pyrroles has been researched along with Necrosis in 61 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (8.20) | 18.7374 |
| 1990's | 4 (6.56) | 18.2507 |
| 2000's | 19 (31.15) | 29.6817 |
| 2010's | 31 (50.82) | 24.3611 |
| 2020's | 2 (3.28) | 2.80 |
| Authors | Studies |
|---|---|
| Armitage, JN; Barrett, T; Connolly, S; Eisen, TGQ; Fife, KM; Gallagher, FA; Ingleson, V; Machin, AJ; Matakidou, A; Mullin, J; Priest, AN; Qian, W; Riddick, ACP; Stewart, GD; Thompson, N; Ursprung, S; Warren, A; Welsh, SJ; Zaccagna, F | 1 |
| Hu, C; Hu, X; Wang, L; Zhao, Y | 1 |
| Boger, DL; Boyle, KE; Vazquez, M; Wroe, A | 1 |
| Basit, F; Cristofanon, S; Fulda, S | 1 |
| Bahleda, R; Escudier, B; Gueutin, V; Izzedine, H; Rouvier, P; Soria, JC; Varga, A | 1 |
| Biondi-Zoccai, G; Calcagno, S; Canali, E; Conti, G; Fedele, F; Lucisano, L; Mancone, M; Pennacchi, M; Sardella, G; Stio, RE | 1 |
| Amantini, C; Berardi, R; Bonfili, L; Burattini, L; Cascinu, S; Eleuteri, AM; Farfariello, V; Liberati, S; Morelli, MB; Mozzicafreddo, M; Nabissi, M; Santoni, G; Santoni, M | 1 |
| Lan, L; Liu, Z; Mao, Z; Qin, W; Zhan, X | 1 |
| Chen, S; Ge, Y; Niu, X; Tan, W; Wang, G; Wang, H; Zhao, J; Zhao, L | 1 |
| He, GX; Liu, XL; Xu, HP; Zhao, XJ | 1 |
| Krossnes, BK; Ljøstad, U; Mygland, Å | 1 |
| Schmutz, JL | 1 |
| Bousquet, G; Duval, A; Ferreira, I; Feugeas, JP; Gapihan, G; Germain, S; Janin, A; Leboeuf, C; Mongiat-Artus, P; Ratajczak, P; Setterblad, N; Tan, S; Varna, M; Verine, J | 1 |
| He, S; Shen, G; Wang, Y; Yin, T | 1 |
| Dervan, PB; Kang, JS | 1 |
| Champa, D; Cuervo, AM; Di Cristofano, A; Orlacchio, A; Patel, B; Ranieri, M; Shemetov, AA; Verkhusha, VV | 1 |
| Huang, XR; Lai, W; Lan, HY; Lou, TQ; Ming-Kuen Tang, P; Szalai, AJ; Tang, Y; Xu, A | 1 |
| Ha, HK; Kim, AY; Kim, HJ; Kim, JS; Lee, JS; Park, SH | 1 |
| Hernando, E; Korrodi-Gregório, L; Manuel-Manresa, P; Pérez-Tomás, R; Quesada, R; Rodilla, AM; Soto-Cerrato, V | 1 |
| Lóopez-Marure, R; Massó, FA; Montaño, LF; Páez, A; Rodríguez, E; Sánchez, CA; Varela, E; Zapata, E | 1 |
| Berneburg, M; Guenova, E; Hoetzenecker, W; Metzler, G; Mitev, V; Röcken, M; Voykov, B; Weber, HO | 1 |
| Clementi, F; Di Luozzo, M; Luciani, G; Mango, R; Martuscelli, E; Mehta, JL; Pizzuto, F; Romeo, F; Trivisonno, A | 1 |
| Connault, J; Durant, C; Pistorius, MA; Planchon, B; Saint-Jean, M | 1 |
| Beynat, C; Coudert, B; Diaz, P; Favier, L; Ghiringhelli, F; Ladoire, S | 1 |
| Bregman, CL; Fang, H; Fletcher, AM; Janke, HE; Janusz, WJ; Mense, MG; Salcedo, TW; Schulze, GE; Woicke, J; Zidell, RH | 1 |
| Derugin, N; Ferriero, DM; Shimotake, J; Vexler, ZS; Wendland, M | 1 |
| Fesler, MJ; Katta, A; Richart, JM; Tan, A; Vuong, G | 1 |
| Arioka, H; Ikeda, M; Kanai, F; Kawabe, T; Kondo, Y; Morizane, C; Obi, S; Okusaka, T; Omata, M; Sato, S; Shiina, S; Tagawa, K; Taniguchi, M; Tateishi, R; Yoshida, H | 1 |
| Benesch, M; Hanzer, M; Nebl, A; Pilhatsch, A; Spendel, S; Urban, C | 1 |
| Dodo, K; Sodeoka, M | 1 |
| Akram, S; Chakravarthi, S; Judson, JP; Lim, AY; Segarra, I | 1 |
| Alegret, M; Ađalsteisson, GS; Laguna, JC; Merlos, M; Rebollo, A; Roglans, N; Vilà, L | 1 |
| Ghilencea, L; Mario, CD; Moreno-Ambroj, C; Tyczyński, P; Witkowska, AB | 1 |
| Cho, BR; Hahn, JS; Hong, JY; Jang, J; Jeong, YS; Kim, S; Oh, WK | 1 |
| Birrer, MJ; Bowtell, D; Ellard, SL; Gilks, CB; Gout, PW; Huntsman, DG; Kagami, T; Lopez-Berestein, G; McAlpine, JN; Miller, DM; Mok, SC; Ozbun, L; Sood, AK; Stany, MP; Stone, RL; Vathipadiekal, V; Vivas-Mejia, P; Wang, Y; Wang, YZ; Xue, H | 1 |
| Chu, B; Dong, L; Hatsukami, T; Lane, T; Lee, C; Monick, D; Moore, A; Neradilek, MB; Phan, BA; Polissar, N; Underhill, H; Yuan, C; Zhao, XQ | 1 |
| Atlas, SR; Bantly, AD; Barrett, JS; Cao, K; Carroll, AJ; Chen, IM; Cory, L; Devidas, M; Dreyer, ZE; Edwards, AY; Felix, CA; Heerema, NA; Hilden, JM; Hudome, A; Hunger, SP; Kundu, M; Moore, JS; Reaman, GH; Robinson, BW; Urtishak, KA; Wang, LS; Willman, CL; Yu, QC | 1 |
| Albitar, M; Cherrington, JM; Cooper, MA; Cortes, JE; Giles, FJ; Hannah, AL; Hong, W; Kantarjian, HM; Karp, JE; Lancet, JE; Louie, SG; O'Brien, SM; O'Farrell, AM; Silverman, LR; Stopeck, AT; Verstovsek, S; Yuen, HA | 1 |
| THIELE, S; WITH, TK | 1 |
| Barbosa, E; Pannu, R; Singh, AK; Singh, I | 1 |
| Bernsen, HJ; Bussink, J; Peeters, W; Schuuring, J; van Der Kogel, AJ | 1 |
| Iwano, C; Matsuyama, K; Matzno, S; Nishikata, M; Yasuda, N | 1 |
| Di Sciascio, G; Nusca, A; Pasceri, V; Patti, G | 1 |
| Balaraman, R; Bothara, SB; Majithiya, JB; Trivedi, CJ | 1 |
| Chander, R; Deorukhkar, AA; Pandey, R; Sainis, KB | 1 |
| Braunwald, E | 1 |
| Baccala, A; Fergany, A; Gilligan, T; Hedgepeth, R; Kaouk, J; Magi-Galluzzi, C | 1 |
| Dham, A; Dudek, AZ; Truskinovsky, AM | 1 |
| Kasper, KA; Kuzel, TM; Meeks, JJ; Smith, ND; Yang, X | 1 |
| Han, HJ; Jin, YR; Kim, DW; Kim, TJ; Ryu, CK; Seo, JM; Sheen, YY; Yun, YP | 1 |
| Cuny, GD; Degterev, A; Keys, H; Teng, X; Yuan, J | 1 |
| Bar-Eli, M; Fan, D; Fidler, IJ; Kerbel, RS; Kim, SJ; Kuwai, T; Nakamura, T; Sasaki, T; Villares, GJ; Wang, H; Zigler, M | 1 |
| Driver, HE; Mattocks, AR | 1 |
| Moore, TL; Shebuski, RJ; Toombs, CF | 1 |
| Jasmin, G; Proschek, L | 1 |
| Gardner, DR; James, LF; Molyneux, RJ; Stegelmeier, BL | 1 |
| Cano-Abad, MF; Gabilan, NH; García, AG; López, MG; Villarroya, M | 1 |
| Dominick, MA; McGuire, EJ; Sigler, RE | 1 |
| Allen, JR; Chesney, CF | 1 |
| Grasso, P; Hooson, J; Mattocks, AR | 1 |
| Edwin, EE; Jackman, R; Machin, AF; Quick, MP | 1 |
3 review(s) available for pyrroles and Necrosis
| Article | Year |
|---|---|
A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma.
Topics: Adenosine Triphosphate; Animals; Calreticulin; DNA; Enzyme-Linked Immunosorbent Assay; HMGB1 Protein; Humans; Imidazoles; Immunoblotting; Inflammation; K562 Cells; Luminescence; Lymphoma, B-Cell; Macrophages; Necrosis; Neoplasms; Nylons; Phagocytosis; Pyrroles; Signal Transduction; Telomere; Up-Regulation | 2015 |
Development of selective inhibitors of necrosis.
Topics: Cardiotonic Agents; Humans; Indoles; Maleimides; Necrosis; Oxidative Stress; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Reperfusion Injury | 2010 |
[Prevention of periprocedural myocardial damage in patients undergoing percutaneous coronary intervention].
Topics: Actuarial Analysis; Adenosine; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Anticholesteremic Agents; Atorvastatin; Biomarkers; Clopidogrel; Creatine Kinase, MB Form; Electrocardiography; Embolism; Female; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Infarction; Myocardium; Necrosis; Placebos; Platelet Aggregation Inhibitors; Prospective Studies; Pyrroles; Randomized Controlled Trials as Topic; Risk Factors; Stents; Ticlopidine; Time Factors; Vasodilator Agents | 2005 |
6 trial(s) available for pyrroles and Necrosis
| Article | Year |
|---|---|
Dynamic biomarker and imaging changes from a phase II study of pre- and post-surgical sunitinib.
Topics: Antineoplastic Agents; Biomarkers; Carcinoma, Renal Cell; Humans; Indoles; Kidney Neoplasms; Necrosis; Pyrroles; Sunitinib; Vascular Endothelial Growth Factor C | 2022 |
Comparison of high reloading ROsuvastatin and Atorvastatin pretreatment in patients undergoing elective PCI to reduce the incidence of MyocArdial periprocedural necrosis. The ROMA II trial.
Topics: Aged; Angina, Stable; Atorvastatin; Elective Surgical Procedures; Female; Fluorobenzenes; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Male; Middle Aged; Myocardial Infarction; Necrosis; Percutaneous Coronary Intervention; Postoperative Complications; Preoperative Care; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Sulfonamides; Treatment Outcome | 2013 |
A phase I/II trial of the oral antiangiogenic agent TSU-68 in patients with advanced hepatocellular carcinoma.
Topics: Administration, Oral; Aged; Angiogenesis Inhibitors; Angiogenesis Modulating Agents; Area Under Curve; Biomarkers; Carcinoma, Hepatocellular; Female; Humans; Indoles; Liver Neoplasms; Male; Middle Aged; Necrosis; Oxindoles; Propionates; Pyrroles; Survival Analysis; Treatment Outcome; Vascular Cell Adhesion Molecule-1 | 2011 |
MR imaging of carotid plaque composition during lipid-lowering therapy a prospective assessment of effect and time course.
Topics: Apolipoproteins B; Atorvastatin; Biomarkers; Calcium; Carotid Arteries; Carotid Artery Diseases; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Female; Fibrosis; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Idaho; Lipid Metabolism; Magnetic Resonance Angiography; Male; Middle Aged; Necrosis; Predictive Value of Tests; Prospective Studies; Pyrroles; Time Factors; Treatment Outcome; Washington | 2011 |
Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Regulation, Leukemic; Histone-Lysine N-Methyltransferase; Humans; Indoles; Infant; Infant, Newborn; Myeloid-Lymphoid Leukemia Protein; Necrosis; Oncogene Proteins, Fusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-bcl-2; Pyrroles | 2013 |
SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes.
Topics: Acute Disease; Adult; Aged; Antineoplastic Agents; Apoptosis; Bone Marrow Cells; Bone Marrow Examination; Humans; Indoles; Leukemia, Myeloid; Middle Aged; Myelodysplastic Syndromes; Necrosis; Pharmacokinetics; Protein-Tyrosine Kinases; Pyrroles; Remission Induction; Salvage Therapy | 2003 |
52 other study(ies) available for pyrroles and Necrosis
| Article | Year |
|---|---|
Novel smac mimetic ASTX660 (Tolinapant) and TNF-α synergistically induce necroptosis in bladder cancer cells in vitro upon apoptosis inhibition.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Caspases; Female; Humans; Male; Morpholines; Necroptosis; Necrosis; Piperazines; Pyrroles; Receptor-Interacting Protein Serine-Threonine Kinases; Tumor Necrosis Factor-alpha; Urinary Bladder Neoplasms | 2022 |
Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
Topics: Antibiotics, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Duocarmycins; Glioblastoma; Humans; Indoles; Necrosis; Protons; Pyrroles; Radiation-Sensitizing Agents | 2018 |
Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes.
Topics: Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Cell Death; Cell Line; Fas-Associated Death Domain Protein; GTPase-Activating Proteins; HEK293 Cells; Humans; Imidazoles; Indoles; Microtubule-Associated Proteins; Necrosis; Phagosomes; Pyrroles; Receptor-Interacting Protein Serine-Threonine Kinases; RNA Interference; RNA, Small Interfering | 2013 |
Acute tubular necrosis associated with mTOR inhibitor therapy: a real entity biopsy-proven.
Topics: Acute Kidney Injury; Adenocarcinoma; Adenocarcinoma of Lung; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Density Conservation Agents; Carcinoma, Renal Cell; Cisplatin; Cyclophosphamide; Diphosphonates; Doxorubicin; Female; Glutamates; Guanine; Humans; Imidazoles; Indoles; Interferons; Kidney Tubules; Lung Neoplasms; Lymphoma, B-Cell; Male; Mediastinal Neoplasms; Middle Aged; Necrosis; Nephrectomy; Pemetrexed; Prednisone; Pyrroles; Sunitinib; TOR Serine-Threonine Kinases; Vincristine; Zoledronic Acid | 2013 |
Pazopanib and sunitinib trigger autophagic and non-autophagic death of bladder tumour cells.
Topics: Antineoplastic Agents; Autophagy; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cell Death; Cell Line, Tumor; Cell Survival; Humans; Indazoles; Indoles; Inhibitory Concentration 50; Membrane Potential, Mitochondrial; Necrosis; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Reactive Oxygen Species; Sulfonamides; Sunitinib; Urinary Bladder Neoplasms | 2013 |
Synthesis and biological evaluation of 3-substituted-4-(4-methylthio phenyl)-1H-pyrrole derivatives as potential anticancer agents.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Necrosis; Pyrroles; Structure-Activity Relationship | 2014 |
Combination of AZD2281 (Olaparib) and GX15-070 (Obatoclax) results in synergistic antitumor activities in preclinical models of pancreatic cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; BRCA1 Protein; BRCA2 Protein; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Humans; Indoles; Mice, Inbred BALB C; Mice, Nude; Necrosis; Pancreatic Neoplasms; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Time Factors; Xenograft Model Antitumor Assays | 2014 |
Effects of single-dose atorvastatin on interleukin-6, interferon gamma, and myocardial no-reflow in a rabbit model of acute myocardial infarction and reperfusion.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Coronary Occlusion; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Heptanoic Acids; Immunohistochemistry; Inflammation; Interferon-gamma; Interleukin-6; Ligation; Male; Multivariate Analysis; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Necrosis; No-Reflow Phenomenon; Pyrroles; Rabbits; Random Allocation | 2014 |
Persisting weakness after withdrawal of a statin.
Topics: Aged, 80 and over; Atorvastatin; Autoimmune Diseases; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscle Weakness; Myositis; Necrosis; Pyrroles | 2014 |
[Adverse effects of Sutent(®): pseudoporphyria and scrotal necrosis].
Topics: Antineoplastic Agents; Blister; Genital Diseases, Male; Humans; Imatinib Mesylate; Indoles; Male; Necrosis; Neoplasm Proteins; Photosensitivity Disorders; Protein Kinase Inhibitors; Pyrroles; Scrotum; Sunitinib | 2014 |
Stem cells increase in numbers in perinecrotic areas in human renal cancer.
Topics: Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Drug Resistance, Neoplasm; Humans; Indoles; Kidney Neoplasms; Mice; Mice, Nude; Necrosis; Neoplastic Stem Cells; Pyrroles; Sunitinib; Xenograft Model Antitumor Assays | 2015 |
HIF-1 Dimerization Inhibitor Acriflavine Enhances Antitumor Activity of Sunitinib in Breast Cancer Model.
Topics: Acriflavine; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Drug Synergism; Female; Hypoxia-Inducible Factor 1; Indoles; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Myeloid Cells; Necrosis; Neovascularization, Pathologic; Protein Multimerization; Pyrroles; Spleen; Sunitinib; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A | 2014 |
Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Cell Proliferation; Enzyme Inhibitors; Humans; Indoles; Lysosomes; Mefloquine; Mice; Mice, Knockout; Necrosis; Proto-Oncogene Proteins c-bcl-2; Pyrroles; RNA Interference; RNA, Small Interfering; Spheroids, Cellular; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Tumor Cells, Cultured | 2016 |
C-reactive protein promotes acute kidney injury via Smad3-dependent inhibition of CDK2/cyclin E.
Topics: Acute Kidney Injury; Animals; C-Reactive Protein; Cell Line, Tumor; Cell Proliferation; Creatinine; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Epithelial Cells; G1 Phase Cell Cycle Checkpoints; Humans; Isoquinolines; Kidney Tubules; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Phosphorylation; Pyridines; Pyrroles; Rats; Receptors, IgG; Regeneration; Smad3 Protein; Transforming Growth Factor beta | 2016 |
Computed tomography features and predictive findings of ruptured gastrointestinal stromal tumours.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Ascites; Disease Progression; Female; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Hematoma; Hemoperitoneum; Humans; Imatinib Mesylate; Indoles; Intestine, Small; Male; Middle Aged; Necrosis; Peritonitis; Pyrroles; Rupture, Spontaneous; Sensitivity and Specificity; Sunitinib; Tomography, X-Ray Computed; Young Adult | 2017 |
Synthetic tambjamine analogues induce mitochondrial swelling and lysosomal dysfunction leading to autophagy blockade and necrotic cell death in lung cancer.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Humans; Hydrogen-Ion Concentration; Ionophores; Lysosomes; Mitochondria; Mitochondrial Size; Necrosis; Neoplastic Stem Cells; Pyrroles | 2017 |
Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Atorvastatin; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Membrane; Cell Proliferation; DNA Replication; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Membrane Potential, Mitochondrial; Necrosis; Oxidative Stress; Pyrroles; Reactive Oxygen Species; Simvastatin | 2008 |
Palmar-plantar erythrodysesthesia secondary to sunitinib treatment resulting in necrotic foot syndrome aggravated by background diabetic vascular disease.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Carcinoma, Renal Cell; Diabetic Angiopathies; Drug Eruptions; Foot; Foot Diseases; Humans; Indoles; Kidney Neoplasms; Male; Middle Aged; Necrosis; Paresthesia; Pyrroles; Skin; Sunitinib | 2008 |
Regression and shift in composition of coronary atherosclerotic plaques by pioglitazone: insight from an intravascular ultrasound analysis.
Topics: Aged; Atorvastatin; Calcinosis; Coronary Artery Disease; Diabetes Mellitus; Drug Therapy, Combination; Female; Fibrosis; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Male; Middle Aged; Necrosis; Pilot Projects; Pioglitazone; Prospective Studies; Pyrroles; Registries; Thiazolidinediones; Time Factors; Treatment Outcome; Ultrasonography, Interventional; User-Computer Interface | 2009 |
[Necrotizing hand-foot skin reaction induced by antiangiogenic in a patient with Thevenard neuroacropathy].
Topics: Angiogenesis Inhibitors; Anti-Bacterial Agents; Antineoplastic Agents; Female; Foot; Hand; Hereditary Sensory and Autonomic Neuropathies; Humans; Indoles; Kidney Neoplasms; Lung Neoplasms; Middle Aged; Necrosis; Pyrroles; Skin Ulcer; Sunitinib | 2009 |
Spontaneous pyopneumothorax in patients treated with mTOR inhibitors for subpleural pulmonary metastases.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Calcitonin; Carcinoma, Renal Cell; Combined Modality Therapy; Disease Susceptibility; Everolimus; Fatal Outcome; Female; Humans; Indoles; Kidney Neoplasms; Lung Neoplasms; Male; Middle Aged; Necrosis; Neoplasm Proteins; Nephrectomy; Niacinamide; Phenylurea Compounds; Pneumonia, Bacterial; Pneumothorax; Protein Precursors; Pyridines; Pyrroles; Rupture, Spontaneous; Sirolimus; Sorafenib; Sunitinib; TOR Serine-Threonine Kinases | 2010 |
Incisor degeneration in rats induced by vascular endothelial growth factor/fibroblast growth factor receptor tyrosine kinase inhibition.
Topics: Angiogenesis Inhibitors; Animals; Dentin; Dose-Response Relationship, Drug; Female; Incisor; Male; Necrosis; Odontoblasts; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor, Fibroblast Growth Factor, Type 1; Toxicity Tests; Triazines; Vascular Endothelial Growth Factor Receptor-2 | 2010 |
Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke.
Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Apoptosis; Calpain; Caspase 3; Cell Proliferation; Cerebral Arteries; Disease Models, Animal; Endothelial Cells; Indoles; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Necrosis; Neovascularization, Physiologic; Pyrroles; Rats; Rats, Sprague-Dawley; Stroke; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2010 |
Spontaneous bilateral pneumothorax in metastatic renal cell carcinoma on sunitinib therapy.
Topics: Adult; Antineoplastic Agents; Carcinoma, Renal Cell; Humans; Indoles; Interleukin-2; Kidney Neoplasms; Male; Necrosis; Neoplasm Metastasis; Pneumothorax; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Sunitinib; Tomography, X-Ray Computed | 2010 |
Necrosis of a skin autograft after short-term treatment with sunitinib in a 14-year-old girl with metastatic alveolar soft part sarcoma of the thigh.
Topics: Adolescent; Angiogenesis Inhibitors; Antineoplastic Agents; Chemotherapy, Adjuvant; Combined Modality Therapy; Compassionate Use Trials; Female; Follow-Up Studies; Humans; Indoles; Lung Neoplasms; Necrosis; Postoperative Complications; Pyrroles; Radiotherapy, Adjuvant; Reoperation; Sarcoma, Alveolar Soft Part; Skin Transplantation; Soft Tissue Neoplasms; Sunitinib; Surgical Flaps; Thigh | 2010 |
Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antineoplastic Agents; Antipyretics; Biomarkers; Brain; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Interactions; Hyperemia; Indoles; Kidney; Liver; Male; Mice; Mice, Inbred ICR; Necrosis; Protein Kinase Inhibitors; Pyrroles; Random Allocation; Sunitinib | 2010 |
Reduction of liver fructokinase expression and improved hepatic inflammation and metabolism in liquid fructose-fed rats after atorvastatin treatment.
Topics: Animals; Atorvastatin; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cyclic AMP-Dependent Protein Kinases; Dietary Carbohydrates; Disease Models, Animal; Down-Regulation; Fatty Acids; Fatty Liver; Fructokinases; Fructose; Gene Expression Regulation; Hepatitis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertriglyceridemia; I-kappa B Proteins; Inflammation Mediators; Lipid Metabolism; Liver; Male; Metallothionein; Necrosis; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Triglycerides | 2011 |
Long term observation of thin-cap fibroatheroma by optical coherence tomography.
Topics: Atorvastatin; Coronary Artery Disease; Coronary Vessels; Fibrosis; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Necrosis; Pyrroles; Time Factors; Tomography, Optical Coherence; Treatment Outcome | 2010 |
Cytotoxicity of, and innate immune response to, size-controlled polypyrrole nanoparticles in mammalian cells.
Topics: Animals; Biomarkers; Cell Death; Cell Line; Cell Survival; Fibroblasts; Humans; Immunity, Innate; Macrophages; Mammals; Mice; Nanoparticles; Necrosis; Particle Size; Polymers; Pyrroles; Reactive Oxygen Species | 2011 |
Identification of novel therapeutic targets in microdissected clear cell ovarian cancers.
Topics: Animals; Cell Death; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Disease Progression; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome, Human; Glucose; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Mice; Mice, Nude; Microdissection; Microvessels; Molecular Targeted Therapy; Necrosis; Ovarian Neoplasms; Pyrroles; RNA, Small Interfering; Signal Transduction; Sunitinib; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2011 |
ACUTE INTERMITTENT PORPHYRIA; DIAGNOSIS FOUR YEARS POST MORTEM BY CHEMICAL STUDIES IN RELATIVES.
Topics: Diagnosis, Differential; Genetics, Medical; Humans; Levulinic Acids; Necrosis; Pancreas; Paralysis; Porphyria, Acute Intermittent; Porphyrias; Porphyrins; Pyrroles; Urine | 1964 |
Attenuation of acute inflammatory response by atorvastatin after spinal cord injury in rats.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Disease Models, Animal; Female; Gliosis; Heptanoic Acids; Interleukin-1; Motor Activity; Myelitis; Necrosis; Nerve Degeneration; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oligodendroglia; Oxidative Stress; Pyrroles; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Treatment Outcome; Tumor Necrosis Factor-alpha | 2005 |
Irradiation combined with SU5416: microvascular changes and growth delay in a human xenograft glioblastoma tumor line.
Topics: Angiogenesis Inhibitors; Animals; Cell Hypoxia; Cell Line, Tumor; Combined Modality Therapy; Dose-Response Relationship, Radiation; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Indoles; Mice; Mice, Inbred BALB C; Mice, Nude; Microcirculation; Necrosis; Pyrroles; Recurrence; Remission Induction; Transplantation, Heterologous | 2005 |
Evaluation of apoptosis and necrosis induced by statins using fluorescence-enhanced flow cytometry.
Topics: Apoptosis; Atorvastatin; Avidin; Biotin; Cell Line; Cell Separation; Cells, Cultured; Drug Industry; Drug Screening Assays, Antitumor; Fatty Acids, Monounsaturated; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Leukemia; Microscopy, Fluorescence; Necrosis; Pharmaceutical Preparations; Pravastatin; Propidium; Pyridines; Pyrroles; Simvastatin; Time Factors | 2005 |
Effect of atorvastatin treatment on isoproterenol-induced myocardial infarction in rats.
Topics: Adenosine Triphosphatases; Animals; Atorvastatin; Body Weight; Catalase; Glutathione; Heart; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoproterenol; Lipid Peroxidation; Male; Myocardial Infarction; Myocardium; Necrosis; Organ Size; Pyrroles; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2006 |
A novel N-alkylated prodigiosin analogue induced death in tumour cell through apoptosis or necrosis depending upon the cell type.
Topics: Alkenes; Alkylation; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Membrane Permeability; Cell Survival; Dactinomycin; Diploidy; DNA Fragmentation; DNA, Neoplasm; Enzyme Inhibitors; Lymphoma, T-Cell; Mice; Necrosis; Prodigiosin; Pyrroles; Rats; Sarcoma 180; Staurosporine; Tetrazolium Salts; Thiazoles | 2008 |
Reducing myocardial injury by minimizing imbalance between oxygen supply and demand.
Topics: Anesthesiology; Animals; Atorvastatin; Blood Pressure; Cardiovascular Agents; Coronary Disease; Dogs; Heart Diseases; Heart Rate; Heptanoic Acids; History, 20th Century; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Ischemia; Myocardial Revascularization; Necrosis; Oxygen; Pyrroles | 2007 |
Pathological evidence of necrosis in recurrent renal mass following treatment with sunitinib.
Topics: Aged; Carcinoma, Renal Cell; Humans; Indoles; Male; Necrosis; Pyrroles; Sunitinib | 2007 |
Thymic carcinoid responds to neoadjuvant therapy with sunitinib and octreotide: a case report.
Topics: Adult; Antineoplastic Agents, Hormonal; Biopsy, Needle; Carcinoid Tumor; Follow-Up Studies; Humans; Indoles; Ki-67 Antigen; Lymphatic Diseases; Male; Necrosis; Neoplasm Staging; Octreotide; Pneumonectomy; Positron-Emission Tomography; Proto-Oncogene Proteins c-kit; Pyrroles; Radiography, Thoracic; Sunitinib; Synaptophysin; Thymus Neoplasms; Time Factors; Tomography, X-Ray Computed; Treatment Outcome | 2008 |
Metastatic renal cell carcinoma with partial response to sunitinib complicated by ureteral obstruction from necrotic tumor.
Topics: Antineoplastic Agents; Carcinoma, Renal Cell; Female; Humans; Indoles; Kidney Neoplasms; Kidney Pelvis; Liver Neoplasms; Middle Aged; Necrosis; Pyrroles; Sunitinib; Ureteral Obstruction | 2009 |
YSK2821, a newly synthesized indoledione derivative, inhibits cell proliferation and cell cycle progression via the cell cycle-related proteins by regulating phosphatidylinositol-3 kinase cascade in vascular smooth muscle cells.
Topics: Apoptosis; Blotting, Western; Cell Count; Cell Cycle; Cell Cycle Proteins; Cell Death; Cell Proliferation; Humans; Magnetic Resonance Spectroscopy; Muscle, Smooth, Vascular; Necrosis; Phosphatidylinositol 3-Kinases; Platelet-Derived Growth Factor; Pyrroles; Quinolones; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thymidine | 2008 |
Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors.
Topics: Apoptosis; Humans; Jurkat Cells; Microsomes, Liver; Molecular Structure; Necrosis; Pyrroles; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2008 |
Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitors.
Topics: Animals; Apoptosis; Blotting, Western; Camptothecin; Cecum; Cell Proliferation; Colonic Neoplasms; Drug Therapy, Combination; Endothelial Cells; Enzyme Inhibitors; ErbB Receptors; Humans; Immunoenzyme Techniques; In Situ Nick-End Labeling; Irinotecan; Lymphatic Metastasis; Male; Mice; Mice, Nude; Necrosis; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptor, ErbB-2; RNA, Small Interfering; Topoisomerase I Inhibitors; Transforming Growth Factor alpha | 2008 |
The toxic effects in rats of some synthanecine carbamate and phosphate esters analogous to hepatotoxic pyrrolizidine alkaloids.
Topics: Alkaloids; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Kidney; Lethal Dose 50; Liver; Lung; Male; Myocardium; Necrosis; Phenobarbital; Pyrroles; Pyrrolizidine Alkaloids; Rats; Structure-Activity Relationship; Time Factors | 1984 |
Cardioprotection with U-89232 is not reversible with glibenclamide: evidence of a novel anti-ischemic agent derived from cromakalim.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Heart; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Necrosis; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1994 |
Prevention by cromakalim of spontaneously occurring cardiac necroses in polymyopathic hamsters.
Topics: Animals; Benzopyrans; Cardiomyopathies; Creatine Kinase; Cricetinae; Cromakalim; Female; Male; Myocardium; Necrosis; Parasympatholytics; Potassium Channels; Pyrroles | 1996 |
Pyrrole detection and the pathologic progression of Cynoglossum officinale (houndstongue) poisoning in horses.
Topics: Alkaloids; Animals; Biopsy; Cecum; Colon; Dermatitis; Edema; Horse Diseases; Horses; Infarction; Liver; Necrosis; Plants, Toxic; Poisoning; Pyrroles | 1996 |
Calcium entry through L-type calcium channels causes mitochondrial disruption and chromaffin cell death.
Topics: Adrenal Medulla; Animals; Apoptosis; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cattle; Chromaffin Cells; Cytochrome c Group; Cytoprotection; Free Radicals; Mitochondria; Necrosis; Nimodipine; Pyrroles | 2001 |
Subacute toxicity of a halogenated pyrrole hydroxymethylglutaryl-coenzyme A reductase inhibitor in Wistar rats.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Keratosis; Liver; Male; Mevalonic Acid; Necrosis; Neoplasms, Experimental; Organ Size; Pyrroles; Rats; Rats, Wistar; Stomach; Stomach Diseases | 1992 |
Effect of age on development of cor pulmonale in nonhuman primates following pyrrolizidine alkaloid intoxication.
Topics: Age Factors; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Enzymes; Female; Formaldehyde; Haplorhini; Hepatic Veins; Injections, Subcutaneous; Liver; Liver Diseases; Lung; Macaca; Male; Microsomes, Liver; Myocardium; Necrosis; Pulmonary Artery; Pulmonary Heart Disease; Pyrroles; Pyrrolizidine Alkaloids | 1972 |
An investigation into the carcinogenicity of monocrotaline pyrrole.
Topics: Carcinogens; Necrosis; Pyrroles; Pyrrolizidine Alkaloids; Sarcoma | 1973 |
The importance of delta1-pyrroline in the aetiology of cerebrocortical necrosis.
Topics: Animals; Brain Diseases; Cattle; Cerebral Cortex; Magnetic Resonance Spectroscopy; Mass Spectrometry; Necrosis; Pyrroles; Sheep; Species Specificity | 1976 |