Page last updated: 2024-08-07 12:48:11
L-lactate dehydrogenase A chain
An L-lactate dehydrogenase A chain that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00338]
Synonyms
LDH-A;
EC 1.1.1.27;
Cell proliferation-inducing gene 19 protein;
LDH muscle subunit;
LDH-M;
Renal carcinoma antigen NY-REN-59
Research
Bioassay Publications (13)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 10 (76.92) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
Compounds (17)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| oxamic acid | Homo sapiens (human) | IC50 | 57.2000 | 2 | 2 |
| oxamic acid | Homo sapiens (human) | Ki | 109.5000 | 4 | 4 |
| gossypol | Homo sapiens (human) | Ki | 1.9000 | 3 | 3 |
| adenosine monophosphate | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| 1-hydroxy-2-naphthoic acid | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| dronabinol | Homo sapiens (human) | Ki | 14.0000 | 1 | 1 |
| cannabichromene | Homo sapiens (human) | Ki | 8.5000 | 1 | 1 |
| delta(9)-tetrahydrocannabinolic acid | Homo sapiens (human) | Ki | 6.5000 | 1 | 1 |
| gossylic nitrile-1,1'-diacetate | Homo sapiens (human) | Ki | 2.0000 | 1 | 1 |
| cannabidiol | Homo sapiens (human) | Ki | 24.0000 | 1 | 1 |
| rutin | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| 3-dihydroxy-6-methyl-7-(phenylmethyl)-4-propylnaphthalene-1-carboxylic acid | Homo sapiens (human) | IC50 | 346.6667 | 3 | 3 |
| 3-dihydroxy-6-methyl-7-(phenylmethyl)-4-propylnaphthalene-1-carboxylic acid | Homo sapiens (human) | Ki | 4.0875 | 4 | 4 |
| adenosine monophosphate | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1h-indole-2-carboxylate | Homo sapiens (human) | IC50 | 12.6000 | 2 | 2 |
| methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1h-indole-2-carboxylate | Homo sapiens (human) | Ki | 5.1000 | 1 | 1 |
| galloflavin | Homo sapiens (human) | Ki | 5.4600 | 1 | 1 |
| gossylic iminolactone | Homo sapiens (human) | Ki | 2.5000 | 1 | 1 |
| gossylic lactone | Homo sapiens (human) | Ki | 0.6000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| malonic acid | Homo sapiens (human) | Kd | 5,000.0000 | 1 | 1 |
| adenosine monophosphate | Homo sapiens (human) | Kd | 650.0000 | 1 | 1 |
| 1-hydroxy-2-naphthoic acid | Homo sapiens (human) | Kd | 640.0000 | 2 | 2 |
| adenosine monophosphate | Homo sapiens (human) | Kd | 650.0000 | 1 | 1 |
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| L-lactate dehydrogenase activity | molecular function | Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. [EC:1.1.1.27, RHEA:23444] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| cadherin binding | molecular function | Binding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf] |
Located In
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| oxidoreductase complex | cellular component | Any protein complex that possesses oxidoreductase activity. [GOC:bhm, PMID:18982432] |
Involved In
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| lactate metabolic process | biological process | The chemical reactions and pathways involving lactate, the anion of lactic acid. [ISBN:0198547684] |
| pyruvate metabolic process | biological process | The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. [GOC:go_curators] |
| glycolytic process | biological process | The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] |