A 3-oxo-5-alpha-steroid 4-dehydrogenase 1 that is encoded in the genome of rat. [OMA:P24008, PRO:DNx]
EC 1.3.1.22;
SR type 1;
Steroid 5-alpha-reductase 1;
S5AR 1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 6 (54.55) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| nifedipine | Rattus norvegicus (Norway rat) | IC50 | 1.1200 | 1 | 0 |
| ethinyl estradiol | Rattus norvegicus (Norway rat) | IC50 | 960.0000 | 1 | 1 |
| anthralin | Rattus norvegicus (Norway rat) | IC50 | 19.9000 | 1 | 0 |
| hesperidin | Rattus norvegicus (Norway rat) | IC50 | 9.5000 | 1 | 0 |
| 1,2-benzisothiazoline-3-one | Rattus norvegicus (Norway rat) | IC50 | 12.2000 | 1 | 0 |
| finasteride | Rattus norvegicus (Norway rat) | IC50 | 180.0078 | 5 | 7 |
| finasteride | Rattus norvegicus (Norway rat) | Ki | 0.0595 | 3 | 4 |
| epristeride | Rattus norvegicus (Norway rat) | IC50 | 0.0475 | 2 | 2 |
| epristeride | Rattus norvegicus (Norway rat) | Ki | 0.0300 | 1 | 1 |
| 2,2'-((3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)diimino)bis-benzoic acid | Rattus norvegicus (Norway rat) | IC50 | 7.6000 | 1 | 0 |
| 1-ethyl-2-benzo[cd]indolone | Rattus norvegicus (Norway rat) | IC50 | 20.5000 | 1 | 0 |
| fce 28260 | Rattus norvegicus (Norway rat) | IC50 | 0.0150 | 1 | 1 |
| ly 300502 | Rattus norvegicus (Norway rat) | Ki | 0.0080 | 1 | 1 |
| 17-(3-pyridyl)androsta-5,16-dien-3-one | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Poriol | Rattus norvegicus (Norway rat) | IC50 | 13.1000 | 1 | 0 |
| 2,3-dichloro-5,8-dimethoxy-1,4-naphthoquinone | Rattus norvegicus (Norway rat) | IC50 | 9.5300 | 1 | 0 |
| 2,3-diaminophenazine | Rattus norvegicus (Norway rat) | IC50 | 9.8600 | 1 | 0 |
| 4-chloro-N-(3,4,5-trimethoxyphenyl)-5-dithiazolimine | Rattus norvegicus (Norway rat) | IC50 | 10.8000 | 1 | 0 |
| 1-(3,4-dichlorophenyl)-3-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)urea | Rattus norvegicus (Norway rat) | IC50 | 21.1000 | 1 | 0 |
| 2-(4-methoxyphenyl)-N-[4-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl]acetamide | Rattus norvegicus (Norway rat) | IC50 | 14.4000 | 1 | 0 |
| 4-chloro-N-(4-chloro-2-methylphenyl)-5-dithiazolimine | Rattus norvegicus (Norway rat) | IC50 | 15.4000 | 1 | 0 |
| 3-[4-[(4,6-dioxo-2-sulfanylidene-1,3-diazinan-5-ylidene)methyl]-3-(2-oxo-1-benzopyran-3-yl)-1-pyrazolyl]propanoic acid | Rattus norvegicus (Norway rat) | IC50 | 17.8000 | 1 | 0 |
| N-[2-(1-naphthalenyl)-1,3-benzoxazol-5-yl]-1H-1,2,4-triazole-5-carboxamide | Rattus norvegicus (Norway rat) | IC50 | 2.9200 | 1 | 0 |
| 2-[2-(4-fluoroanilino)-4-thiophen-2-yl-5-thiazolyl]acetic acid | Rattus norvegicus (Norway rat) | IC50 | 9.2100 | 1 | 0 |
| 3-bromo-N-(4-methyl-2-oxo-1-benzopyran-7-yl)benzamide | Rattus norvegicus (Norway rat) | IC50 | 5.3200 | 1 | 0 |
| 5-(2-chloroanilino)-3-oxo-4-isothiazolecarbonitrile | Rattus norvegicus (Norway rat) | IC50 | 4.7600 | 1 | 0 |
| N-(4-oxo-2-thieno[3,2-d][1,3]thiazinyl)-2-furancarboxamide | Rattus norvegicus (Norway rat) | IC50 | 11.8000 | 1 | 0 |
| N-[4-(1H-benzimidazol-2-yl)phenyl]-4-ethoxy-3-nitrobenzamide | Rattus norvegicus (Norway rat) | IC50 | 12.2000 | 1 | 0 |
| 6-amino-5-cyano-4-(2-fluorophenyl)-2-sulfanylidene-3,4-dihydro-1H-pyridine-3-carboxamide | Rattus norvegicus (Norway rat) | IC50 | 13.6000 | 1 | 0 |
| salazinic acid | Rattus norvegicus (Norway rat) | IC50 | 14.8000 | 1 | 0 |
| 17-n,n-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one | Rattus norvegicus (Norway rat) | IC50 | 0.0106 | 2 | 4 |
| 17-n,n-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| LSM-16789 | Rattus norvegicus (Norway rat) | IC50 | 56.8000 | 1 | 0 |
| N-[4-[2-[3-(dimethylsulfamoyl)anilino]-6H-1,3,4-thiadiazin-5-yl]phenyl]acetamide | Rattus norvegicus (Norway rat) | IC50 | 3.5600 | 1 | 0 |
| 5-(1,3-benzodioxol-5-yl)-3-phenyl-2-sulfanylidene-4H-thiazolo[4,5-d]pyrimidin-7-one | Rattus norvegicus (Norway rat) | IC50 | 5.1300 | 1 | 0 |
| 5-(4-chlorophenyl)-3-(4-nitrophenyl)-1H-pyrazole | Rattus norvegicus (Norway rat) | IC50 | 56.8000 | 1 | 0 |