Proteins > Angiotensin-converting enzyme
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Angiotensin-converting enzyme
An angiotensin-converting enzyme that is encoded in the genome of rat. [OMA:P47820, PRO:DNx]
Synonyms
ACE;
EC 3.2.1.-;
EC 3.4.15.1;
Dipeptidyl carboxypeptidase I;
Kininase II
Research
Bioassay Publications (24)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 11 (45.83) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 5 (20.83) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (34)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| dihydrotestosterone | Rattus norvegicus (Norway rat) | EC50 | 0.0060 | 2 | 7 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| fosinoprilat | Rattus norvegicus (Norway rat) | T50 | 0.0110 | 1 | 1 |
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Switching androgen receptor antagonists to agonists by modifying C-ring substituents on piperidino[3,2-g]quinolinone.Bioorganic & medicinal chemistry letters, , Apr-05, Volume: 9, Issue:7, 1999
New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g] quinolinone.Bioorganic & medicinal chemistry letters, , Apr-07, Volume: 8, Issue:7, 1998
[no title available]European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines.Journal of medicinal chemistry, , Volume: 31, Issue:6, 1988
Synthesis and structure-activity relationships of potent new angiotensin converting enzyme inhibitors containing saturated bicyclic amino acids.Journal of medicinal chemistry, , Volume: 30, Issue:6, 1987
Angiotensin converting enzyme inhibitors as antihypertensive agents: 1-[(2-mercaptocycloalkyl)carbonyl]-L-prolines.Journal of medicinal chemistry, , Volume: 29, Issue:3, 1986
Angiotensin converting enzyme inhibitors: 1,5-benzothiazepine derivatives.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Synthesis and biological activity of pentapeptide analogues of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline.Journal of medicinal chemistry, , Volume: 28, Issue:8, 1985
(Mercaptopropanoyl)indoline-2-carboxylic acids and related compounds as potent angiotensin converting enzyme inhibitors and antihypertensive agents.Journal of medicinal chemistry, , Volume: 26, Issue:3, 1983
Antihypertensive agents: angiotensin converting enzyme inhibitors. 1-[3-(Acylthio)-3-aroylpropionyl]-L-prolines.Journal of medicinal chemistry, , Volume: 26, Issue:3, 1983
Angiotensin converting enzyme inhibitors: spirapril and related compounds.Journal of medicinal chemistry, , Volume: 32, Issue:7, 1989
Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines.Journal of medicinal chemistry, , Volume: 31, Issue:6, 1988
Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome.Bioorganic & medicinal chemistry letters, , 06-01, Volume: 27, Issue:11, 2017
Excursions in drug discovery.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
Design, synthesis, and physicochemical properties of a novel, conformationally restricted 2,3-dihydro-1,3,4-thiadiazole-containing angiotensin converting enzyme inhibitor which is preferentially eliminated by the biliary route in rats.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines.Journal of medicinal chemistry, , Volume: 31, Issue:6, 1988
Synthesis and structure-activity relationships of potent new angiotensin converting enzyme inhibitors containing saturated bicyclic amino acids.Journal of medicinal chemistry, , Volume: 30, Issue:6, 1987