylphenyl)propane (TMBPA), to circumvent adverse effects of BPA. "	( Endocrine disruption: Molecular interactions of environmental bisphenol contaminants with thyroid hormone receptor and thyroxine-binding globulin. Beg, MA; Sheikh, IA, 2020)	1.07
"Bisphenol A (BPA) has been mentioned as a possible factor contributing to feline hyperthyroidism. "	( Serum concentration of bisphenol A in elderly cats and its association with clinicopathological findings. Habánová, M; Konvalinová, J; Kovaříková, S; Maršálek, P, 2021)	2.37
"Bisphenol A (BPA) has been reported that among other male reproductive dys-functions, it can cause marked estrogenic effects including alteration in serum hormones as well as testicular lesions in exposed animals. "	( Chronic exposure of adult male Wistar rats to bisphenol A causes testicular oxidative stress: Role of gallic acid. Lanipekun, DO; Oke, BO; Ola-Davies, EO; Olukole, SG, 2020)	2.26
"Bisphenol A (BPA) has been linked with pediatric asthma development and allergic airway inflammation in animal models. "	( Exposure to bisphenols and asthma morbidity among low-income urban children with asthma. Calafat, AM; Hansel, NN; Matsui, EC; McCormack, M; Peng, RD; Quirós-Alcalá, L; Ye, X, 2021)	2.06
"Bisphenol A (BPA) has been shown to induce liver fibrosis in rodents. "	( Antifibrotic effect of curcumin, N-acetyl cysteine and propolis extract against bisphenol A-induced hepatotoxicity in rats: Prophylaxis versus co-treatment. Abdallah, FR; Atteia, HH; Elswefy, SE; Hasan, RA; Wahba, AS, 2020)	2.23
"Bisphenol analogues (BPs) have been widely applied to industry as the substitutes for bisphenol A (BPA), which have been detected frequently in surface water, sediment, sewage and sludge. "	( Occurrence, toxicity and ecological risk of Bisphenol A analogues in aquatic environment - A review. Jiang, R; Li, Y; Liu, J; Lu, G; Yan, Z; Zhang, L, 2021)	2.33
"Bisphenol analogues (BPs) have been widely used in industrial production as substitutes of bisphenol A (BPA). "	( The sinking behavior of micro-nano particulate matter for bisphenol analogues in the surface water of an ecological demonstration zone, China. Cai, Y; Li, J; Li, Y; Liu, J; Lu, G; Ren, J; You, Z, 2021)	2.31
"Bisphenol A and phthalate have been found in the environment, as well as in humans. "	( A Review of Recent Studies on Bisphenol A and Phthalate Exposures and Child Neurodevelopment. Kishi, R; Minatoya, M, 2021)	2.35
"Bisphenol A (BPA) has been found to promote hepatotoxicity, reproductive toxicity, and developmental toxicity. "	( Bisphenol A impairs cognitive function and 5-HT metabolism in adult male mice by modulating the microbiota-gut-brain axis. Fu, Z; Hu, L; Jin, Y; Ma, L; Ni, L; Ni, Y; Yang, S; Zhao, Y; Zheng, A, 2021)	3.51
"Bisphenol A (BPA) has been documented as a mediator for a number of health effects, including inflammation, oxidative stress, carcinogenicity, and mood dysfunction. "	( Suppression of bisphenol A-induced oxidative stress by taurine promotes neuroprotection and restores altered neurobehavioral response in zebrafish (Danio rerio). Aparna, S; Biswal, AK; Chauhan, NR; Das, SK; Polai, O; Pradhan, LK; Sahoo, PK; Sargam, M, 2021)	2.42
"Bisphenol A (BPA) has been associated with variable metabolic effects in animal models. "	( Urinary Bisphenol A Concentration and Gestational Diabetes Mellitus in Chinese Women. Chen, Q; Luo, ZC; Ouyang, F; Wang, W; Wang, X; Zhang, HJ; Zhang, J; Zhao, S, 2017)	2.33
"Bisphenol A (BPA) has been well documented for its endocrine disrupting potential however, very little is known about endocrine disrupting abilities of bisphenol S (BPS). "	( Comparative effects of Bisphenol S and Bisphenol A on the development of female reproductive system in rats; a neonatal exposure study. Ahsan, N; Jahan, S; Ullah, H; Ullah, W, 2018)	2.19
"Bisphenol A (BPA) has been associated with adverse human health outcomes and exposure to this compound is near-ubiquitous in the Western world. "	( An engaged research study to assess the effect of a 'real-world' dietary intervention on urinary bisphenol A (BPA) levels in teenagers. Baglin, N; Galloway, TS; Harries, LW; Kocur, AL; Lee, BP; Shepherd, MH; Steele, AM, 2018)	2.14
"Bisphenol A (BPA) has been regarded as a possible risk factor for reproductive health. "	( Protective effect of Lespedeza cuneata ethanol extract on Bisphenol A-induced testicular dysfunction in vivo and in vitro. Cho, SM; Kang, SC; Kim, CW; Koo, YT; Kwon, JE; Lee, DE; Lee, HM; Lee, SH; Park, B, 2018)	2.17
"Bisphenol A (BPA) has estrogenic activity and therefore the capacity of interfering with endocrine pathways."	( Bisphenol A exposure during early pregnancy impairs uterine spiral artery remodeling and provokes intrauterine growth restriction in mice. Luque, EH; Meyer, N; Müller, JE; Rodriguez, HA; Santamaria, CG; Schumacher, A; Zenclussen, AC; Zenclussen, ML, 2018)	2.64
"Bisphenol A (BPA) has been implicated in altered human reproductive function. "	( Bisphenol A modulates inflammation and proliferation pathway in human endometrial stromal cells by inducing oxidative stress. Cho, YJ; Han, M; Oh, SR; Park, JW; Park, SB, 2018)	3.37
"Bisphenol A (BPA) has been recognized by the European Chemicals Agency (ECHA) as an endocrine disruptor, and its use in thermo paper has been restricted from 2020 under the Regulation concerning the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH). "	( Deriving the freshwater quality criteria of BPA, BPF and BPAF for protecting aquatic life. Ji, G; Liu, J; Shi, L; Wang, L; Wang, Z; Xu, J; Yang, J, 2018)	1.92
"Bisphenol A (BPA) has been used in the plastics industry for several decades. "	( Chlorinated and brominated bisphenol A derivatives: Synthesis, characterization and determination in water samples. Carato, P; Chavatte, P; Doumas, M; Dupuis, A; Farce, A; Migeot, V; Nadeau, C; Pierre Eugene, P; Rouillon, S; Venisse, N, 2018)	2.22
"Bisphenol A (BPA) has been identified as one of the endocrine disrupting chemicals. "	( Preparation of laccase-loaded magnetic nanoflowers and their recycling for efficient degradation of bisphenol A. Fu, M; Ge, Z; Xing, J, 2019)	2.17
"Bisphenol A (BPA) has been associated with male reproductive dysfunction. "	( Serum Bisphenol A concentrations in men with idiopathic infertility. Bliatka, D; Goulis, DG; Iliadou, PK; Kousta, E; Mantzouki, C; Margeli, A; Mastorakos, G; Papassotiriou, I, 2019)	2.44
"Some bisphenol alternatives have been introduced to replace BPA in its many applications."	( Embryonic stem cell- and transcriptomics-based in vitro analyses reveal that bisphenols A, F and S have similar and very complex potential developmental toxicities. Cheng, Z; Dong, H; Faiola, F; Hu, B; Liang, S; Liang, X; Liu, S; Yang, R; Yin, N, 2019)	0.97
"Bisphenol A (BPA) has been shown to be potentially associated with type 2 diabetes; however, there is little evidence associating BPA exposure with glucose metabolic outcomes prior to diabetes onset. "	( Urinary bisphenol A concentration and glucose homeostasis in non-diabetic adults: a repeated-measures, longitudinal study. Bi, Y; Chen, Y; Li, M; Lu, J; Ning, G; Wang, B; Wang, T; Wang, W; Xu, M; Xu, Y; Zhao, Z, 2019)	2.39
"Bisphenol A (BPA) has been associated with impairments in children's behavior, but few studies have investigated its relationship with cognitive function."	( Bisphenol A and cognitive function in school-age boys: Is BPA predominantly related to behavior? Fernández, MF; Molina-Molina, JM; Mustieles, V; Olea, N; Pérez-Lobato, R; Reina-Pérez, I; Rodríguez-Carrillo, A; Rubio, S; Vela-Soria, F, 2019)	3.4
"Bisphenol A (BPA) has been widely used in the manufacture of polycarbonate plastic and epoxy resins. "	( Quantification of eight bisphenol analogues in blood and urine samples of workers in a hazardous waste incinerator. Cunha, SC; Domingo, JL; Fernandes, JO; González, N; Marquès, M; Monteiro, C; Nadal, M, 2019)	2.26
"Bisphenol A has been widely used in plastic containers and this has raised safety concerns for fetuses, infants, and young children. "	( Simultaneous determination of bisphenol A, aflatoxin B1, ochratoxin A, and patulin in food matrices by liquid chromatography/mass spectrometry. Li, C; Moezzi, B; Song, W, 2013)	2.12
"Bisphenol A (BPA) has been shown to affect brain and behavior in rodents and nonhuman primates, but there are few studies focusing on its relationship to human neurobehavior. "	( Bisphenol A in relation to behavior and learning of school-age children. Bhang, SY; Cho, IH; Cho, SC; Hong, SB; Hong, YC; Kim, BN; Kim, JW; Park, EJ; Shin, MS; Yoo, HJ, 2013)	3.28
"Bisphenol A (BPA) has been detected in human body fluids, such as serum and ovarian follicular fluids. "	( Bisphenol A exposure during adulthood causes augmentation of follicular atresia and luteal regression by decreasing 17β-estradiol synthesis via downregulation of aromatase in rat ovary. Chung, JY; Kim, JM; Kim, JY; Kim, YJ; Lee, SG; Oh, S; Park, JE; Yoo, KS; Yoo, YH; Yoon, YD, 2013)	3.28
"Bisphenol A (BPA) has received considerable attention throughout the last decade due to its widespread use in consumer products. "	( Prediction and evaluation of route dependent dosimetry of BPA in rats at different life stages using a physiologically based pharmacokinetic model. Doerge, DR; Fisher, JW; Yang, X, 2013)	1.83
"Bisphenol A (BPA) has been found in plastic food containers, paper currencies and toys. "	( Genotoxic potentials and related mechanisms of bisphenol A and other bisphenol compounds: a comparison study employing chicken DT40 cells. Choi, K; Lee, S; Liu, X; Takeda, S, 2013)	2.09
"Bisphenol A (BPA) has many toxic effects on aquatic organisms, of which the most obvious effect is the estrogenic effect. "	( [Ecological risk assessment of bisphenol A in Chinese freshwaters]. Feng, CL; Guo, GH; Liu, YD; Wang, H; Wu, FC; Zhang, RQ, 2013)	2.12
"As bisphenol A (BPA) has been shown to induce adverse effects on human health, especially through the activation of endocrine pathways, it is about to be withdrawn from the European market and replaced by analogues such as bisphenol S (BPS). "	( Is bisphenol S a safe substitute for bisphenol A in terms of metabolic function? An in vitro study. Chagnon, MC; Costanzo, C; Héliès-Toussaint, C; Peyre, L; Rahmani, R, 2014)	1.3
"Bisphenol A (BPA) has one of the highest production volumes of all chemicals worldwide. "	( Bisphenol A exposure via thermal paper receipts. Heinälä, M; Porras, SP; Santonen, T, 2014)	3.29
"Bisphenol A (BPA) has been widely used as a monomer for the synthesis of polycarbonate and epoxy resins."	( Preparation of molecule-responsive microsized hydrogels via photopolymerization for smart microchannel microvalves. Kawamura, A; Kawano, R; Miyata, T; Morimoto, J; Ohba, C; Shiraki, Y; Tsuruta, K; Uragami, T; Yoshida, R, 2015)	1.14
"Bisphenol A (BPA) has been shown to provoke many deleterious impacts on human health, and thus it is now successively substituted by BPA analogues, whose effects have been poorly investigated. "	( Comparative study of the effect of BPA and its selected analogues on hemoglobin oxidation, morphological alterations and hemolytic changes in human erythrocytes. Bukowska, B; Maćczak, A; Michałowicz, J, )	1.57
"Bisphenol A has epigenetic effects as deregulated expression of microRNAs; such epigenetic marks can induce up/down alterations in gene expression that may persist throughout a lifetime."	( Genome-wide microRNA expression profiling in placentas from pregnant women exposed to BPA. De Felice, B; De Stefano, N; Di Carlo, C; Di Spiezio Sardo, A; Ferbo, U; Guida, M; Manfellotto, F; Palumbo, A; Troisi, J; Zullo, F, 2015)	1.14
"Bisphenol A (BPA) has been reported as a potential estrogenic substance that could affect human health and reproduction. "	( Competitive immunoassay for analysis of bisphenol A in children's sera using a specific antibody. Liu, R; Meng, W; Xu, L; Yang, F; Zhang, Y; Zhu, L, 2016)	2.14
"Bisphenol A (BPA) has been implicated as an 'endocrine disruptor'. "	( Higher Serum Bisphenol A Levels in Diabetic Hemodialysis Patients. Gokce, C; Okur, R; Ozsan, M; Sungur, S; Turgut, F; Ustun, I; Yaprak, M, 2016)	2.25
"Bisphenol A (BPA) has been linked to changes in the dopamine system and development of an Attention-Deficit/Hyperactivity Disorder (ADHD) phenotype in animal models, with differing effects in males compared to females. "	( Association of Bisphenol A exposure and Attention-Deficit/Hyperactivity Disorder in a national sample of U.S. children. Auinger, P; Braun, JM; Ehrlich, S; Epstein, JN; Froehlich, TE; Lanphear, B; Tewar, S; Yolton, K, 2016)	2.23
"Bisphenol A (BPA) has been widely used for manufacturing polycarbonate plastics and epoxy resins and has been extensively tested in animals to predict human toxicity. "	( Estimation of bisphenol A-Human toxicity by 3D cell culture arrays, high throughput alternatives to animal tests. Cho, YH; Ku, B; Lee, DW; Lee, MY; Oh, WY; Yang, M; Yi, SH, 2016)	2.24
"Bisphenol A has been the subject of intense investigation for nearly two decades, and exposure effects have been described in hundreds of experimental, epidemiological, and clinical studies."	( An old culprit but a new story: bisphenol A and "NextGen" bisphenols. Hunt, PA; Sartain, CV, 2016)	1.44
"Bisphenol A (BPA) has been shown to exert biological effects through estrogen receptor (ER)-dependent and ER-independent mechanisms. "	( Bisphenol A exposure alters release of immune and developmental modulators and expression of estrogen receptors in human fetal lung fibroblasts. Cao, XL; Chen, Q; Coughlan, MC; Florian, M; Jin, X; Mahemuti, L; Mailloux, RJ; Scoggan, KA; Willmore, WG; Zhang, M, 2016)	3.32
"Bisphenol A (BPA) has been reported to be associated with adverse health effects, including high blood pressure (BP). "	( Maternal Urinary Bisphenol A Concentration During Midterm Pregnancy and Children's Blood Pressure at Age 4. Bae, S; Hong, YC; Lee, YA; Lim, YH; Oh, SY; Shin, CH, 2017)	2.24
"Bisphenol A (BPA) has been reported to adversely affect the mammalian reproductive system in both sexes. "	( Melatonin protects oocyte quality from Bisphenol A-induced deterioration in the mouse. Cui, Z; Dai, X; Liu, H; Lu, Y; Miao, Y; Xiong, B; Zhang, M; Zhou, C, 2017)	2.17
"Bisphenol A (BPA) has become a target of intense public scrutiny since concerns about its association with human diseases such as obesity, diabetes, reproductive disorders, and cancer have emerged. "	( Induction of oxidative stress by bisphenol A and its pleiotropic effects. Gassman, NR, 2017)	2.18
"Bisphenol A (BPA) has long been suspected to promote carcinogenesis, but the high doses of BPA used in many studies generated conflicting results."	( Bisphenol A at low nanomolar doses confers chemoresistance in estrogen receptor-alpha-positive and -negative breast cancer cells. Ben-Jonathan, N; Fox, SR; Lapensee, EW; Tuttle, TR, 2009)	2.52
"Bisphenol AF has been acknowledged to be useful for the production of CF3-containing polymers with improved chemical, thermal, and mechanical properties. "	( Bisphenol AF is a full agonist for the estrogen receptor ERalpha but a highly specific antagonist for ERbeta. Liu, X; Matsushima, A; Okada, H; Shimohigashi, M; Shimohigashi, Y, 2010)	3.25
"Bisphenol A (BPA) has been considered as an endocrine disruptor due to its ability to interact with estrogen receptors (ERs). "	( Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells. Dong, S; Kiyama, R; Terasaka, S, 2011)	3.25
"Bisphenol A (BPA) has been implicated as an endocrine-disrupting chemical (EDC) due to its ability to mimic the action of endogenous estrogenic hormones."	( Developmental and metabolic brain alterations in rats exposed to bisphenol A during gestation and lactation. Aubert, ML; Camm, EJ; Darbre, S; Gruetter, R; Hüppi, PS; Kunz, N; Lodygensky, G; Sizonenko, SV; Somm, E, 2011)	1.33
"Bisphenol A (BPA) has been reported to possess hepatic toxicity. "	( Bisphenol A impairs mitochondrial function in the liver at doses below the no observed adverse effect level. Ann, HY; Cho, BJ; Jang, HC; Jung, IK; Kim, MJ; Kim, SH; Koo, YD; Lee, KJ; Moon, MK; Park, KS; Park, YJ; Yoon, YC, 2012)	3.26
"Bisphenol A has several implications on the health of human beings as well it can also affect the growth of plants and animals."	( Biological and enzymatic treatment of bisphenol A and other endocrine disrupting compounds: a review. Husain, Q; Qayyum, S, 2013)	1.38
"Bisphenol A (BPA) has been reported to have an adverse effect on mammalian reproduction and recognized as an endocrine disruptor. "	( Bisphenol A modulates germ cell differentiation and retinoic acid signaling in mouse ES cells. Aoki, T; Takada, T, 2012)	3.26
"Bisphenol A has been reported to be a ubiquitous contaminant in indoor dust, and human exposure to this compound is well documented. "	( Occurrence of eight bisphenol analogues in indoor dust from the United States and several Asian countries: implications for human exposure. Guo, Y; Kannan, K; Liao, C; Liu, F; Moon, HB; Nakata, H; Wu, Q, 2012)	2.15
"Bisphenol A (BPA) has attracted considerable public attention as it leaches from plastic used in food containers, is detectable in human fluids and recent epidemiologic studies link BPA exposure with diseases including cardiovascular disorders. "	( Bisphenol A binds to the local anesthetic receptor site to block the human cardiac sodium channel. Alzheimer, C; Eberhardt, E; Lampert, A; O'Reilly, AO; Wallace, BA; Weidner, C, 2012)	3.26
"Bisphenol A (BPA) has been widely used in the manufacture of polycarbonate plastic, water bottles and food containers. "	( Bisphenol A inhibits proliferation and induces apoptosis in micromass cultures of rat embryonic midbrain cells through the JNK, CREB and p53 signaling pathways. Hao, W; Jiang, J; Kong, D; Liu, R; Shang, L; Xing, L, 2013)	3.28
"Bisphenol A has been shown to affect the reproduction of male rats and mice. "	( Induction of oxidative stress by bisphenol A in the epididymal sperm of rats. Chitra, KC; Latchoumycandane, C; Mathur, PP, 2003)	2.04
"Bisphenol A (BPA) has been treated with electrochemically generated Fenton's reagent in aqueous medium. "	( Indirect electrochemical treatment of bisphenol A in water via electrochemically generated Fenton's reagent. Erbatur, O; Gözmen, B; Oturan, MA; Oturan, N, 2003)	2.03
"Bisphenol A (BPA) has been shown to disrupt thyroid hormone function. "	( Murine neocortical histogenesis is perturbed by prenatal exposure to low doses of Bisphenol A. Fujiwara, Y; Fushiki, S; Itoh, K; Nakamura, K; Sugimoto, T; Yaoi, T, 2006)	2
"Bisphenol A (BPA) has been acknowledged as an estrogenic chemical able to interact with human estrogen receptors (ER). "	( Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor gamma (ERRgamma) with high constitutive activity. Liu, X; Matsushima, A; Okada, H; Shimohigashi, Y; Takayanagi, S; Tokunaga, T, 2006)	2.1
"Bisphenol A (BPA) has been shown to interfere with thyroid hormone receptors (THRs) and to influence the expression of THR-responsive elements in vivo and in vitro, while some studies reported hyperactivity induced by BPA treatment. "	( Perinatal bisphenol A affects the behavior and SRC-1 expression of male pups but does not influence on the thyroid hormone receptors and its responsive gene. Akaike, M; Kato, N; Liu, Y; Sadamatsu, M; Tsutsumi, S; Ushijima, H; Xu, X, 2007)	2.18
"Bisphenol A (BPA) has been evaluated in eight independent immature mouse uterotrophic assays using the subcutaneous route of administration, and in a single study employing oral gavage. "	( Uterotrophic activity of bisphenol A in the immature mouse. Ashby, J; Foster, J; Joiner, R; Pate, I; Soames, A; Tinwell, H, 2000)	2.05

Actions

Bisphenol A (BPA) plays a substantial role in industry, as it is used for polycarbonate (PC) plastics and epoxy resins which are required for various plastic consumer products. It could be a weak carcinogen by a mechanism similar to that of estrone (E(1), estradiol (2) and the synthetic estrogen diethylstilbestrol.

Excerpt	Reference	Relevance
"Bisphenol A (BPA) promotes colon cancer by altering the physiological functions of hormones. "	( Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Campos-Vega, R; García-Gutiérrez, N; García-Solis, P; Herrera-Hernández, G; Lozano-Herrera, SJ; Luna-Bárcenas, G; Sánchez-Tusié, AA; Vergara-Castañeda, HA, 2023)	2.59
"Bisphenol A (BPA) may cause some adverse effects on human health by mimicking estrogen activities. "	( Trimester-specific, gender-specific, and low-dose effects associated with non-monotonic relationships of bisphenol A on estrone, 17β-estradiol and estriol. Cai, Z; Li, J; Li, Y; Xia, W; Xu, S; Zhang, W; Zhao, H; Zhou, Y, 2020)	2.21
"Bisphenol A (BPA) can inhibit the differentiation and function of regulatory T cells (Treg), and affect the balance of helper T cell (Th) 1/Th2, therefore, the immunotoxicity of BPA has attracted widespread attention in recent years, but its mechanism is not clear. "	( The imbalance of Treg/Th17 cells induced by perinatal bisphenol A exposure is associated with activation of the PI3K/Akt/mTOR signaling pathway in male offspring mice. Dong, Y; Gao, L; Jia, L; Lin, R; Meng, Y; Wu, F, 2020)	2.25
"Bisphenol A may cause oxidative stress by inducing excessive ROS production in liver cells, leading to liver damage and disorder of lipid metabolism in the body, thereby showing liver toxicity."	( [Effect of the reactive oxygen species-induced by bisphenol A on liver lipid metabolism disorder]. Liu, F; Liu, H; Ma, Y; Wang, G; Wang, L, 2021)	2.32
"Bisphenol A promotes hyperuricemia via activating xanthine oxidase."	( Bisphenol A promotes hyperuricemia via activating xanthine oxidase. Gao, R; He, JC; Hu, J; Li, J; Li, Q; Luo, T; Ma, L; Peng, C; Qing, H; Wang, Y; Wang, Z; Wu, C; Xiang, X; Xiao, X; Yang, S; Yang, Y; Zhang, L; Zou, L, 2018)	2.64
"Bisphenol A causes the increase in the number of neurons immunoreactive to the majority of substances studied."	( Neurochemical characterization of the enteric neurons within the porcine jejunum in physiological conditions and under the influence of bisphenol A (BPA). Gonkowski, S; Szymanska, K, 2019)	1.44
"Bisphenol A could enhance cell proliferation and colony-forming efficiency, induce COX-2 gene expression, and promote migration and invasion of hUM-MSCs."	( Bisphenol A at environmentally relevant doses induces cyclooxygenase-2 expression and promotes invasion of human mesenchymal stem cells derived from uterine myoma tissue. Chang, CC; Kao, AP; Kuo, TC; Lin, TC; Wang, KH, 2013)	2.55
"Bisphenol A (BPA) plays a substantial role in industry, as it is used for polycarbonate (PC) plastics and epoxy resins which are required for various plastic consumer products. "	( The influence of bisphenol A on mammalian cell cultivation. Herold, EM; Hesse, F; Jacopo, T; Paul, AJ; Sgueglia, A; Stiefel, F; Stützle, M, 2016)	2.22
"Bisphenol A (BPA) displays weak estrogenic properties and could be a weak carcinogen by a mechanism similar to that of estrone (E(1)), estradiol (E(2)) and the synthetic estrogen diethylstilbestrol, a human carcinogen. "	( Is bisphenol A a weak carcinogen like the natural estrogens and diethylstilbestrol? Cavalieri, EL; Rogan, EG, 2010)	2.42

Treatment

Bisphenol A (BPA) was treated with hyper lignin-degrading fungus Phanerochaete sordida YK-624 under ligninolytic condition. Treatment with BPA, nonylphenol (NNP), or tributyltin chloride (TBTC) reduced NO production and induced cell death.

Excerpt	Reference	Relevance
"Bisphenol A treatment of these hUM-MSCs enhanced cell proliferation and colony-forming efficiency in a dose-responsive manner."	( Bisphenol A at environmentally relevant doses induces cyclooxygenase-2 expression and promotes invasion of human mesenchymal stem cells derived from uterine myoma tissue. Chang, CC; Kao, AP; Kuo, TC; Lin, TC; Wang, KH, 2013)	2.55
"Bisphenol A treatment concentration-dependently increased MMP-9 output by GLCs with a maximal effect observed at 1000 ng/ml."	( Bisphenol A concentration-dependently increases human granulosa-lutein cell matrix metalloproteinase-9 (MMP-9) enzyme output. Dominguez, MA; Foster, WG; Neal, MS; Petre, MA, 2008)	2.51
"Bisphenol A (BPA) was treated with hyper lignin-degrading fungus Phanerochaete sordida YK-624 under ligninolytic condition. "	( Dimerization of bisphenol A by hyper lignin-degrading fungus Phanerochaete sordida YK-624 under ligninolytic condition. Hirai, H; Kawagishi, H; Wang, J; Yamamoto, Y, 2013)	2.18
"In bisphenol A-treated rats there was a significant decrease in the weight of the testis and epididymis; the weight of ventral prostate increased significantly whereas there was no significant change in the weight of seminal vesicles as compared with the corresponding group of control animals."	( Induction of oxidative stress by bisphenol A in the epididymal sperm of rats. Chitra, KC; Latchoumycandane, C; Mathur, PP, 2003)	1.11
"Treatment with bisphenol A (BPA), nonylphenol (NNP), or tributyltin chloride (TBTC) reduced NO production and induced cell death."	( Diverse influences of androgen-disrupting chemicals on immune responses mounted by macrophages. Byun, Y; Choi, HS; Choi, SE; Ha, UH; Jung, YW; Kang, H; Kim, HG; Kim, KH; Lee, EH; Lee, KS; Pack, SP; Park, HD; Park, TW; Yeon, SM, 2014)	0.74
"The treatment of bisphenol A (BPA)-contaminated water has attracted great interest recently. "	( Ultrasonic irradiation-induced degradation of low-concentration bisphenol A in aqueous solution. Feng, R; Guo, Z, 2009)	0.93
"Pretreatment with bisphenol A (IC(50) = 60 microM, for 30 min) prevented isoproterenol (10 nM)-generated short-circuit current (I(sc)) more potently than 17beta-estradiol or tamoxifen (IC(50) = 1 mM)."	( Bisphenol A inhibits Cl(-) secretion by inhibition of basolateral K+ conductance in human airway epithelial cells. Ito, Y; Kondo, M; Kume, H; Sato, S; Son, M; Takagi, K; Yamaki, K, 2002)	2.08

Toxicity

Bisphenol A (BPA) is an abundant endocrine-disrupting compound that is found in the aquatic environment and has adverse effects. The toxic effects of three polybrominated diphenyl ether (PBDE) congeners were evaluated by determining their 24h and 96 h median lethal concentrations using a zebrafish liver cell line.

Excerpt	Reference	Relevance
" Thus, BPA treatment at maternally toxic dose levels during organogenesis produced fetal toxicity in mice but not in rats and did not alter fetal morphologic development in either species."	( The developmental toxicity of bisphenol A in rats and mice. George, JD; Kimmel, CA; Marr, MC; Morrissey, RE; Price, CJ; Tyl, RW, 1987)	0.56
"Commonly used dental resins should not be of concern to the general public; however, pharmacological evaluation of dental materials is needed to ensure biologically safe and therapeutically effective substances."	( BIS-GMA--based resins in dentistry: are they safe? Mariotti, A; Söderholm, KJ, 1999)	0.3
"25 mM) in the hepatocyte suspensions was rapidly converted to its major conjugate, BPA-glucuronide, and other minor products without marked loss of cell viability, although at a toxic level (0."	( Metabolism and cytotoxicity of bisphenol A and other bisphenols in isolated rat hepatocytes. Nakagawa, Y; Tayama, S, 2000)	0.59
" The present study was conducted in an attempt to evaluate the adverse effects of the environmental estrogen BPA on initiation and maintenance of pregnancy and embryofetal development after maternal exposure during the entire period of pregnancy in Sprague-Dawley rats."	( Evaluation of developmental toxicity in rats exposed to the environmental estrogen bisphenol A during pregnancy. Cha, SW; Chung, MK; Han, SS; Kim, JC; Koh, WS; Shin, HC, 2001)	0.54
" The highest dose of BPA was decreased to 600 mg/kg per day from the second week of administration because a male rat given 1000 mg/kg BPA had died within 1 week with toxic clinical signs."	( Subacute oral toxicity study of ethynylestradiol and bisphenol A, based on the draft protocol for the "Enhanced OECD Test Guideline no. 407". Imatanaka, N; Noda, S; Sawaki, M; Takatsuki, M; Yamasaki, K, 2002)	0.56
" We examined toxic effects of three substances (ethylbenzene, nonylphenol, and bisphenol A), that are known to be hormonally active in many animals, on growth and development of two species of freshwater sponge."	( Toxic effects of endocrine disrupters on freshwater sponges: common developmental abnormalities. Hill, A; Hill, M; Stabile, C; Steffen, LK, 2002)	0.54
" The highest dose of BPA was reduced to 600 mg/kg per day from the second week of the study onwards because a male rat given 1000 mg/kg per day of BPA died within the first week, showing toxic clinical signs."	( Changes of serum alpha 2u-globulin in the subacute oral toxicity study of ethynyl estradiol and bisphenol A based on the draft protocol for the 'Enhanced OECD Test Guideline No. 407'. Noda, S; Takatsuki, M; Takeyoshi, M; Yamasaki, K, 2002)	0.53
" Adult systemic no observed adverse effect level (NOAEL) = 75 ppm (5 mg/kg/day); reproductive and postnatal NOAELs = 750 ppm (50 mg/kg/day)."	( Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats. Brine, DR; Butala, JH; Cagen, SZ; Chang, TY; Dimond, SS; Fail, PA; Joiner, RL; Keimowitz, AR; Marr, MC; Myers, CB; Seely, JC; Shiotsuka, RN; Stropp, GD; Thomas, BF; Tyl, RW; Veselica, MM; Waechter, JM, 2002)	0.56
" BPA was moderately toxic to Daphnia magna (48-h EC(50) was 10 mg/L) and weakly estrogenic, with activity that was 5 orders of magnitude lower than that of 17beta-estradiol in the yeast screen, though no mutagenicity was observed."	( Acute toxicity, mutagenicity, and estrogenicity of biodegradation products of bisphenol-A. Chen, MY; Fujita, M; Ike, M; Jin, CS, 2002)	0.31
"It has been shown that numerous natural and synthetic chemicals with estrogenic activities are reproductive or developmental toxic factors in humans or animals by epidemiological investigations and animal experiments."	( [Molecular mechanisms of environmental estrogens on reproductive and developmental toxicity]. Chen, F; Li, Y; Long, D, 2002)	0.31
" These results indicate that dietarily administered BPA is less toxic to most strains of rats and mice, and the maximum non-toxic dose and/or minimum toxic dose may be about 200 mg/kg/day."	( Testicular toxicity of dietarily or parenterally administered bisphenol A in rats and mice. Oishi, S; Takahashi, O, 2003)	0.56
" Although there are still open questions regarding in utero or early postnatal exposure, the low potencies and concentrations of manmade chemicals as compared with the endogenous hormones in humans make it unlikely that adverse effects occur at common exposure."	( The endocrine and reproductive system: adverse effects of hormonally active substances? Greim, HA, 2004)	0.32
" Since similar adverse effects were observed when adult mice were treated with beta-estradiol 3-benzoate, the effects of BPA reported here seem to reflect the estrogenic effects on the testes."	( Adverse effects of bisphenol A to spermiogenesis in mice and rats. Ito, C; Maekawa, M; Suzuki-Toyota, F; Toshimori, K; Toyama, Y, 2004)	0.65
" Bisphenol A (BPA) at 2-4 mg/L given to male or female hydra had adverse effects on both sexual and asexual reproduction."	( Toxic effects of bisphenol A on sexual and asexual reproduction in Hydra oligactis. Fukuhori, N; Kimura, H; Kitano, M, 2005)	1.58
" Recently, attention has focused on the estrogen-like and carcinogenic adverse effects of BPA and HQ."	( Cytotoxicity and apoptosis-inducing activity of bisphenol A and hydroquinone in HL-60 cells. Fujisawa, S; Kadoma, Y; Sakagami, H; Terasaka, H, )	0.39
" After the photocatalysis, however, no toxic effects on the hatching rates or morphogenesis of the zebrafish were observed."	( Photodecomposition of bisphenol A on nanometer-sized TiO2 thin film and the associated biological toxicity to zebrafish (Danio rerio) during and after photocatalysis. Kang, M; Yeo, MK, 2006)	0.65
"Xenobiotics may cause long-term adverse effects in humans, especially at the embryonic level, raising questions about their levels of exposure, combined effects, and crucial endpoints."	( Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination. Benachour, N; Moslemi, S; Seralini, GE; Sipahutar, H, 2007)	0.34
" The adverse effects of prenatal diethylstilbestrol (DES) exposure are a classic example."	( Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract. Jefferson, WN; Newbold, RR; Padilla-Banks, E, )	0.38
" According to their median effective concentrations (EC(50) values) in the single exposure, the toxic level of PCP was about two orders of magnitude higher than that of BPA."	( Individual and joint toxic effects of pentachlorophenol and bisphenol A on the development of zebrafish (Danio rerio) embryo. Duan, Z; Kun, Y; Zhu, L; Zhu, X, 2008)	0.59
" At 3500 ppm, BPA also reduced F1/F2 weanling body weight, reduced weanling spleen and testes weights (with seminiferous tubule hypoplasia), slightly delayed preputial separation (PPS), and apparently increased the incidence of treatment-related, undescended testes only in weanlings, which did not result in adverse effects on adult reproductive structures or functions; this last finding is considered a developmental delay in the normal process of testes descent."	( Two-generation reproductive toxicity study of dietary bisphenol A in CD-1 (Swiss) mice. Beyer, D; Castillo, NP; Dimond, SS; Hentges, SG; Marr, MC; Myers, CB; Seely, JC; Shiotsuka, RN; Sloan, CS; Tyl, RW; Van Miller, JP; Veselica, MM; Waechter, JM, 2008)	0.59
" In this study, we investigated toxic effects of BPA concentrations close to levels found in serum of pregnant women on human cytotrophoblasts (CTB)."	( Toxic effects of low doses of Bisphenol-A on human placental cells. Aris, A; Benachour, N, 2009)	0.35
" New research on very-low-dose exposure to BPA suggests an association with adverse health effects, including breast and prostate cancer, obesity, neurobehavioral problems, and reproductive abnormalities."	( The politics of plastics: the making and unmaking of bisphenol a "safety". Vogel, SA, 2009)	0.6
" Food safety is threatened by numerous pathogens that cause a variety of foodborne diseases, algal toxins that cause mostly acute disease, and fungal toxins that may be acutely toxic but may also have chronic sequelae, such as teratogenic, immunotoxic, nephrotoxic, and estrogenic effects."	( Food safety. Borchers, A; Gershwin, ME; Keen, CL; Teuber, SS, 2010)	0.36
" There are various other factors involved with toxic responses, including age, with the fetus and infants being the most vulnerable."	( How safe is bisphenol A? Fundamentals of toxicity: metabolism, electron transfer and oxidative stress. Kovacic, P, 2010)	0.74
" National Toxicology Program (NTP) expressed some concern for adverse effects, at current level of exposure to BPA, on developmental toxicity."	( Conclusions of the French Food Safety Agency on the toxicity of bisphenol A. Arnich, N; Canivenc-Lavier, MC; Coffigny, H; Cravedi, JP; Grob, K; Kolf-Clauw, M; Macherey, AC; Masset, D; Maximilien, R; Narbonne, JF; Nesslany, F; Stadler, J; Tulliez, J, 2011)	0.61
"Acute toxic effects and mechanisms of two typical endocrine disrupting chemicals, nonylphenols (NPs) and bisphenol A (BPA), to the embryonic development of the abalone Haliotis diversicolor supertexta, were investigated by the two-stage embryo toxicity test."	( Acute toxicity of nonylphenols and bisphenol A to the embryonic development of the abalone Haliotis diversicolor supertexta. Gao, B; Guan, Y; Liu, Y; Tam, NF; Yasojima, M; Zhou, J, 2011)	0.86
"To investigate possible joint toxic effects of diazinon, propoxur and bisphenol A (BPA) on proliferation of RAW264."	( [Study of three methods on joint toxicity of diazinon, propoxur and bisphenol A on proliferation of mouse RAW264.7 cell]. Hao, W; Huang, J; Huang, Q; Li, N; Tan, X; Yang, X, 2011)	0.84
" The types of toxic interaction of diazinon & BPA and propoxur & BPA were assessed by three methods commonly used for binary mixtures, which were Additional Index Method, Equivalent Effect Curve Method and Logistic Regression Method."	( [Study of three methods on joint toxicity of diazinon, propoxur and bisphenol A on proliferation of mouse RAW264.7 cell]. Hao, W; Huang, J; Huang, Q; Li, N; Tan, X; Yang, X, 2011)	0.6
" It has endocrine-disrupting potential and exerts both toxic and estrogenic effects on mammalian cells."	( Melatonin ameliorates bisphenol A-induced biochemical toxicity in testicular mitochondria of mouse. Ahmad, F; Anjum, S; Ansari, RA; Kaur, M; Rahman, S; Raisuddin, S; Rashid, H, 2011)	0.68
" The results suggest adverse effects of BPA on sperm motility and velocity via modifications of testicular steroidogenesis that might correspond to alternation in sperm maturation."	( Adverse effects of bisphenol A on reproductive physiology in male goldfish at environmentally relevant concentrations. Abdulfatah, A; Alavi, SM; Fontaine, P; Hatef, A; Linhart, O; Rodina, M, 2012)	0.71
" The use of vtg1 mRNA induction in zebrafish embryos and larvae was found to be a sensitive biomarker of exposure to these organic compounds, and was helpful in elucidating their adverse effects and setting water quality guidelines."	( Toxicity assessment and vitellogenin expression in zebrafish (Danio rerio) embryos and larvae acutely exposed to bisphenol A, endosulfan, heptachlor, methoxychlor and tetrabromobisphenol A. Chan, KM; Chan, WK; Chow, WS, 2013)	0.6
" Embryo toxic responses showed a clear dose-related tendency whereas no clear dose-dependent effect was observed in micronucleus induction."	( Linking embryo toxicity with genotoxic responses in the freshwater snail Physa acuta: single exposure to benzo(a)pyrene, fluoxetine, bisphenol A, vinclozolin and exposure to binary mixtures with benzo(a)pyrene. Aparicio, N; Fernández, C; Sánchez-Argüello, P, 2012)	0.58
" We investigated the hypothesis that BPA, below the no observed adverse effect level (NOAEL), can induce hepatic damage and mitochondrial dysfunction by increasing oxidative stress in the liver."	( Bisphenol A impairs mitochondrial function in the liver at doses below the no observed adverse effect level. Ann, HY; Cho, BJ; Jang, HC; Jung, IK; Kim, MJ; Kim, SH; Koo, YD; Lee, KJ; Moon, MK; Park, KS; Park, YJ; Yoon, YC, 2012)	1.82
"Bisphenol A (BPA), an estrogenic compound, is used in manufacturing plastics and is known to produce toxic effects on various systems in man and animals."	( Acute toxicity of bisphenol A in rats. Deshpande, SB; Pant, J, 2012)	2.16
" Cell growth was analyzed with an inverted light microscope, photomicrographs were obtained, and the results were recorded as response rates based on modifications of the parameters of Stanford according to the size of diffusion halo of toxic substances."	( Cytotoxicity of esthetic, metallic, and nickel-free orthodontic brackets: cellular behavior and viability. De Menezes, LM; Freitas, MP; Luz, TB; Machado, DC; Marinowic, DR; Oshima, HM; Retamoso, LB, 2012)	0.38
"The acute and chronic toxic effects of Bisphenol A (BPA) on Chlorella pyrenoidosa (C."	( Acute and chronic toxic effects of bisphenol A on Chlorella pyrenoidosa and Scenedesmus obliquus. An, S; Cui, XH; Guo, MJ; Lin, KF; Sun, WF; Xiong, B; Zhang, W, 2014)	0.95
" Bisphenol A (BPA) is a contaminant with increasing exposure to it and exerts both toxic and estrogenic effects on mammalian cells."	( Bisphenol A induces hepatotoxicity through oxidative stress in rat model. AlOlayan, EM; Daghestani, MH; ElAmin, M; Elobeid, MA; Hassan, ZK; Omer, SA; Virk, P, 2012)	2.73
" Multigenerational tests also revealed magnification of the adverse effects, not only on fecundity but also on mortality, which represents a worrying trend for organisms that are chronically exposed to xenoestrogens for many generations."	( Bisphenol A migration from plastic materials: direct insight of ecotoxicity in Daphnia magna. Domingues, V; Ferreira, IM; Gameiro, P; Mansilha, C; Pinho, C; Rocha, S; Silva, P, 2013)	1.83
" Through the application of D-S theory to toxicity risk assessment, we show how a multiplicity of scientific evidence can be converted into a unified risk estimate, and how this information can be effectively used for comparative assessments to select potentially less toxic alternative chemicals."	( Dempster-Shafer theory applied to regulatory decision process for selecting safer alternatives to toxic chemicals in consumer products. Lejano, RP; Ogunseitan, OA; Park, SJ, 2014)	0.4
" Studies suggest that interactions of TiO2 NPs with other chemicals or physical factors may result in an increase in toxicity or adverse effects."	( Toxic effects of the interaction of titanium dioxide nanoparticles with chemicals or physical factors. Lin, X; Liu, K; Zhao, J, 2013)	0.39
" Considering the actual daily intake of these chemicals, it is concluded that BPA alone might not have adverse reproductive or developmental effects on human being."	( Individual and combined developmental toxicity assessment of bisphenol A and genistein using the embryonic stem cell test in vitro. Hao, W; Jiang, J; Kong, D; Liu, R; Shang, L; Wang, W; Wei, X; Xing, L, 2013)	0.63
" To better understand the adverse effects caused by exposure to BPA, we performed an up-to-date literature review on the topic, with particular emphasis on in utero exposure, and associated effects on spermatogenesis, steroidogenesis, and accessory organs."	( Adverse effects of bisphenol A on male reproductive function. Jubendradass, R; Manfo, FP; Mathur, PP; Moundipa, PF; Nantia, EA, 2014)	0.73
" The results indicate that the oxidative treatment (O3 or UV/H2O2) of Bisphenol A, Metoprolol, Sulfamethoxazole or Ciprofloxacin in waste water did not result in toxic oxidation by-products, whereas the UV/H2O2 treatment of Bisphenol A and Ciprofloxacin in pure water resulted in by-products with cytotoxic but no estrogenic effects after 60min."	( Toxicity of the micropollutants Bisphenol A, Ciprofloxacin, Metoprolol and Sulfamethoxazole in water samples before and after the oxidative treatment. Bester, K; Boergers, A; Richard, J; Tuerk, J; Vom Eyser, C, )	0.65
" Guideline studies used to set regulatory limits detected adverse effects only at doses well above human exposures and established a no-observed-adverse-effect level (NOAEL) of 5 mg/kg body weight (bw)/day."	( Toxicity evaluation of bisphenol A administered by gavage to Sprague Dawley rats from gestation day 6 through postnatal day 90. Bryant, MS; Camacho, L; Chidambaram, M; Davis, KJ; Delclos, KB; Felton, RP; Gamboa da Costa, G; Juliar, BE; Latendresse, JR; Lewis, SM; Olson, GR; Patton, RE; Thorn, BT; Trbojevich, R; Vanlandingham, MM; Woodling, KA, 2014)	0.71
"Bisphenol A (BPA) is a well-known endocrine disruptor with adverse oestrogen-like effects eliciting adverse effects in humans and wildlife."	( Efficiency of advanced oxidation processes in lowering bisphenol A toxicity and oestrogenic activity in aqueous samples. Pintar, A; Plahuta, M; Tišler, T; Toman, MJ, 2014)	2.09
" extract ameliorates the toxic effects of BPA and is proved to have antioxidant potential and antitoxic effect."	( Influence of Genista tinctoria L. or methylparaben on subchronic toxicity of bisphenol A in rats. Bolfa, P; Cătoi, C; Crişan, G; Kiss, B; Loghin, F; Păltinean, R; Pop, A; Popa, DS; Vlase, L, 2014)	0.63
" BPA is toxic to aquatic organisms, animals and humans."	( Nephrotoxicity of bisphenol A (BPA)--an updated review. Gowder, SJ, 2013)	0.72
"Battery tests serve as integral tools to decide whether a treatment process is ecotoxicologically safe or not."	( Effect of Fenton treatment on the aquatic toxicity of bisphenol A in different water matrices. Arslan-Alaton, I; Aytac, E; Kusk, KO, 2014)	0.65
"The toxic effects of bisphenol A (BPA) in aquatic organisms have attracted global attention."	( Toxic effects of bisphenol A on early life stages of Japanese medaka (Oryzias latipes). Fu, Z; Jin, R; Lin, X; Peng, T; Peng, Z; Sun, L, 2014)	1.06
" Seabream was chosen as model, as it is one of the primary commercial species valued by consumers and these results could provide important findings on adverse effects that could be passed on to humans by eating contaminated fish."	( A developmental hepatotoxicity study of dietary bisphenol A in Sparus aurata juveniles. Benato, F; Carnevali, O; Colletti, E; Dalla Valle, L; Di Marco Pisciottano, I; Gallo, P; Gioacchini, G; Hardiman, G; Mandich, A; Maradonna, F; Mita, DG; Nozzi, V; Traversi, I, 2014)	0.66
"fischeri bioassay results indicated that degradation products being more toxic than BPA were formed at the initial stages of H2O2/UV-C whereas a rapid and steady reduction in toxicity was observed during S2O8(2-)/UV-C treatment in pure water."	( S2O8(2-)/UV-C and H2O2/UV-C treatment of Bisphenol A: assessment of toxicity, estrogenic activity, degradation products and results in real water. Arslan-Alaton, I; Aydin, E; Diano, N; Dursun, D; Girit, B; Guida, M; Mita, DG; Mita, L; Olmez-Hanci, T, 2015)	0.68
" The persistence and prevalence of H-BPAs in the environment underscore the need to in-depth understand their adverse effects to humans and other organisms."	( Assessing developmental toxicity and estrogenic activity of halogenated bisphenol A on zebrafish (Danio rerio). Chen, M; Jiang, G; Liang, D; Liang, Y; Song, M; Wang, F; Wang, H, 2014)	0.63
"As bisphenol A (BPA) has been shown to induce adverse effects on human health, especially through the activation of endocrine pathways, it is about to be withdrawn from the European market and replaced by analogues such as bisphenol S (BPS)."	( Is bisphenol S a safe substitute for bisphenol A in terms of metabolic function? An in vitro study. Chagnon, MC; Costanzo, C; Héliès-Toussaint, C; Peyre, L; Rahmani, R, 2014)	1.3
" Male CD1 mice were exposed during 8 months to five different BPA doses below or equivalent to the current no observed adverse effect level (NOAEL: 5000 μg/kg/day) through drinking water."	( Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice. Beuzelin, D; Chetivaux, M; Ducheix, S; Guillou, H; Huc, L; Lasserre, F; Marmugi, A; Martin, P; Mselli-Lakhal, L; Pineau, T; Polizzi, A, 2014)	0.67
"Bisphenol A (BPA) is a widely studied typical endocrine-disrupting chemical, and one of the major new issues is the safe replacement of this commonly used compound."	( A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound. Benachi, A; Eladak, S; Grisin, T; Guerquin, MJ; Habert, R; Livera, G; Moison, D; N'Tumba-Byn, T; Pozzi-Gaudin, S; Rouiller-Fabre, V, 2015)	2.18
"Bisphenol A (BPA) is a ubiquitous pollutant around the globe, but whether environmental concentrations have toxic effects remains controversial."	( Temperature determines toxicity: bisphenol A reduces thermal tolerance in fish. Little, AG; Seebacher, F, 2015)	2.14
"The toxic effects of three polybrominated diphenyl ether (PBDE) congeners (BDE-47, -99, and -209), tetrabromobisphenol A (TBBPA) and bisphenol A (BPA), were evaluated by determining their 24h and 96 h median lethal concentrations using a zebrafish liver cell line, ZFL."	( Evaluation of the toxic effects of brominated compounds (BDE-47, 99, 209, TBBPA) and bisphenol A (BPA) using a zebrafish liver cell line, ZFL. Chan, KM; Yang, J, 2015)	0.85
" The observed endpoints are recorded at very low, non-toxic exposure concentrations, indicating that BPA acts as an endocrine disrupting compound, as well as a toxic substance."	( Adverse effects of bisphenol A on water louse (Asellus aquaticus). Pintar, A; Plahuta, M; Tišler, T; Toman, MJ, 2015)	0.75
" The current study was designed to (1) Assess the adverse effect of oral administration of BPA on liver of male rats and (2) Evaluate the role of thymoquinone (TQ), the major bioactive ingredient in the oil of Nigella sativa seed, in alleviating the possible detrimental effects of BPA on the liver."	( Thymoquinone attenuates toxicity and oxidative stress induced by bisphenol A in liver of male rats. Abdel-Wahab, WM, 2014)	0.64
" However, its toxic effects on the germ cells are still poorly understood."	( The toxic effects of Bisphenol A on the mouse spermatocyte GC-2 cell line: the role of the Ca2+-calmodulin-Ca2+/calmodulin-dependent protein kinase II axis. Cheng, J; Huan, F; Liu, Y; Mao, C; Qian, W; Wang, J; Wang, Q; Wang, Y; Xiao, H; Zhu, J, 2015)	0.74
" Consequently, the inductively coupled plasma mass spectrometry (ICP-MS) analysis indicated higher concentrations of some toxic metals like chromium, nickel, molybdenum, silver, and zinc in the recycled samples in comparison to both the single-pass sample and the photocatalytically treated solution."	( Unexpected toxicity to aquatic organisms of some aqueous bisphenol A samples treated by advanced oxidation processes. Erjavec, B; Kaplan, R; Pintar, A; Şenilă, M; Tišler, T, 2015)	0.66
"The adverse effects of environmental pollution on our well-being have been intensively studied with many in vitro and in vivo systems."	( Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells. Faiola, F; Qin, Z; Wang, YL; Yao, X; Yin, N, 2015)	0.78
" Females were less sensitive to BPA exposures than males as no adverse effects were found in female gonads or gametes."	( Reproductive toxicity of low level bisphenol A exposures in a two-generation zebrafish assay: Evidence of male-specific effects. Bai, C; Chen, J; Dong, Q; Gai, Z; Huang, C; Li, R; Tanguay, RL; Xiao, Y; Xu, X; Zhu, Z, 2015)	0.69
" Our findings provide evidences that different concentrations of BPA can induce a toxic response in fish to produce reactive free radicals which can affect the function of T lymphocytes and decrease the transcription levels of cytokine genes."	( Oxidative stress and immunotoxic effects of bisphenol A on the larvae of rare minnow Gobiocypris rarus. Gao, J; Tao, S; Wang, Z; Wu, F; Yuan, C; Zhang, Y, 2016)	0.7
"Membrane concentrates of landfill leachates contain organic and inorganic contaminants that could be highly toxic and carcinogenic."	( Genotoxicity assessment of membrane concentrates of landfill leachate treated with Fenton reagent and UV-Fenton reagent using human hepatoma cell line. Lu, G; Wang, G; Yin, P; Yu, QJ; Zhao, L, 2016)	0.43
"The potentially adverse health implications of bisphenol A (BPA) have led to increasing use of alternative bisphenols (BPs)."	( In vitro profiling of toxicity and endocrine disrupting effects of bisphenol analogues by employing MCF-7 cells and two-hybrid yeast bioassay. Chen, T; Lei, B; Peng, W; Wang, Y; Wen, Y; Xu, J; Yu, Z; Zeng, X, 2017)	0.95
" BPA has been associated with adverse effects attributed to its estrogenic properties in various animal models."	( Bisphenol A and food safety: Lessons from developed to developing countries. Baluka, SA; Rumbeiha, WK, 2016)	1.88
" Compared to the previous short-term toxicity evaluation, long-term exposure to BPA induced a more obvious response at the same concentration, and the phenomenon might be due to cumulative toxic effects."	( The chronic toxicity of bisphenol A to Caenorhabditis elegans after long-term exposure at environmentally relevant concentrations. Cui, C; Li, H; Lin, K; Liu, Y; Yang, J; Yu, Y; Zhou, D, 2016)	0.74
" Previous studies demonstrated that BPA activates estrogenic signaling pathways associated with adverse effects on reproduction in vertebrates and that exposure can induce epigenetic changes."	( Bisphenol A causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio). Dempster, EL; Laing, LV; Mill, J; Paull, GC; Santos, EM; Trunkfield, LA; Trznadel, M; Uren Webster, TM; van Aerle, R; Viana, J; Wilson, RJ, 2016)	1.88
" For aquatic organisms, BPA was the most toxic (96 h LC50s) to aquatic invertebrates (0."	( Influence of Lipophilicity on the Toxicity of Bisphenol A and Phthalates to Aquatic Organisms. de Solla, SR; Langlois, VS; Mathieu-Denoncourt, J; Wallace, SJ, 2016)	0.69
" There are concerns about adverse health effects in humans due to exposure to bisphenol A (BPA)."	( Assessment of recent developmental immunotoxicity studies with bisphenol A in the context of the 2015 EFSA t-TDI. DeWitt, J; Ezendam, J; Granum, B; Guzylack, L; Hakkert, B; Hessel, EV; Lawrence, BP; Penninks, A; Piersma, AH; Rooney, AA; van Broekhuizen, FA; van Loveren, H, 2016)	0.9
" Degradation of BPA could lead to the formation of toxic products."	( Screening of Toxic Effects of Bisphenol A and Products of Its Degradation: Zebrafish (Danio rerio) Embryo Test and Molecular Docking. Kurkowiak, J; Makarova, K; Siudem, P; Zawada, K, 2016)	0.72
" The addition of peripubertal BPA exposure following the initial perinatal exposure exacerbated adverse effects in the females but appeared to reduce differences in body weight and body composition between control and BPA exposed males."	( Perinatal BPA exposure alters body weight and composition in a dose specific and sex specific manner: The addition of peripubertal exposure exacerbates adverse effects in female mice. DaFonte, T; Greenberg, AS; Obin, M; Paranjpe, M; Rubin, BS; Schaeberle, C; Soto, AM, 2017)	0.46
" However, the molecular basis for the adverse effect of BPA on male reproductive toxicity remains unclear."	( The regulation of cellular apoptosis by the ROS-triggered PERK/EIF2α/chop pathway plays a vital role in bisphenol A-induced male reproductive toxicity. Cao, J; Cui, Z; Dai, Y; Han, F; Jiang, X; Lin, A; Liu, J; Liu, W; Yin, L, 2017)	0.67
" In this study, we observed behavioral adverse effects of the offspring of mice exposed to BPA or BPF in fetal period."	( Adverse effects of maternal exposure to bisphenol F on the anxiety- and depression-like behavior of offspring. Inoue, H; Iwano, H; Ohtani, N; Suda, K; Tanemura, K; Tsuji, E; Yokota, H, 2017)	0.46
"Thermal paper contains potentially toxic additives, such as bisphenol A (BPA), as a common color developer."	( Bisphenol A alternatives in thermal paper from the Netherlands, Spain, Sweden and Norway. Screening and potential toxicity. Ballesteros-Gómez, A; Björnsdotter, MK; Jonker, W; Kool, J; Legradi, J, 2017)	2.14
" In conclusion, chronic exposure to a low level of BPA had adverse effects on brain cells and altered the learning and memory ability of adolescent mice."	( Neurotoxicity of low bisphenol A (BPA) exposure for young male mice: Implications for children exposed to environmental levels of BPA. Fan, R; Gong, X; Li, C; Lu, S; Pan, J; Pang, Q; Wang, Z; Xia, M; Zhou, Y; Zhuang, S, 2017)	0.77
" The same product was also the most toxic to water flea reproduction, requiring ca."	( Corrosion protection products as a source of bisphenol A and toxicity to the aquatic environment. Burkhardt, M; Dietschweiler, C; Vermeirssen, ELM; Werner, I, 2017)	0.71
"Plastic particles have been proven to be abundant in the aquatic environment, raising concerns about their potential toxic effects."	( Enhanced uptake of BPA in the presence of nanoplastics can lead to neurotoxic effects in adult zebrafish. Chen, Q; Hollert, H; Jia, Y; Legradi, J; Schiwy, S; Yang, S; Yin, D, 2017)	0.46
" Thus, its capability to alleviate the toxic effect of BPA on Nile tilapia, Oreochromis niloticus (L."	( Ameliorative effect of propolis supplementation on alleviating bisphenol-A toxicity: Growth performance, biochemical variables, and oxidative stress biomarkers of Nile tilapia, Oreochromis niloticus (L.) fingerlings. Abdel-Tawwab, M; Hamed, HS, 2017)	0.46
"Bisphenol A (BPA), a chemical incorporated into plastics and resins, has estrogenic activity and is associated with adverse health effects in humans and wildlife."	( Acute Toxicity, Teratogenic, and Estrogenic Effects of Bisphenol A and Its Alternative Replacements Bisphenol S, Bisphenol F, and Bisphenol AF in Zebrafish Embryo-Larvae. David, A; Kudoh, T; Lee, O; Moreman, J; Trznadel, M; Tyler, CR, 2017)	2.15
" This research also demonstrated that the toxic effect of BPA on liver is induced by oxidative stress."	( Low dose administration of Bisphenol A induces liver toxicity in adult rats. Ghasemi-Kasman, M; Kazemi, S; Moghadamnia, AA; Mousavi Kani, SN; Pouramir, M; Rezazadeh, L, 2017)	0.75
" phospholipophilicity) were determined by immobilized artificial membrane liquid chromatography (IAM-LC) and possible relationships with in vitro toxic activity were also investigated."	( Cytotoxicity of seven bisphenol analogues compared to bisphenol A and relationships with membrane affinity data. Barbato, F; Capuozzo, A; Grumetto, L; Irace, C; Russo, G; Santamaria, R, 2018)	0.8
"A growing body of evidence has shown bisphenol A (BPA), an estrogen-like industrial chemical, has adverse effects on the nervous system."	( Microarray expression profiling and co-expression network analysis of circulating LncRNAs and mRNAs associated with neurotoxicity induced by BPA. Gao, ZX; Jiang, YG; Leng, X; Li, KR; Li, YB; Lian, FZ; Pang, W; Wang, SM; Wang, ZY, 2018)	0.75
" However, BPA is known to act as an endocrine disruptor and has been found to be toxic to human health."	( Cytotoxicity measurement of Bisphenol A (BPA) and its substitutes using human keratinocytes. Gye, MC; Kim, H; Nam, K; Shin, I; Son, S, 2018)	0.77
" The results confirm the reprotoxicity of DEHP and BPA as endocrine disruptors and indicate that ginseng could be used to alleviate the toxic effects of these chemicals."	( Ameliorative effect of ginseng extract on phthalate and bisphenol A reprotoxicity during pregnancy in rats. Abdel-Aziz Swelum, A; Abohassan, MG; Ahmed, MM; Hussein, MA; Moumen, AF; Moustafa, AA; Saadeldin, IM; Suleiman, AH, 2018)	0.73
"Because of increasing concerns about its toxic effects, bisphenol A (BPA) has been gradually replaced in industrial applications by analogs such as bisphenol S (BPS)."	( Ecotoxicity of bisphenol S to Caenorhabditis elegans by prolonged exposure in comparison with bisphenol A. Zhou, D, 2018)	0.95
" It appears that the toxic effects of BPA on testis might be minimized by FA treatment."	( Effects of folic acid on testicular toxicity induced by bisphenol-A in male Wistar rats. Gules, O; Naseer, Z; Tatar, M; Yildiz, M, 2019)	0.51
" Studies conducted on the neurotoxicity of BPA demonstrated that at excessive, high concentrations (≥ 200 µM) adverse responses occurred which were not detectable using traditional toxicity tests at lower chemical quantities than 200 µM."	( Sensitive neurotoxicity assessment of bisphenol A using double immunocytochemistry of DCX and MAP2. Chang, SC; Cho, JH; Kim, AH; Lee, J; Lee, S; Lee, WJ; Lee, Y, 2018)	0.75
" Bisphenol A (BPA) is a widespread environmental chemical that has been associated with adverse endocrine and neurodevelopmental effects, some of which may be mediated by microbiota."	( Host Developmental Toxicity of BPA and BPA Alternatives Is Inversely Related to Microbiota Disruption in Zebrafish. Brinkman, NE; Catron, TR; Gaballah, S; Keely, SP; Kvasnicka, A; Lamendella, R; Phelps, D; Tal, T; Wheaton, E; Wood, CE; Wright, JR; Zurlinden, TJ, 2019)	1.42
"Bisphenol A (BPA) is an abundant endocrine-disrupting compound that is found in the aquatic environment and has adverse effects on fish reproduction; however, the exact pathway of these impacts is unclear."	( Toxic effects of bisphenol A on goldfish gonad development and the possible pathway of BPA disturbance in female and male fish reproduction. Li, Y; Liu, X; Wang, Q; Wang, Y; Xiao, S; Yan, M; Yang, H; Yang, M; Yang, Y; Yu, Y; Zhao, H; Zheng, L; Zhou, L, 2019)	2.3
"Recent studies have demonstrated that bisphenol A (BPA) has an adverse or toxic effect on the kidney."	( The ameliorative effect of quercetin on bisphenol A-induced toxicity in mitochondria isolated from rats. Alizadeh, S; Dehghani, MA; Mahdavinia, M; Shirani, M, 2019)	1.05
" In addition, non-monotonic dose-response relationships were observed between the concentrations of bisphenols and the toxic effects mentioned above."	( Neurotoxicity of BPA, BPS, and BPB for the hippocampal cell line (HT-22): An implication for the replacement of BPA in plastics. Fan, R; Li, G; Li, Y; Luo, Z; Meng, L; Pang, Q, 2019)	0.51
" There is evidence that BHPF exerts an antioestrogenic effect on mice, induces endometrial atrophy and leads to adverse pregnancy outcomes."	( Fluorene-9-bisphenol exposure induces cytotoxicity in mouse oocytes and causes ovarian damage. Feng, D; Feng, X; Feng, Z; Jia, Z; Liu, Q; Wang, H; Wang, L; Zhang, J; Zhang, S; Zhao, X, 2019)	0.51
" Since the replacement of BPA by its analogues, their presence has been found to increase in the environment leading to increased human exposure that makes it essential to investigate their toxic effects."	( In vitro study to evaluate the cytotoxicity of BPA analogues based on their oxidative and genotoxic potential using human peripheral blood cells. Ahmad, M; Ikhlas, S; Usman, A, 2019)	0.51
" The present study was aimed to investigate the adverse effects of BPA and its protection by taurine and curcumin."	( Testicular toxicity of orally administrated bisphenol A in rats and protective role of taurine and curcumin. Apaydin, FG; Kalender, S; Kalender, Y, 2019)	0.78
"Bisphenol analogues including bisphenol A and its derivatives are ubiquitous environmental contaminants and have been linked to adverse neurodevelopment effects on animals and humans."	( New insights into mechanism of bisphenol analogue neurotoxicity: implications of inhibition of O-GlcNAcase activity in PC12 cells. Faiola, F; Gu, YX; Guo, LH; Liang, XX; Wan, B; Yang, Y; Yin, NY, 2019)	2.24
" To evaluate the cardio toxicity of bisphenol A and to assess copeptin as a cardio toxic diagnostic and prognostic biomarker in Wistar rats."	( Role of copeptin as a novel biomarker of bisphenol A toxic effects on cardiac tissues: biochemical, histological, immunohistological, and genotoxic study. Amin, DM, 2019)	1.05
" Recently, we developed a novel in vitro three-dimensional (3D) testicular cell co-culture model, enabling the classification of reproductive toxic substances."	( High-Content Image-Based Single-Cell Phenotypic Analysis for the Testicular Toxicity Prediction Induced by Bisphenol A and Its Analogs Bisphenol S, Bisphenol AF, and Tetrabromobisphenol A in a Three-Dimensional Testicular Cell Co-culture Model. Edenfield, C; Guan, X; Liang, S; Measel, E; Siracusa, JS; Yin, L; Yu, X, 2020)	0.77
" Thus, our findings provide insights into the molecular mechanisms of bisphenol-dependent neurotoxicity at low nanomolar levels and support the view that BPA substitutes may not be sufficiently safe for widespread use as industrial chemicals."	( Bisphenol A and several derivatives exert neural toxicity in human neuron-like cells by decreasing neurite length. Faiola, F; Jiang, G; Jiang, L; Liang, S; Liang, X; Liu, S; Lu, Y; Yang, R; Yin, N; Zhou, Q, 2020)	2
" The aim of this study on male rats was to compare the subacute toxic effects of low doses of single compounds (bis (2 -ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA)) with the effects of their mixture through different biochemical, hormonal, and hematological parameters."	( Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats. Antonijević, B; Antonijević, E; Anđelković, M; Baralić, K; Buha Djordjevic, A; Bulat, Z; Ćurčić, M; Javorac, D; Živančević, K; Đukić-Ćosić, D, 2020)	1.01
" BPA exposure especially occupational perinatal exposure to has been linked to numerous adverse effects for the offspring."	( Prenatal bisphenol A exposure contributes to Tau pathology: Potential roles of CDK5/GSK3β/PP2A axis in BPA-induced neurotoxicity. Gao, R; Gao, Y; Jiang, L; Wang, J; Wang, Y; Xiao, H; Xie, X; Xue, J; Yu, J; Zhang, L, 2020)	0.98
" VAM co-administration to BPA-treated rats attenuated the toxic effects of BPA and restored the body and testis weights."	( Gonadoprotective ability of Vincetoxicum arnottianum extract against bisphenol A-induced testicular toxicity and hormonal imbalance in male Sprague Dawley rats. Khan, MR; Majid, M; Maryam, S; Sajid, M; Zahra, Z, 2020)	0.79
" In this study, curcumin and taurine application provided protection against renal toxicity caused by BPA but did not prevent toxic effect completely."	( Protective potential of curcumin or taurine on nephrotoxicity caused by bisphenol A. Aslanturk, A; Uzunhisarcikli, M, 2020)	0.79
"Bisphenol A (BPA) is one of the widely used chemical as a plasticizer and regarded as endocrine disruptor because of its ability to derail body metabolic functions and adverse effect on the vital organs."	( Subchronic toxicity of bisphenol A on the architecture of spleen and hepatic trace metals and protein profile of adult male Wistar rats. Abbasi, MH; Akhtar, T; Basit, F; Hameed, N; Sheikh, N, 2020)	2.31
" In fact, the brain has consistently emerged as one of the most sensitive organs disrupted by BPA, even at doses below those considered safe by regulatory agencies such as the European Food Safety Authority (EFSA)."	( Bisphenol A shapes children's brain and behavior: towards an integrated neurotoxicity assessment including human data. Fernández, MF; Mustieles, V, 2020)	2
" Our study indicates a novel and safe strategy that utilizes LA to repair reproductive damage caused by low testosterone levels through activating the GPR120/ERK pathway in Leydig cells."	( Linoleic acid promotes testosterone production by activating Leydig cell GPR120/ ERK pathway and restores BPA-impaired testicular toxicity. Gong, D; Huang, L; Li, K; Li, X; Li, Y; Lin, P; Xu, A; Yuan, M; Zhang, J; Zhao, G; Zheng, Q, 2020)	0.56
" integerrima has shown its ameliorative potential by mitigating the adverse effects of BPA."	( Pistacia integerrima alleviated Bisphenol A induced toxicity through Ubc13/p53 signalling. Ajmal, S; Ali, T; Anees, M; Bakhtiar, A; Ishtiaq, A; Khan, U; Khan, W; Murtaza, I; Mushtaq, I; Saeed, J; Silas, E; Sultan, A; Wahedi, HM, 2020)	0.84
" Furthermore, the results demonstrated that the toxic impacts exerted by BPA were significantly aggravated by the co-presence of MPs, which may be due to interactions between BPA and MPs as well as those between MPs and clam individuals."	( Immunotoxicity and neurotoxicity of bisphenol A and microplastics alone or in combination to a bivalve species, Tegillarca granosa. Du, X; Han, Y; Liu, G; Shi, W; Sun, S; Tang, Y; Zhou, W, 2020)	0.83
" Although multiple toxicities have been reported for BPA, molecular mechanisms underlying the transgenerational toxic effects of BPA are still underestimated."	( A transcriptomics-based analysis of toxicity mechanisms of zebrafish embryos and larvae following parental Bisphenol A exposure. Cai, Z; Huang, W; Liu, C; Wang, X; Wu, K; Xiao, J; Zheng, S, 2020)	0.77
" These findings advanced the field of the parental-mediated subsequent generational toxic effects of BPA."	( A transcriptomics-based analysis of toxicity mechanisms of zebrafish embryos and larvae following parental Bisphenol A exposure. Cai, Z; Huang, W; Liu, C; Wang, X; Wu, K; Xiao, J; Zheng, S, 2020)	0.77
" Thus, our study suggests that BPA at environmentally relevant concentrations might cause reproductive dysfunction in seahorses, potentially exerting adverse effects on the seahorse population since most of them inhabit shallow coastal areas with prevalent estrogenic contaminants."	( Bioaccumulation and reproductive toxicity of bisphenol A in male-pregnant seahorse (Hippocampus erectus) at environmentally relevant concentrations. Chen, Y; Lin, Q; Liu, Y; Qin, G; Wang, X; Wu, Y, 2021)	0.88
" Compound 2,6-dibromo-4-[3,5-dibromo-4-(2-hydroxyethoxy)benzene-1-sulfonyl]phenol was more toxic than other compounds in various cells, and the sensitivity of this compound to the normal hepatocytes and cancer cells was inconsistent."	( Synthesis and Toxicity of Halogenated Bisphenol Monosubstituted-Ethers: Establishing a Library for Potential Environmental Transformation Products of Emerging Contaminant. Cao, M; Deng, W; Gao, Y; Guo, R; Hu, M; Shi, J; Ye, S; Zhang, W; Zhou, W, 2020)	0.56
" In this study, the obese model of laying hens were induced using high-fat diet (HFD) to determine the lipid metabolism interference of BPA, especially its influence on estrogen receptors (ERs) and oxidative damage, at the dose of tolerable daily intake (TDI, 50 μg/kg body weight [BW]/day) and no observable adverse effect level (NOAEL, 5000 μg/kg BW/day)."	( Effects of bisphenol A at the safe reference dose on abdominal fat deposition in aged hens. Ding, C; Fan, W; Gao, X; Gao, Z; Li, M; Liu, S; Miao, Y; Shi, X; Song, S; Tan, L, 2020)	0.95
" We found bisphenol A has more adverse effects on male sexual behavior than females."	( Genes regulating development and behavior exhibited altered expression in Drosophila melanogaster exposed to bisphenol A: use of real-time quantitative PCR (qRT-PCR) and droplet digital PCR (ddPCR) in genotoxicity study. Begum, M; Bhattacharjee, A; Chakraborty, K; Das, D; Ghosh, S; Paul, P, 2021)	1.24
" The current data supports that exposure to BPs may have adverse effects on dysfunction of endocrine system such as thyroid hormone concentration, enzyme activity, and even cell dysfunction, gene damage and chromosomal abnormalities."	( Occurrence, toxicity and ecological risk of Bisphenol A analogues in aquatic environment - A review. Jiang, R; Li, Y; Liu, J; Lu, G; Yan, Z; Zhang, L, 2021)	0.88
" The combination of these chemicals is hypothesized to have a toxic impact on the fetus."	( The effect of hormonal levels and oxidative stress on bisphenol A and soy isoflavone reproductive toxicity in murine offspring. Huang, Y; Liu, Y; Lu, Y; Mo, J; Niu, Y; Wang, S; Yang, L; Yi, P; Zhao, Y; Zou, H, 2020)	0.81
" Nevertheless, only few studies have reported on the toxic effect of bisphenol analogues on phytoplankton."	( Toxic effects of bisphenol A and its analogues on cyanobacteria Anabaena variabilis and Microcystis aeruginosa. Czarny, K; Krawczyk, B; Szczukocki, D, 2021)	1.2
" Concerning the possible toxicity of BPA, no conclusive scientific evidence could be drawn, but it seems that orthodontic biomaterials containing BPA have potential adverse biological effects in humans."	( Release and toxicity of bisphenol-A (BPA) contained in orthodontic adhesives: A systematic review. Bauer, C; El Helou, M; Roger-Leroi, V; Sabour, A, 2021)	0.62
"Until we have solid evidence from clinical trials, clinicians should consider that orthodontic adhesives containing BPA have potential short- and long-term adverse biological effects in humans."	( Release and toxicity of bisphenol-A (BPA) contained in orthodontic adhesives: A systematic review. Bauer, C; El Helou, M; Roger-Leroi, V; Sabour, A, 2021)	0.62
"The huge production and application of bisphenol A (BPA) and graphene oxide (GO) inevitably lead to their co-presence in aquatic ecosystems, which might cause joint toxic effects to aquatic organisms."	( Mechanisms for the impacts of graphene oxide on the developmental toxicity and endocrine disruption induced by bisphenol A on zebrafish larvae. Chen, P; Liu, S; Xiao, B; Yang, J; Zhang, Y; Zhu, L, 2021)	1.1
" However, melatonin treatment significantly attenuated BPA-induced toxic effects by scavenging ROS, boosting antioxidant enzyme activities, and interestingly enervated brain apoptosis by normalizing p53, PUMA, and Drp-1 expressions at both transcriptional and translational level."	( Melatonin abated Bisphenol A-induced neurotoxicity via p53/PUMA/Drp-1 signaling. Ali, T; Anees, M; Anis, RA; Bakhtiar, A; Bibi, K; Bibi, R; Ishtiaq, A; Khan, U; Khan, W; Li, S; Murtaza, I; Mushtaq, I; Sultan, A, 2021)	0.96
" deltoidea has the potential to counter the toxic effects of BPA on the female reproductive system."	( Protective role of Mas Cotek (Ficus deltoidea) against the toxic effects of bisphenol A on morphology and sex steroid receptor expression in the rat uterus. Kassim, NM; Othman, S; Zaid, SSM, 2021)	0.85
"Bisphenol A (BPA) is a widely used chemical with toxic effects on the liver."	( A Quantitative Study on the Protective Effects of Resveratrol against Bisphenol A-induced Hepatotoxicity in Rats: A Stereological Study. Bordbar, H; Fazelian-Dehkordi, K; Nadimi, E; Soleymani, F; Yahyavi, SS, 2021)	2.3
" The purpose of this study was to study the toxic effects of BPA on the biochemical variables and oxidative stress in female African catfish, Clarias gariepinus and to estimate the protective role of chitosan nanoparticles (CSNPs) against BPA toxicity."	( Chitosan nanoparticles alleviated endocrine disruption, oxidative damage, and genotoxicity of Bisphenol-A- intoxicated female African catfish. Ali, RM; Hamed, HS; Hussein, NM; Shaheen, AA, 2021)	0.62
"Bisphenol A (BPA), which is used in a variety of consumer-related plastic products, was reported to cause adverse effects, including disruption of adipocyte differentiation, interference with obesity mechanisms, and impairment of insulin- and glucose homeostasis."	( Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Bauer, M; Blüher, M; Escher, BI; Heiker, JT; Junge, KM; Karkossa, I; Körner, A; Krieg, L; Landgraf, K; Lehmann, J; Schaffert, A; Schlichting, R; Schubert, K; Ueberham, E; von Bergen, M; Wabitsch, M; Weiner, J; Zenclussen, AC, 2021)	2.3
" Perturbations of these endpoints are described as common key events in adverse outcome pathways (AOPs) specific for DNT."	( Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures. Bal-Price, A; Bopp, SK; Carpi, D; Mendoza-de Gyves, E; Paini, A; Pistollato, F; Worth, A, 2021)	0.62
"Bisphenol A (or BPA) is a toxic endocrine disrupting chemical that is released into the environment through modern manufacturing practices."	( The hazardous threat of Bisphenol A: Toxicity, detection and remediation. Balakumaran, PA; Binod, P; Kumar, D; Kumar, Y; Madhavan, A; Reshmy, R; Sim, SJ; Sindhu, R; Sirohi, R; Tarafdar, A, 2022)	2.47
" Several epidemiological and animal studies have demonstrated the correlation between pollutants and gastrointestinal diseases, but detailed molecular mechanisms responsible for adverse effects of environmental pollutants on UC are still unknown."	( Analyzing the synergistic adverse effects of BPA and its substitute, BHPF, on ulcerative colitis through comparative metabolomics. Chan, TF; Huang, X; Lai, KP; Li, R; Lin, X; Yin, F, 2022)	0.72
"In the present study, toxic effects, both alone and combined, of bisphenol A (BPA), lead (Pb) and endosulfan (ES) in the low doses were investigated in rat liver and kidney functions."	( Toxicological assessment of low-dose bisphenol A, lead and endosulfan combination: chronic toxicity study in male rats. Dökmeci, AH; Erboğa, ZF; Güzel, S; Karaboğa, İ; Yılmaz, A, 2022)	1.23
"Due to the prevalence of hypertension (one of the major risk factors of CVD) in the population, it is necessary to explore the adverse effects of daily tolerable and "safe" dose of bisphenol A (BPA) under hypertensive conditions."	( Exposure to a "safe" dose of environmental pollutant bisphenol A elevates oxidative stress and modulates vasoactive system in hypertensive rats. Manivannan, J; Nagarajan, M; Raja, B, 2021)	1.06
"Bisphenol-A (BPA), an environmental endocrine disruptor, is toxic to the central nervous system."	( Bisphenol-A exposure leads to neurotoxicity through upregulating the expression of histone deacetylase 2 in vivo and in vitro. Bi, N; Fan, A; Gu, X; Li, D; Sun, QC; Wang, HL; Wang, M; Zhou, R, 2022)	0.72
"Bisphenol A (BPA) exposure has many adverse effects on the reproductive system in animals and humans."	( TET1 mediated male reproductive toxicity induced by Bisphenol A through Catsper-Ca Cao, J; Chen, HQ; Fan, J; Li, JZ; Liu, JY; Liu, WB; Yuan, WB; Zeng, Y; Zhang, Z; Zhou, SM, 2022)	2.41
" Its inhalation or ingestion from particles in suspension, water, and/or polluted foods can trigger toxic effects related to endocrine disruption, resulting in hormonal, reproduction, and immunological alterations in humans and animals."	( Evaluation of the Toxicity of Bisphenol A in Reproduction and Its Effect on Fertility and Embryonic Development in the Zebrafish ( Ayala-Soldado, N; Lora-Benítez, AJ; Molina-López, AM; Mora-Medina, R; Moyano-Salvago, MDR; Reis, LPG, 2022)	1.01
" Both epidemiological and experimental studies have reported associations between BPA exposure and adverse cardiovascular health outcomes."	( Characteristics of Bisphenol Cardiotoxicity: Impaired Excitability, Contractility, and Relaxation. Cooper, BL; Posnack, NG, 2022)	0.72
"Bisphenol A (BPA) is of great concern in public health, of which female reproductive toxicity is one major adverse health effect with the unclear mode of action (MOA) yet."	( Transcriptomics analysis and benchmark concentration estimating-based in vitro test with IOSE80 cells to unveil the mode of action for female reproductive toxicity of bisphenol A at human-relevant levels. Chen, J; Li, X; Ni, M; Tian, L; Xiong, W; Yang, Z; Zhang, L, 2022)	2.36
" Overall, our studies indicated that BPS, BPF, and BPAF could induce testicular toxic effects similar to that of BPA, which were associated with the PPARα pathway."	( Testicular toxicity of bisphenol compounds: Homeostasis disruption of cholesterol/testosterone via PPARα activation. Ding, C; Fan, W; Gao, X; Gao, Z; Li, M; Liu, S; Luo, Y; Shi, X; Song, S; Tan, L; Tang, Z, 2022)	0.72
" The toxic effects elicited by the bisphenols were both concentration- and duration-dependent."	( Cytotoxicity, redox and immune status in African catfish, Clarias gariepinus (Burchell, 1822) exposed to bisphenol A (BPA) and its analogues. Adedire, CO; Adeyemi, JA; Bamidele, OS; Barbosa, F; Samuel, OD, 2022)	0.94
" An adverse effect on the hematological system arising out of xenobiotic exposure causes impaired hemostasis and coagulation leading to disease."	( Hematotoxicity of Co-Administration of Bisphenol A and Acetaminophen in Rats and its Amelioration by Melatonin. Akhter, MS; Alshahrani, S; Dobie, G; Hamali, HA; Madkhali, AM; Mobarki, AA; Qadri, M; Rashid, H, 2023)	1.18
" BPA exposure has toxic effects on the glandular portion of the stomach in rats."	( Curcumin ameliorated low dose-Bisphenol A induced gastric toxicity in adult albino rats. El-Meligy, MMS; Ismail, OI, 2022)	1.01
" We determined that BPA administration causes apoptosis, histological damage, inflammation, oxidative stress and toxic effects on spermatogenesis and steroidogenic enzymes in testicles."	( Investigation of the effect of hesperidin on some reproductive parameters in testicular toxicity induced by Bisphenol A. Çelebi, F; Tekin, S, 2022)	0.93
"BPA is a known endocrine-disrupting agent that is capable of binding to the estrogen receptor and has exhibited adverse effects in many laboratory animal and in vitro studies."	( Adverse Effects of Bisphenol A on the Liver and Its Underlying Mechanisms: Evidence from Abdulhameed, AAR; Abdullah, MNH; Bahari, H; Khoo, BY; Lim, V; Tan, JJ; Yong, YK, 2022)	1.05
" In this review, we highlight existing experimental evidence of NPs against BPA exposure-induced adverse effects, which involve the body's reproductive, neurological, hepatic, renal, cardiovascular, and endocrine systems."	( Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use. Abu, IF; Al-Huseini, I; Das, S; Juliana, N; Moqadass, M; Sakr, H; Sirasanagandla, SR, 2022)	1
" However, the combined toxic effect of MP and BPA on human liver is unclear."	( Combined effect of polystyrene microplastics and bisphenol A on the human embryonic stem cells-derived liver organoids: The hepatotoxicity and lipid accumulation. Cheng, W; Feng, Y; Li, Y; Wang, H; Wang, Y; Xie, Y; Zhou, R; Zhou, Y, 2023)	1.16
" The frequent detection of bisphenols in maternal and fetal samples has raised concerns about their toxic effects on human embryonic development, especially on the development of the central nervous system."	( Development of human retinal organoid models for bisphenol toxicity assessment. Fang, Y; Gao, H; Ge, L; Gong, J; Kang, J; Li, M; Xu, H; Yang, C; Yang, J, 2022)	0.72
"Every day, we are exposed to many environmental pollutants that can enter our body through different routes and cause adverse effects on our health."	( Interaction between environmental pollutants and cancer drug efficacy: Bisphenol A, Bisphenol A diglycidyl ether and Perfluorooctanoic acid reduce vincristine cytotoxicity in acute lymphoblastic leukemia cells. Lagunas-Rangel, FA; Liu, W; Schiöth, HB, 2023)	1.14
" Pretreatment of mito-TEMPO protected animals from toxic effects of BPA as indicated by the normalization of sperm parameters and preserved histoarchitecture of testis."	( Mito-TEMPO protects against bisphenol-A-induced testicular toxicity: an in vivo study. Bharati, S; Kumar, V; Ramesh, V; Shetty, S, )	0.13
"Plastic pollution is recognized as a global environmental threat and concern is increasing regarding the potential interactions of the smallest fragments, nanoplastics (1 µm), with either physical and chemical entities encountered in the natural environment, including toxic pollutants."	( Short-Term Exposure to Nanoplastics Does Not Affect Bisphenol A Embryotoxicity to Marine Ascidian Bellingeri, A; Corsi, I; Eliso, MC; Ferrari, E; Spagnuolo, A, 2022)	0.97
"Bisphenols are frequently found in the environment and have been of emerging concern because of their adverse effects on aquatic animals and humans."	( Bisphenols induce cardiotoxicity in zebrafish embryos: Role of the thyroid hormone receptor pathway. Hao, L; Jia, W; Qin, JY; Ru, S; Wang, J; Wang, W; Xiong, JQ; Zhang, X, 2023)	0.91
" The primary objective of this study was to summarise and analyse multiple toxicity endpoints of adverse reproductive effects caused by BPA exposure in rodent models."	( Hazard characterization of bisphenol A (BPA) based on rodent models - Multilevel meta-analysis and dose-response analysis for reproductive toxicity. Bakar Siddique, MA; Brunton, NP; Cummins, E; Harrison, SM; Monahan, FJ; Nag, R; Wang, X, 2023)	1.21
" Because of its adverse effects, the European Union has restricted its use to protect human health and the environment."	( Adverse (geno)toxic effects of bisphenol A and its analogues in hepatic 3D cell model. Figueras, A; Fras, K; Novoa, B; Sendra, M; Štampar, M; Žegura, B, 2023)	1.2
" The ubiquitous occurrence of bisphenol A and its substitutes in the environment and their endocrine activity as well as adverse effects on aquatic organisms is a global concern, especially because many available literature reports show that many substitutes (e."	( Bisphenol A and its substitutes in the aquatic environment: Occurrence and toxicity assessment. Czarny-Krzymińska, K; Krawczyk, B; Szczukocki, D, 2023)	2.64
"Bisphenol A (BPA) is putatively regarded as an environmental neurotoxicant found in everyday plastic products and materials, however, the possible neurobehavioral adverse consequences and molecular mechanisms in animals have not been clearly characterized."	( Neurotoxicity of bisphenol A exposure on Caenorhabditis elegans induced by disturbance of neurotransmitter and oxidative damage. Chen, L; Gai, T; Wang, S; Wang, Y; Ye, T; Zhang, L; Zhang, W, 2023)	2.69
" Our results showed that many BPA analogues are more toxic than BPA in the embryonic zebrafish assay regarding teratogenic effect and mortality, which may partially due to differences in lipophilicity and/or different substitutes of structural function groups such as CF3, benzene, or cyclohexane."	( Structure-based developmental toxicity and ASD-phenotypes of bisphenol A analogues in embryonic zebrafish. Bai, C; Chen, J; Dong, Q; Huang, C; Lin, J; Song, Y; Tian, L; Zheng, Y, 2023)	1.15
" The toxic effects of polystyrene nanoplastics (PS-NPs) and BPA were examined in this study, as well as the combined toxic impacts of these substances on the freshwater microalgae Scenedesmus obliquus."	( The role of algal EPS in reducing the combined toxicity of BPA and polystyrene nanoparticles to the freshwater algae Scenedesmus obliquus. Chandrasekaran, N; Christudoss, AC; Giri, S; Mukherjee, A; Peijnenburg, WJGM, 2023)	0.91
"Bisphenol A (BPA) and its analogs are common environmental chemicals with many potential adverse health effects."	( Proarrhythmic toxicity of low dose bisphenol A and its analogs in human iPSC-derived cardiomyocytes and human cardiac organoids through delay of cardiac repolarization. Jagani, R; Ma, J; Wang, HS; Wang, NY, 2023)	2.63
" In the present study, we investigated the toxic effects caused by single bisphenols and by the combined exposure of BPA and its two analogues, BPAP and BPC, after short (24-h) and prolonged (96-h) exposure in HepG2 spheroids."	( Combined Toxic Effects of BPA and Its Two Analogues BPAP and BPC in a 3D HepG2 Cell Model. Domijan, AM; Ravnjak, T; Štampar, M; Žegura, B, 2023)	0.91
" Here, we evaluated the toxic effects of five common BPs on freshwater microalga Chlamydomonas mexicana and removal of the BPs by the alga."	( Fate of five bisphenol derivatives in Chlamydomonas mexicana: Toxicity, removal, biotransformation and microalgal metabolism. Ahn, HJ; Ahn, Y; Jeon, BH; Khan, MA; Kurade, MB; Li, X; Park, YK; Salama, ES; Yadav, N, 2023)	0.91
" Bisphenols were shown to have a toxic effect on the cardiovascular system of larvae and can cause neurotoxicity and endocrine disruption, such as changes to thyroid-related hormones."	( Effects of bisphenols on lipid metabolism and neuro-cardiovascular toxicity in marine medaka larvae. Dong, Z; Gao, J; Guo, Y; He, X; Li, W; Li, X; Lin, X; Wang, Z; Zhang, B; Zhang, N; Zhao, N, 2023)	0.91
" In summary, this study revealed that mixture exposure to PSNPs and BPA exacerbated toxic effects on histopathology, oxidative stress, immune function and intestinal microbiota in channel catfish."	( Combined exposure to polystyrene nanoplastics and bisphenol A induces hepato- and intestinal-toxicity and disturbs gut microbiota in channel catfish (Ictalurus punctatus). Cui, L; Gao, D; Junaid, M; Li, Z; Liao, H; Liu, S; Lu, S; Qiu, J; Wang, J; Zheng, Q; Zheng, Y, 2023)	1.16
" In this study, we conducted BPS toxicity tests on aquatic plants (acute), cladocerans (acute and chronic), and fish (chronic) to determine its adverse effects, and calculated the toxicity values."	( Identification of aquatic ecological risk of bisphenol S in four Asian countries based on the SSD and alternative toxicity data of model species Danio rerio. Bae, S; Chae, Y; Kim, DW; Kim, S; Kim, YJ; Moon, HG; Park, CB; Park, JW; Seo, JS, 2023)	0.91
" However, there are no effective methods for assessing the neurodevelopmental toxic effects of BPs."	( Developmental neurotoxic effects of bisphenol A and its derivatives in Drosophila melanogaster. Song, Y; Sun, M; Wang, B; Wang, J; Wu, C; Zhang, K; Zhang, X, 2023)	1.19
" When co-exposed, BPA mitigated all the adverse developmental effects caused by PS-NPs."	( Bisphenol A decreases the developmental toxicity and histopathological alterations caused by polystyrene nanoplastics in developing marine medaka Oryzias melastigma. Chen, J; Cong, Y; Ding, B; Jin, F; Li, R; Li, Z; Lou, Y; Wang, J; Wang, Y; Yu, F, 2023)	2.35
" Our findings suggest that vitamins could act as an endocrine disruptor, and melatonin is most effective in protecting against the toxic effects of bisphenols."	( Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis. Cerbón-Gutiérrez, JL; Chávez-Corona, JI; Herrera-Barragán, JA; Leyva-Gómez, G; Mendoza-Rodríguez, CA; Peña-Corona, SI; Pérez-Caltzontzin, LE; Quintanar-Guerrero, D; Ramos-Martínez, E; Vargas-Estrada, D, 2023)	0.91
" Different adverse effects of BPA are still under investigation, and multiple mechanisms of action remain unexplored."	( IVIVE-PBPK based new approach methodology for addressing early life toxicity induced by Bisphenol A. Chen, J; Deepika, D; Kumar, V; Li, X; Ni, M; Xiong, W; Zhang, L, 2024)	1.66

Pharmacokinetics

A physiologically based pharmacokinetic (PBPK) model was developed to predict the tissue distribution and blood pharmacokinetics of bisphenol A in rats and humans. The model includes vein, artery, lung, liver, spleen, kidneys, heart, testes, muscle, brain, adipose tissue, stomach, and small intestine.

Excerpt	Reference	Relevance
"5, 1, or 2 mg/kg, serum levels of bisphenol A declined biexponentially, with mean initial distribution and elimination half-life ranges of 4-8."	( Pharmacokinetic disposition and tissue distribution of bisphenol A in rats after intravenous administration. Han, SY; Kim, HS; Kwack, SJ; Lee, BM; Park, KL; Shin, BS; Yoo, SD, 2000)	0.83
" The study was performed to predict the pharmacokinetic disposition of bisphenol A in humans using simple allometry and several species-invariant time methods based on animal data."	( Pharmacokinetic scaling of bisphenol A by species-invariant time methods. Cho, CY; Han, SY; Jung, JH; Kim, DH; Kim, HS; Lee, BM; Lee, KC; Shin, BS; Yoo, SD, 2002)	0.84
" Accurate comparison of the potency of endocrine active compounds requires characterization of biochemical and pharmacokinetic factors that affect their free concentration."	( Computational modeling of serum-binding proteins and clearance in extrapolations across life stages and species for endocrine active compounds. Barton, HA; Teeguarden, JG, 2004)	0.32
"A physiologically based pharmacokinetic (PBPK) model consisting of vein, artery, lung, liver, spleen, kidneys, heart, testes, muscle, brain, adipose tissue, stomach, and small intestine was developed to predict the tissue distribution and blood pharmacokinetics of bisphenol A in rats and humans."	( Physiologically based pharmacokinetics of bisphenol A. Han, SY; Jun, YS; Kim, CH; Kim, DH; Kim, HS; Lee, BM; Lee, KC; Park, EH; Park, KL; Shin, BS; Yoo, SD; Yoon, CH, 2004)	0.77
" A physiologically based pharmacokinetic (PBPK) model of BPA pharmacokinetics in rats and humans was developed to provide a physiological context in which the processes controlling BPA pharmacokinetics (e."	( Evaluation of oral and intravenous route pharmacokinetics, plasma protein binding, and uterine tissue dose metrics of bisphenol A: a physiologically based pharmacokinetic approach. Barton, HA; Clewell, HJ; Covington, TR; Teeguarden, JG; Waechter, JM, 2005)	0.54
" To date, no physiologically based pharmacokinetic (PBPK) model has been located for BPA in pregnant mice with or without fetuses."	( Development of a physiologically based pharmacokinetic model for bisphenol A in pregnant mice. Chan, MP; Hishikawa, J; Kawamoto, Y; Matsuyama, W; Morisawa, S; Nakayama, A; Wada, M, 2007)	0.58
" The concentration-time profiles observed in adult monkeys following oral administration of 100 μg/kg bw were remarkably similar to those previously reported in human volunteers given a similar dose; moreover, minimal pharmacokinetic differences were observed between neonatal and adult monkeys for the receptor-active aglycone form of BPA."	( Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys. Doerge, DR; Fisher, JW; Twaddle, NC; Woodling, KA, 2010)	0.68
"The objective of this study was to predict the exposure to bisphenol A (BPA) after oral intake in human blood and tissues using physiologically based pharmacokinetic (PBPK) modeling."	( Assessment of bisphenol A exposure in Korean pregnant women by physiologically based pharmacokinetic modeling. Bulitta, JB; Hwang, SW; Kim, DJ; Kwon, MC; Lee, JB; Park, JS; Shin, BS; Yang, SD; Yoo, SD; Yoon, HS, 2010)	0.96
"A physiologically based pharmacokinetic (PBPK) model was developed for bisphenol A (BPA) in adult rhesus monkeys using intravenous (iv) and oral bolus doses of 100 μg d6-BPA/kg (Doerge et al."	( Pharmacokinetic modeling: prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans. Doerge, DR; Fisher, JW; Twaddle, NC; Vanlandingham, M, 2011)	0.83
" This study in a non-human primate model provides additional pharmacokinetic data for use in PBPK modeling of perinatal exposures to BPA from food contact, medical devices, and other environmental sources."	( Concurrent determination of bisphenol A pharmacokinetics in maternal and fetal rhesus monkeys. Callicott, RJ; Doerge, DR; Fisher, JW; Patterson, TA; Roegge, CS; Twaddle, NC, 2013)	0.68
" For the first time a physiologically based pharmacokinetic (PBPK) model was developed in neonatal and adult rats to quantitatively evaluate age-dependent pharmacokinetics of BPA and its phase II metabolites."	( Prediction and evaluation of route dependent dosimetry of BPA in rats at different life stages using a physiologically based pharmacokinetic model. Doerge, DR; Fisher, JW; Yang, X, 2013)	0.39
" We constructed and calibrated a simple pharmacokinetic model to predict urinary concentrations of BPA based on a known initial dose."	( Reconstruction of bisphenol A intake using a simple pharmacokinetic model. Calafat, AM; Christensen, KL; Lorber, M; Ye, X, 2015)	0.75
"1mg/kg bisphenol A were reasonably estimated using the current semi-physiological pharmacokinetic model extrapolated from humanized mice data using algometric scaling."	( Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling. Miyaguchi, T; Murayama, N; Nishiyama, S; Shida, S; Shimizu, M; Suemizu, H; Takano, R; Yamazaki, H, 2015)	1.14
" This study consisted of 3 phases: (1) mass-balance phase in which effective dose delivery procedures for oral or SC administration of (3)H-BPA to postnatal day three (PND3) mice were developed; (2) pharmacokinetic phase during which systemic exposure to total (3)H-BPA-derived radioactivity in female PND3 mice was established; and (3) metabolite profiling phase in which 50 female PND3 pups received either a single oral or SC dose of (3)H-BPA."	( Extensive metabolism and route-dependent pharmacokinetics of bisphenol A (BPA) in neonatal mice following oral or subcutaneous administration. Beyer, D; Budinsky, RA; Dimond, SS; Draganov, DI; Ehman, KD; Hentges, SG; Markham, DA; Shiotsuka, RN; Snyder, SA; Waechter, JM, 2015)	0.66
"Using more sensitive methods, our study expands the findings of other human oral pharmacokinetic studies."	( Pharmacokinetics of bisphenol A in humans following a single oral administration. Birnbaum, LS; Bucher, JR; Churchwell, MI; Doerge, DR; Easterling, MR; Garantziotis, S; Hunt, D; Kissling, GE; Schurman, SH; Thayer, KA; Twaddle, NC, 2015)	0.74
"A previously developed physiologically based pharmacokinetic (PBPK) model for bisphenol A (BPA) in adult rhesus monkeys was modified to characterize the pharmacokinetics of BPA and its phase II conjugates in adult humans following oral ingestion."	( Development of a physiologically based pharmacokinetic model for assessment of human exposure to bisphenol A. Doerge, DR; Fisher, JW; Teeguarden, JG; Yang, X, 2015)	0.86
" Research has shown that only the parent compounds have affinity to the estrogen receptors, suggesting that the pharmacokinetic behavior of bisphenols (BPs) can influence their potency."	( Physiologically Based Pharmacokinetic (PBPK) Modeling of the Bisphenols BPA, BPS, BPF, and BPAF with New Experimental Metabolic Parameters: Comparing the Pharmacokinetic Behavior of BPA with Its Substitutes. Gramec Skledar, D; Hungerbühler, K; Karrer, C; Peterlin Mašič, L; Roiss, T; von Goetz, N, 2018)	0.48
"Our goal was to compare the pharmacokinetic behaviors of BPA, BPS, BPF, and BPAF for different age groups after environmentally relevant external exposures by taking into account substance-specific metabolism kinetics and partitioning behavior."	( Physiologically Based Pharmacokinetic (PBPK) Modeling of the Bisphenols BPA, BPS, BPF, and BPAF with New Experimental Metabolic Parameters: Comparing the Pharmacokinetic Behavior of BPA with Its Substitutes. Gramec Skledar, D; Hungerbühler, K; Karrer, C; Peterlin Mašič, L; Roiss, T; von Goetz, N, 2018)	0.48
"We readjusted a physiologically based pharmacokinetic (PBPK) model for peroral exposure to BPA and extended it to include dermal exposure."	( Physiologically Based Pharmacokinetic (PBPK) Modeling of the Bisphenols BPA, BPS, BPF, and BPAF with New Experimental Metabolic Parameters: Comparing the Pharmacokinetic Behavior of BPA with Its Substitutes. Gramec Skledar, D; Hungerbühler, K; Karrer, C; Peterlin Mašič, L; Roiss, T; von Goetz, N, 2018)	0.48
" We present time-course serum and urine concentrations of total and unconjugated ("free") d6-BPA and used this information to calculate terminal half-life and area under the curve."	( Pharmacokinetics of bisphenol A in humans following dermal administration. Andra, SS; Arora, M; Birnbaum, LS; Bucher, JR; Church, R; Kapraun, DF; Linke, S; Nachman, RM; Pirow, R; Sasso, AF; Schurman, SH; Thayer, KA, 2020)	0.88
" This study conducted a population-based in vitro-to-in vivo extrapolation using physiologically based pharmacokinetic (PBPK) models coupled with Monte Carlo simulations to convert ToxCast in vitro estrogen receptor (ER) assays to human equivalent doses (HEDs)."	( In vitro-in silico-based probabilistic risk assessment of combined exposure to bisphenol A and its analogues by integrating ToxCast high-throughput in vitro assays with in vitro to in vivo extrapolation (IVIVE) via physiologically based pharmacokinetic (P Lin, YJ; Lin, Z, 2020)	0.79

Compound-Compound Interactions

We investigated the possible transmission of heritable changes via the sperm, following preconceptional exposure of mice to bisphenol A (BPA), either alone or in combination with X-irradiation. This study was aimed at determining the male-mediated F1 effects induced following 8-weeks of subchronic exposure of F0 male mice to BPA.

Excerpt	Reference	Relevance
" Taken together, our results indicate that BPA in combination with INS can accelerate the adipocyte conversion."	( Bisphenol A in combination with insulin can accelerate the conversion of 3T3-L1 fibroblasts to adipocytes. Honda, K; Kidani, T; Masuno, H; Sakayama, K; Sekiya, K; Shiosaka, T; Yamamoto, H, 2002)	1.76
" Subsequently, we examined triclosan in combination with bisphenol-A (BPA), which also can disrupt implantation."	( Disruption of blastocyst implantation by triclosan in mice: impacts of repeated and acute doses and combination with bisphenol-A. Crawford, BR; Decatanzaro, D, 2012)	0.38
" The study was designed to examine the effects of 8-week exposure (a full cycle of spermatogenesis) to BPA alone and in a combination with X-irradiation on the reproductive organs and germ cells of adult and pubescent male mice."	( Comparison of the effects of bisphenol A alone and in a combination with X-irradiation on sperm count and quality in male adult and pubescent mice. Dobrzyńska, MM; Gajowik, A; Jankowska-Steifer, EA; Pachocki, KA; Radzikowska, J; Tyrkiel, EJ, 2014)	0.69
"Dispersive liquid-liquid microextraction combined with capillary zone electrophoresis-UV detection was developed for analyzing triclosan (TCS) and bisphenol A (BPA) in water, beverage, and urine samples."	( Separation and determination of triclosan and bisphenol A in water, beverage, and urine samples by dispersive liquid-liquid microextraction combined with capillary zone electrophoresis-UV detection. Liu, H; Wang, H; Wang, W; Wang, X; Zhang, A; Zhang, M, )	0.59
" We investigated the effects of 2-week exposure to BPA, either alone or in combination with X-rays, on the induction of DNA damage in somatic cells of female mice in vivo."	( Genotoxic effects of bisphenol A on somatic cells of female mice, alone and in combination with X-rays. Dobrzyńska, MM; Gajowik, A; Radzikowska, J, 2013)	0.71
"We investigated the possible transmission of heritable changes via the sperm, following preconceptional exposure of mice to bisphenol A (BPA), either alone or in combination with X-irradiation."	( Male-mediated F1 effects in mice exposed to bisphenol A, either alone or in combination with X-irradiation. Dobrzyńska, MM; Gajowik, A; Jankowska-Steifer, EA; Radzikowska, J; Tyrkiel, EJ, 2015)	0.88
"Juvenile female Fischer 344 rats were exposed to 5, 50, and 500 μg BPA/kg bodyweight/day in their drinking water from 5 to 15 weeks of age, in combination with 5% fructose."	( Low-dose exposure to bisphenol A in combination with fructose increases expression of genes regulating angiogenesis and vascular tone in juvenile Fischer 344 rat cardiac tissue. Brittebo, E; Karimullina, E; Klint, H; Lejonklou, MH; Lind, L; Lind, PM; Rönn, M, 2017)	0.77
" This study was aimed at determining the male-mediated F1 effects induced following 8-weeks of subchronic exposure of F0 male mice to bisphenol A (BPA) alone and in a combination with X-rays irradiation (IR) started during their puberty."	( Reproductive and developmental F1 toxicity following exposure of pubescent F0 male mice to bisphenol A alone and in a combination with X-rays irradiation. Dobrzyńska, MM; Gajowik, A; Jankowska-Steifer, EA; Radzikowska, J; Tyrkiel, EJ, 2018)	0.91
" Herein, we applied metabolomics combined with MALDI-mass spectrometry imaging (MSI) to investigate the proliferation of three-dimensional MDA-MB-231 breast cancer cell spheroids treated with bisphenol S (BPS)."	( Mass Spectrometry Imaging Combined with Metabolomics Revealing the Proliferative Effect of Environmental Pollutants on Multicellular Tumor Spheroids. Cai, Z; Liang, X; Song, Y; Xie, P, 2020)	0.56

Bioavailability

This is possibly due to the low bioavailability of free bisphenol A in the systemic circulation. The study reports the absolute oral bioavailability and mammary excretion of BPA in rats.

Excerpt	Reference	Relevance
" The relative bioavailability of BPA and plasma radioactivity was markedly lower following oral administration as compared to sc or ip administration."	( The relative bioavailability and metabolism of bisphenol A in rats is dependent upon the route of administration. Cagen, SZ; Domoradzki, JY; Hansen, SC; Markham, DA; Pottenger, LH; Waechter, JM, 2000)	0.56
"This study reports the absolute oral bioavailability and mammary excretion of bisphenol A in rats."	( Bioavailability and mammary excretion of bisphenol a in Sprague-Dawley rats. Han, SY; Kim, HS; Kwack, SJ; Lee, BM; Lee, KC; Park, KL; Shin, BS; Yoo, SD, 2001)	0.8
" Therefore, we investigated the metabolism and toxicokinetics of bisphenol A in humans exposed to low doses since systemic bioavailability has a major influence on possible estrogenic effects in vivo."	( Metabolism and kinetics of bisphenol a in humans at low doses following oral administration. Colnot, T; Csanády, GA; Dekant, W; Filser, JG; Völkel, W, 2002)	0.85
" However, further studies are needed to clarify their bioavailability and metabolism as well as whether compound mixtures could produce noticeable effects by synergistic activity."	( Xenoestrogens and the induction of proliferative effects in breast cancer cells via direct activation of oestrogen receptor alpha. Bonofiglio, D; Carpino, A; Fasanella, G; Gabriele, S; Maggiolini, M; Rago, V; Recchia, AG; Vivacqua, A, 2004)	0.32
" In all species, the oral administration of BPA resulted in much lower C(max) and AUCs than subcutaneous administration at the corresponding doses, indicating the low bioavailability of oral administration."	( Toxicokinetics of bisphenol A in rats, monkeys and chimpanzees by the LC-MS/MS method. Hayasaka, I; Hirooka, H; Inoue, A; Miyachi, A; Negishi, T; Tominaga, T; Yoshikawa, Y, 2006)	0.67
" These findings suggest that BPA can augment the Th1-type responses of naïve immune systems, though the bioavailability of orally administered BPA was low in our experiments."	( Orally administered bisphenol A disturbed antigen specific immunoresponses in the naïve condition. Goto, M; Ono, H; Shinmoto, H; Takano-Ishikawa, Y; Yamaki, K; Yoshida, M, 2007)	0.66
" This is possibly due to the low bioavailability of free bisphenol A in the systemic circulation."	( Disruption of the blood-testis barrier integrity by bisphenol A in vitro: is this a suitable model for studying blood-testis barrier dynamics? Cheng, CY; Lee, WM; Li, MW; Mruk, DD, 2009)	0.85
" Overall metabolic rates decreased with increasing number of substitution at 2- and 6-position of BPA structures, which may be consequences of limited bioavailability or steric hindrance to conjugate-forming reaction."	( Biodegradation of bisphenol A and its halogenated analogues by Cunninghamella elegans ATCC36112. Keum, YS; Kim, JH; Lee, HR; Park, HW, 2010)	0.69
" The risk from copper was highest if bioavailability was not considered, although toxicity correction by a biotic ligand model greatly reduced the estimated risk."	( A Bayesian approach to probabilistic ecological risk assessment: risk comparison of nine toxic substances in Tokyo surface waters. Hayashi, TI; Kashiwagi, N, 2011)	0.37
"The serum BPA level of mouse is significantly higher than the rat after oral administration at 300 mg/kg BPA, which may be caused by BPA high absorption rate of mouse small intestine and strong ability of BPA glucuronidation and excretion of the rat."	( [The differences in absorption and metabolism of bisphenol A between rats and mice]. Chen, G; Huang, CY; Ju, JY; Pan, SC; Ren, FL; Yao, CJ, 2010)	0.62
" Relative BPA-d6 bioavailability (unconjugated BPA-d6) was higher in diet-exposed mice than in the bolus group despite a relative lower absorption, a phenomenon consistent with an inhibitory effect of food on first-pass hepatic metabolism."	( Comparison of serum bisphenol A concentrations in mice exposed to bisphenol A through the diet versus oral bolus exposure. Collet, SH; Ellersieck, MR; Jašarevic, E; Kannan, K; Liao, C; Mao, J; Rosenfeld, CS; Sieli, PT; Toutain, PL; Vom Saal, FS; Warzak, DA, 2011)	0.69
" It suggested that the presence of paper with a high sorption capacity in MSW will restrain BPA transport and bioavailability in landfills."	( Leaching behaviour of bisphenol A from municipal solid waste under landfill environment. He, PJ; Shao, LM; Xu, SY; Zhang, H, )	0.45
" For further improvement of the in vitro to in vivo predictive value of in vitro assays, the relevance of other kinetic characteristics should be studied, including binding to carrier proteins, oral bioavailability and the formation of estrogenic metabolites."	( Effect of combining in vitro estrogenicity data with kinetic characteristics of estrogenic compounds on the in vivo predictive value. Brand, W; Heringa, MB; Murk, AJ; Punt, A; Schriks, M; van Wezel, AP, 2013)	0.39
" There is indication for considerable oral bioavailability and for the potential to accumulate in the human body."	( Migration of cyclo-diBA from coatings into canned food: method of analysis, concentration determined in a survey and in silico hazard profiling. Biedermann, S; Brüschweiler, BJ; Grob, K; Vedani, A; Zurfluh, M, 2013)	0.39
" It is important to determine the bioavailability of EEDCs in soil to inform risk assessment concerning their environmental presence; Eisenia fetida (earthworms) are typically used in traditional in vivo bioavailability experiments."	( Development of an in vitro thin-film solid-phase microextraction method to determine the bioavailability of xenoestrogens in soil. Engler, KN; Lemley, AT, 2013)	0.39
"Using dogs as a valid model, we compared plasma concentrations of BPA over a 24-hr period after intravenous, orogastric, and sublingual administration in order to establish the absolute bioavailability of BPA administered sublingually and to compare it with oral bioavailability."	( High bioavailability of bisphenol A from sublingual exposure. Bousquet-Melou, A; Collet, SH; Gayrard, V; Lacroix, MZ; Picard-Hagen, N; Toutain, PL; Viguié, C, 2013)	0.7
"The data indicated that the systemic bioavailability of BPA deposited sublingually was high (70-90%) and that BPA transmucosal absorption from the oral cavity led to much higher BPA internal exposure than obtained for BPA absorption from the gastrointestinal tract."	( High bioavailability of bisphenol A from sublingual exposure. Bousquet-Melou, A; Collet, SH; Gayrard, V; Lacroix, MZ; Picard-Hagen, N; Toutain, PL; Viguié, C, 2013)	0.7
" The BPA-R bioreporter is a robust and cost-efficient choice for high-throughput monitoring of BPA and its bioavailability in complex samples."	( Characterization of a bisphenol A specific yeast bioreporter utilizing the bisphenol A-targeted receptor. Rajasärkkä, J; Virta, M, 2013)	0.7
"The authors studied the effects of dissolved organic matter (DOM) on the bioavailability of bisphenol A (BPA) and chloramphenicol by measuring the freely dissolved concentrations of the contaminants in solutions containing DOM that had been isolated from a mesocosm in a eutrophic lake."	( Effects of dissolved organic matter from a eutrophic lake on the freely dissolved concentrations of emerging organic contaminants. Chen, L; Huang, QH; Li, FP; Vähätalo, AV; Xiao, YH, 2014)	0.62
" We hypothesized that the extensive interaction with the oral mucosa by a liquid matrix, like soup, relative to solid food or capsules, might enhance absorption through non-metabolizing oral cavity tissues in humans, producing higher bioavailability and higher serum BPA concentrations."	( 24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup. Churchwell, MI; Doerge, DR; Fisher, JW; Seryak, LM; Teeguarden, JG; Twaddle, NC; Yang, X, 2015)	0.68
" In conclusion, BPAF was well absorbed following gavage administration and highly metabolized and excreted mostly in the feces as BPAF."	( Disposition of bisphenol AF, a bisphenol A analogue, in hepatocytes in vitro and in male and female Harlan Sprague-Dawley rats and B6C3F1/N mice following oral and intravenous administration. Black, SR; Fennell, TR; Mathews, JM; Patel, PR; Snyder, RW; Waidyanatha, S, 2015)	0.77
" We hypothesized that n-TiO2 may adsorb BPA, and thus modify its bioavailability and toxicity to aquatic organisms."	( Enhanced Bioconcentration of Bisphenol A in the Presence of Nano-TiO2 Can Lead to Adverse Reproductive Outcomes in Zebrafish. Fang, Q; Guo, Y; Hua, J; Shi, Q; Wang, X; Zhou, B, 2016)	0.73
"Despite its very low oral bioavailability and rapid elimination, multiple reports of unexpectedly high bisphenol A (BPA) concentrations in the serum of pregnant mothers or cord blood have raised questions about BPA exposures during pregnancy."	( Urine and serum biomonitoring of exposure to environmental estrogens I: Bisphenol A in pregnant women. Churchwell, MI; Doerge, DR; Teeguarden, JG; Twaddle, NC, 2016)	0.88
" The dietary route led to 3-fold higher bioavailability as compared to gavage."	( Characterization of the contribution of buccal absorption to internal exposure to bisphenol A through the diet. Gauderat, G; Gayrard, V; Guignard, D; Lacroix, MZ; Picard-Hagen, N; Puel, S; Toutain, PL; Viguié, C, 2016)	0.66
" Taking into account age-dependent bioavailability differences, internal exposure of premature neonates hosted in intensive care units was reckoned close to the biologically effective dose (BED) resulting from translating the EFSA temporary total daily intake (t-TDI) into equivalent internal dose."	( Integrated exposure and risk characterization of bisphenol-A in Europe. Gotti, A; Handakas, E; Karakitsios, SP; Sarigiannis, DA; Simou, K; Solomou, E, 2016)	0.43
" We hypothesized that DEHP might increase the bioavailability of BPA in tissues by competing for metabolic enzymes."	( Diethylhexyl phthalate magnifies deposition of Borman, ED; deCatanzaro, D; Pollock, T; Vecchi, N, 2017)	0.46
" Overall, the present study demonstrates that the presence of NPPs can increase BPA bioavailability and cause neurotoxicity in adult zebrafish."	( Enhanced uptake of BPA in the presence of nanoplastics can lead to neurotoxic effects in adult zebrafish. Chen, Q; Hollert, H; Jia, Y; Legradi, J; Schiwy, S; Yang, S; Yin, D, 2017)	0.46
"The data indicated that almost all the BPS oral dose was absorbed and transported into the liver where only 41% of BPS was glucuronidated, leading to a systemic bioavailability of 57."	( Oral Systemic Bioavailability of Bisphenol A and Bisphenol S in Pigs. Bouchard, M; Collet, SH; Gayrard, V; Gély, CA; Grandin, FC; Lacroix, MZ; Léandri, R; Mila, H; Picard-Hagen, N; Rabozzi, B; Toutain, PL; Viguié, C, 2019)	0.8
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51
" The reduced early-gestational placental efficiency may be a function of increased inflammation/oxidative stress and reduced IGF bioavailability with the mid-gestational restoration of placental efficiency likely driven by improved IGF bioavailability and the time-lagged response to antioxidant increase."	( Developmental programming: Prenatal bisphenol A treatment disrupts mediators of placental function in sheep. Padmanabhan, V; Pennathur, S; Puttabyatappa, M; Song, W; Vazquez, D; Zeng, L, 2020)	0.83
" The bioavailability and choice of bioassay endpoints played important roles in elucidating causality."	( Identifying bioaccessible suspect toxicants in sediment using adverse outcome pathway directed analysis. Cheng, F; Fu, Z; Li, H; Ma, H; Wu, F; You, J, 2020)	0.56
" However, it exhibits low bioavailability in humans and animals."	( Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota. Chang, SKC; Chen, YW; Chiu, MH; Hou, CY; Liao, JX; Shih, MK; Tain, YL; Yeh, YT, 2021)	0.62
"The bioconcentration factor (BCF) is a key parameter for bioavailability assessment of environmental pollutants in regulatory frameworks."	( Predicting bioconcentration factor and estrogen receptor bioactivity of bisphenol a and its analogues in adult zebrafish by directed message passing neural networks. Chen, G; Chen, P; He, K; Shan, G; Wang, R; Yang, L; Zhu, L, 2022)	0.95
" Despite their structural similarities, for the same oral dose, all BPA analogues investigated showed a higher systemic exposure (area under the plasma concentration-time curve (AUC) of the unconjugated Bisphenol) than BPA (2 to 4 fold for 3-3BPA, BPAF, BPB and BPZ, 7-20 fold for BP4-4, BPAP, BPP, BPFL, BPF and BPM and 150 fold for BPS) due mainly to a considerable variation of oral bioavailability (proportion of BP administered by oral route that attains the systemic circulation unchanged)."	( Comparison of toxicokinetic properties of eleven analogues of Bisphenol A in pig after intravenous and oral administrations. Gayrard, V; Gély, CA; Lacroix, MZ; Picard-Hagen, N; Roques, BB; Toutain, PL, 2023)	1.15
"Herein, in order to improve the bioavailability of a non-biodegradable pollutant, inclusion complexation procedures had been used to develop better formulations of this pollutant, Bisphenol A (BPA)."	( Assembled Bisphenol A with cyclic oligosaccharide as the controlled release complex to reduce risky effects. Ali, S; Basak, S; Ghosh, NN; Haydar, MS; Mondal, M; Roy, D; Roy, K; Roy, MN; Sarkar, K, 2023)	1.5

Dosage Studied

The objective of this study was to determine to what extent bisphenol A (BPA) and its derivatives are extractable from epoxy-based coatings of aluminium tubes for pharmaceutical use. The removal efficiency of BPA could be measure up to 70%, 82%, 90% when the dosage of ozone was 1mg/L, 1.0 mg/L.

Excerpt	Relevance	Reference
"Bisphenol A (BPA) was evaluated for developmental toxicity in CD rats (0, 160, 320, or 640 mg/kg/day) and CD-1 mice (0, 500, 750, 1000, or 1250 mg/kg/day) dosed daily by gastric intubation on Gestational Days 6 through 15."	( The developmental toxicity of bisphenol A in rats and mice. George, JD; Kimmel, CA; Marr, MC; Morrissey, RE; Price, CJ; Tyl, RW, 1987)	2
" This study determined the rate- and time-course of BPA released from a dental sealant (Delton Opaque Light-cure Pit and Fissure Sealant, Preventive Care/Dentsply) when applied at a dosage of 8 milligrams (one tooth) or 32 mg (8 mg on each of four teeth) to 40 healthy adults."	( Pharmacokinetics of bisphenol A released from a dental sealant. Chou, HN; Ewoldsen, NO; Fung, EY; Gruninger, SE; Marx, DB; Meyer, DM; Miaw, CL; Siew, C; St Germain, HA, 2000)	0.63
" BPA increased the level of mRNA for the immediate early gene, c-fos, with similar dose-response curves in both rat strains."	( Strain differences in vaginal responses to the xenoestrogen bisphenol A. Ben-Jonathan, N; Bigsby, RM; Caperell-Grant, A; Long, X; Nephew, KP; Steinmetz, R; Young, PC, 2000)	0.55
" The major fraction of plasma radioactivity following oral dosing was the monoglucuronide conjugate of BPA (68-100% of plasma radioactivity)."	( The relative bioavailability and metabolism of bisphenol A in rats is dependent upon the route of administration. Cagen, SZ; Domoradzki, JY; Hansen, SC; Markham, DA; Pottenger, LH; Waechter, JM, 2000)	0.56
" In vivo studies indicated that the 3-day uterotrophic assay in prepubertal rats was the best method for detecting estrogenic activity when compared with all other end points, based upon the dose-response data for ethynyl estradiol (0."	( Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats. Bodman, GJ; Carey, SA; Cooper, RL; Ferrell, JM; Laws, SC, 2000)	0.56
" This is the first demonstration that environmental chemicals program AR function permanently at the dosage consumed by the general population."	( Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals. Gupta, C, 2000)	0.31
" It is concluded that BPA may be weakly uterotrophic to the mouse under specific conditions of test, and in the complete absence of a dose-response relationship to this activity."	( Uterotrophic activity of bisphenol A in the immature mouse. Ashby, J; Foster, J; Joiner, R; Pate, I; Soames, A; Tinwell, H, 2000)	0.61
" These concentrations are far less than the toxic dosage reported so far, so that CAPD is unlikely to contaminate patients seriously."	( Endocrine-disrupting chemicals in CAPD dialysate and effluent. Kakiya, Y; Kishimoto, T; Naganuma, T; Okada, C; Sugimura, K; Sugimura, T, 2001)	0.31
" Plasma concentrations of BPA at 1 hr after the last administration were detected in all groups given BPA sc and in groups given 160 and 800 mg/kg BPA orally, with a dose-response effect."	( Immature rat uterotrophic assay of bisphenol A. Sawaki, M; Takatsuki, M; Yamasaki, K, 2000)	0.58
"; dose-response curves did not differ between strains."	( Effects of the xenoestrogen bisphenol A on expression of vascular endothelial growth factor (VEGF) in the rat. Bigsby, RM; Burke, KA; Long, X; Nephew, KP, 2001)	0.6
" The number of egg-ropes produced by the first generation females varied between treatments but no dose-response pattern was evident."	( Chronic exposure to 17 alpha-ethinylestradiol and bisphenol A-effects on development and reproduction in the freshwater invertebrate Chironomus riparius (Diptera: Chironomidae). Carroll, K; Pascoe, D; Watts, MM, 2001)	0.56
" The steady-state serum levels of bisphenol A were linearly increased with higher dosing rates."	( Bioavailability and mammary excretion of bisphenol a in Sprague-Dawley rats. Han, SY; Kim, HS; Kwack, SJ; Lee, BM; Lee, KC; Park, KL; Shin, BS; Yoo, SD, 2001)	0.86
" To resolve this important question, it will be necessary to conduct detailed dose-response studies where the no-observed-effect level (NOEL) for the proposed surrogate end points are compared with the NOEL for the gravimetric end point."	( Increasing the sensitivity of the rodent uterotrophic assay to estrogens, with particular reference to bisphenol A. Ashby, J, 2001)	0.53
" EPA), the National Toxicology Program organized an independent and open peer review to evaluate the scientific evidence on low-dose effects and nonmonotonic dose-response relationships for endocrine-disrupting chemicals in mammalian species."	( Summary of the National Toxicology Program's report of the endocrine disruptors low-dose peer review. Brown, T; Gallo, M; Hall, R; Haseman, J; Ho, SM; Kohn, M; Leakey, J; Lucier, G; Melnick, R; Moore, J; Prins, G; Reuhl, K; Stancel, G; Wolfe, M, 2002)	0.31
" Concentrations leading to 50% cell survival (TC50 values) were calculated from fitted dose-response curves."	( Responses of L929 mouse fibroblasts, primary and immortalized bovine dental papilla-derived cell lines to dental resin components. Hiller, KA; Schmalz, G; Schweikl, H; Thonemann, B, 2002)	0.31
"001-5 mg/kg/day) on any parameters and no evidence of nonmonotonic dose-response curves across generations for either sex."	( Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats. Brine, DR; Butala, JH; Cagen, SZ; Chang, TY; Dimond, SS; Fail, PA; Joiner, RL; Keimowitz, AR; Marr, MC; Myers, CB; Seely, JC; Shiotsuka, RN; Stropp, GD; Thomas, BF; Tyl, RW; Veselica, MM; Waechter, JM, 2002)	0.56
" The high level of BPA appeared to be cytotoxic to Wistar rat embryo limb bud cells in culture and inhibited the clone formation with dose-response relationship."	( [Study on the developmental toxicity of Bisphenol A by using micromass culture in vitro]. Li, Y; Long, D; Pei, X, 2002)	0.58
" The results obtained suggested that BPA could be easily chlorinated by sodium hypochlorite with a dosage of 4 to 5 mg L(-1) and a contact time of 1 to 2 min."	( Identification and quantification of bisphenol A by gas chromatography and mass spectrometry in a lab-scale dual membrane system. Hu, JY; Ng, WJ; Ong, SL; Song, LF; Yuan, T, 2003)	0.59
" In this study, we examined the effect of BPA on the sexual differentiation of open-field behavior and the sexually dimorphic nuclei in the brain in the offspring of rats exposed to BPA during the fetal and suckling periods at a dosage below the human tolerable daily intake (TDI) level."	( Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats. Aou, S; Arai, O; Kubo, K; Ogata, R; Omura, M; Watanabe, R, 2003)	0.64
" The results showed that the BPA inhibited the development of embryos in vitro and there was a dose-response relationship between concentrations of BPA."	( [Teratogenicity of bisphenol A on post-implanted rat and mouse embryos: an in vitro study]. Chen, X; Li, Y; Long, D; Pei, X, 2003)	0.65
" Kinetic and PAC dose-response experiments were conducted with the two best performing PACs."	( HPLC-fluorescence detection and adsorption of bisphenol A, 17beta-estradiol, and 17alpha-ethynyl estradiol on powdered activated carbon. Esparza, M; Snyder, SA; Westerhoff, P; Yoon, Y, 2003)	0.58
" heteroclitus appeared similar to two other species dosed with the same compounds."	( Vitellogenesis in male Fundulus heteroclitus (killifish) induced by selected estrogenic compounds. Nelson, JO; Pait, AS, 2003)	0.32
" Additional rats were dosed orally at 10 mg 14C-BPA/kg (0."	( Metabolism and pharmacokinetics of bisphenol A (BPA) and the embryo-fetal distribution of BPA and BPA-monoglucuronide in CD Sprague-Dawley rats at three gestational stages. Card, TL; Domoradzki, JY; Dryzga, MD; Hansen, SC; Markham, DA; Pottenger, LH; Shiotsuka, RN; Thornton, CM; Waechter, JM, 2003)	0.6
"We previously performed dose-response studies of genistein, diisononyl phthalate, 4-nonylphenol, methoxychlor (MXC), and bisphenol A to examine the impact of maternal dietary exposure from gestational day 15 to postnatal day 10 on the development of rat reproductive system in later life."	( Alteration of pituitary hormone-immunoreactive cell populations in rat offspring after maternal dietary exposure to endocrine-active chemicals. Hirose, M; Lee, KY; Masutomi, N; Shibutani, M; Takagi, H; Uneyama, C, 2004)	0.53
" Equally, isobole analysis is only suitable for two- or three-component mixtures, and concentration addition requires access to dose-response data and EC50 values (concentration giving 50% of the maximum response) for the individual components of the mixture--requirements that will rarely be fulfilled for complex environmental samples."	( Sensitivity of the immature rat uterotrophic assay to mixtures of estrogens. Ashby, J; Tinwell, H, 2004)	0.32
"Assessing for interactions among chemicals in a mixture involves the comparison of actual mixture responses to those predicted under the assumption of zero interaction (additivity), based on individual chemical dose-response data."	( A novel flexible approach for evaluating fixed ratio mixtures of full and partial agonists. Carchman, RA; Carney, EW; Carter, WH; Charles, GD; Gennings, C; Gollapudi, BB, 2004)	0.32
" For making simple comparisons, receptor-binding affinity has been equated to in vivo potency, which consequently defines the dose-response characteristics for the compound."	( Computational modeling of serum-binding proteins and clearance in extrapolations across life stages and species for endocrine active compounds. Barton, HA; Teeguarden, JG, 2004)	0.32
" Because of the disappearance of BPA from the water-phase, a pulse dosed exposure in weekly intervals was established."	( Bisphenol-A in artificial indoor streams: I. Fate and effects on aufwuchs. Jungmann, D; Ladewig, V; Licht, O; Ludwichowski, KU; Nagel, R, 2004)	0.32
"5-dpc-embryos, AhR mRNA levels were elevated and showed diphasic (U) dose-response curves following exposure to BPA, but inverted U dose-response curves were obtained for 18."	( Effects of in utero exposure to bisphenol A on mRNA expression of arylhydrocarbon and retinoid receptors in murine embryos. Imanishi, S; Manabe, N; Morita, M; Nishizawa, H; Sugimoto, M, 2005)	0.61
" Only the extract in the acidic fraction showed cell proliferation activity in a dose-response manner."	( Bisphenol A in ambient air particulates responsible for the proliferation of MCF-7 human breast cancer cells and Its concentration changes over 6 months. Adachi, S; Matsumoto, H; Suzuki, Y, 2005)	1.77
", a non-monotonic dose-response curve)."	( Gene expression changes induced in the testis by transplacental exposure to high and low doses of 17{alpha}-ethynyl estradiol, genistein, or bisphenol A. Carr, GJ; Daston, GP; Foertsch, LM; Hess, KA; Martinez, JE; Naciff, JM; Overmann, GJ; Richardson, BD; Tiesman, JP; Torontali, SM, 2005)	0.53
" On day 18, however, radioactivity was detected in the fetal intestine and urinary bladder 24 h after oral dosing of 14C-BPA to the pregnant rats."	( Disposition of low doses of 14C-bisphenol A in male, female, pregnant, fetal, and neonatal rats. Kurebayashi, H; Nagatsuka, S; Nemoto, H; Noguchi, H; Ohno, Y, 2005)	0.61
" However, when O3 dosage decreased the amount of BPA conversion exhibits significant differences between two processes."	( Degradation of 17beta-estradiol and bisphenol A in aqueous medium by using ozone and ozone/UV techniques. Akgerman, A; Erbatur, O; Irmak, S, 2005)	0.6
" In vivo dose-response analysis for each estrogenic compound was performed by brief (6-min) intracerebellar injection, followed by rapid fixation and phosphorylation-state-specific immunohistochemistry to quantitatively characterize changes in activated ERK1/2 (pERK) immunopositive cell numbers."	( Ontogeny of rapid estrogen-mediated extracellular signal-regulated kinase signaling in the rat cerebellar cortex: potent nongenomic agonist and endocrine disrupting activity of the xenoestrogen bisphenol A. Belcher, SM; Le, HH; Wang, HS; Zsarnovszky, A, 2005)	0.52
" Both types of phenomena can induce an inverted-U dose-response curve, resulting from low-dose stimulation of response, and thus challenge current methods of risk assessment."	( Reproductive stimulation by low doses of xenoestrogens contrasts with the view of hormesis as an adaptive response. Oehlmann, J; vom Saal, FS; Weltje, L, 2005)	0.33
" Based on the kinetic model the effects of particle size, initial bisphenol-A concentration, initial solution pH, and adsorbent dosage on the adsorption rate constant and equilibrium capacity have been estimated, showing that the adsorption process could be simulated well by the simplified kinetic model."	( Adsorption characteristics of bisphenol-A in aqueous solutions onto hydrophobic zeolite. Hsu, HC; Lin, CM; Lin, KY; Su, TY; Tsai, WT, 2006)	0.33
" BPA at 400 mg/kg was toxic and dosed rats died."	( Effects of perinatal exposure to bisphenol A on brain neurotransmitters in female rat offspring. Honma, T; Kobayashi, K; Miyagawa, M; Sekiguchi, S; Suda, M; Wang, RS, 2006)	0.62
" For EE2 a dose-response relationship was established with EC50 = 60."	( Testing estrogenicity of known and novel (xeno-)estrogens in the MolDarT using developing zebrafish (Danio rerio). Eggen, RI; Junghans, M; Muncke, J, 2007)	0.34
" It has been confirmed that the BET surface area and micropore surface area of Al(2)O(3)-Fe(2)O(3) catalysts increased with an increased dosage of alumina and with decreased sintering temperature."	( Effect of alumina on photocatalytic activity of iron oxides for bisphenol A degradation. Li, FB; Li, XZ; Liu, CS; Liu, TX, 2007)	0.58
" Furthermore, higher dosage of BPA (50 mg/L) and hydrocortisone (50 and 500 mg/L) suppressed the macrophages respiratory burst while estradiol is stimulative all the doses tested (0."	( Immunotoxicity of bisphenol A to Carassius auratus lymphocytes and macrophages following in vitro exposure. Gu, Y; Hu, SQ; Liu, SS; Wei, L; Yin, DQ; Zhang, AQ, 2007)	0.67
" The hypothesis that BPA dose-response may be described by a J- or U-shape curve was not supported by toxicogenomic data collected in fetal rat testes and epididymes (after repeated parenteral exposure at 2-400,000 microg/kg-d), where a clear monotonic dose-response both in the numbers of genes and magnitude of individual gene expression was evident."	( Derivation of a bisphenol A oral reference dose (RfD) and drinking-water equivalent concentration. Ball, GL; McLellan, CJ; Willhite, CC, 2008)	0.69
" A dose-response related reduction was observed in fertilization success and significant increases in the number of larvae with skeleton malformations at the pluteus stage when the sperms were exposed BPA."	( Effects of bisphenol A on the embryonic development of sea urchin (Paracentrotus lividus). Hatice, P; Ozlem, CA, 2008)	0.74
"018-30 ppm), there were no treatment-related effects and no evidence of nonmonotonic dose-response curves for any parameter."	( Two-generation reproductive toxicity study of dietary bisphenol A in CD-1 (Swiss) mice. Beyer, D; Castillo, NP; Dimond, SS; Hentges, SG; Marr, MC; Myers, CB; Seely, JC; Shiotsuka, RN; Sloan, CS; Tyl, RW; Van Miller, JP; Veselica, MM; Waechter, JM, 2008)	0.59
" Mass-balance experiments showed that above 99% of the dosed BPA and 90% of the dosed NP is removed by biodegradation at steady-state."	( Examining the biodegradation of endocrine disrupting bisphenol A and nonylphenol in WWTPs. Henze, M; Lindblom, E; Press-Kristensen, K; Schmidt, JE, 2008)	0.6
" The luc induction was determined in different tissues 8h after dosing the ER-luc male mice intraperitoneally (IP) or 14h after oral dosing."	( Food-associated estrogenic compounds induce estrogen receptor-mediated luciferase gene expression in transgenic male mice. Murk, AJ; Rietjens, IM; Ter Veld, MG; van den Berg, JH; van der Saag, PT; Zawadzka, E, 2008)	0.35
"The objective of this study was to determine to what extent bisphenol A (BPA), bisphenol A diglycidyl ether (BADGE) and its derivatives are extractable from epoxy-based coatings of aluminium tubes for pharmaceutical use and to monitor their leaching into different kinds of semi-solid dosage forms."	( Contamination of semi-solid dosage forms by leachables from aluminium tubes. Galensa, R; Haverkamp, JB; Lipke, U; Lipperheide, C; Zapf, T, 2008)	0.59
" Firstly, toxicity tests should be designed with more elaboration to ensure a sufficient number of animals with careful handling of litters to allow adequate statistical analysis and appropriate selection of dosages to obtain insight in dose-response relationship."	( Low-dose effects of bisphenol A: a serious threat to human health? Sekizawa, J, 2008)	0.67
"05), and a dose-response relationship was observed."	( [Estrogen-like activity of 4-nonylphenol and bisphenol in immature SD rats]. Cai, D; Lu, J, 2008)	0.35
" Also, the patterns of urinary nucleosides in three dosage groups (control, BPA1, BPA2) were significantly different."	( Metabolic significance of bisphenol A-induced oxidative stress in rat urine measured by liquid chromatography-mass spectrometry. Cho, SH; Choi, MH; Chung, BC; Kwon, OS; Lee, WY, 2009)	0.65
", 1-50 mg L(-1)), TiO(2) dosage (i."	( Photodegradation of bisphenol-A in a batch TiO2 suspension reactor. Chang, YM; Lee, MK; Su, TY; Tsai, WT, 2009)	0.35
" Dose-response patterns of ERK activation at 5 min were similar for E2, BPA, and PP, whereas EP caused larger effects."	( Alkylphenol xenoestrogens with varying carbon chain lengths differentially and potently activate signaling and functional responses in GH3/B6/F10 somatomammotropes. Jeng, YJ; Kochukov, MY; Watson, CS, 2009)	0.35
" The effects of initial BPA concentration, initial pH, TiO(2) dosage and temperature on BPA photodegradation were investigated in order to obtain the optimum operational conditions."	( Photocatalytic degradation of Bisphenol A (BPA) using immobilized TiO2 and UV illumination in a horizontal circulating bed photocatalytic reactor (HCBPR). Ren, D; Wang, R; Xia, S; Zhang, Y; Zhao, J, 2009)	0.64
" The effects of ionic liquid kinds, temperature, time, and methanol dosage on methanolysis results of PC were examined."	( Environmentally benign methanolysis of polycarbonate to recover bisphenol A and dimethyl carbonate in ionic liquids. Cui, X; Ge, X; Li, Z; Liu, F; Yu, S, 2010)	0.6
" These results demonstrate that developmental exposure to pharmacologically relevant dosage levels of EE2 can permanently disrupt the reproductive morphology and function of the female rat."	( In utero and lactational exposure to bisphenol A, in contrast to ethinyl estradiol, does not alter sexually dimorphic behavior, puberty, fertility, and anatomy of female LE rats. Crofton, KM; Gray, LE; Hotchkiss, AK; Ryan, BC, 2010)	0.63
" The lowest dosage (0."	( Effects of bisphenol A in the ring-legged earwig, Euborellia annulipes. Grosjean, EM; Rankin, SM, 2010)	0.75
" A dose-response relationship was observed with an increasing level of cumulative BPA exposure associated with a higher risk of sexual dysfunction."	( Occupational exposure to bisphenol-A (BPA) and the risk of self-reported male sexual dysfunction. Checkoway, H; Ferber, JR; Gao, E; He, Y; Herrinton, LJ; Li, D; Miao, M; Qing, D; Wang, J; Weng, X; Wu, T; Yuan, W; Zhou, Z; Zhu, Q, 2010)	0.36
" Under otherwise identical conditions, a lower dosage of laccase was needed for the higher conversion of BPA in the presence of Triton X-100."	( Effects of nonionic surfactant Triton X-100 on the laccase-catalyzed conversion of bisphenol A. Huang, F; Huang, X; Ji, G; Zhang, H, 2009)	0.58
" The dose-response curve of DEHP in the YES assay showed a relevant antagonist effect of this phthalate."	( Determination of trace endocrine disruptors in ultrapure water for laboratory use by the yeast estrogen screen (YES) and chemical analysis (GC/MS). Bartolucci, U; Colombini, MP; Pinto, B; Reali, D; Sanfilippo, K, 2010)	0.36
" The current study was designed to characterize the individual dose-response curves of estradiol-17beta (E(2)), bisphenol A (BPA), tetrabromo-bisphenol A (TBBPA), and bisphenol AF (BPAF, 4,4'-hexafluoroisopropylidene diphenol) on estrogen-dependent luciferase expression in T47D-KBluc cells and to determine how binary (8 x 8 factorial) and ternary (4 x 4 x 4 factorial) mixtures of an endogenous estrogen (E(2)) interact with BPA and/or BPAF."	( Modeling the interaction of binary and ternary mixtures of estradiol with bisphenol A and bisphenol AF in an in vitro estrogen-mediated transcriptional activation assay (T47D-KBluc). Bermudez, DS; Gray, LE; Wilson, VS, 2010)	0.8
" In addition, dosage amounts of the dental sealant material used in this study do not influence the serum concentration levels of BPA."	( Bisphenol A blood and saliva levels prior to and after dental sealant placement in adults. Ratzlaff, RE; Shuman, D; Stull, SC; Zimmerman-Downs, JM, 2010)	1.8
" However, at the higher dose (200 mg/kg/d), the effects of BPA on these subunits were different, with a stronger inhibition of NR1 expression and a slighter inhibition of NR2A, 2B expression when compared with those at the lower dosage of BPA."	( Perinatal exposure to bisphenol-A changes N-methyl-D-aspartate receptor expression in the hippocampus of male rat offspring. Luo, QQ; Ruan, Q; Wang, YM; Xu, XH; Ye, YP; Zhang, J, 2010)	0.36
" The current study validated using liquid chromatography/tandem mass spectrometry (LC/MS/MS) in conjunction with deuterated BPA as the dosing material to circumvent contamination for high sensitivity quantifications in rat serum, tissues, urine, and feces."	( Quantification of deuterated bisphenol A in serum, tissues, and excreta from adult Sprague-Dawley rats using liquid chromatography with tandem mass spectrometry. Churchwell, MI; Doerge, DR; Twaddle, NC; Vanlandingham, M, 2010)	0.65
"The forced breeding experiment revealed a decrease in the cumulative number of pups, observed as a nonmonotonic dose-response effect, and a decline in fertility and fecundity over time in female mice exposed perinatally to BPA."	( Perinatal exposure to environmentally relevant levels of bisphenol A decreases fertility and fecundity in CD-1 mice. Askenase, MH; Cabaton, NJ; Gadbois, JL; Rubin, BS; Schaeberle, CM; Sonnenschein, C; Soto, AM; Tharp, AP; Wadia, PR; Whitt, GS; Zalko, D, 2011)	0.61
" Males receiving the highest dose (5 mg/kg bw/day), however, were indistinguishable from controls with respect to consummatory sexual behaviors but showed decreased latencies to engage in those behaviors when sexually naïve, with significant non-linear, or U-shaped, dose-response relationships observed on the first and last day of testing."	( Pre- and postnatal bisphenol A treatment results in persistent deficits in the sexual behavior of male rats, but not female rats, in adulthood. Jones, BA; Shimell, JJ; Watson, NV, 2011)	0.7
" The quantity we calculate, the biological pathway altering dose (BPAD), is analogous to current risk assessment metrics in that it combines dose-response data with analysis of uncertainty and population variability to arrive at conservative exposure limits."	( Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment. Dix, DJ; Houck, KA; Hubal, EA; Judson, RS; Kavlock, RJ; Knudsen, TB; Martin, MT; Setzer, RW; Thomas, RS; Wetmore, BA, 2011)	0.37
" The effects of temperature, time, methanol dosage and [Bmim][Ac] dosage on the methanolysis reaction were examined."	( Methanolysis of polycarbonate catalysed by ionic liquid [Bmim][Ac]. Ge, X; Li, L; Liu, F; Lv, Z; Yu, S, 2011)	0.37
" A dose-response relationship was observed with increased BPA exposure levels in pregnancy associated with greater magnitude of decrease of birth weight in offspring (P=0."	( In utero exposure to bisphenol-A and its effect on birth weight of offspring. He, X; Li, DK; Miao, M; Yuan, W; Zhu, G, 2011)	0.37
" These strains indicate the presence of ligands for these receptors by changes in growth phenotype, and can differentiate agonist from antagonist and give a rough indication of binding affinity via dose-response curves."	( Bacterial biosensors for evaluating potential impacts of estrogenic endocrine disrupting compounds in multiple species. Eyster, TW; Gierach, I; Shapero, K; Wood, DW, 2013)	0.39
" The important parameters that affect the extraction efficiency such as the solution pH, dosage of magnetic submicron particles, nature of elution solution and its volume were optimized."	( [Determination of bisphenol A in milk by liquid chromatography-tandem mass spectrometry coupled with solid phase extraction of monodisperse magnetic submicron particles as adsorbent]. Ding, L; Li, Z; Long, Y; Wang, L; Wu, X; Xiao, J; Xu, Z, 2011)	0.7
" Strikingly, the effect of BPA on the expression of de novo lipogenesis followed a nonmonotonic dose-response curve, with more important effects at lower doses than at the higher dose."	( Low doses of bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver. Bertrand-Michel, J; Ducheix, S; Guillou, H; Lasserre, F; Marmugi, A; Martin, PG; Mselli-Lakhal, L; Paris, A; Pineau, T; Polizzi, A; Priymenko, N, 2012)	0.75
" Hits that inhibited ATPase activity by >44% in the primary screen were tested in dose-response efficacy and eukaryotic cytotoxicity assays."	( High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity. Ananthan, S; Aubé, J; Brodsky, JL; Evans, CW; Golden, JE; Maki, BE; Matharu, DS; McKellip, S; Nebane-Akah, M; Noah, JW; Rasmussen, L; Seguin, SP; Sosa, M; Tower, NA; White, EL, 2012)	0.38
" The present study indicates that a single exposure to Bisphenol A on postnatal day 10 can alter adult spontaneous behavior and cognitive function in mice, effects that are both dose-response related and long-lasting/irreversible."	( Dose-dependent behavioral disturbances after a single neonatal Bisphenol A dose. Buratovic, S; Eriksson, P; Fredriksson, A; Viberg, H, 2011)	0.86
" These results suggest that an adverse effect from BPA observed in rodent models, attributable to exposure during a discrete time period of neonatal development, would be less likely for comparable neonatal primate dosing based on internal dosimetry."	( Pharmacokinetics of bisphenol A in neonatal and adult CD-1 mice: inter-species comparisons with Sprague-Dawley rats and rhesus monkeys. Doerge, DR; Fisher, JW; Twaddle, NC; Vanlandingham, M, 2011)	0.69
" A dose-response relationship was observed with increased BPA exposure level associated with more oocytes in germ cell cyst and less primordial follicle at postnatal day 3 (P < 0."	( Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocytes. Chao, HH; Feng, YM; Li, L; Pan, B; Shen, W; Sun, XF; Zhang, HQ; Zhang, LJ; Zhang, XF, 2012)	0.71
" Here we analyzed the antiandrogenic activity of six binary, and one ternary mixture of phthalates exhibiting complete antiandrogenic dose-response curves, and binary mixtures of phthalates and bisphenol A at equi-effective concentrations of EC(10), EC(25) and EC(50) in MDA-kb2 cells."	( Antiandrogenic activity of phthalate mixtures: validity of concentration addition. Christen, V; Crettaz, P; Fent, K; Oberli-Schrämmli, A, 2012)	0.57
" No effect of BPA was observed in the MWM, but on both the EPM and FST, low doses (5 μg/kg) of BPA eliminated sex differences found between controls; furthermore, a non-monotonic dose-response observed in previous studies was confirmed for these tasks."	( Perinatal BPA exposure demasculinizes males in measures of affect but has no effect on water maze learning in adulthood. Jones, BA; Watson, NV, 2012)	0.38
"9)O(8)I was as high as 92% within 12 h visible light irradiation under the optimal conditions: initial MO concentration of 5-10 mg L(-1), catalyst dosage of 6 g L(-1) and natural pH (6-8), the MO molecules could be completely degradated by Bi(4)Nb(0."	( Photocatalytic removal of organic pollutants in aqueous solution by Bi(4)Nb(x)Ta((1-x))O(8)I. Fan, J; Hu, XY; Wang, JJ; Zhang, KL, 2012)	0.38
" Additionally, we explore nonmonotonic dose-response curves, defined as a nonlinear relationship between dose and effect where the slope of the curve changes sign somewhere within the range of doses examined."	( Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Colborn, T; Hayes, TB; Heindel, JJ; Jacobs, DR; Lee, DH; Myers, JP; Shioda, T; Soto, AM; Vandenberg, LN; vom Saal, FS; Welshons, WV; Zoeller, RT, 2012)	0.38
" In particular, the maternal BPA oral dosing related to the effects on intermediate progenitor cells (IPCs, neural progenitor cells) in the subventricular zone (SVZ) of dorsal telencephalon."	( Maternal bisphenol A oral dosing relates to the acceleration of neurogenesis in the developing neocortex of mouse fetuses. Asai, Y; Komada, M; Matsuki, M; Morii, M; Nagao, T; Sato, M, 2012)	0.8
"There was a positive linear dose-response association between BPA urinary concentrations and implantation failure."	( Urinary bisphenol A concentrations and implantation failure among women undergoing in vitro fertilization. Berry, KF; Calafat, AM; Ehrlich, S; Flaws, JA; Hauser, R; Missmer, SA; Petrozza, JC; Williams, PL; Wright, D; Ye, X, 2012)	0.81
" Further complicating their assessment as health risks are questions about nonmonotonic dose-response functions and about transgenerational effects incurred via epigenetic mechanisms."	( The intersection of neurotoxicology and endocrine disruption. Weiss, B, 2012)	0.38
" This method was successfully applied to the determination of BPAF in tissues, serum, urine and feces of orally dosed rats."	( Determination of bisphenol AF (BPAF) in tissues, serum, urine and feces of orally dosed rats by ultra-high-pressure liquid chromatography-electrospray tandem mass spectrometry. Shao, B; Wu, Y; Yang, Y; Yin, J; Zhang, J; Zhou, N, 2012)	0.72
", nearly 100%, was observed with the BiOI/BiOCl composite (containing 90% BiOI) using a catalyst dosage of 1 g L(-1) in the BPA solution (C(0)=20 mg L(-1), pH=7."	( One-pot solvothermal synthesis of three-dimensional (3D) BiOI/BiOCl composites with enhanced visible-light photocatalytic activities for the degradation of bisphenol-A. Hao, R; Li, L; Liang, M; Nan, J; Xiao, X; Zhang, W; Zuo, X, 2012)	0.38
" Urinary BPA was significantly associated with sensitization to various specific allergens in a dose-response manner."	( Association of urinary bisphenol A concentration with allergic asthma: results from the National Health and Nutrition Examination Survey 2005-2006. Kulkarni, H; Vaidya, SV, 2012)	0.69
"The results from this extended study, using IVF as a model to study early reproductive health outcomes in humans, indicate a negative dose-response association between urinary BPA concentrations and serum peak E(2) and oocyte yield, confirming our previous findings."	( Urinary bisphenol A concentrations and early reproductive health outcomes among women undergoing IVF. Calafat, AM; Ehrlich, S; Flaws, JA; Hauser, R; Missmer, SA; Petrozza, JC; Williams, PL; Wright, D; Ye, X, 2012)	0.81
" The influences of temperature, time, water dosage and [Bmim][Ac] dosage on the hydrolysis reaction were examined."	( Hydrolysis of polycarbonate catalyzed by ionic liquid [Bmim][Ac]. Ge, X; Li, L; Liu, F; Song, X; Yang, X; Yu, S, 2013)	0.39
" The dose-response curves (DRC) between the observed inhibition toxicities and concentrations of the BPA compounds in MTS assay were fitted by using the nonlinear least squares (NLS) and the results showed that all the dose-response relationships were effectively described by the Weibull or Logit function."	( [Detecting the cytotoxicities of five bisphenol A analogues to the MCF-7 human breast carcinoma cell line through different endpoints]. Liu, SS; Liu, Y; Zhang, SS; Zhu, XW, 2012)	0.65
" To achieve the optimum derivatization performance, the derivatization time and dosage of derivatization reagent etc."	( [Determination of bisphenol A from toys and food contact materials by derivatization and gas chromatography-mass spectrometry]. Chen, J; Gao, J; Gao, Y; Zhang, H; Zhang, Y; Zheng, L, 2012)	0.71
" Considering the adverse endocrine disruptive effects of BPA and the dosage exposure level (from tens to hundreds ng (kgbw)(-1)day(-1)), human exposure to BPA in Shenzhen deserves more attention."	( Bisphenol A in supermarket receipts and its exposure to human in Shenzhen, China. Chang, WJ; Lu, SY; Ni, HG; Sojinu, SO, 2013)	1.83
" The results showed that the photocatalytic degradation efficiency of the micrometer Gd-TiO2 particles was similar to that of the nanometer P-25 particles at their respective optimum dosage but the former could be easily separated out by gravity."	( Photocatalytic degradation of bisphenol A using an integrated system of a new gas-liquid-solid circulating fluidized bed reactor and micrometer Gd-doped TiO2 particles. Cheng, Z; Huang, Y; Quan, X; Xiang, J; Xu, Y, 2012)	0.67
" Two plausible explanations for the observed results could be given: a non-monotonic dose-response relationship or a mixture toxicity effect."	( Bisphenol A migration from plastic materials: direct insight of ecotoxicity in Daphnia magna. Domingues, V; Ferreira, IM; Gameiro, P; Mansilha, C; Pinho, C; Rocha, S; Silva, P, 2013)	1.83
"Distinguishing between clastogens and aneugens is vital in cancer risk assessment because the default assumption is that clastogens and aneugens have linear and non-linear dose-response curves, respectively."	( A mode-of-action approach for the identification of genotoxic carcinogens. Hernández, LG; Johnson, GE; van Benthem, J, 2013)	0.39
"A dose-response study was conducted in adult Wistar rats randomized into five groups (n = 12)."	( Oral homeostasis disruption by medical plasticizer component bisphenol A in adult male rats. Artur, Y; Bergès, R; Boudalia, S; Canivenc-Lavier, MC; Decocq, L; Folia, M; Ménétrier, F; Pasquis, B; Schneider, C, 2013)	0.63
"According to the dose-response curve, BPA decreased total drinking but increased salt preference, which was inversely proportional to water consumption (Kruskal-Wallis, P < ."	( Oral homeostasis disruption by medical plasticizer component bisphenol A in adult male rats. Artur, Y; Bergès, R; Boudalia, S; Canivenc-Lavier, MC; Decocq, L; Folia, M; Ménétrier, F; Pasquis, B; Schneider, C, 2013)	0.63
" The association showed a dose-response relationship with increasing urine BPA level associated with further increased risk of overweight (p = 0."	( Urine bisphenol-A level in relation to obesity and overweight in school-age children. Li, DK; Liu, X; Miao, M; Shi, H; Wang, S; Wu, C; Yuan, W; Zhou, Z, 2013)	0.39
" For most of these outcomes non-monotonic dose-response relationships were observed; the highest BPA dose did not produce a significant effect for any outcome."	( Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation. Angle, BM; Besch-Williford, CL; Do, RP; Drury, BE; Nagel, SC; Palanza, P; Parmigiani, S; Ponzi, D; Stahlhut, RW; Taylor, JA; vom Saal, FS; Welshons, WV, 2013)	0.61
"There was a dose-response association of BPA exposure with altered human oocyte maturation in vitro."	( Bisphenol-A and human oocyte maturation in vitro. Combelles, CM; Correia, KF; Hauser, R; Machtinger, R; Missmer, SA; Racowsky, C; Williams, P, 2013)	0.39
"Although biological effects of endocrine disrupting chemicals (EDCs) are often observed at unexpectedly low doses with occasional nonmonotonic dose-response characteristics, transcriptome-wide profiles of sensitivities or dose-dependent behaviors of the EDC responsive genes have remained unexplored."	( Expressomal approach for comprehensive analysis and visualization of ligand sensitivities of xenoestrogen responsive genes. Carey, VJ; Coser, KR; Isselbacher, KJ; Medvedovic, M; Phatak, M; Rosenthal, NF; Shioda, T; Suto, M, 2013)	0.39
" Chlorination was relatively not effective for the removal of micropollutants due to the lower chlorine dosage (2 mg L(-1)), lower contact time (1h), and already lower levels of micropollutants at the chlorination stage at WTP."	( Occurrence and removal of selected micropollutants in a water treatment plant. Jo, BI; Nam, SW; Yoon, Y; Zoh, KD, 2014)	0.4
" For both cyclins protein levels, the maximum stimulation was present at 10-9M BPA and the effects resembled the "inverted U"-shape, a nonmonotonic dose-response curve reported for the action of xenoestrogens."	( Bisphenol A alone or in combination with estradiol modulates cell cycle- and apoptosis-related proteins and genes in MCF7 cells. Fickova, M; Macho, L; Mlynarcikova, A, 2013)	1.83
"We report the use of three different statistical models in the analysis of BPA: (1) logistic regression, (2) log-linear regression, and (3) dose-response logistic regression."	( Disconcordance in statistical models of bisphenol A and chronic disease outcomes in NHANES 2003-08. Casey, MF; Neidell, M, 2013)	0.66
" BPA amendment had a significant impact on sediment bacterial community, influenced by dosage levels."	( Aerobic biodegradation of bisphenol A in river sediment and associated bacterial community change. Wang, Z; Xie, S; Yang, Y, 2014)	0.7
" In 19-month-old male offspring, epididymal sperm counts were lower than controls, and in ventral prostate an overrepresentation of findings related to hyperplasia was observed in exposed groups compared with controls, particularly in the group dosed with anti-androgens."	( Late-life effects on rat reproductive system after developmental exposure to mixtures of endocrine disrupters. Axelstad, M; Boberg, J; Christiansen, S; Hass, U; Isling, LK; Jacobsen, PR; Kortenkamp, A; Mandrup, KR; Taxvig, C; Vinggaard, AM, 2014)	0.4
"002 mg/kg body weight), with non-monotonic dose-response (NMDR) curves, using few animals per group and few groups; contract research organizations, in good laboratory practice- and guideline-compliant large studies in rats and mice, report no low-dose effects or NMDR curves."	( Abbreviated assessment of bisphenol A toxicology literature. Tyl, RW, 2014)	0.7
" Sprague Dawley rat dams were dosed daily from gestation day 6 until the start of labor, and their pups were directly dosed from day 1 after birth to termination."	( Toxicity evaluation of bisphenol A administered by gavage to Sprague Dawley rats from gestation day 6 through postnatal day 90. Bryant, MS; Camacho, L; Chidambaram, M; Davis, KJ; Delclos, KB; Felton, RP; Gamboa da Costa, G; Juliar, BE; Latendresse, JR; Lewis, SM; Olson, GR; Patton, RE; Thorn, BT; Trbojevich, R; Vanlandingham, MM; Woodling, KA, 2014)	0.71
"5 μg/kg bw/day BPA (7-10nM), despite careful attention to potential BPA inputs (diet, drinking water, vehicle, cages, bedding, and dust) and rigorous dosing solution certification and delivery."	( Comparison of life-stage-dependent internal dosimetry for bisphenol A, ethinyl estradiol, a reference estrogen, and endogenous estradiol to test an estrogenic mode of action in Sprague Dawley rats. Camacho, L; Churchwell, MI; Delclos, KB; Doerge, DR; Fisher, JW; Sepehr, E; Twaddle, NC; Vanlandingham, MM, 2014)	0.65
" This finding reflects a non-monotonic dose-response that has been observed for an increasing number of endocrine disrupting compounds."	( Bisphenol A affects larval growth and advances the onset of metamorphosis in Drosophila melanogaster. Bennett, K; Johndreau, K; Parker, AL; Rachfalski, C; Ramirez, A; Rose, RW; Smith, ST; Weiner, AK; Wolff, E; Zhou, J; Zintel, T, 2014)	1.85
" Several phthalate metabolites, including phthalic acid, MBzP and monobutyl phthalate, were also associated with faster prospective weight gain in a dose-response fashion (P-trend<0."	( Urinary concentrations of bisphenol A and phthalate metabolites and weight change: a prospective investigation in US women. Franke, AA; Hauser, R; Hu, FB; Liu, S; Song, Y; Sun, Q, 2014)	0.7
"These data suggest urinary concentrations of BPA and certain individual phthalate metabolites that were associated with modestly greater weight gain in a dose-response fashion."	( Urinary concentrations of bisphenol A and phthalate metabolites and weight change: a prospective investigation in US women. Franke, AA; Hauser, R; Hu, FB; Liu, S; Song, Y; Sun, Q, 2014)	0.7
" High dosage of H2O2 and low pH were favorable for the degradation of EDCs."	( Removal of phenolic endocrine disrupting compounds from waste activated sludge using UV, H2O2, and UV/H2O2 oxidation processes: effects of reaction conditions and sludge matrix. Li, Y; Zhang, A, 2014)	0.4
" Increasing the Fe(VI) dosage can reduce the effects of soluble organic matter and clay particles present in source waters on the degradation process, leading to the complete removal of target micropollutants."	( Ferrate(VI) oxidation of tetrabromobisphenol A in comparison with bisphenol A. Chen, XW; Chen, ZF; Peng, FQ; Yang, B; Ying, GG; Zhao, JL, 2014)	0.68
" The optimal dosage of TiO2 in the TZ system was 60% and that of Cu20 in the CTZ system was 20%."	( Synergistic effects of TiO2 and Cu2O in UV/TiO2/zeolite-based systems on photodegradation of bisphenol A. Kuo, CY; Lin, HY; Wu, CH, 2014)	0.62
" In addition to generating data from combined exposure, we fitted these to a four-parametric logistic dose-response model."	( Effect of estrogenic binary mixtures in the yeast estrogen screen (YES). Buechse, A; Dammann, M; Melching-Kollmuß, S; Ramirez, T; van Ravenzwaay, B; Woitkowiak, C, 2014)	0.4
" bi-hourly) was not observed to affect the removal efficiency of the cited conventional water quality parameters, significantly lower removal efficiencies were found for tonalide and bisphenol A for the VF wetland that received bi-hourly dosing (VS2p) (higher volume per pulse), probably due to the more reducing conditions observed in that system."	( Emerging organic contaminants in vertical subsurface flow constructed wetlands: influence of media size, loading frequency and use of active aeration. Avila, C; Bayona, JM; García, J; Headley, T; Kassa, K; Mueller, RA; Nivala, J; Olsson, L, 2014)	0.59
" U-shaped, inverted U-shaped and J-shaped dose-response curves were found to describe the relationships between bisphenol-A with the behavioural outcomes."	( Bisphenol-A exposures and behavioural aberrations: median and linear spline and meta-regression analyses of 12 toxicity studies in rodents. Ceppi, M; Munnia, A; Peluso, ME, 2014)	0.4
"Eighteen four-week-old female Sprague-Dawley (SD) rats were randomly divided into BPA group (50mg/kg BPA), BPA+CGE group (50mg/kg BPA+50mg/kg CGE), and control group (equivalent dosage of vehicle) with 6 rats in each group."	( The extracts of Pacific oyster (Crassostrea gigas) alleviate ovarian functional disorders of female rats with exposure to bisphenol a through decreasing FSHR expression in ovarian tissues. Jin, Y; Qu, F; Yang, DX; Zhou, J, 2014)	0.61
" Then, using the FeTA system without LH (the experimental conditions in which mouse and human fetal testes are most sensitive to BPA), we found that, as for BPA, 10 nmol/L BPS or BPF is sufficient to decrease basal testosterone secretion by human fetal testes with often nonmonotonic dose-response curves."	( A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound. Benachi, A; Eladak, S; Grisin, T; Guerquin, MJ; Habert, R; Livera, G; Moison, D; N'Tumba-Byn, T; Pozzi-Gaudin, S; Rouiller-Fabre, V, 2015)	0.74
" CN might be partly determined by the requirement of dosage balance between the 5S and 45S rDNA arrays."	( Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomes. Branco, AT; Gibbons, JG; Godinho, SA; Lemos, B; Yu, S, 2015)	0.42
" Effects of initial pH and CaO2 dosage were investigated."	( Performance of calcium peroxide for removal of endocrine-disrupting compounds in waste activated sludge and promotion of sludge solubilization. Li, Y; Wang, J; Zhang, A, 2015)	0.42
" To investigate the potential epigenetic mechanisms behind developmental BPA-induced hepatic steatosis, pregnant Sprague-Dawley rats were dosed with vehicle (oil) or BPA (100μg/kg/day) from gestational day 6 until postnatal day (PND) 21."	( Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis. Engeseth, NJ; Flaws, JA; Helferich, WG; Lezmi, S; Pan, YX; Strakovsky, RS; Wang, H, 2015)	0.78
" In this study, pregnant mice (F0) were orally dosed with vehicle, BPA (0."	( The effects of in utero bisphenol A exposure on reproductive capacity in several generations of mice. Flaws, JA; Wang, W; Zhou, C; Ziv-Gal, A, 2015)	0.72
" Our quantitative real-time PCR analyses revealed that the expression levels of several hepatic estrogen-responsive biomarker genes in male medaka responded to various types and concentrations of BPs in a dose-response manner."	( In vivo and in silico analyses of estrogenic potential of bisphenol analogs in medaka (Oryzias latipes) and common carp (Cyprinus carpio). Arizono, K; Ishibashi, H; Tominaga, N; Yamaguchi, A, 2015)	0.66
" Restricted cubic spline analysis was performed to help assess linearity and nature of any dose-response relationships."	( Exposure to phthalates, bisphenol A and metals in pregnancy and the association with impaired glucose tolerance and gestational diabetes mellitus: The MIREC study. Arbuckle, TE; Ashley-Martin, J; Bouchard, MF; Dallaire, R; Dodds, L; Ettinger, AS; Fisher, M; Fraser, W; Keely, E; Monnier, P; Morisset, A; Shapiro, GD; Taback, S, 2015)	0.72
" Our previous published study showed that BPA has non-monotonic (inverted U-shaped) dose-response effect on rare minnow Gobiocypris rarus ovarian weight at different concentrations."	( Non-monotonic dose-response effect of bisphenol A on rare minnow Gobiocypris rarus ovarian development. Liu, Y; Tao, S; Wang, Z; Yuan, C; Zhang, Y, 2016)	0.71
" Pregnant NCTR Sprague-Dawley rats were orally dosed from gestational day 6 to parturition, and offspring were directly orally dosed until weaning (postnatal day 21)."	( Effects of developmental exposure to bisphenol A on spatial navigational learning and memory in rats: A CLARITY-BPA study. Camacho, L; Ellersieck, MR; Ferguson, SA; Javurek, AB; Johnson, SA; Lewis, SM; Painter, MS; Rosenfeld, CS; Vanlandingham, MM; Welsh, TH, 2016)	0.71
" Also, factors including initial solution pH, initial Cd(2+)/BPA concentration, contact time and adsorbent dosage on the adsorption processes were shown to be crucial for Cd(2+) adsorption, whereas had negligible effects on BPA adsorption."	( Simultaneous adsorption of Cd²⁺ and BPA on amphoteric surfactant activated montmorillonite. Liu, C; Tran, L; Wu, P; Zhu, Y, 2016)	0.43
" Young adult female C57BL/6J mice (39 days old) were orally dosed with corn oil (vehicle) or 50 μg/kgbw/day BPA for a period encompassing the first three reproductive cycles (12-15 days)."	( Exposure to bisphenol A in young adult mice does not alter ovulation but does alter the fertilization ability of oocytes. Acuña-Hernández, DG; Hernández-Ochoa, I; Moore-Ambriz, TR; Piña-Guzmán, B; Ramos-Robles, B; Sánchez-Gutiérrez, M; Santacruz-Márquez, R; Shibayama, M; Sierra-Santoyo, A, 2015)	0.8
" A hypothesis of decreased oral uptake was needed to account for the reduced peak levels observed in adult humans, where d6-BPA was delivered in soup and food was provided prior to BPA ingestion, suggesting the potential impact of dosing vehicles and/or fasting on BPA disposition."	( Development of a physiologically based pharmacokinetic model for assessment of human exposure to bisphenol A. Doerge, DR; Fisher, JW; Teeguarden, JG; Yang, X, 2015)	0.63
" One of the aims was to perform a study robust enough to contribute to the risk assessment of BPA and to elucidate possible biphasic dose-response relationships."	( Low-dose effects of bisphenol A on mammary gland development in rats. Boberg, J; Christiansen, S; Hass, U; Isling, LK; Mandrup, K, 2016)	0.76
" Dose-response curves in response to estrogenic standard 17β-estradiol were compared."	( Assessment of methods of detection of water estrogenicity for their use as monitoring tools in a process of estrogenicity removal. Blavier, J; Debaste, F; Flahaut, S; Penninckx, M; Scippo, ML; Simon, C; Songulashvili, G, 2016)	0.43
" Serum VTG contents demonstrated a similar dose-response pattern in the epidermis and the blood."	( Kinetic determination of vitellogenin induction in the epidermis of cyprinid and perciform fishes: Evaluation of sensitive enzyme-linked immunosorbent assays. Allner, B; Hennies, M; Lerche, CF; Schmidt, T; Schneider, K; Stahlschmidt-Allner, P; Willner, M, 2016)	0.43
" There is still no satisfactory model that would be capable of predicting the toxic effects of mixtures containing partial receptor agonists and compounds with different parameters of their dose-response curves."	( Novel full logistic model for estimation of the estrogenic activity of chemical mixtures. Cajthaml, T; Ezechiáš, M, 2016)	0.43
" The elimination of radioactivity was rapid, but residues were still detectable 24 hr after dosing in all tissues analyzed."	( Maternal and Fetal Pharmacokinetics of Oral Radiolabeled and Authentic Bisphenol A in the Rhesus Monkey. Gerona, RR; Hillenweck, A; Hunt, PA; Tarantal, AF; VandeVoort, CA; Vom Saal, FS; Zalko, D, 2016)	0.67
" To test this hypothesis, rats were dosed with vehicle, ethinyl estradiol (0."	( Bisphenol A Exposure, Ovarian Follicle Numbers, and Female Sex Steroid Hormone Levels: Results From a CLARITY-BPA Study. Brehm, E; Flaws, JA; Gao, L; Patel, S; Rattan, S; Ziv-Gal, A, 2017)	1.9
" The effects of various parameters including adsorption time, equilibrium pH, adsorbent dosage and initial adsorbate concentration were investigated."	( Kinetic and isotherm studies of bisphenol A adsorption onto orange albedo(Citrus sinensis): Sorption mechanisms based on the main albedo components vitamin C, flavones glycosides and carotenoids. Doungmo, G; Gouoko Kouonang, JJ; Kamgaing, T; Mbadcam, KJ; Melataguia Tchieno, FM, 2017)	0.74
" Across all exposure groups including vehicle controls, body weight of continuously dosed males was reduced compared to males dosed only until PND21."	( Effects of bisphenol A on incidence and severity of cardiac lesions in the NCTR-Sprague-Dawley rat: A CLARITY-BPA study. Belcher, SM; Gear, R; Kendziorski, JA, 2017)	0.84
" These preliminary results seems to indicate very low or absence of estrogenic activity for Pergafast 201, D-8, D-90, TGSA and BPS-MAE in comparison to BPA and BPS, although further dose-response tests with authentic standards are required to confirm these results."	( Bisphenol A alternatives in thermal paper from the Netherlands, Spain, Sweden and Norway. Screening and potential toxicity. Ballesteros-Gómez, A; Björnsdotter, MK; Jonker, W; Kool, J; Legradi, J, 2017)	1.9
" In the cerebellum, we found an increase in Ngb and Cat, in the hypothalamus, there was a decrease in Cygb and an increase in glutathione peroxidase and Cat and in hypoxia-inducible factor 1 alpha (Hif1α) at the low dosage and a decrease in Hif1α at the high BPA dosage."	( Anatomical specificity of the brain in the modulation of Neuroglobin and Cytoglobin genes after chronic bisphenol a exposure. Chiamolera, MI; da Conceição, RR; da Silva, MRD; de Barros Maciel, RM; de Oliveira, KC; de Souza, JS; Giannocco, G; Romano, MA; Romano, RM, 2017)	0.67
"A complete BPA dose-response analysis of prostate lesions across multiple prostatic lobes was conducted that included internal BPA dosimetry, progression to adenocarcinoma with aging and mechanistic connections to epigenetically reprogramed genes."	( Prostate Cancer Risk and DNA Methylation Signatures in Aging Rats following Developmental BPA Exposure: A Dose-Response Analysis. Birch, L; Calderon-Gierszal, E; Cheong, A; Groen, J; Ho, SM; Hu, WY; Lin, H; Prins, GS; van Breemen, RB; Ye, SH; Zhang, X, 2017)	0.46
"In regulatory toxicology, the dose-response relationship is a key element towards fulfilling safety assessments and satisfying regulatory authorities."	( Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on ca2+ entry in mouse pancreatic β-cells. Alonso-Magdalena, P; Castellano-Muñoz, M; Gustafsson, JA; Marroqui, L; Martinez-Pinna, J; Nadal, A; Quesada, I; Villar-Pazos, S, 2017)	0.46
" BPA toxicokinetics have been well studied, with controlled oral dosing studies in several species and across a wide dose range."	( Extrapolation of plasma clearance to understand species differences in toxicokinetics of bisphenol A. Hays, S; Poet, T, 2018)	0.7
" Fluid intakes displayed inverted U-shaped dose-response curves, with different dose dependencies in spontaneously drinker rats than after 24 h water deprivation dehydration."	( Short-term exposure to bisphenol A affects water and salt intakes differently in male and ovariectomised female rats. Arguelles, J; Nuñez, P; Perillan, C, 2018)	0.79
" With this increased diversity of receptor targets, it may be possible to explain some of the more puzzling aspects of BPA pharmacology, including its non-monotonic dose-response curve, as well as experimental results which disagree with estrogenic positive controls."	( A plurality of molecular targets: The receptor ecosystem for bisphenol-A (BPA). Abizaid, A; MacKay, H, 2018)	0.48
" At concentrations higher than 10 μM, these effects disappeared, reflecting a non-monotonic dose-response relationship."	( Submicromolar bisphenol A induces proliferation and DNA damage in human hepatocyte cell lines in vitro and in juvenile rats in vivo. Choi, E; Jee, S; Jeong, JS; Kang, KW; Kim, M; Kim, S; Lee, YS; Lim, KM; Mun, GI, 2018)	0.84
" We also explored whether the BPA level exhibited dose-response relationships with liver enzyme levels."	( A prospective cohort study of the association between bisphenol A exposure and the serum levels of liver enzymes in children. Ha, EH; Han, H; Hong, YS; Lee, HA; Lee, S; Oh, SY; Park, B; Park, BH; Park, H, 2018)	0.73
" After adjustment for covariates, dose-response relationships of the BPA level with liver enzyme levels were evident at 7-9 years, but not at 3-5 years."	( A prospective cohort study of the association between bisphenol A exposure and the serum levels of liver enzymes in children. Ha, EH; Han, H; Hong, YS; Lee, HA; Lee, S; Oh, SY; Park, B; Park, BH; Park, H, 2018)	0.73
" Pregnant CD-1 mice (F0) were dosed daily with 0, 5, or 500 μg/kg/d BPA during gestational days 9 to 18, and the weaned F1 animals were fed ad libitum with standard chow until they were euthanized at 19 weeks old."	( Prenatal Exposure to Bisphenol A Disrupts Naturally Occurring Bimodal DNA Methylation at Proximal Promoter of fggy, an Obesity-Relevant Gene Encoding a Carbohydrate Kinase, in Gonadal White Adipose Tissues of CD-1 Mice. Angle, BM; Mitsunaga, S; Nagel, SC; Shioda, K; Shioda, T; Taylor, JA; Vom Saal, FS; Yawata, S, 2018)	0.8
" In vitro concentration-response data of 17β-estradiol (E2) and bisphenol A (BPA) obtained in the MCF-7/BOS proliferation assay, the U2OS ER-CALUX assay and the yeast estrogen screen (YES) assay, were translated into in vivo dose-response data in rat, using a PBK model with a minimum number of in vitro and in silico determined parameter values."	( Towards a generic physiologically based kinetic model to predict in vivo uterotrophic responses in rats by reverse dosimetry of in vitro estrogenicity data. Fabian, E; Louisse, J; Rietjens, IMCM; van Ravenzwaay, B; Zhang, M, 2018)	0.72
" Toward this end, lymphoid tissues from a total of 641 rats were assayed after being continuously dosed with BPA or controls for up to one year."	( CLARITY-BPA: Effects of chronic Bisphenol A exposure on the immune system: Part 1 - Quantification of the relative number and proportion of leukocyte populations in the spleen and thymus. Bach, A; Chen, W; Crawford, RB; D'Ingillo, S; Kaminski, NE; Kaplan, BLF; Kovalova, N; Li, J; Phadnis-Moghe, AS; Suarez-Martinez, JE; Zhou, J, 2018)	0.76
"05) in response to each dosage of bisphenol analogs exposures."	( Effects of bisphenol A and its analogs bisphenol F and S on life parameters, antioxidant system, and response of defensome in the marine rotifer Brachionus koreanus. Han, J; Hwang, UK; Jung, JH; Kim, M; Lee, JS; Lee, MC; Park, JC; Yoon, DS, 2018)	1.15
" Data from live cell measurements were fit to a log-linear dose-response model."	( A Ternary Mixture of Common Chemicals Perturbs Benign Human Breast Epithelial Cells More Than the Same Chemicals Do Individually. Dairkee, SH; Goodson, WH; Jaffee, IM; Luciani-Torres, G; Moore, DH, 2018)	0.48
"X-chromosome inactivation (XCI) occurs during the gestation period to compensate for the dosage of X-linked genes in female mammals."	( [New Approach to the Investigation of DOHaD Using X-inactivation Gene Expression System]. Kumamoto, T; Oshio, S, 2018)	0.48
"The BPA oral intake at low and ten times higher dosage caused an increase of the number of sympa-thetic nerve fibers within the porcine liver by 48."	( Alterations in porcine intrahepatic sympathetic nerves after bisphenol A administration. Bejer-Olenska, E; Dzika, E; Godlewski, J; Rytel, L; Thoene, M; Wojtkiewicz, J, 2018)	0.72
" Furthermore, it is unclear whether effects of BPA/phthalates on the placenta in animal models mediate fetal outcomes, as most studies have dosed after the earliest stages of placental and fetal development."	( Using Experimental Models to Assess Effects of Bisphenol A (BPA) and Phthalates on the Placenta: Challenges and Perspectives. Schantz, SL; Strakovsky, RS, 2018)	0.74
" Dose-response relationships of BPA with LIN, WOB, ALH, MAD and sperm concentration were demonstrated by statistically significant trends across tertiles of creatinine-adjusted BPA concentrations."	( Exposure of environmental Bisphenol A in relation to routine sperm parameters and sperm movement characteristics among fertile men. Ji, H; Li, Y; Liang, H; Miao, M; Ruan, D; Shi, H; Wang, J; Yuan, W, 2018)	0.78
" The pups were individually dosed with BPA from postnatal days (P) 1-10, while the dams continued to consume one of the two diets."	( Perinatal High-Fat Diet and Bisphenol A: Effects on Behavior and Gene Expression in the Medial Prefrontal Cortex. Boas, SM; Hernández-Saavedra, D; Juraska, JM; Pan, YX; Wise, LM, 2019)	0.81
" Thus, immediately after releasing the results from their core portion of CLARITY-BPA, the FDA issued a statement concluding BPA was "safe," and they ignored non-monotonic dose-response relationships."	( Flaws in design, execution and interpretation limit CLARITY-BPA's value for risk assessments of bisphenol A. Vom Saal, FS, 2019)	0.73
" No clear dose-response relationship between maternal BPA and ADHD scores above the 85th percentile was found for either sex."	( Prenatal bisphenol A exposure is associated with language development but not with ADHD-related behavior in toddlers from the Odense Child Cohort. Andersen, HR; Andersson, AM; Bilenberg, N; Bleses, D; Frederiksen, H; Grandjean, P; Jensen, TK; Juul, A; Kyhl, HB; Mustieles, V; Schoeters, G; Trecca, F, 2019)	0.93
" The strongest effect was observed in high does-exposure rats, indicating dose-response relationship between BPA-treatment and urinary nucleosides."	( Evaluation of bisphenol A exposure induced oxidative RNA damage by liquid chromatography-mass spectrometry. Cai, Z; Jiang, Y; Jin, Y; Li, S; Zhao, H, 2019)	0.87
" The characteristics of the changes clearly depended on the part of the uterus, the neuronal factors studied, and the dosage of BPA."	( The Neurochemical Characterization of Parasympathetic Nerve Fibers in the Porcine Uterine Wall Under Physiological Conditions and After Exposure to Bisphenol A (BPA). Andrzej, P; Joanna, W; Liliana, R; Slawomir, G; Tomasz, J, 2019)	0.71
" Female and male NOD offspring were exposed to 0 or 300 µg BPA/kg BW perinatally from gestation day 5 to PND28 by dosing the dams."	( Bisphenol A alteration of type 1 diabetes in non-obese diabetic (NOD) female mice is dependent on window of exposure. Guo, TL; Huang, G; Nagy, T; Xu, J, 2019)	1.96
" The Gaddum equation, which is fundamental for both methods, should be extended to incorporate the slope parameter of the dose-response curves and this extension should diminish the differences between the Schild and Cheng-Prusoff methods."	( Estimation of competitive antagonist affinity by the Schild method and from functional inhibition curves using a novel form of the Gaddum equation. Cajthaml, T; Ezechiáš, M, 2019)	0.51
" In addition, non-monotonic dose-response relationships were observed between the concentrations of bisphenols and the toxic effects mentioned above."	( Neurotoxicity of BPA, BPS, and BPB for the hippocampal cell line (HT-22): An implication for the replacement of BPA in plastics. Fan, R; Li, G; Li, Y; Luo, Z; Meng, L; Pang, Q, 2019)	0.51
" Due to the non-monotonic dose-response effect of bisphenol, the data of both BPS groups were directly compared with those of the controls, not to each other."	( Short and long-term effects of bisphenol S (BPS) exposure during pregnancy and lactation on plasma lipids, hormones, and behavior in rats. Bertasso, IM; Carvalho, JC; Claudio-Neto, S; da Silva, BS; de Moura, EG; Lisboa, PC; Lopes, BP; Manhães, AC; Oliveira, E; Peixoto-Silva, N; Pietrobon, CB; Santos, TR, 2019)	0.51
" Timed-pregnant National Center for Toxicological Research Sprague-Dawley rats (strain code 23) were dosed by gavage with vehicle control (0."	( CLARITY-BPA: Bisphenol A or Propylthiouracil on Thyroid Function and Effects in the Developing Male and Female Rat Brain. Bansal, R; Zoeller, RT, 2019)	0.88
" Transcriptomic dose-response analysis following short-term exposures may provide a more reliable and biologically-based alternative for estimating chronic toxicity."	( Transcriptomic points-of-departure from short-term exposure studies are protective of chronic effects for fish exposed to estrogenic chemicals. Crump, D; O'Brien, JM; Pagé-Larivière, F, 2019)	0.51
" The whole dose-response relationship follows non-monotonic dose responses, such as an inverted U-shape."	( Bisphenol A induces cholesterol biosynthesis in HepG2 cells via SREBP-2/HMGCR signaling pathway. Feng, D; Feng, X; Li, Q; Zhang, H; Zou, J, 2019)	1.96
" The influences of modifier dosage and adsorbent dosage on the adsorption performance were investigated as well."	( Design and synthesis of organic rectorite-based composite nanofiber membrane with enhanced adsorption performance for bisphenol A. Shen, X; Sun, B; Sun, Z; Wang, B; Yuan, F; Zhang, X; Zhu, R, 2019)	0.72
" Male mice were dosed orally to 40 μg and 400 μg BPA/kg body weight for 60 days."	( Bisphenol A triggers axonal injury and myelin degeneration with concomitant neurobehavioral toxicity in C57BL/6J male mice. Akhter, J; Banerjee, BD; Goswami, P; Gupta, S; Jahan, S; Khan, J; Parvez, S; Raisuddin, S; Salhotra, S; Sharma, S, 2019)	1.96
"5 mg/L, adsorbent dosage 1 g/L and pH = 6."	( Adsorptive removal of endocrine disrupting compounds from aqueous solutions using magnetic multi-wall carbon nanotubes modified with chitosan biopolymer based on response surface methodology: Functionalization, kinetics, and isotherms studies. Dehghani, MH; Es'haghi, Z; Mesdaghinia, A; Mohammadi, AA; Yaghmaian, K, 2020)	0.56
" The effects of catalyst dosage and pH on the removal efficiency of BPA were also investigated."	( Degradation of Bisphenol A by CeCu Oxide Catalyst in Catalytic Wet Peroxide Oxidation: Efficiency, Stability, and Mechanism. Chen, L; Gao, X; Gong, H; Jiao, Z; Liu, Y; Zhang, X; Zhou, G, 2019)	0.87
" The dose-response relationship was explored by the restricted cubic spline model."	( Association of bisphenol A and its alternatives bisphenol S and F exposure with hypertension and blood pressure: A cross-sectional study in China. Jiang, S; Liu, H; Lu, Q; Peng, C; Tong, Y; Zhang, X; Zhou, H; Zhou, S, 2020)	0.91
" In this study, pregnant mice (F0) were orally dosed with BPA (i."	( Maternal exposure to environmental bisphenol A impairs the neurons in hippocampus across generations. Fan, R; Kuang, H; Liu, J; Lv, X; Meng, L; Pang, Q; Wang, Z; Zhang, H, 2020)	0.84
" In this review, we present striking evidence of the correlation between BPA exposure and various CVDs, and show that a nonmonotonic dose-response curve (NMDRC) was common in studies of the CV effects of BPA in vivo."	( Cardiovascular toxicity and mechanism of bisphenol A and emerging risk of bisphenol S. Hao, XD; Jia, DD; Qian, LL; Shan, C; Wang, Y; Xu, HM; Zhang, YF, 2020)	0.82
" Pregnant Sprague-Dawley rats (n = 3) were divided into four groups (control, BPA (50 mg/kg/day), DEHP (30 mg/kg/day), and BPA (50 mg/kg/day) + DEHP (30 mg/kg/day)) and dosed by oral gavage during pregnancy and lactation."	( Histopathologic, apoptotic and autophagic, effects of prenatal bisphenol A and/or di(2-ethylhexyl) phthalate exposure on prepubertal rat testis. Balci, A; Erkekoglu, P; Kocer-Gumusel, B; Ozkemahli, G; Yersal, N; Zeybek, ND, 2020)	0.8
" We also observed a shallow concave dose-response relationship about the overall association between BPA and NSCLC."	( Urinary bisphenol A and its interaction with ESR1 genetic polymorphism associated with non-small cell lung cancer: findings from a case-control study in Chinese population. Cheng, L; Ji, Z; Li, J; Li, Y; Long, J; Lu, Q; Luo, X; Shen, N; Shen, Y; Yuan, P; Zeng, Q; Zhong, R, 2020)	0.99
"Sprague-Dawley rats were exposed to BPA, vehicle, or positive control [ethinyl estradiol (EE2)] by oral gavage beginning on gestational day (GD)6 and continuing with direct dosing of the pups after birth."	( A Combined Morphometric and Statistical Approach to Assess Nonmonotonicity in the Developing Mammary Gland of Rats in the CLARITY-BPA Study. Acevedo, N; Bharadwaj, M; Fenton, SE; Montévil, M; Schaeberle, CM; Soto, AM, 2020)	0.56
" We tested this using a dose-response approach in C2C12 mouse and L6 rat myoblast cell lines."	( In Vitro Effects of Emerging Bisphenols on Myocyte Differentiation and Insulin Responsiveness. Jing, J; Lyu, L; Pu, Y; Veiga-Lopez, A, 2020)	0.56
"We dermally administered deuterated BPA (d6-BPA) to 10 subjects (6 men and 4 women) at a dose of 100 µg/kg over a 12-hour period and conducted blood and urine analysis from the beginning of dosing through a three- or six-day period."	( Pharmacokinetics of bisphenol A in humans following dermal administration. Andra, SS; Arora, M; Birnbaum, LS; Bucher, JR; Church, R; Kapraun, DF; Linke, S; Nachman, RM; Pirow, R; Sasso, AF; Schurman, SH; Thayer, KA, 2020)	0.88
"Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)."	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Xun, J; Yaffe, MB; Yalew, A; Yamamoto, S; Yan, D; Yan, H; Yan, S; Yan, X; Yang, AD; Yang, E; Yang, H; Yang, J; Yang, JL; Yang, K; Yang, M; Yang, P; Yang, Q; Yang, S; Yang, W; Yang, X; Yang, Y; Yao, JC; Yao, WL; Yao, Y; Yaqub, TB; Ye, J; Ye, W; Yen, CW; Yeter, HH; Yin, C; Yip, V; Yong-Yi, J; Yu, HJ; Yu, MF; Yu, S; Yu, W; Yu, WW; Yu, X; Yuan, P; Yuan, Q; Yue, XY; Zaia, AA; Zakhary, SY; Zalwango, F; Zamalloa, A; Zamparo, P; Zampini, IC; Zani, JL; Zeitoun, R; Zeng, N; Zenteno, JC; Zepeda-Palacio, C; Zhai, C; Zhang, B; Zhang, G; Zhang, J; Zhang, K; Zhang, Q; Zhang, R; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, B; Zhao, D; Zhao, G; Zhao, H; Zhao, Q; Zhao, R; Zhao, S; Zhao, T; Zhao, X; Zhao, XA; Zhao, Y; Zhao, Z; Zheng, Z; Zhi-Min, G; Zhou, CL; Zhou, HD; Zhou, J; Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y, 2022)	0.72
" After serum BPA levels were divided into three groups (low, middle, and high), BPA showed a positive dose-response relationship with blood glucose, insulin, and HOMA-IR in the middle term of pregnancy."	( Serum Bisphenol A, glucose homeostasis, and gestational diabetes mellitus in Chinese pregnant women: a prospective study. Chen, Y; Du, H; He, G; Jiang, Q; Liu, S; Wang, H; Xu, L; Yang, J; Yi, J, 2021)	1.1
" Interestingly, the steady-state approximation following this dosing strategy achieved a fetal concentration of unconjugated BPA to levels observed in cord blood from human biomonitoring studies."	( Pregnancy-specific physiologically-based toxicokinetic models for bisphenol A and bisphenol S. Bhattacharya, S; Conolly, R; Filipovic, D; Gingrich, J; Veiga-Lopez, A, 2021)	0.86
" Pregnant Sprague-Dawley rats were orally dosed with vehicle, 5 μg/kg body weight (BW)/day of BPA, BPS and BPF, or 1 μg/kg BW/day of BPF on gestational days 6-21."	( Prenatal exposure to bisphenols affects pregnancy outcomes and offspring development in rats. Al Mansi, MH; Almond, AE; Beyene, HK; Bougouma, BDK; Bradford, WT; Cagle, LA; Campbell, EJ; Chuang, YJ; Dagher, JB; Kaimal, A; Mandal, A; MohanKumar, PS; MohanKumar, SMJ; Pope, C; Rifai, KJ; Rudi, TB; Varghese, MG; Whisnant, BB, 2021)	0.62
" Therefore, in addition to providing a current assessment of the states of academic research, government policies, and consumer behaviors, we make several reasonable and actionable recommendations for limiting human exposure to BPA through improved labeling, science-based dosage limits, and public awareness campaigns."	( Drivers of owning more BPA. Adegoke, EO; Pang, MG; Rahman, MS, 2021)	0.62
" We also found a non-monotonic dose-response curve of bisphenol effect in ZO-1 protein expression; low and high doses presented a significant decrease compared to control, while moderate dose presented no change."	( Effects of bisphenols on Blood-Testis Barrier protein expression in vitro: A systematic review and meta-analysis. Juárez, I; Mendoza-Rodríguez, CA; Peña-Corona, SI; Vargas, D; Vásquez Aguire, WS, 2021)	0.62
" Both plantation and BPA dosage had significant effects on bacterial abundance."	( Metagenomic analysis of microbial communities continuously exposed to Bisphenol A in mangrove rhizosphere and non-rhizosphere soils. Chai, M; Li, R; Tong, T; Wang, Q; Xie, S; Yang, Y, 2021)	0.86
"In the toxicological regime, the toxicological endpoint and its dose-response relationship are two of the most prominent characters in conducting a risk assessment for chemical exposure."	( Dose-response metabolomics and pathway sensitivity to map molecular cartography of bisphenol A exposure. Fang, M; Liu, M; Lv, Y; Zhao, H, 2022)	0.95
" A dose-response pattern was observed for the associations of BPAF, BPAP and BPB quartiles with URM."	( Environmental exposure to bisphenol analogues and unexplained recurrent miscarriage: A case-control study. Ao, J; Bao, S; Huo, X; Jin, F; Li, G; Mao, Y; Shi, Y; Ye, J; Zhang, J, 2022)	1.02
" The effects of degree of lignin depolymerization, chemical composition of lignin oligomers and dosage of ECGE on thermal and mechanical properties of the cured products were investigated."	( Preparation and properties of novel bio-based epoxy resin thermosets from lignin oligomers and cardanol. Chu, F; Huo, S; Jin, C; Kong, Z; Liu, G, 2021)	0.62
" When independent variables were categorized in tertiles, positive dose-response associations were observed between BPA-thought problems (p-trend = 0."	( BDNF as a potential mediator between childhood BPA exposure and behavioral function in adolescent boys from the INMA-Granada cohort. Arrebola, JP; D'Cruz, SC; David, A; Fernández, MF; Freire, C; Mundo-López, A; Mustieles, V; Olea, N; Olivas-Martínez, A; Reina-Pérez, I; Rodríguez-Carrillo, A; Smagulova, F; Vela-Soria, F, 2022)	0.72
" Upon screening, 11 articles were finalized to be further reviewed and data extraction tables containing information on (1) the type of animal model (2) duration and dosage of BPA exposure (3) changes in the lipid profile or weight (4) genes, signaling mechanism, or any neuroimmune signal involved, and (5) transgenerational effects were created."	( Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study. Bahari, H; Embong, H; Halim, S; Keong, YY; Naomi, R; Othman, F; Rajandram, R; Teoh, SH; Yazid, MD, 2022)	2.16
" Controversies in regards to the: (a) dose-response curves; (b) the complexity of sources, release mechanisms, and pathways of exposure; and/or (c) the quality and reliability of toxicological studies, appear to currently stifle progress toward the regulation of BPA-based plastic MCPs."	( An overview of the occurrence, fate, and human risks of the bisphenol-A present in plastic materials, components, and products. Gerassimidou, S; Hahladakis, JN; Iacovidou, E, 2023)	0.91
" Male Sprague-Dawley (28 days old) rats were dosed with 0, 10, 100, 200 mg/kg/day BPFL via gavage for 28 days."	( Fluornen-9-bisphenol increases Leydig cell proliferation but inhibits maturation in pubertal male rats via interacting with androgen receptor as an antagonist and estrogen receptor α as an agonist. Ge, RS; Li, J; Li, X; Meng, F; Su, M; Wang, Y; Zhang, B; Zhu, Y, 2022)	0.72
" The Bayesian kernel machine regression (BKMR) and restricted cubic spline (RCS) models showed a U-shaped dose-response relationship between bisphenol A (BPA) and free triiodothyronine (FT3) (p < 0."	( Associations of bisphenol exposure with thyroid hormones in pregnant women: a prospective birth cohort study in China. Fan, H; Huang, D; Huang, H; Liang, J; Liao, Q; Liu, S; Long, J; Pan, D; Qiu, X; Tang, P; Yu, C; Zeng, X, 2022)	0.92
" Overall, exposure to BPA increased the odds of having endometriosis, and there appeared to be a dose-response relationship."	( Association of environmental phenols with endometriosis and uterine leiomyoma: An analysis of NHANES, 2003-2006. Eata, V; Lee, AW, 2022)	0.72
"8 times that of human, which suggested that swine and bovine likely encountered high dosage exposure of BPs in the two Chinese livestock farms."	( Ten bisphenol analogs were abundantly found in swine and bovine urines collected from two Chinese farms: concentration profiles and risk evaluation. Dang, Z; Liu, ZH; Tang, Z; Wang, H; Zeng, F; Zhang, J, 2023)	1.47
" Pregnant Sprague Dawley rats were dosed via continuous gavage of TMBPA (0, 10, 50, and 200 mg/kg/day) from gestational day 14 to 21."	( Tetramethyl bisphenol A stimulates proliferation but inhibits fetal Leydig cell function in male rats by targeting estrogen receptor α after in utero exposure. Ge, RS; Li, J; Li, X; Lin, L; Meng, F; Qiao, X; Su, M; Tian, L; Wang, Y; Ye, L, 2022)	1.1
" Dose-response relationships were discovered between BPA, BPS, BPZ, and BPAF quartiles and PCOS."	( Exposure to bisphenol A and its analogs and polycystic ovarian syndrome in women of childbearing age: A multicenter case-control study. Shen, X; Tang, W; Xu, H; Zhan, W; Zhang, J, 2023)	1.29
" Furthermore, this paper highlighted the role of non-monotonic dose-response (NMDR) in BPA exposure, which will help to improve the overall understanding of the harmful effects of BPA on the male reproductive system."	( Susceptibility of male reproductive system to bisphenol A, an endocrine disruptor: Updates from epidemiological and experimental evidence. Bijalwan, V; Das, S; Sarkar, K; Singh, DP; Yadav, S; Yadav, SK, 2023)	1.17
" Therefore, a multilevel meta-analysis and subsequent dose-response analysis were conducted."	( Hazard characterization of bisphenol A (BPA) based on rodent models - Multilevel meta-analysis and dose-response analysis for reproductive toxicity. Bakar Siddique, MA; Brunton, NP; Cummins, E; Harrison, SM; Monahan, FJ; Nag, R; Wang, X, 2023)	1.21
" For six weeks, the animals were dosed intraperitoneally (i."	( Therapeutic potential of vitamin D against bisphenol A-induced spleen injury in Swiss albino mice. AbuGamja, ISA; Al-Griw, MA; Alansari, WS; AlBadawi, AB; Alfarga, A; Alghazeer, R; Alnajeebi, AM; Babteen, NA; Balog, HN; Elmoaket, MF; Eskandrani, AA; Shaibi, T; Shamlan, G, 2023)	1.17
" Although studies have confirmed that BPA exposure causes a decrease in sperm quality in offspring, the dosage used, and the underlying mechanism is not clear."	( Cuscuta chinensis flavonoids reducing oxidative stress of the improve sperm damage in bisphenol A exposed mice offspring. Bao, Y; Jiao, Y; Liu, Y; Shi, W; Wang, X; Zhao, Q; Zhu, Y, 2023)	1.13
" Meanwhile, a significant dose-response relationship was found between BPA and BPZ concentrations and NTD risk."	( Associations among bisphenol A, its analogs, and chlorinated derivatives in placenta and risk for neural tube defects: A case-control study. Cheng, Q; Jin, L; Li, Z; Liu, J; Ren, A; Wang, L; Zhu, H, 2023)	1.24
" We observed a positive trend in the cumulative effects of BPs and iodine on serum triiodothyronine (FT3) and free thyroxine (FT4), as well as a U-shaped dose-response relationship between BPs and the probability of occurrence of thyroperoxidase autoantibody positivity in women with low urinary iodine concentration."	( The Joint Effects of Bisphenols and Iodine Exposure on Thyroid during Pregnancy. Hong, X; Lu, W; Mai, S; Qu, M; Shen, L; Shi, Z; Song, Q; Sun, Z; Wang, Y; Wang, Z; Zang, J, 2023)	0.91
" Both BPA and BPS showed a positive dose-response relationship with trunk fat (BPA: P=."	( Association Between Urinary Bisphenols and Body Composition Among American Adults: Cross-Sectional National Health and Nutrition Examination Survey Study. Deng, Q; Dong, Q; Li, J; Li, Y; Qiu, S; Shen, B; Tang, T; Wang, J; Wei, Q; Wu, E; Wu, R; Yang, L; Zhang, C; Zhang, Y; Zhang, Z; Zhao, J; Zheng, J; Zhu, Q; Zong, H, 2023)	0.91
" Subgroup analysis and subsequent dose-response analysis were conducted if applicable."	( Multilevel meta-analysis and dose-response analysis for bisphenol A (BPA) exposure on metabolic and neurobehavioral effects. Brunton, NP; Cummins, E; Harrison, SM; Nag, R; Siddique, MAB; Wang, X, 2023)	1.16
" In conclusion, in-vitro toxicogenomics dose-response data combined with PBPK modeling can become a promising alternative new approach methodology (NAM) to support decision-making in chemical risk assessment."	( IVIVE-PBPK based new approach methodology for addressing early life toxicity induced by Bisphenol A. Chen, J; Deepika, D; Kumar, V; Li, X; Ni, M; Xiong, W; Zhang, L, 2024)	1.66
" We find that the fragmented, endpoint-oriented study evaluation system used by EFSA and BfR, with its emphasis on data that can support dose-response analyses, has obscured the overall BPA effect pattern relevant to male reproductive effects."	( Drivers of divergent assessments of bisphenol-A hazards to semen quality by various European agencies, regulators and scientists. Iacovidou, E; Kortenkamp, A; Martin, O; Scholze, M, 2024)	1.44