Proteins > Muscarinic acetylcholine receptor M1
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Muscarinic acetylcholine receptor M1
A muscarinic acetylcholine receptor M1 that is encoded in the genome of mouse. [OMA:P12657, PRO:DNx]
Synonyms
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (17)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| arecoline | Mus musculus (house mouse) | Ki | 0.0044 | 2 | 2 |
| pirenzepine | Mus musculus (house mouse) | IC50 | 0.7500 | 1 | 3 |
| carbachol | Mus musculus (house mouse) | Ki | 4.7822 | 5 | 5 |
| pinacidil | Mus musculus (house mouse) | IC50 | 8.9000 | 1 | 3 |
| dimethindene | Mus musculus (house mouse) | Ki | 0.2630 | 1 | 1 |
| dexetimide | Mus musculus (house mouse) | IC50 | 0.0033 | 1 | 3 |
| xanomeline | Mus musculus (house mouse) | Ki | 0.1585 | 1 | 1 |
| afdx 384 | Mus musculus (house mouse) | Ki | 0.0309 | 1 | 1 |
| tripitramine | Mus musculus (house mouse) | Ki | 0.0016 | 1 | 1 |
| himbacine | Mus musculus (house mouse) | Ki | 0.1072 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| arecoline | Mus musculus (house mouse) | EC50 | 27.0000 | 1 | 1 |
| oxotremorine | Mus musculus (house mouse) | EC50 | 0.2700 | 1 | 1 |
| carbachol | Mus musculus (house mouse) | EC50 | 40.0000 | 1 | 1 |
| pilocarpine | Mus musculus (house mouse) | EC50 | 6.9000 | 1 | 1 |
| phencyclidine | Mus musculus (house mouse) | Kd | 9.1000 | 1 | 1 |
| xanomeline | Mus musculus (house mouse) | EC50 | 5.7000 | 1 | 1 |
Drugs with Other Measurements
Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists.Journal of medicinal chemistry, , Apr-11, Volume: 40, Issue:8, 1997
Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists.Journal of medicinal chemistry, , Apr-11, Volume: 40, Issue:8, 1997
Synthesis and biological characterization of 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as muscarinic agonists for the treatment of neurological disorders.Journal of medicinal chemistry, , Sep-25, Volume: 46, Issue:20, 2003
Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists.Journal of medicinal chemistry, , Apr-11, Volume: 40, Issue:8, 1997
Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists.Journal of medicinal chemistry, , Apr-11, Volume: 40, Issue:8, 1997
Synthesis and biological characterization of 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as muscarinic agonists for the treatment of neurological disorders.Journal of medicinal chemistry, , Sep-25, Volume: 46, Issue:20, 2003
Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists.Journal of medicinal chemistry, , Apr-11, Volume: 40, Issue:8, 1997