Page last updated: 2024-08-07 13:44:01
Carbapenem-hydrolyzing beta-lactamase KPC
A protein that is a translation product of any of the plasmid-encoded copies of the blaKPC-2 gene in Klebsiella pneumoniae. [PRO:DAN, UniProtKB:Q9F663]
Synonyms
EC 3.5.2.6;
Carbapenem-hydrolyzing beta-lactamase KPC-1
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (16)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| tazobactam | Klebsiella pneumoniae | IC50 | 0.3720 | 2 | 2 |
| tazobactam | Klebsiella pneumoniae | Ki | 74.0000 | 1 | 1 |
| sulbactam | Klebsiella pneumoniae | Ki | 167.0000 | 1 | 1 |
| clavulanic acid | Klebsiella pneumoniae | IC50 | 10.5000 | 1 | 1 |
| clavulanic acid | Klebsiella pneumoniae | Ki | 11.0000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| cephaloridine | Klebsiella pneumoniae | Km | 510.0000 | 1 | 1 |
| penicillin g | Klebsiella pneumoniae | Km | 30.0000 | 1 | 1 |
| cephalothin | Klebsiella pneumoniae | Km | 33.5000 | 2 | 2 |
| ampicillin | Klebsiella pneumoniae | Km | 130.0000 | 1 | 1 |
| piperacillin | Klebsiella pneumoniae | Km | 16.5000 | 2 | 2 |
| doripenem | Klebsiella pneumoniae | Km | 1.6000 | 1 | 1 |
| imipenem, anhydrous | Klebsiella pneumoniae | Km | 63.3333 | 3 | 3 |
| meropenem | Klebsiella pneumoniae | Km | 12.5000 | 2 | 2 |
| cefoxitin | Klebsiella pneumoniae | Km | 120.0000 | 1 | 1 |
| ceftazidime | Klebsiella pneumoniae | Km | 162.0000 | 2 | 2 |
| cefotaxime | Klebsiella pneumoniae | Km | 183.5000 | 2 | 2 |
| aztreonam | Klebsiella pneumoniae | Km | 310.0000 | 1 | 1 |
| nitrocefin | Klebsiella pneumoniae | Km | 6.0000 | 1 | 1 |