Proteins > Type-1A angiotensin II receptor
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Type-1A angiotensin II receptor
An angiotensin II receptor 1A that is encoded in the genome of rat. [PRO:DAN]
Synonyms
Angiotensin II type-1A receptor;
AT1A
Research
Bioassay Publications (37)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (5.41) | 18.7374 |
| 1990's | 21 (56.76) | 18.2507 |
| 2000's | 11 (29.73) | 29.6817 |
| 2010's | 1 (2.70) | 24.3611 |
| 2020's | 2 (5.41) | 2.80 |
Compounds (41)
Drugs with Potency Measurements
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Synthesis and evaluation of novel angiotensin II receptor 1 antagonists as anti-hypertension drugs.Bioorganic & medicinal chemistry, , May-01, Volume: 24, Issue:9, 2016
Design, synthesis, and evaluation of 5-sulfamoyl benzimidazole derivatives as novel angiotensin II receptor antagonists.Bioorganic & medicinal chemistry, , Dec-15, Volume: 16, Issue:24, 2008
Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist.Journal of medicinal chemistry, , Nov-18, Volume: 47, Issue:24, 2004
AT2-selective angiotensin II analogues containing tyrosine-functionalized 5,5-bicyclic thiazabicycloalkane dipeptide mimetics.Journal of medicinal chemistry, , Nov-18, Volume: 47, Issue:24, 2004
Non-peptide angiotensin II receptor antagonists: chemical feature based pharmacophore identification.Journal of medicinal chemistry, , Feb-27, Volume: 46, Issue:5, 2003
Angiotensin II analogues encompassing 5,9- and 5,10-fused thiazabicycloalkane tripeptide mimetics.Journal of medicinal chemistry, , Nov-04, Volume: 42, Issue:22, 1999
Design, synthesis, and biological activities of four angiotensin II receptor ligands with gamma-turn mimetics replacing amino acid residues 3-5.Journal of medicinal chemistry, , Mar-14, Volume: 40, Issue:6, 1997
Synthesis and structure-activity relationship of a new series of potent AT1 selective angiotensin II receptor antagonists: 5-(biphenyl-4-ylmethyl)pyrazoles.Journal of medicinal chemistry, , Feb-14, Volume: 40, Issue:4, 1997
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.Journal of medicinal chemistry, , Feb-02, Volume: 39, Issue:3, 1996
Diphenylpropionic acids as new AT1 selective angiotensin II antagonists.Journal of medicinal chemistry, , May-24, Volume: 39, Issue:11, 1996
4-(Heteroarylthio)-2-biphenylyltetrazoles as nonpeptide angiotensin II antagonists.Journal of medicinal chemistry, , Nov-10, Volume: 38, Issue:23, 1995
N-3-substituted pyrimidinones as potent, orally active, AT1 selective angiotensin II receptor antagonists.Journal of medicinal chemistry, , Nov-24, Volume: 38, Issue:24, 1995
Pyrido[2,3-d]pyrimidine angiotensin II antagonists.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
Bromobenzofuran-based non-peptide antagonists of angiotensin II: GR138950, a potent antihypertensive agent with high oral bioavailability.Journal of medicinal chemistry, , Sep-16, Volume: 37, Issue:19, 1994
Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1' -biphenyl]-4-yl]-methyl]-4-[2-(trifluoroJournal of medicinal chemistry, , Aug-06, Volume: 36, Issue:16, 1993
2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists.Journal of medicinal chemistry, , Sep-03, Volume: 36, Issue:18, 1993
Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.Journal of medicinal chemistry, , Feb-02, Volume: 39, Issue:3, 1996
Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1' -biphenyl]-4-yl]-methyl]-4-[2-(trifluoroJournal of medicinal chemistry, , Aug-06, Volume: 36, Issue:16, 1993
Metabolites of the angiotensin II antagonist tasosartan: the importance of a second acidic group.Journal of medicinal chemistry, , Oct-22, Volume: 41, Issue:22, 1998
Pyrido[2,3-d]pyrimidine angiotensin II antagonists.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
Non-peptide angiotensin II receptor antagonists: chemical feature based pharmacophore identification.Journal of medicinal chemistry, , Feb-27, Volume: 46, Issue:5, 2003
Synthesis and structure-activity relationship of a new series of potent AT1 selective angiotensin II receptor antagonists: 5-(biphenyl-4-ylmethyl)pyrazoles.Journal of medicinal chemistry, , Feb-14, Volume: 40, Issue:4, 1997
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.Journal of medicinal chemistry, , Feb-02, Volume: 39, Issue:3, 1996
N-3-substituted pyrimidinones as potent, orally active, AT1 selective angiotensin II receptor antagonists.Journal of medicinal chemistry, , Nov-24, Volume: 38, Issue:24, 1995
Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives.Journal of medicinal chemistry, , May-27, Volume: 37, Issue:11, 1994
Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1' -biphenyl]-4-yl]-methyl]-4-[2-(trifluoroJournal of medicinal chemistry, , Aug-06, Volume: 36, Issue:16, 1993
Non-peptide angiotensin II receptor antagonists: chemical feature based pharmacophore identification.Journal of medicinal chemistry, , Feb-27, Volume: 46, Issue:5, 2003
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.Journal of medicinal chemistry, , Feb-02, Volume: 39, Issue:3, 1996
N-3-substituted pyrimidinones as potent, orally active, AT1 selective angiotensin II receptor antagonists.Journal of medicinal chemistry, , Nov-24, Volume: 38, Issue:24, 1995
Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
New selective AT2 receptor ligands encompassing a gamma-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists.Journal of medicinal chemistry, , Jun-16, Volume: 48, Issue:12, 2005
AT2-selective angiotensin II analogues containing tyrosine-functionalized 5,5-bicyclic thiazabicycloalkane dipeptide mimetics.Journal of medicinal chemistry, , Nov-18, Volume: 47, Issue:24, 2004
Bicyclic tripeptide mimetics with reverse turn inducing properties.Journal of medicinal chemistry, , Feb-25, Volume: 42, Issue:4, 1999
Angiotensin II analogues encompassing 5,9- and 5,10-fused thiazabicycloalkane tripeptide mimetics.Journal of medicinal chemistry, , Nov-04, Volume: 42, Issue:22, 1999
Design, synthesis, and biological activities of four angiotensin II receptor ligands with gamma-turn mimetics replacing amino acid residues 3-5.Journal of medicinal chemistry, , Mar-14, Volume: 40, Issue:6, 1997
Multiple binding modes for the receptor-bound conformations of cyclic AII agonists.Journal of medicinal chemistry, , Jun-25, Volume: 36, Issue:13, 1993
Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype.Journal of medicinal chemistry, , Volume: 34, Issue:11, 1991
Conformational restriction of angiotensin II: cyclic analogues having high potency.Journal of medicinal chemistry, , Volume: 33, Issue:7, 1990
Topographic probes of angiotensin and receptor: potent angiotensin II agonist containing diphenylalanine and long-acting antagonists containing biphenylalanine and 2-indan amino acid in position 8.Journal of medicinal chemistry, , Volume: 32, Issue:4, 1989
[no title available],
Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives.Journal of medicinal chemistry, , May-27, Volume: 37, Issue:11, 1994
2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists.Journal of medicinal chemistry, , Sep-03, Volume: 36, Issue:18, 1993
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.Journal of medicinal chemistry, , Feb-02, Volume: 39, Issue:3, 1996
Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl)imidazole-5-acrylic acids.Journal of medicinal chemistry, , Jun-25, Volume: 36, Issue:13, 1993
A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site.Journal of medicinal chemistry, , Dec-10, Volume: 36, Issue:25, 1993
Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype.Journal of medicinal chemistry, , Volume: 34, Issue:11, 1991
Multiple binding modes for the receptor-bound conformations of cyclic AII agonists.Journal of medicinal chemistry, , Jun-25, Volume: 36, Issue:13, 1993
Synthesis of angiotensin II antagonists with variations in position 5.Journal of medicinal chemistry, , Volume: 30, Issue:10, 1987
[no title available],
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 65, 2022
First reported nonpeptide AT1 receptor agonist (L-162,313) acts as an AT2 receptor agonist in vivo.Journal of medicinal chemistry, , Mar-11, Volume: 47, Issue:6, 2004
Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist.Journal of medicinal chemistry, , Nov-18, Volume: 47, Issue:24, 2004
First reported nonpeptide AT1 receptor agonist (L-162,313) acts as an AT2 receptor agonist in vivo.Journal of medicinal chemistry, , Mar-11, Volume: 47, Issue:6, 2004
Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist.Journal of medicinal chemistry, , Nov-18, Volume: 47, Issue:24, 2004