Page last updated: 2024-08-07 16:40:42
Carbonic anhydrase 7
A carbonic anhydrase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43166]
Synonyms
EC 4.2.1.1;
Carbonate dehydratase VII;
Carbonic anhydrase VII;
CA-VII
Research
Bioassay Publications (127)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (1.57) | 18.7374 |
| 1990's | 2 (1.57) | 18.2507 |
| 2000's | 29 (22.83) | 29.6817 |
| 2010's | 73 (57.48) | 24.3611 |
| 2020's | 21 (16.54) | 2.80 |
Compounds (187)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| protocatechuic acid | Homo sapiens (human) | Ki | 7.8700 | 1 | 1 |
| 4-hydroxybenzoic acid | Homo sapiens (human) | Ki | 296.2925 | 3 | 16 |
| hydrobromic acid | Homo sapiens (human) | Ki | 1,060.0000 | 1 | 1 |
| cadaverine | Homo sapiens (human) | Ki | 0.4200 | 1 | 1 |
| catechol | Homo sapiens (human) | Ki | 502.0786 | 3 | 14 |
| hydrochloric acid | Homo sapiens (human) | Ki | 1,840.0000 | 1 | 1 |
| coumarin | Homo sapiens (human) | Ki | 401.1000 | 3 | 3 |
| salicylic acid | Homo sapiens (human) | Ki | 167.0286 | 2 | 14 |
| gallic acid | Homo sapiens (human) | Ki | 6.0700 | 1 | 1 |
| hydrogen sulfide | Homo sapiens (human) | Ki | 1,240.0000 | 1 | 1 |
| 4-aminophenol | Homo sapiens (human) | Ki | 575.9357 | 2 | 14 |
| cyanic acid | Homo sapiens (human) | Ki | 15,200.0000 | 1 | 1 |
| carbonic acid | Homo sapiens (human) | Ki | 215.0000 | 1 | 2 |
| hydrogen cyanide | Homo sapiens (human) | Ki | 9,200.0000 | 1 | 1 |
| thiocyanic acid | Homo sapiens (human) | Ki | 170.0000 | 1 | 1 |
| hydroquinone | Homo sapiens (human) | Ki | 179.4636 | 2 | 14 |
| nitric acid | Homo sapiens (human) | Ki | 190.0000 | 1 | 1 |
| phenol | Homo sapiens (human) | Ki | 316.4625 | 5 | 16 |
| sulfurous acid | Homo sapiens (human) | Ki | 7,300.0000 | 1 | 1 |
| spermidine | Homo sapiens (human) | Ki | 1.2300 | 1 | 1 |
| spermine | Homo sapiens (human) | Ki | 0.7100 | 1 | 1 |
| sulfuric acid | Homo sapiens (human) | Ki | 1,380.0000 | 1 | 1 |
| catechin | Homo sapiens (human) | Ki | 0.4500 | 1 | 1 |
| beta-resorcylic acid | Homo sapiens (human) | Ki | 72.0000 | 1 | 1 |
| acetaminophen | Homo sapiens (human) | Ki | 148.0462 | 2 | 13 |
| acetazolamide | Homo sapiens (human) | IC50 | 1.1737 | 6 | 6 |
| acetazolamide | Homo sapiens (human) | Ki | 4.0412 | 87 | 152 |
| bumetanide | Homo sapiens (human) | Ki | 18.3242 | 1 | 12 |
| celecoxib | Homo sapiens (human) | Ki | 2.1700 | 6 | 6 |
| chlorthalidone | Homo sapiens (human) | Ki | 1.2954 | 2 | 14 |
| coumaphos | Homo sapiens (human) | Ki | 4.6800 | 1 | 1 |
| dichlorphenamide | Homo sapiens (human) | Ki | 26.9175 | 11 | 34 |
| ethoxzolamide | Homo sapiens (human) | Ki | 8.3481 | 13 | 24 |
| furosemide | Homo sapiens (human) | Ki | 14.6128 | 2 | 14 |
| 2,5-dihydroxybenzoic acid | Homo sapiens (human) | Ki | 68.0000 | 1 | 1 |
| hydrochlorothiazide | Homo sapiens (human) | Ki | 18.6042 | 1 | 12 |
| hydroflumethiazide | Homo sapiens (human) | Ki | 20.3203 | 1 | 12 |
| indapamide | Homo sapiens (human) | Ki | 17.4942 | 3 | 15 |
| mafenide | Homo sapiens (human) | Ki | 0.0750 | 1 | 1 |
| methazolamide | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
| methazolamide | Homo sapiens (human) | Ki | 8.6055 | 12 | 24 |
| metolazone | Homo sapiens (human) | Ki | 20.3668 | 2 | 13 |
| resorcinol | Homo sapiens (human) | Ki | 323.7143 | 2 | 14 |
| resveratrol | Homo sapiens (human) | Ki | 8.9800 | 1 | 1 |
| saccharin | Homo sapiens (human) | Ki | 0.0100 | 3 | 3 |
| imatinib | Homo sapiens (human) | Ki | 0.1090 | 1 | 1 |
| sulfanilamide | Homo sapiens (human) | Ki | 0.0700 | 3 | 3 |
| sulpiride | Homo sapiens (human) | Ki | 2.4212 | 3 | 3 |
| sulthiame | Homo sapiens (human) | Ki | 52.8232 | 1 | 12 |
| trichlormethiazide | Homo sapiens (human) | Ki | 43.7501 | 2 | 26 |
| trientine | Homo sapiens (human) | Ki | 45.0000 | 1 | 1 |
| zonisamide | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| zonisamide | Homo sapiens (human) | Ki | 97.5477 | 10 | 23 |
| sulfamic acid | Homo sapiens (human) | Ki | 9.5000 | 1 | 1 |
| carbostyril | Homo sapiens (human) | Ki | 0.4200 | 2 | 2 |
| 4-toluenesulfonamide | Homo sapiens (human) | Ki | 0.0880 | 1 | 1 |
| quinethazone | Homo sapiens (human) | Ki | 18.1300 | 1 | 2 |
| veratrole | Homo sapiens (human) | Ki | 7.2500 | 1 | 1 |
| veratric acid | Homo sapiens (human) | Ki | 7.1500 | 1 | 1 |
| benzenearsonic acid | Homo sapiens (human) | Ki | 12.5000 | 1 | 1 |
| benzenesulfonamide | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| alpha-resorcylic acid | Homo sapiens (human) | Ki | 7.1700 | 1 | 1 |
| methylparaben | Homo sapiens (human) | Ki | 0.7800 | 1 | 1 |
| diethylenetriamine | Homo sapiens (human) | Ki | 12.1000 | 1 | 1 |
| ethyl-p-hydroxybenzoate | Homo sapiens (human) | Ki | 8.7000 | 1 | 1 |
| carzenide | Homo sapiens (human) | Ki | 0.0520 | 1 | 1 |
| 1,4-dimethoxybenzene | Homo sapiens (human) | Ki | 3.8800 | 1 | 1 |
| gamma-resorcylic acid | Homo sapiens (human) | Ki | 6.6000 | 1 | 1 |
| ninhydrin | Homo sapiens (human) | Ki | 0.0740 | 1 | 1 |
| syringic acid | Homo sapiens (human) | Ki | 7.8100 | 1 | 1 |
| herniarin | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| coumarin-3-carboxylic acid | Homo sapiens (human) | Ki | 6.2000 | 1 | 1 |
| 3-aminophenol | Homo sapiens (human) | Ki | 5.9000 | 1 | 1 |
| 4-cyanophenol | Homo sapiens (human) | Ki | 257.9863 | 2 | 14 |
| 4-iodobenzenesulfonamide | Homo sapiens (human) | Ki | 0.0755 | 1 | 2 |
| hydrofluoric acid | Homo sapiens (human) | Ki | 1,240.0000 | 1 | 1 |
| n-(1-naphthyl)ethylenediamine | Homo sapiens (human) | Ki | 0.3600 | 1 | 1 |
| 2,6-dimethoxybenzoic acid | Homo sapiens (human) | Ki | 3.2200 | 1 | 1 |
| 1,6-diaminohexane | Homo sapiens (human) | Ki | 0.4400 | 1 | 1 |
| benzolamide | Homo sapiens (human) | Ki | 28.0260 | 2 | 5 |
| benzeneseleninic acid | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| sodium pyrophosphate | Homo sapiens (human) | Ki | 870.0000 | 1 | 1 |
| nitrous acid | Homo sapiens (human) | Ki | 1,780.0000 | 1 | 1 |
| hydrazoic acid | Homo sapiens (human) | Ki | 1,410.0000 | 1 | 1 |
| hydroiodic acid | Homo sapiens (human) | Ki | 250.0000 | 1 | 1 |
| sodium selenate | Homo sapiens (human) | Ki | 215,000.0000 | 1 | 1 |
| 7-ethoxycoumarin | Homo sapiens (human) | Ki | 7.8000 | 1 | 1 |
| dobutamine | Homo sapiens (human) | Ki | 4.3000 | 1 | 1 |
| foscarnet sodium | Homo sapiens (human) | Ki | 560.0000 | 1 | 1 |
| sodium persulfate | Homo sapiens (human) | Ki | 3,110.0000 | 1 | 1 |
| calanolide b | Homo sapiens (human) | Ki | 8.8700 | 1 | 1 |
| xanthyletine | Homo sapiens (human) | Ki | 9.1800 | 1 | 1 |
| xanthoxyletin | Homo sapiens (human) | Ki | 6.2700 | 1 | 1 |
| 4-chlorobenzenesulfonamide | Homo sapiens (human) | Ki | 0.0236 | 2 | 3 |
| benzeneboronic acid | Homo sapiens (human) | Ki | 8.3000 | 2 | 2 |
| 4-amino-6-chloro-1,3-benzenedisulfonamide | Homo sapiens (human) | Ki | 0.2100 | 1 | 1 |
| 1,2,4-trimethoxybenzene | Homo sapiens (human) | Ki | 3.7000 | 1 | 1 |
| 2-benzothiazolesulfonamide | Homo sapiens (human) | Ki | 0.0040 | 1 | 1 |
| brinzolamide | Homo sapiens (human) | Ki | 0.0028 | 8 | 8 |
| 2,4-disulfamyl-5-trifluoromethylaniline | Homo sapiens (human) | Ki | 0.1000 | 1 | 1 |
| 4-bromobenzenesulfonamide | Homo sapiens (human) | Ki | 0.0745 | 1 | 2 |
| isoscopoletin | Homo sapiens (human) | Ki | 23.8000 | 1 | 1 |
| hesperetin | Homo sapiens (human) | Ki | 0.0033 | 1 | 1 |
| methanesulfonamide | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 2-aminobenzenesulfonamide | Homo sapiens (human) | Ki | 0.0450 | 1 | 1 |
| methyl gentisate | Homo sapiens (human) | Ki | 8.3000 | 1 | 1 |
| ethyl protocatechuate | Homo sapiens (human) | Ki | 0.7500 | 1 | 1 |
| 3,7-diazanonane-1,9-diamine | Homo sapiens (human) | Ki | 58.0000 | 1 | 1 |
| sulfamide | Homo sapiens (human) | Ki | 6.8000 | 2 | 2 |
| 5-amino-1,3,4-thiadiazole-2-sulfonamide | Homo sapiens (human) | Ki | 0.0052 | 2 | 2 |
| valdecoxib | Homo sapiens (human) | Ki | 3.9000 | 4 | 4 |
| 1-naphthylacetylspermine | Homo sapiens (human) | Ki | 0.1000 | 1 | 1 |
| chlorzolamide | Homo sapiens (human) | Ki | 0.0054 | 1 | 1 |
| 4-(2-aminoethyl)benzenesulfonamide | Homo sapiens (human) | Ki | 0.2561 | 2 | 2 |
| sorafenib | Homo sapiens (human) | Ki | 8.1364 | 1 | 1 |
| n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide | Homo sapiens (human) | Ki | 0.1220 | 2 | 2 |
| lacosamide | Homo sapiens (human) | Ki | 4.4460 | 1 | 1 |
| methyl 3,4-dihydroxybenzoate | Homo sapiens (human) | Ki | 0.8100 | 1 | 1 |
| u-104 | Homo sapiens (human) | Ki | 8.5500 | 4 | 4 |
| bortezomib | Homo sapiens (human) | Ki | 6.9400 | 1 | 1 |
| naringenin | Homo sapiens (human) | Ki | 0.0043 | 1 | 1 |
| scopolin | Homo sapiens (human) | Ki | 9.1100 | 1 | 1 |
| taxifolin | Homo sapiens (human) | Ki | 0.4931 | 1 | 1 |
| eriodictyol | Homo sapiens (human) | Ki | 0.0043 | 1 | 1 |
| resveratrol | Homo sapiens (human) | Ki | 4.3500 | 1 | 1 |
| rwj 37947 | Homo sapiens (human) | Ki | 0.0360 | 1 | 1 |
| ferulic acid | Homo sapiens (human) | Ki | 7.4100 | 1 | 1 |
| ditiocarb sodium | Homo sapiens (human) | Ki | 1,470.0000 | 1 | 1 |
| hydroxyphenethylferulate | Homo sapiens (human) | Ki | 0.6200 | 1 | 1 |
| 2-hydroxycinnamic acid | Homo sapiens (human) | Ki | 1,000.0000 | 1 | 1 |
| trans-4-coumaric acid | Homo sapiens (human) | Ki | 5.2300 | 1 | 1 |
| s 1033 | Homo sapiens (human) | Ki | 0.0990 | 1 | 1 |
| ethyl coumarate | Homo sapiens (human) | Ki | 0.8500 | 1 | 1 |
| caffeic acid | Homo sapiens (human) | Ki | 6.4200 | 1 | 1 |
| ethyl 2,4-dihydroxybenzoate | Homo sapiens (human) | Ki | 0.8100 | 1 | 1 |
| 7-methoxy-2-oxo-1-benzopyran-3-carboxylic acid ethyl ester | Homo sapiens (human) | Ki | 9.7000 | 1 | 1 |
| N1-[4-(aminosulfonyl)phenyl]-2,2-dimethylpropanamide | Homo sapiens (human) | Ki | 7.2000 | 1 | 1 |
| 6,7,8-trimethoxycoumarin | Homo sapiens (human) | Ki | 9.2800 | 1 | 1 |
| fraxin | Homo sapiens (human) | Ki | 3.8700 | 1 | 1 |
| fraxetin | Homo sapiens (human) | Ki | 4.3200 | 1 | 1 |
| quercetin | Homo sapiens (human) | Ki | 4.8400 | 1 | 1 |
| biochanin a | Homo sapiens (human) | Ki | 0.3715 | 1 | 1 |
| luteolin | Homo sapiens (human) | Ki | 0.0047 | 1 | 1 |
| scopoletin | Homo sapiens (human) | Ki | 8.7100 | 1 | 1 |
| quercetin 3-o-glucopyranoside | Homo sapiens (human) | Ki | 0.0038 | 1 | 1 |
| kaempferol | Homo sapiens (human) | Ki | 0.0250 | 1 | 1 |
| chrysin | Homo sapiens (human) | Ki | 0.1714 | 1 | 1 |
| galangin | Homo sapiens (human) | Ki | 0.0245 | 1 | 1 |
| 3-methylquercetin | Homo sapiens (human) | Ki | 0.0044 | 1 | 1 |
| daidzein | Homo sapiens (human) | Ki | 0.0042 | 1 | 1 |
| salvianolic acid a | Homo sapiens (human) | Ki | 0.0714 | 1 | 1 |
| puerarin | Homo sapiens (human) | Ki | 0.4526 | 1 | 1 |
| ellagic acid | Homo sapiens (human) | Ki | 7.5550 | 2 | 2 |
| astragalin | Homo sapiens (human) | Ki | 0.4237 | 1 | 1 |
| dorzolamide | Homo sapiens (human) | Ki | 39.4633 | 10 | 21 |
| topiramate | Homo sapiens (human) | Ki | 18.9008 | 22 | 42 |
| irosustat | Homo sapiens (human) | Ki | 54.4254 | 2 | 13 |
| methyl-p-coumarate | Homo sapiens (human) | Ki | 0.8200 | 1 | 1 |
| tiliroside | Homo sapiens (human) | Ki | 0.0046 | 1 | 1 |
| 3-cyano-7-hydroxycoumarin | Homo sapiens (human) | Ki | 48.2209 | 1 | 11 |
| famotidine | Homo sapiens (human) | Ki | 0.0030 | 1 | 1 |
| geiparvarin | Homo sapiens (human) | Ki | 7.8200 | 1 | 1 |
| benzeneselenol | Homo sapiens (human) | Ki | 0.7600 | 1 | 1 |
| lithospermic acid | Homo sapiens (human) | Ki | 0.2683 | 1 | 1 |
| sodium bisulfate | Homo sapiens (human) | Ki | 760.0000 | 1 | 1 |
| trans-avicennol | Homo sapiens (human) | Ki | 8.9800 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Natural product coumarins that inhibit human carbonic anhydrases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 22, Issue:6, 2012
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.Journal of medicinal chemistry, , Jan-14, Volume: 53, Issue:1, 2010
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Quantum mechanical study on the activation mechanism of human carbonic anhydrase VII cluster model with bis-histamine schiff bases and bis-spinaceamine derivatives.Bioorganic & medicinal chemistry, , 08-15, Volume: 44, 2021
Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 17, Issue:3, 2007
Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain.European journal of medicinal chemistry, , Jan-05, Volume: 227, 2022
Tellurides bearing benzensulfonamide as carbonic anhydrase inhibitors with potent antitumor activity.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 45, 2021
Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action.European journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer.Journal of medicinal chemistry, , 02-11, Volume: 64, Issue:3, 2021
Handling drug-target selectivity: A study on ureido containing Carbonic Anhydrase inhibitors.European journal of medicinal chemistry, , Feb-15, Volume: 212, 2021
Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII.Bioorganic & medicinal chemistry, , 08-15, Volume: 44, 2021
Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations.Journal of medicinal chemistry, , 03-25, Volume: 64, Issue:6, 2021
Ninhydrins inhibit carbonic anhydrases directly binding to the metal ion.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase-Carbonic Anhydrase Dual-Hybrid Inhibitors.Journal of medicinal chemistry, , 08-12, Volume: 64, Issue:15, 2021
Glycomimetic Based Approach toward Selective Carbonic Anhydrase Inhibitors.ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
[no title available]Journal of medicinal chemistry, , 01-09, Volume: 63, Issue:1, 2020
Azidothymidine "Clicked" into 1,2,3-Triazoles: First Report on Carbonic Anhydrase-Telomerase Dual-Hybrid Inhibitors.Journal of medicinal chemistry, , 07-09, Volume: 63, Issue:13, 2020
[no title available]ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy.Journal of medicinal chemistry, , 05-28, Volume: 63, Issue:10, 2020
Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis.Journal of medicinal chemistry, , 03-12, Volume: 63, Issue:5, 2020
Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action.Journal of medicinal chemistry, , 03-26, Volume: 63, Issue:6, 2020
Direct and straightforward access to substituted alkyl selenols as novel carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells.European journal of medicinal chemistry, , Nov-15, Volume: 182, 2019
Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction.European journal of medicinal chemistry, , Nov-15, Volume: 182, 2019
Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
Famotidine, an Antiulcer Agent, Strongly Inhibits ACS medicinal chemistry letters, , Oct-11, Volume: 9, Issue:10, 2018
Discovery of Benzenesulfonamide Derivatives as Carbonic Anhydrase Inhibitors with Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Evaluation.Journal of medicinal chemistry, , 04-12, Volume: 61, Issue:7, 2018
Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
Benzimidazole design, synthesis, and docking to build selective carbonic anhydrase VA inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects.European journal of medicinal chemistry, , Jun-25, Volume: 154, 2018
Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology.ACS medicinal chemistry letters, , May-10, Volume: 9, Issue:5, 2018
Synthesis of Novel Selenides Bearing Benzenesulfonamide Moieties as Carbonic Anhydrase I, II, IV, VII, and IX Inhibitors.ACS medicinal chemistry letters, , Dec-14, Volume: 8, Issue:12, 2017
Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors.Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Synthesis and biological evaluation of novel aromatic and heterocyclic bis-sulfonamide Schiff bases as carbonic anhydrase I, II, VII and IX inhibitors.Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
Bortezomib inhibits mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , 10-01, Volume: 25, Issue:19, 2017
Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment.Journal of medicinal chemistry, , 03-23, Volume: 60, Issue:6, 2017
Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis.Journal of medicinal chemistry, , 02-09, Volume: 60, Issue:3, 2017
Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties.Bioorganic & medicinal chemistry, , 02-15, Volume: 25, Issue:4, 2017
Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors.Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
Microwave assisted synthesis of novel tetrazole/sulfonamide derivatives based on octahydroacridine, xanthene and chromene skeletons as inhibitors of the carbonic anhydrases isoforms I, II, IV and VII.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 27, Issue:1, 2017
Lucky Switcheroo: Dramatic Potency and Selectivity Improvement of Imidazoline Inhibitors of Human Carbonic Anhydrase VII.ACS medicinal chemistry letters, , Oct-12, Volume: 8, Issue:10, 2017
Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies.European journal of medicinal chemistry, , Feb-15, Volume: 127, 2017
Evaluation of selenide, diselenide and selenoheterocycle derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors.Bioorganic & medicinal chemistry, , 04-15, Volume: 25, Issue:8, 2017
Human carbonic anhydrase inhibitory profile of mono- and bis-sulfonamides synthesized via a direct sulfochlorination of 3- and 4-(hetero)arylisoxazol-5-amine scaffolds.Bioorganic & medicinal chemistry, , 03-15, Volume: 25, Issue:6, 2017
Microwave assisted synthesis of novel acridine-acetazolamide conjugates and investigation of their inhibition effects on human carbonic anhydrase isoforms hCA I, II, IV and VII.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition, and Protein X-ray Structures of Psammaplin C.Journal of medicinal chemistry, , 06-09, Volume: 59, Issue:11, 2016
Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action.Bioorganic & medicinal chemistry, , Feb-15, Volume: 24, Issue:4, 2016
Inhibition of carbonic anhydrase isoforms I, II, IV, VII and XII with carboxylates and sulfonamides incorporating phthalimide/phthalic anhydride scaffolds.Bioorganic & medicinal chemistry, , Jan-01, Volume: 24, Issue:1, 2016
A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Phosphate Chemical Probes Designed for Location Specific Inhibition of Intracellular Carbonic Anhydrases.Journal of medicinal chemistry, , Sep-24, Volume: 58, Issue:18, 2015
New natural product carbonic anhydrase inhibitors incorporating phenol moieties.Bioorganic & medicinal chemistry, , Nov-15, Volume: 23, Issue:22, 2015
Benzenesulfonamides with benzimidazole moieties as inhibitors of carbonic anhydrases I, II, VII, XII and XIII.Journal of enzyme inhibition and medicinal chemistry, , Volume: 29, Issue:1, 2014
Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.European journal of medicinal chemistry, , Volume: 71, 2014
Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.Journal of medicinal chemistry, , Nov-26, Volume: 57, Issue:22, 2014
Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014
Inhibition studies of new ureido-substituted sulfonamides incorporating a GABA moiety against human carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Dec-15, Volume: 22, Issue:24, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Synthesis of novel acridine and bis acridine sulfonamides with effective inhibitory activity against the cytosolic carbonic anhydrase isoforms II and VII.Bioorganic & medicinal chemistry, , Sep-15, Volume: 21, Issue:18, 2013
4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Apr-26, Volume: 55, Issue:8, 2012
Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 22, Issue:4, 2012
Acetaldehyde-derived modifications on cytosolic human carbonic anhydrases.Journal of enzyme inhibition and medicinal chemistry, , Volume: 26, Issue:6, 2011
Structural basis for the interaction between carbonic anhydrase and 1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamides.Journal of medicinal chemistry, , Apr-14, Volume: 54, Issue:7, 2011
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , May-15, Volume: 19, Issue:10, 2011
Synthesis of rhodamine B-benzenesulfonamide conjugates and their inhibitory activity against human α- and bacterial/fungal β-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 21, Issue:18, 2011
Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.Journal of medicinal chemistry, , Jun-09, Volume: 54, Issue:11, 2011
Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.Bioorganic & medicinal chemistry, , Jun-15, Volume: 19, Issue:12, 2011
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Carbonic anhydrase inhibitors: inhibition of cytosolic carbonic anhydrase isozymes II and VII with simple aromatic sulfonamides and some azo dyes.Chemical biology & drug design, , Volume: 74, Issue:2, 2009
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 18, Issue:14, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation.European journal of medicinal chemistry, , Volume: 43, Issue:12, 2008
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.Bioorganic & medicinal chemistry letters, , May-15, Volume: 17, Issue:10, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Acetazolamide-like carbonic anhydrase inhibitors with topical ocular hypotensive activity.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
Synthesis and physicochemical properties of thiadiazolo[3,2-a]pyrimidinesulfonamides and thiadiazolo[3,2-a]triazinesulfonamides as candidates for topically effective carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
N-Substituted sulfonamide carbonic anhydrase inhibitors with topical effects on intraocular pressure.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.European journal of medicinal chemistry, , Volume: 71, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies.Journal of enzyme inhibition and medicinal chemistry, , Volume: 29, Issue:4, 2014
Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.European journal of medicinal chemistry, , Volume: 71, 2014
Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.Bioorganic & medicinal chemistry, , Jun-15, Volume: 19, Issue:12, 2011
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors: inhibition of cytosolic carbonic anhydrase isozymes II and VII with simple aromatic sulfonamides and some azo dyes.Chemical biology & drug design, , Volume: 74, Issue:2, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Benzenesulfonamides with benzimidazole moieties as inhibitors of carbonic anhydrases I, II, VII, XII and XIII.Journal of enzyme inhibition and medicinal chemistry, , Volume: 29, Issue:1, 2014
Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.European journal of medicinal chemistry, , Volume: 71, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Benzimidazole design, synthesis, and docking to build selective carbonic anhydrase VA inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Benzenesulfonamides with benzimidazole moieties as inhibitors of carbonic anhydrases I, II, VII, XII and XIII.Journal of enzyme inhibition and medicinal chemistry, , Volume: 29, Issue:1, 2014
Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.European journal of medicinal chemistry, , Volume: 71, 2014
Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Indapamide-like benzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, and XIII.Bioorganic & medicinal chemistry, , Nov-01, Volume: 18, Issue:21, 2010
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.Bioorganic & medicinal chemistry, , Jun-15, Volume: 19, Issue:12, 2011
Carbonic anhydrase inhibitors: inhibition of cytosolic carbonic anhydrase isozymes II and VII with simple aromatic sulfonamides and some azo dyes.Chemical biology & drug design, , Volume: 74, Issue:2, 2009
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Synthesis and physicochemical properties of thiadiazolo[3,2-a]pyrimidinesulfonamides and thiadiazolo[3,2-a]triazinesulfonamides as candidates for topically effective carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
[no title available]Journal of medicinal chemistry, , 01-09, Volume: 63, Issue:1, 2020
1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions.Journal of medicinal chemistry, , 07-14, Volume: 59, Issue:13, 2016
Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes.Journal of medicinal chemistry, , Apr-24, Volume: 57, Issue:8, 2014
Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.European journal of medicinal chemistry, , Volume: 71, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations.Journal of medicinal chemistry, , 03-25, Volume: 64, Issue:6, 2021
Substituted thieno[2,3-b]thiophenes and related congeners: Synthesis, β-glucuronidase inhibition activity, crystal structure, and POM analyses.Bioorganic & medicinal chemistry, , Dec-01, Volume: 22, Issue:23, 2014
Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.European journal of medicinal chemistry, , Volume: 71, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Apr-26, Volume: 55, Issue:8, 2012
Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.Journal of medicinal chemistry, , Jun-09, Volume: 54, Issue:11, 2011
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?Chemical biology & drug design, , Volume: 74, Issue:3, 2009
Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Carbonic anhydrase inhibitors: inhibition of cytosolic carbonic anhydrase isozymes II and VII with simple aromatic sulfonamides and some azo dyes.Chemical biology & drug design, , Volume: 74, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 17, Issue:17, 2007
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Sulfonylmethanesulfonamide inhibitors of carbonic anhydrase.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Bortezomib inhibits mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , 10-01, Volume: 25, Issue:19, 2017
Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 16, Issue:12, 2006
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action.Journal of medicinal chemistry, , 03-26, Volume: 63, Issue:6, 2020
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 16, Issue:12, 2006
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.European journal of medicinal chemistry, , Volume: 71, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies.European journal of medicinal chemistry, , Feb-15, Volume: 127, 2017
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations.Journal of medicinal chemistry, , 03-25, Volume: 64, Issue:6, 2021
[no title available]Journal of medicinal chemistry, , 01-09, Volume: 63, Issue:1, 2020
[no title available]ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors.Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
Natural product coumarins that inhibit human carbonic anhydrases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action.Journal of medicinal chemistry, , 03-26, Volume: 63, Issue:6, 2020
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII.Bioorganic & medicinal chemistry, , 08-15, Volume: 44, 2021
Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations.Journal of medicinal chemistry, , 03-25, Volume: 64, Issue:6, 2021
Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology.ACS medicinal chemistry letters, , May-10, Volume: 9, Issue:5, 2018
Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment.Journal of medicinal chemistry, , 03-23, Volume: 60, Issue:6, 2017
Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.European journal of medicinal chemistry, , Volume: 71, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Apr-26, Volume: 55, Issue:8, 2012
Structural basis for the interaction between carbonic anhydrase and 1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamides.Journal of medicinal chemistry, , Apr-14, Volume: 54, Issue:7, 2011
Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.Journal of medicinal chemistry, , Jun-09, Volume: 54, Issue:11, 2011
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation.European journal of medicinal chemistry, , Volume: 43, Issue:12, 2008
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.Bioorganic & medicinal chemistry letters, , May-15, Volume: 17, Issue:10, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Enables
This protein enables 2 target(s):
| Target | Category | Definition |
|---|
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| carbonate dehydratase activity | molecular function | Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O. [EC:4.2.1.1] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
Involved In
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|
| positive regulation of synaptic transmission, GABAergic | biological process | Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). [GOC:mah] |
| positive regulation of cellular pH reduction | biological process | Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell. [GOC:mah] |
| neuron cellular homeostasis | biological process | The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. [GOC:BHF, GOC:mah] |
| regulation of chloride transport | biological process | Any process that modulates the frequency, rate or extent of chloride transport. [GOC:dph] |
| regulation of intracellular pH | biological process | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. [GOC:ai, GOC:dph, GOC:tb] |
| one-carbon metabolic process | biological process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. [GOC:hjd, GOC:mah, GOC:pde] |