Proteins > Carbapenem-hydrolyzing beta-lactamase KPC
Page last updated: 2024-08-07 13:44:01

Carbapenem-hydrolyzing beta-lactamase KPC

A protein that is a translation product of any of the plasmid-encoded copies of the blaKPC-2 gene in Klebsiella pneumoniae. [PRO:DAN, UniProtKB:Q9F663]

Synonyms

EC 3.5.2.6;
Carbapenem-hydrolyzing beta-lactamase KPC-1

Research

Bioassay Publications (4)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Compounds (16)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
tazobactamKlebsiella pneumoniaeIC500.372022
tazobactamKlebsiella pneumoniaeKi74.000011
sulbactamKlebsiella pneumoniaeKi167.000011
clavulanic acidKlebsiella pneumoniaeIC5010.500011
clavulanic acidKlebsiella pneumoniaeKi11.000011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
cephaloridineKlebsiella pneumoniaeKm510.000011
penicillin gKlebsiella pneumoniaeKm30.000011
cephalothinKlebsiella pneumoniaeKm33.500022
ampicillinKlebsiella pneumoniaeKm130.000011
piperacillinKlebsiella pneumoniaeKm16.500022
doripenemKlebsiella pneumoniaeKm1.600011
imipenem, anhydrousKlebsiella pneumoniaeKm63.333333
meropenemKlebsiella pneumoniaeKm12.500022
cefoxitinKlebsiella pneumoniaeKm120.000011
ceftazidimeKlebsiella pneumoniaeKm162.000022
cefotaximeKlebsiella pneumoniaeKm183.500022
aztreonamKlebsiella pneumoniaeKm310.000011
nitrocefinKlebsiella pneumoniaeKm6.000011