Adenylate kinase isoenzyme 1

An adenylate kinase isoenzyme 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00568]

AK 1;
EC 2.7.4.3;
EC 2.7.4.6;
ATP-AMP transphosphorylase 1;
ATP:AMP phosphotransferase;
Adenylate monophosphate kinase;
Myokinase

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
adenosine monophosphate	Homo sapiens (human)	Km	175.0000	1	1
2'-deoxy-5'-adenosine monophosphate	Homo sapiens (human)	Km	1,500.0000	1	1
adefovir	Homo sapiens (human)	Km	6,000.0000	1	1
tenofovir	Homo sapiens (human)	Km	3,000.0000	1	1

This protein enables 4 target(s):

Target	Category	Definition
adenylate kinase activity	molecular function	Catalysis of the reaction: ATP + AMP = 2 ADP. [EC:2.7.4.3]
nucleoside diphosphate kinase activity	molecular function	Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. [EC:2.7.4.6]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
nucleoside triphosphate adenylate kinase activity	molecular function	Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP. [EC:2.7.4.10]

This protein is located in 3 target(s):

Target	Category	Definition
outer dense fiber	cellular component	A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins. [GOC:cilia, GOC:krc, ISBN:0824072820, PMID:10381817, PMID:21586547, PMID:25361759]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is active in 2 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is involved in 6 target(s):

Target	Category	Definition
ADP biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate. [GOC:ai]
nucleoside triphosphate biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]
nucleobase-containing small molecule interconversion	biological process	The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. [GOC:mah, ISBN:0306444747, ISBN:0471394831]
AMP metabolic process	biological process	The chemical reactions and pathways involving AMP, adenosine monophosphate. [GOC:go_curators]
ATP metabolic process	biological process	The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. [GOC:go_curators]
nucleoside monophosphate phosphorylation	biological process	The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside. [GOC:ai]