Page last updated: 2024-08-07 12:48:11

L-lactate dehydrogenase A chain

An L-lactate dehydrogenase A chain that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00338]

Synonyms

LDH-A;
EC 1.1.1.27;
Cell proliferation-inducing gene 19 protein;
LDH muscle subunit;
LDH-M;
Renal carcinoma antigen NY-REN-59

Research

Bioassay Publications (13)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's0 (0.00)29.6817
2010's10 (76.92)24.3611
2020's2 (15.38)2.80

Compounds (17)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
oxamic acidHomo sapiens (human)IC5057.200022
oxamic acidHomo sapiens (human)Ki109.500044
gossypolHomo sapiens (human)Ki1.900033
adenosine monophosphateHomo sapiens (human)IC50500.000011
1-hydroxy-2-naphthoic acidHomo sapiens (human)IC50500.000022
dronabinolHomo sapiens (human)Ki14.000011
cannabichromeneHomo sapiens (human)Ki8.500011
delta(9)-tetrahydrocannabinolic acidHomo sapiens (human)Ki6.500011
gossylic nitrile-1,1'-diacetateHomo sapiens (human)Ki2.000011
cannabidiolHomo sapiens (human)Ki24.000011
rutinHomo sapiens (human)IC50500.000011
3-dihydroxy-6-methyl-7-(phenylmethyl)-4-propylnaphthalene-1-carboxylic acidHomo sapiens (human)IC50346.666733
3-dihydroxy-6-methyl-7-(phenylmethyl)-4-propylnaphthalene-1-carboxylic acidHomo sapiens (human)Ki4.087544
adenosine monophosphateHomo sapiens (human)IC50500.000011
methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1h-indole-2-carboxylateHomo sapiens (human)IC5012.600022
methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1h-indole-2-carboxylateHomo sapiens (human)Ki5.100011
galloflavinHomo sapiens (human)Ki5.460011
gossylic iminolactoneHomo sapiens (human)Ki2.500011
gossylic lactoneHomo sapiens (human)Ki0.600011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
malonic acidHomo sapiens (human)Kd5,000.000011
adenosine monophosphateHomo sapiens (human)Kd650.000011
1-hydroxy-2-naphthoic acidHomo sapiens (human)Kd640.000022
adenosine monophosphateHomo sapiens (human)Kd650.000011

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
L-lactate dehydrogenase activitymolecular functionCatalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. [EC:1.1.1.27, RHEA:23444]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
identical protein bindingmolecular functionBinding to an identical protein or proteins. [GOC:jl]
cadherin bindingmolecular functionBinding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
extracellular exosomecellular componentA vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
mitochondrioncellular componentA semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
oxidoreductase complexcellular componentAny protein complex that possesses oxidoreductase activity. [GOC:bhm, PMID:18982432]

Involved In

This protein is involved in 3 target(s):

TargetCategoryDefinition
lactate metabolic processbiological processThe chemical reactions and pathways involving lactate, the anion of lactic acid. [ISBN:0198547684]
pyruvate metabolic processbiological processThe chemical reactions and pathways involving pyruvate, 2-oxopropanoate. [GOC:go_curators]
glycolytic processbiological processThe chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]