Page last updated: 2024-12-05

2-vinylpyridine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

2-Vinylpyridine is a heterocyclic organic compound with the formula C7H7N. It is a colorless liquid with a pungent odor. 2-Vinylpyridine is a versatile building block for the synthesis of various polymers, pharmaceuticals, and other organic compounds. It is widely used in the production of polyvinylpyridine, which is a polymer with excellent adhesion and film-forming properties. It is also an important intermediate in the synthesis of various pharmaceuticals, including antihistamines, anti-inflammatory drugs, and anticonvulsants. The compound is a key intermediate in the production of pyridyl containing polymers that are used in a variety of applications, including adhesives, coatings, and resins. The synthesis of 2-vinylpyridine is typically accomplished through the reaction of pyridine with acetylene, a process known as the Reppe reaction. The compound is also a valuable research tool, and it is studied for its potential applications in various fields, including medicine, materials science, and agriculture.'

Cross-References

ID SourceID
PubMed CID7521
CHEMBL ID2134875
SCHEMBL ID15193
SCHEMBL ID12305235
MeSH IDM0097609

Synonyms (71)

Synonym
nsc-118993
pyridine, dimer
27476-03-5
EN300-21363
nsc118993
2-ethenylpyridine
ccris 5238
alpha-vinylpyridine
nsc 18255
einecs 202-879-8
hsdb 1508
ai3-24116
100-69-6
nsc18255
2-vinylpyridine
pyridine, 2-ethenyl-
pyridine, 2-vinyl-
nsc-18255
inchi=1/c7h7n/c1-2-7-5-3-4-6-8-7/h2-6h,1h
NCGC00091100-01
2-vinylpyridine, 97%
2-vinyl pyridine
MLS002454369
smr001261681
V0024
25014-15-7
STK802315
A800261
AKOS005622542
NCGC00091100-02
dt4uv4nnkx ,
ec 202-879-8
unii-dt4uv4nnkx
NCGC00257589-01
dtxcid406667
dtxsid1026667 ,
tox21_200035
cas-100-69-6
nsc 118993
pyridine, 2-ethenyl-, dimer
vinylpyridine
pyridine, ethenyl-
unii-jr931x5841
1337-81-1
jr931x5841 ,
FT-0612192
2-vinylpyridine [hsdb]
.alpha.-vinylpyridine
2-pyridylethylene
AM20090687
BBL027578
SCHEMBL15193
CHEMBL2134875
vinyl pyridine
2-vinyl-pyridine
2-vinylpyridin
2-vinylpiridine
2-(ethenyl)pyridine
SCHEMBL12305235
STR01590
W-108947
mfcd00006355
F0001-0024
2-vinylpyridine (stabilized with 0.1per cent 4-tert-butylcatechol)
2-ethenylpyridine (2-vinylpyridine)
Q4596922
vinylidenepyridine
2-vinylpyridine (stabilized with tbc)
pyridine,ethenyl-
Z104495554
PD065571
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RAR-related orphan receptor gammaMus musculus (house mouse)Potency0.24580.006038.004119,952.5996AID1159521
AR proteinHomo sapiens (human)Potency61.75280.000221.22318,912.5098AID743040
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency49.05200.003041.611522,387.1992AID1159552
estrogen nuclear receptor alphaHomo sapiens (human)Potency31.15400.000229.305416,493.5996AID743075; AID743079
nuclear factor NF-kappa-B p105 subunit isoform 1Homo sapiens (human)Potency50.11874.466824.832944.6684AID651749
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1637722Glutathione reactivity assessed as half life at 250 uM up to 72 hrs by HPLC-MS or NMR analysis2019MedChemComm, Feb-01, Volume: 10, Issue:2
Design and characterization of a heterocyclic electrophilic fragment library for the discovery of cysteine-targeted covalent inhibitors.
AID1637723Stability of the compound assessed as half life for degradation2019MedChemComm, Feb-01, Volume: 10, Issue:2
Design and characterization of a heterocyclic electrophilic fragment library for the discovery of cysteine-targeted covalent inhibitors.
AID1149238Dissociation constant, pKa of the compound1976Journal of medicinal chemistry, Apr, Volume: 19, Issue:4
Mode of action and quantitative structure-activity correlations of tuberculostatic drugs of the isonicotinic acid hydrazide type.
AID1637721Glutathione reactivity assessed as thiol reactivity rate constant at 250 uM up to 72 hrs by HPLC-MS or NMR analysis2019MedChemComm, Feb-01, Volume: 10, Issue:2
Design and characterization of a heterocyclic electrophilic fragment library for the discovery of cysteine-targeted covalent inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (34)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (8.82)18.7374
1990's9 (26.47)18.2507
2000's8 (23.53)29.6817
2010's12 (35.29)24.3611
2020's2 (5.88)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 45.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index45.78 (24.57)
Research Supply Index3.56 (2.92)
Research Growth Index4.97 (4.65)
Search Engine Demand Index65.25 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (45.78)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.94%)6.00%
Case Studies2 (5.88%)4.05%
Observational0 (0.00%)0.25%
Other31 (91.18%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]