Proteins > Phenylethanolamine N-methyltransferase
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Phenylethanolamine N-methyltransferase
[no definition available]
Synonyms
PNMTase;
EC 2.1.1.28;
Noradrenaline N-methyltransferase
Research
Bioassay Publications (27)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 14 (51.85) | 18.7374 |
| 1990's | 8 (29.63) | 18.2507 |
| 2000's | 5 (18.52) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (48)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| caprylic aldehyde | Bos taurus (cattle) | IC50 | 216.0000 | 1 | 1 |
| phenethylamine | Bos taurus (cattle) | Ki | 537.0000 | 2 | 2 |
| 2,3-dichloro-alpha-methylbenzylamine | Bos taurus (cattle) | Ki | 0.5600 | 1 | 1 |
| 2-cyclooctyl-2-hydroxyethylamine | Bos taurus (cattle) | IC50 | 7.0000 | 1 | 1 |
| amphetamine | Bos taurus (cattle) | IC50 | 0.9600 | 1 | 1 |
| amphetamine | Bos taurus (cattle) | Ki | 740.0000 | 2 | 3 |
| sk&f 29661 | Bos taurus (cattle) | Ki | 139,976,923,077.4154 | 13 | 13 |
| tyramine | Bos taurus (cattle) | Ki | 294.0000 | 1 | 1 |
| dextroamphetamine | Bos taurus (cattle) | Ki | 435.3333 | 2 | 3 |
| n-hexanal | Bos taurus (cattle) | IC50 | 314.0000 | 1 | 1 |
| 1,2,3,4-tetrahydroisoquinoline | Bos taurus (cattle) | Ki | 8,527,416,675.4142 | 12 | 12 |
| 1-phenethylamine | Bos taurus (cattle) | Ki | 424.0000 | 4 | 5 |
| benzylamine | Bos taurus (cattle) | Ki | 1,874,470,116.3333 | 3 | 3 |
| cyclohexanone | Bos taurus (cattle) | IC50 | 1,000.0000 | 1 | 1 |
| 2-heptanone | Bos taurus (cattle) | IC50 | 669.0000 | 1 | 1 |
| pentanal | Bos taurus (cattle) | IC50 | 345.0000 | 1 | 1 |
| 2-octanone | Bos taurus (cattle) | IC50 | 664.0000 | 1 | 1 |
| heptanal | Bos taurus (cattle) | IC50 | 109.0000 | 1 | 1 |
| cyclopentanone | Bos taurus (cattle) | IC50 | 1,000.0000 | 1 | 1 |
| cycloheptanone | Bos taurus (cattle) | IC50 | 510.0000 | 1 | 1 |
| cyclooctanone | Bos taurus (cattle) | IC50 | 72.0000 | 1 | 1 |
| 3-tyramine | Bos taurus (cattle) | Ki | 1,250.0000 | 1 | 1 |
| isovalerylaldehyde | Bos taurus (cattle) | IC50 | 1,000.0000 | 1 | 1 |
| 2-methyl-1,2,3,4-tetrahydroisoquinoline | Bos taurus (cattle) | Ki | 19,952,600,000.0000 | 1 | 1 |
| exp561 | Bos taurus (cattle) | Ki | 27.0000 | 1 | 1 |
| l-amphetamine | Bos taurus (cattle) | Ki | 1,381.0000 | 2 | 3 |
| 2-aminotetralin | Bos taurus (cattle) | Ki | 12.9500 | 4 | 4 |
| norsalsolinol | Bos taurus (cattle) | Ki | 128,520,000,002.8500 | 2 | 2 |
| 1-phenethylamine, (s)-isomer | Bos taurus (cattle) | Ki | 1,729,577,609.5000 | 3 | 4 |
| 1,3-diphenyl-2-aminopropane | Bos taurus (cattle) | Ki | 1,000.0000 | 1 | 2 |
| 1-methyl-1,2,3,4-tetrahydroisoquinoline | Bos taurus (cattle) | Ki | 33.1000 | 1 | 1 |
| 2-aminobenzonorbornene | Bos taurus (cattle) | Ki | 474.5000 | 2 | 2 |
| 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid | Bos taurus (cattle) | Ki | 2,000.0000 | 2 | 2 |
| ly 134046 | Bos taurus (cattle) | Ki | 543,127,142,857.3599 | 7 | 7 |
| 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline | Bos taurus (cattle) | Ki | 445,253,636,363.8166 | 11 | 11 |
| 4,9-dihydro-7-methoxy-3h-pyrido(3,4b)indole | Bos taurus (cattle) | Ki | 2.7000 | 3 | 3 |
| s-adenosylhomocysteine | Bos taurus (cattle) | Ki | 45.6500 | 1 | 2 |
| norpseudoephedrine | Bos taurus (cattle) | Ki | 3,700.0000 | 1 | 1 |
| phenylalaninol | Bos taurus (cattle) | Ki | 664.0000 | 1 | 2 |
| 3-methyl-1,2,3,4-tetrahydroisoquinoline | Bos taurus (cattle) | Ki | 2.3256 | 9 | 9 |
| 1-phenethylamine, (r)-isomer | Bos taurus (cattle) | Ki | 154,149,989.5000 | 3 | 4 |
| n,n-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine | Bos taurus (cattle) | Ki | 0.3250 | 1 | 1 |
| 3-trifluoromethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline | Bos taurus (cattle) | Ki | 1,103,770.3467 | 3 | 3 |
| 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine | Bos taurus (cattle) | Ki | 0.6830 | 1 | 1 |
| 2-cyclooctyl-2-hydroxyethylamine hydrochloride | Bos taurus (cattle) | IC50 | 8.0000 | 1 | 1 |
Drugs with Other Measurements
Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.Bioorganic & medicinal chemistry, , Jan-01, Volume: 16, Issue:1, 2008
Conformationally restricted and conformationally defined tyramine analogues as inhibitors of phenylethanolamine N-methyltransferase.Journal of medicinal chemistry, , Volume: 32, Issue:2, 1989
Directional probes of the hydrophobic component of the aromatic ring binding site of norepinephrine N-methyltransferase.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Probes of the active site of norepinephrine N-methyltransferase: effect of hydrophobic and hydrophilic interactions on side-chain binding of amphetamine and alpha-methylbenzylamine.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Conformationally rigid amphetamine analogs as inhibitors of monoamine uptake by brain synaptosomes.Journal of medicinal chemistry, , Volume: 19, Issue:5, 1976
Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.Bioorganic & medicinal chemistry, , Jan-01, Volume: 16, Issue:1, 2008
Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase.Journal of medicinal chemistry, , Jan-01, Volume: 47, Issue:1, 2004
Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Aug-16, Volume: 44, Issue:17, 2001
Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.Bioorganic & medicinal chemistry letters, , Jun-18, Volume: 11, Issue:12, 2001
Enantiospecific synthesis of 3-fluoromethyl-, 3-hydroxymethyl-, and 3-chloromethyl-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Oct-21, Volume: 42, Issue:21, 1999
Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Aug-26, Volume: 42, Issue:17, 1999
3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferase versus the alpha2-adrenoceptor.Journal of medicinal chemistry, , Jun-03, Volume: 42, Issue:11, 1999
Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-1,2,3,4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and thJournal of medicinal chemistry, , Jan-14, Volume: 42, Issue:1, 1999
Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT.Bioorganic & medicinal chemistry letters, , Feb-08, Volume: 9, Issue:3, 1999
Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the alpha 2-adrenoceptor.Journal of medicinal chemistry, , Dec-05, Volume: 40, Issue:25, 1997
Inhibition of phenylethanolamine N-methyltransferase (PNMT) by aromatic hydroxy-substituted 1,2,3,4,-tetrahydroisoquinolines: further studies on the hydrophilic pocket of the aromatic ring binding region of the active site.Journal of medicinal chemistry, , Volume: 30, Issue:12, 1987
Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.Bioorganic & medicinal chemistry, , Jan-01, Volume: 16, Issue:1, 2008
Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.Bioorganic & medicinal chemistry letters, , Jun-18, Volume: 11, Issue:12, 2001
Enantiospecific synthesis of 3-fluoromethyl-, 3-hydroxymethyl-, and 3-chloromethyl-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Oct-21, Volume: 42, Issue:21, 1999
Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-1,2,3,4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and thJournal of medicinal chemistry, , Jan-14, Volume: 42, Issue:1, 1999
Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Aug-26, Volume: 42, Issue:17, 1999
3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferase versus the alpha2-adrenoceptor.Journal of medicinal chemistry, , Jun-03, Volume: 42, Issue:11, 1999
Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT.Bioorganic & medicinal chemistry letters, , Feb-08, Volume: 9, Issue:3, 1999
Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-methyltransferase.Journal of medicinal chemistry, , Aug-30, Volume: 39, Issue:18, 1996
Conformational and steric aspects of the inhibition of phenylethanolamine N-methyltransferase by benzylamines.Journal of medicinal chemistry, , Volume: 31, Issue:2, 1988
Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
Conformational requirements of substrates for activity with phenylethanolamine N-methyltransferase.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
Inhibition of phenylethanolamine N-methyltransferase (PNMT) by aromatic hydroxy-substituted 1,2,3,4,-tetrahydroisoquinolines: further studies on the hydrophilic pocket of the aromatic ring binding region of the active site.Journal of medicinal chemistry, , Volume: 30, Issue:12, 1987
Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.Bioorganic & medicinal chemistry letters, , Jun-18, Volume: 11, Issue:12, 2001
Conformational preference for the binding of biaryl substrates and inhibitors to the active site of phenylethanolamine N-methyltransferase.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
Directional probes of the hydrophobic component of the aromatic ring binding site of norepinephrine N-methyltransferase.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Probes of the active site of norepinephrine N-methyltransferase: effect of hydrophobic and hydrophilic interactions on side-chain binding of amphetamine and alpha-methylbenzylamine.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.Bioorganic & medicinal chemistry, , Jan-01, Volume: 16, Issue:1, 2008
Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT.Bioorganic & medicinal chemistry letters, , Feb-08, Volume: 9, Issue:3, 1999
Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-methyltransferase.Journal of medicinal chemistry, , Aug-30, Volume: 39, Issue:18, 1996
Conformational and steric aspects of the inhibition of phenylethanolamine N-methyltransferase by benzylamines.Journal of medicinal chemistry, , Volume: 31, Issue:2, 1988
Conformationally restricted and conformationally defined tyramine analogues as inhibitors of phenylethanolamine N-methyltransferase.Journal of medicinal chemistry, , Volume: 32, Issue:2, 1989
Conformational and steric aspects of the inhibition of phenylethanolamine N-methyltransferase by benzylamines.Journal of medicinal chemistry, , Volume: 31, Issue:2, 1988
Conformational requirements of substrates for activity with phenylethanolamine N-methyltransferase.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
Binding orientation of amphetamine and norfenfluramine analogues in the benzonorbornene and benzobicyclo[3.2.1]octane ring systems at the active site of phenylethanolamine N-methyltransferase (PNMT)Journal of medicinal chemistry, , Volume: 30, Issue:12, 1987
Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT.Bioorganic & medicinal chemistry letters, , Feb-08, Volume: 9, Issue:3, 1999
Inhibition of phenylethanolamine N-methyltransferase (PNMT) by aromatic hydroxy-substituted 1,2,3,4,-tetrahydroisoquinolines: further studies on the hydrophilic pocket of the aromatic ring binding region of the active site.Journal of medicinal chemistry, , Volume: 30, Issue:12, 1987
Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.Bioorganic & medicinal chemistry letters, , Jun-18, Volume: 11, Issue:12, 2001
Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT.Bioorganic & medicinal chemistry letters, , Feb-08, Volume: 9, Issue:3, 1999
Probes of the active site of norepinephrine N-methyltransferase: effect of hydrophobic and hydrophilic interactions on side-chain binding of amphetamine and alpha-methylbenzylamine.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferase versus the alpha2-adrenoceptor.Journal of medicinal chemistry, , Jun-03, Volume: 42, Issue:11, 1999
Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase.Journal of medicinal chemistry, , Jan-01, Volume: 47, Issue:1, 2004
Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Aug-16, Volume: 44, Issue:17, 2001
Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.Bioorganic & medicinal chemistry letters, , Jun-18, Volume: 11, Issue:12, 2001
Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Aug-26, Volume: 42, Issue:17, 1999
Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT.Bioorganic & medicinal chemistry letters, , Feb-08, Volume: 9, Issue:3, 1999
Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.Bioorganic & medicinal chemistry, , Jan-01, Volume: 16, Issue:1, 2008
Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase.Journal of medicinal chemistry, , Jan-01, Volume: 47, Issue:1, 2004
Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Aug-16, Volume: 44, Issue:17, 2001
Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.Bioorganic & medicinal chemistry letters, , Jun-18, Volume: 11, Issue:12, 2001
Enantiospecific synthesis of 3-fluoromethyl-, 3-hydroxymethyl-, and 3-chloromethyl-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Oct-21, Volume: 42, Issue:21, 1999
Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Aug-26, Volume: 42, Issue:17, 1999
Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT.Bioorganic & medicinal chemistry letters, , Feb-08, Volume: 9, Issue:3, 1999
Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the alpha 2-adrenoceptor.Journal of medicinal chemistry, , Dec-05, Volume: 40, Issue:25, 1997
Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Aug-16, Volume: 44, Issue:17, 2001
Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Aug-26, Volume: 42, Issue:17, 1999
Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.Bioorganic & medicinal chemistry, , Jan-01, Volume: 16, Issue:1, 2008
Enantiospecific synthesis of 3-fluoromethyl-, 3-hydroxymethyl-, and 3-chloromethyl-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Oct-21, Volume: 42, Issue:21, 1999
Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Aug-26, Volume: 42, Issue:17, 1999
Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferase versus the alpha2-adrenoceptor.Journal of medicinal chemistry, , Jun-03, Volume: 42, Issue:11, 1999
Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-methyltransferase.Journal of medicinal chemistry, , Aug-30, Volume: 39, Issue:18, 1996
Conformational and steric aspects of the inhibition of phenylethanolamine N-methyltransferase by benzylamines.Journal of medicinal chemistry, , Volume: 31, Issue:2, 1988
Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.Bioorganic & medicinal chemistry letters, , Jun-18, Volume: 11, Issue:12, 2001
Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT.Bioorganic & medicinal chemistry letters, , Feb-08, Volume: 9, Issue:3, 1999
Probes of the active site of norepinephrine N-methyltransferase: effect of hydrophobic and hydrophilic interactions on side-chain binding of amphetamine and alpha-methylbenzylamine.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Aug-26, Volume: 42, Issue:17, 1999
Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT.Bioorganic & medicinal chemistry letters, , Feb-08, Volume: 9, Issue:3, 1999