methyl 2-cyanoacrylate profile

Methyl 2-cyanoacrylate, commonly known as superglue, is a fast-acting adhesive formed by the reaction of methyl acrylate and formaldehyde in the presence of a base catalyst. It is known for its strong bonding capabilities, particularly to materials like plastics, metals, and skin. Its effectiveness stems from its rapid polymerization reaction, which is triggered by moisture. When applied to a surface, the moisture present in the air or on the surface initiates a chain reaction that rapidly converts the liquid monomer into a solid polymer, forming a strong bond. Due to its rapid bonding properties, it is used extensively in various applications, including industrial repairs, medical adhesives, and craft projects. However, its strong bonding ability also makes it a potential hazard, as it can cause skin and eye irritation and bonding to sensitive surfaces. It is also important to note that methyl 2-cyanoacrylate is highly reactive with certain materials and should be handled with caution. Its unique bonding properties, ease of use, and wide range of applications make it a widely studied compound in the field of materials science and chemistry.'

methyl 2-cyanoacrylate: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	8711
CHEMBL ID	2106424
SCHEMBL ID	15701
MeSH ID	M0052264

Synonym
aron alpha a
2-propenoic acid, 2-cyano-, methyl ester
mecrylate
cyanoacrylate (jan)
mecrilate (inn)
aron alpha a (tn)
D03460
mecrylate (usan)
137-05-3
methyl cyanoacrylate
hsdb 1207
eastman 910 monomer
cemedine 3000 type ii
acrylic acid, 2-cyano-, methyl ester
mecrilato [inn-spanish]
cemedine 3000
2-cyano-2-propenoic acid methyl ester
einecs 205-275-2
brn 1751282
2-cyanoacrylic acid, methyl ester
methyl 2-cyano-2-propenoate
mecrilate
eastman 910
ccris 1692
mecrilat
eastman 910 adhesive
mecrilatum [inn-latin]
mecrylate [usan]
krazy-glue
adhere
borden ad/here
alpha-cyanoacrylic acid methyl ester
cyanolit
coapt
methyl 2-cyanoacrylate
methyl 2-cyanoprop-2-enoate
FT-0693584
AKOS006274385
mecrilate [inn]
cyanoacrylate
ec 205-275-2
wn7979561r ,
mecrilato
mecrilatum
unii-wn7979561r
25067-29-2
CHEMBL2106424
mecrylate [hsdb]
cyanoacrylate methyl ester
mecrilate [who-dd]
mecrilate [mart.]
methyl cyanoacrylate [mi]
SCHEMBL15701
methyl-2-cyanoacrylate
methyl .alpha.-cyanoacrylate
methyl ester of 2-cyano-2-propenoic acid
coapt.
.alpha.-cyanoacrylic acid, methyl ester
cyanoacrylic acid methyl ester
DTXSID4025589
Q209367
A855868
mfcd00079082

Excerpt	Reference	Relevance
" There were no signs of intimal thickening or of adverse reactions in nervous tissue."	( A novel coating biomaterial for intracranial aneurysms: effects and safety in extra- and intracranial carotid artery. Ishikawa, T; Iwasaki, Y; Kuroda, S; Nagashima, K; Nanba, R; Shinya, N; Terasaka, S; Yasuda, H, 2005)	0.33

Excerpt	Relevance	Reference
" Optimizing the dosage of CA, choice of animal model, inverted anastomosis construction, and other method details may improve intestinal and colorectal anastomoses with CA application in future studies."	( Critical analysis of cyanoacrylate in intestinal and colorectal anastomosis. Boersema, GS; Daams, F; Jeekel, J; Kleinrensink, GJ; Lange, JF; Sparreboom, CL; Vakalopoulos, KA; Wu, Z, 2014)	0.4

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	29 (72.50)	18.7374
1990's	3 (7.50)	18.2507
2000's	5 (12.50)	29.6817
2010's	3 (7.50)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	3 (6.82%)	5.53%
Reviews	4 (9.09%)	6.00%
Case Studies	2 (4.55%)	4.05%
Observational	0 (0.00%)	0.25%
Other	35 (79.55%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
quinacrine Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.. quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.	1.96	1	0	acridines; aromatic ether; organochlorine compound; tertiary amino compound	antimalarial; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
formaldehyde paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy	2.01	1	0	aldehyde; one-carbon compound	allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
nickel Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.	3.41	1	1	metal allergen; nickel group element atom	epitope; micronutrient
diatrizoic acid Diatrizoate: A commonly used x-ray contrast medium. As DIATRIZOATE MEGLUMINE and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.. amidotrizoic acid : A member of the class of benzoic acids that is benzoic acid having iodo substituents at the 2-, 4- and 6-positions and acetamido substituents at the 3- and 5-positions. It is used, mainly as its N-methylglucamine and sodium salts, as an X-ray contrast medium in gastrointestinal studies, angiography, and urography.	1.96	1	0	acetamides; benzoic acids; organoiodine compound	environmental contaminant; radioopaque medium; xenobiotic
trifluoroacetic acid Trifluoroacetic Acid: A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.. trifluoroacetic acid : A monocarboxylic acid that is the trifluoro derivative of acetic acid.	1.96	1	0	fluoroalkanoic acid	human xenobiotic metabolite; NMR chemical shift reference compound; reagent
diatrizoate meglumine Diatrizoate Meglumine: A versatile contrast medium used for DIAGNOSTIC X-RAY RADIOLOGY.. meglumine amidotrizoate : The N-methylglucamine salt of amidotrizoic acid. Both the sodium and the meglumine salts of amidotrizoic acid have been widely used as water-soluble radioopaque media in diagnostic radiography. The use of a mixture of the two salts is often preferred, as adverse effects can be reduced.	1.96	1	0	monocarboxylic acid anion	radioopaque medium
bucrylate Bucrylate: Cyanoacrylate tissue adhesive also used to occlude blood vessels supplying neoplastic or other diseased tissue.	6.01	4	0
bisphenol a-glycidyl methacrylate Bisphenol A-Glycidyl Methacrylate: The reaction product of bisphenol A and glycidyl methacrylate that undergoes polymerization when exposed to ultraviolet light or mixed with a catalyst. It is used as a bond implant material and as the resin component of dental sealants and composite restorative materials.	1.98	1	0	diarylmethane
enbucrilate Enbucrilate: A tissue adhesive that is applied as a monomer to moist tissue and polymerizes to form a bond. It is slowly biodegradable and used in all kinds of surgery, including dental.	5.21	3	0	alpha,beta-unsaturated monocarboxylic acid; nitrile
titanium Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.	3.41	1	1	titanium group element atom
isoamyl 2-cyanoacrylate [no description available]	3.06	1	0
ethyl 2-cyanoacrylate ethyl 2-cyanoacrylate: RN given refers to monomer	3.79	3	0
fibrinogen Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.. D-iditol : The D-enantiomer of iditol.	3.47	2	0	iditol	fungal metabolite
cellulose DEAE-Cellulose: Cellulose derivative used in chromatography, as ion-exchange material, and for various industrial applications.	2.02	1	0	glycoside
sodium hypochlorite Sodium Hypochlorite: It is used as an oxidizing and bleaching agent and as a disinfectant. (From Grant & Hackh's Chemical Dictionary, 5th ed). sodium hypochlorite : An inorganic sodium salt in which hypochlorite is the counterion. It is used as a bleaching and disinfecting agent and is commonly found in household bleach.	3.41	1	1	inorganic sodium salt	bleaching agent; disinfectant
sodium tetradecyl sulfate [no description available]	1.96	1	0
urografin 76 urovision: urovision contains a mixture of sodium & meglumine salts of diatrizoic acid in the ratio of 50:18 in aqueous solution used in urography	1.96	1	0
tetracycline Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.	1.96	1	0

Condition	Relationship Strength	Studies	Trials
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	7.64	3	0
Central Nervous System Disease [description not available]	1.93	1	0
Central Nervous System Diseases Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.	1.93	1	0
Infarct [description not available]	1.94	1	0
Complication, Postoperative [description not available]	2.35	2	0
Blood Clot [description not available]	1.94	1	0
Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.	2.35	2	0
Thrombosis Formation and development of a thrombus or blood clot in the blood vessel.	1.94	1	0
Fusiform Aneurysm Elongated, spindle-shaped dilation in the wall of blood vessels, usually large ARTERIES with ATHEROSCLEROSIS.	1.94	1	0
Aneurysm Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM). It indicates a thin and weakened area in the wall which may later rupture. Aneurysms are classified by location, etiology, or other characteristics.	1.94	1	0
Adhesions, Tissue [description not available]	1.94	1	0
Pneumothorax, Primary Spontaneous [description not available]	1.94	1	0
Pneumothorax An accumulation of air or gas in the PLEURAL CAVITY, which may occur spontaneously or as a result of trauma or a pathological process. The gas may also be introduced deliberately during PNEUMOTHORAX, ARTIFICIAL.	1.94	1	0
Aneurysm, Anterior Cerebral Artery [description not available]	2.02	1	0
Intracranial Aneurysm Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (	2.02	1	0
Facial Injuries General or unspecified injuries to the soft tissue or bony portions of the face.	2.03	1	0
Lacerations Torn, ragged, mangled wounds.	2.03	1	0
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	4.04	3	1
Hypospermatogenesis [description not available]	1.96	1	0
Acrocephaly Premature closing of the lambdoid and coronal sutures.	1.99	1	0
Symptom Cluster [description not available]	1.99	1	0
Craniosynostoses Premature closure of one or more CRANIAL SUTURES. It often results in plagiocephaly. Craniosynostoses that involve multiple sutures are sometimes associated with congenital syndromes such as ACROCEPHALOSYNDACTYLIA; and CRANIOFACIAL DYSOSTOSIS.	1.99	1	0
Syndrome A characteristic symptom complex.	1.99	1	0
Obstructive Lung Diseases [description not available]	2	1	0
Diseases, Occupational [description not available]	2	1	0
Lung Diseases, Obstructive Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.	2	1	0
Pleural Diseases Diseases involving the PLEURA.	1.97	1	0
Bronchial Fistula An abnormal passage or communication between a bronchus and another part of the body.	1.97	1	0
Arteriovenous Malformations Abnormal formation of blood vessels that shunt arterial blood directly into veins without passing through the CAPILLARIES. They usually are crooked, dilated, and with thick vessel walls. A common type is the congenital arteriovenous fistula. The lack of blood flow and oxygen in the capillaries can lead to tissue damage in the affected areas.	2.88	1	0
Brain Hemorrhage, Cerebral [description not available]	2.88	1	0
Innate Inflammatory Response [description not available]	2.88	1	0
Cerebral Hemorrhage Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.	2.88	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.88	1	0

methyl 2-cyanoacrylate

Description

Cross-References

Synonyms (63)

Research Excerpts

Toxicity

Dosage Studied

Research

Studies (40)

Market Indicators

Research Demand Index: 38.35

Study Types