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Prostaglandin G/H synthase 1
A prostaglandin G/H synthase 1 that is encoded in the genome of cow. [OMA:O62664, PRO:DNx]
Synonyms
EC 1.14.99.1;
Cyclooxygenase-1;
COX-1;
Prostaglandin H2 synthase 1;
PGH synthase 1;
PGHS-1;
PHS 1;
Prostaglandin-endoperoxide synthase 1
Research
Bioassay Publications (20)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 4 (20.00) | 18.7374 |
| 1990's | 5 (25.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (38)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| indomethacin | Bos taurus (cattle) | ID50 | 0.4300 | 1 | 1 |
| phenidone | Bos taurus (cattle) | ID50 | 6.9000 | 1 | 1 |
| zileuton | Bos taurus (cattle) | ID50 | 750.0000 | 1 | 1 |
| arachidonic acid | Bos taurus (cattle) | Km | 8.8000 | 1 | 1 |
Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory acBioorganic & medicinal chemistry letters, , Dec-15, Volume: 19, Issue:24, 2009
Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis.Journal of natural products, , Volume: 61, Issue:1, 1998
Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives.Journal of medicinal chemistry, , Volume: 27, Issue:10, 1984
Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy.European journal of medicinal chemistry, , Jan-27, Volume: 108, 2016
Synthesis and biological evaluation of some new 2-pyrazolines bearing benzene sulfonamide moiety as potential anti-inflammatory and anti-cancer agents.European journal of medicinal chemistry, , Volume: 46, Issue:12, 2011
Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities.Bioorganic & medicinal chemistry, , Jan-15, Volume: 17, Issue:2, 2009
Synthesis of celecoxib analogues possessing a N-difluoromethyl-1,2-dihydropyrid-2-one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.Journal of medicinal chemistry, , Mar-26, Volume: 52, Issue:6, 2009
Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory acBioorganic & medicinal chemistry letters, , Dec-15, Volume: 19, Issue:24, 2009
Synthesis of celecoxib analogues possessing a N-difluoromethyl-1,2-dihydropyrid-2-one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.Journal of medicinal chemistry, , Mar-26, Volume: 52, Issue:6, 2009
Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis.Journal of natural products, , Volume: 61, Issue:1, 1998
Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 22, Issue:15, 2012
Cox-2 inhibitory effects of naturally occurring and modified fatty acids.Journal of natural products, , Volume: 64, Issue:6, 2001
1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthase and aromatase.Journal of medicinal chemistry, , May-04, Volume: 43, Issue:9, 2000
Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis.Journal of natural products, , Volume: 61, Issue:1, 1998
Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity.Journal of medicinal chemistry, , Aug-21, Volume: 35, Issue:17, 1992
Synthesis, chemical, and biological properties of vinylogous hydroxamic acids: dual inhibitors of 5-lipoxygenase and IL-1 biosynthesis.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
2-substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogues.Journal of medicinal chemistry, , Volume: 27, Issue:11, 1984
Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives.Journal of medicinal chemistry, , Volume: 27, Issue:10, 1984
Antiinflammatory agents. 2. Syntheses and antiinflammatory activity of substituted 2-aminophenylacetic acid derivatives.Journal of medicinal chemistry, , Volume: 25, Issue:4, 1982
Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities.Bioorganic & medicinal chemistry, , Jan-15, Volume: 17, Issue:2, 2009
2-substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 22, Issue:15, 2012
Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities.Bioorganic & medicinal chemistry, , Jan-15, Volume: 17, Issue:2, 2009
(6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase.Journal of medicinal chemistry, , Jun-10, Volume: 37, Issue:12, 1994