Proteins > cGMP-specific 3',5'-cyclic phosphodiesterase
Page last updated: 2024-08-07 15:25:55
cGMP-specific 3',5'-cyclic phosphodiesterase
A cGMP-specific 3,5-cyclic phosphodiesterase that is encoded in the genome of rat. [PRO:DNx]
Synonyms
EC 3.1.4.35;
cGMP-binding cGMP-specific phosphodiesterase;
CGB-PDE
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (7)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| tadalafil | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| sophoflavescenol | Rattus norvegicus (Norway rat) | IC50 | 0.0130 | 1 | 1 |
| sophoflavescenol | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| kuraridin | Rattus norvegicus (Norway rat) | IC50 | 0.6400 | 1 | 1 |
| kurarinol | Rattus norvegicus (Norway rat) | IC50 | 6.1000 | 1 | 1 |
| sildenafil | Rattus norvegicus (Norway rat) | IC50 | 0.0012 | 2 | 2 |
| sildenafil | Rattus norvegicus (Norway rat) | Ki | 0.0018 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| tadalafil | Rattus norvegicus (Norway rat) | EC50 | 0.0780 | 1 | 1 |
| zaprinast | Rattus norvegicus (Norway rat) | EC50 | 9.0000 | 1 | 1 |
| sk&f 96231 | Rattus norvegicus (Norway rat) | EC50 | 2.0000 | 1 | 1 |
Design, synthesis and evaluation of NBioorganic & medicinal chemistry letters, , 01-15, Volume: 29, Issue:2, 2019
Pyrroloquinolone PDE5 inhibitors with improved pharmaceutical profiles for clinical studies on erectile dysfunction.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5.Bioorganic & medicinal chemistry letters, , Sep-02, Volume: 12, Issue:17, 2002