Page last updated: 2024-08-08 00:05:36
Oxoeicosanoid receptor 1
An oxoeicosanoid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS5]
Synonyms
5-oxo-ETE G-protein coupled receptor;
G-protein coupled receptor 170;
G-protein coupled receptor R527;
G-protein coupled receptor TG1019
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (7)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| docosahexaenoate | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| eicosapentaenoic acid | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| 8,11,14-eicosatrienoic acid | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| 12-hydroxy-5,8,10,14-eicosatetraenoic acid | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| 5-oxo-6,8,11,14-eicosatetraenoic acid | Homo sapiens (human) | IC50 | 0.0030 | 1 | 1 |
| 11,14,17-eicosatrienoate | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
Drugs with Activation Measurements
Synthesis, molecular modelling studies and biological evaluation of new oxoeicosanoid receptor 1 agonists.Bioorganic & medicinal chemistry, , 07-23, Volume: 26, Issue:12, 2018
C20-trifluoro-5-oxo-ETE: a metabolically stable 5-oxo-ETE derivative.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 21, Issue:7, 2011
5-oxo-15-HETE: total synthesis and bioactivity.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 21, Issue:6, 2011
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|
| G protein-coupled receptor activity | molecular function | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding | molecular function | Binding to 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. [GOC:ai] |
| 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding | molecular function | Binding to 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. [GOC:ai] |
| 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding | molecular function | Binding to 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. [GOC:ai] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|
| adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] |
| G protein-coupled receptor signaling pathway | biological process | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] |