Page last updated: 2024-08-07 16:34:21
Nociceptin receptor
A nociceptin receptor that is encoded in the genome of mouse. [OMA:P35377, PRO:DNx]
Synonyms
K3 opiate receptor;
Kappa-type 3 opioid receptor;
KOR-3;
ORGC;
Orphanin FQ receptor
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (6)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| nociceptin | Mus musculus (house mouse) | EC50 | 0.0061 | 4 | 6 |
Novel helix-constrained nociceptin derivatives are potent agonists and antagonists of ERK phosphorylation and thermal analgesia in mice.Journal of medicinal chemistry, , Dec-09, Volume: 53, Issue:23, 2010
Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist.Bioorganic & medicinal chemistry, , Mar-01, Volume: 16, Issue:5, 2008
Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Calpha,alpha-dialkylated amino acids.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
N- and C-terminal modifications of nociceptin/orphanin FQ generate highly potent NOP receptor ligands.Journal of medicinal chemistry, , Mar-10, Volume: 48, Issue:5, 2005