Page last updated: 2024-08-07 16:08:52
Cannabinoid receptor 1
A cannabinoid receptor 1 that is encoded in the genome of rat. [OMA:P20272, PRO:DNx]
Synonyms
CB-R;
CB1;
Brain-type cannabinoid receptor
Research
Bioassay Publications (81)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (20.99) | 18.2507 |
| 2000's | 30 (37.04) | 29.6817 |
| 2010's | 30 (37.04) | 24.3611 |
| 2020's | 4 (4.94) | 2.80 |
Compounds (87)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| cadaverine | Rattus norvegicus (Norway rat) | Ki | 0.6300 | 1 | 1 |
| phenol | Rattus norvegicus (Norway rat) | Ki | 500.0000 | 1 | 1 |
| spermidine | Rattus norvegicus (Norway rat) | Ki | 11.6000 | 1 | 1 |
| spermine | Rattus norvegicus (Norway rat) | Ki | 22.6000 | 1 | 1 |
| tryptamine | Rattus norvegicus (Norway rat) | Ki | 0.0610 | 1 | 1 |
| 4-phenyl-3-furoxancarbonitrile | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| acetazolamide | Rattus norvegicus (Norway rat) | Ki | 0.0390 | 2 | 2 |
| am 251 | Rattus norvegicus (Norway rat) | Ki | 0.0029 | 2 | 3 |
| cannabinol | Rattus norvegicus (Norway rat) | Ki | 0.2112 | 1 | 1 |
| dichlorphenamide | Rattus norvegicus (Norway rat) | Ki | 0.0230 | 1 | 1 |
| vorinostat | Rattus norvegicus (Norway rat) | IC50 | 0.1160 | 2 | 3 |
| trientine | Rattus norvegicus (Norway rat) | Ki | 52.0000 | 1 | 1 |
| diethylenetriamine | Rattus norvegicus (Norway rat) | Ki | 11.5000 | 1 | 1 |
| n-methylpyrrolidone | Rattus norvegicus (Norway rat) | IC50 | 34,000.0000 | 1 | 2 |
| n-(1-naphthyl)ethylenediamine | Rattus norvegicus (Norway rat) | Ki | 0.6200 | 1 | 1 |
| dronabinol | Rattus norvegicus (Norway rat) | IC50 | 0.2180 | 1 | 1 |
| dronabinol | Rattus norvegicus (Norway rat) | Ki | 0.0468 | 10 | 10 |
| 1,6-diaminohexane | Rattus norvegicus (Norway rat) | Ki | 0.6900 | 1 | 1 |
| acetylglucosamine | Rattus norvegicus (Norway rat) | IC50 | 2.5119 | 1 | 1 |
| stearoylethanolamide | Rattus norvegicus (Norway rat) | Ki | 0.2170 | 1 | 2 |
| staurosporine | Rattus norvegicus (Norway rat) | IC50 | 0.0100 | 1 | 1 |
| pravadoline | Rattus norvegicus (Norway rat) | Ki | 2.5110 | 1 | 1 |
| litoxetine | Rattus norvegicus (Norway rat) | IC50 | 1.4000 | 1 | 1 |
| 3,7-diazanonane-1,9-diamine | Rattus norvegicus (Norway rat) | Ki | 66.0000 | 1 | 1 |
| sr141716 | Rattus norvegicus (Norway rat) | IC50 | 0.0081 | 3 | 3 |
| sr141716 | Rattus norvegicus (Norway rat) | Ki | 0.0046 | 8 | 11 |
| cp-55,940 | Rattus norvegicus (Norway rat) | IC50 | 0.0040 | 1 | 2 |
| cp-55,940 | Rattus norvegicus (Norway rat) | Ki | 0.0014 | 1 | 1 |
| 1,1-dimethylheptyl-11-hydroxytetrahydrocannabinol | Rattus norvegicus (Norway rat) | Ki | 1.9900 | 1 | 1 |
| 1-naphthylacetylspermine | Rattus norvegicus (Norway rat) | Ki | 10.2000 | 1 | 1 |
| delta(9-11)-tetrahydrocannabinol | Rattus norvegicus (Norway rat) | IC50 | 0.3340 | 1 | 1 |
| n,n-di-n-propylserotonin | Rattus norvegicus (Norway rat) | IC50 | 0.8200 | 1 | 2 |
| piboserod | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| nikkomycin | Rattus norvegicus (Norway rat) | IC50 | 0.0002 | 1 | 1 |
| delta-8-tetrahydrocannabinol | Rattus norvegicus (Norway rat) | IC50 | 0.1790 | 1 | 1 |
| delta-8-tetrahydrocannabinol | Rattus norvegicus (Norway rat) | Ki | 0.2114 | 4 | 4 |
| cannabidiol | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| tandutinib | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 2 |
| 11-hydroxycannabinol | Rattus norvegicus (Norway rat) | Ki | 0.1134 | 2 | 2 |
| am 281 | Rattus norvegicus (Norway rat) | Ki | 0.0045 | 1 | 2 |
| anandamide | Rattus norvegicus (Norway rat) | Ki | 0.6393 | 11 | 12 |
| arachidonyl dopamine | Rattus norvegicus (Norway rat) | Ki | 0.2500 | 2 | 2 |
| homo-gamma-linolenylethanolamide | Rattus norvegicus (Norway rat) | Ki | 0.0532 | 2 | 2 |
| 7,10,13,16-docosatetraenylethanolamide | Rattus norvegicus (Norway rat) | Ki | 0.0342 | 2 | 2 |
| glyceryl 2-arachidonate | Rattus norvegicus (Norway rat) | Ki | 0.3480 | 3 | 3 |
| oleylamide | Rattus norvegicus (Norway rat) | Ki | 1.1400 | 1 | 1 |
| n-arachidonylglycine | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| arachidonoyl amine | Rattus norvegicus (Norway rat) | Ki | 6.7333 | 2 | 3 |
| linoleoyl ethanolamide | Rattus norvegicus (Norway rat) | Ki | 12.4000 | 2 | 4 |
| n-oleoylethanolamine | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 2 |
| nabilone | Rattus norvegicus (Norway rat) | Ki | 0.0022 | 1 | 1 |
| arachidonylcyclopropylamide | Rattus norvegicus (Norway rat) | Ki | 0.0027 | 1 | 1 |
| hu 243 | Rattus norvegicus (Norway rat) | Ki | 0.0026 | 2 | 2 |
| l 745870 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| (3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone | Rattus norvegicus (Norway rat) | Ki | 182,402.2084 | 5 | 5 |
| cannabigerol | Rattus norvegicus (Norway rat) | Ki | 0.4400 | 1 | 1 |
| virodhamine | Rattus norvegicus (Norway rat) | Ki | 1.9000 | 1 | 1 |
| am-356 | Rattus norvegicus (Norway rat) | Ki | 0.0216 | 4 | 5 |
| (2E,4E)-N-isobutyl-2,4-dodecadienamide | Rattus norvegicus (Norway rat) | Ki | 1.9400 | 1 | 1 |
| noladin ether | Rattus norvegicus (Norway rat) | Ki | 0.0210 | 2 | 2 |
| am 404 | Rattus norvegicus (Norway rat) | Ki | 1.7600 | 2 | 3 |
| jwh-133 | Rattus norvegicus (Norway rat) | Ki | 0.4523 | 3 | 3 |
| CB-13 | Rattus norvegicus (Norway rat) | IC50 | 0.0220 | 1 | 1 |
| am-411 | Rattus norvegicus (Norway rat) | Ki | 0.0068 | 2 | 2 |
| spc-839 | Rattus norvegicus (Norway rat) | IC50 | 0.3440 | 2 | 4 |
| hu 210 | Rattus norvegicus (Norway rat) | Ki | 0.0007 | 2 | 2 |
| slv 319 | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 1 |
| l 772405 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| fauc 346 | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 1 | 1 |
| (1-((1-methylpiperidin-2-yl)methyl)-1h-indol-3-yl)(naphthalen-1-yl)methanone | Rattus norvegicus (Norway rat) | Ki | 252,859.3339 | 3 | 3 |
| 2-iodophenyl-(1-(1-methylpiperidin-2-ylmethyl)-1h-indol-3-yl)methanone | Rattus norvegicus (Norway rat) | Ki | 0.0018 | 1 | 1 |
| amg 3 | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 1 |
| cp 945598 | Rattus norvegicus (Norway rat) | Ki | 0.0018 | 1 | 2 |
| n,n-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine | Rattus norvegicus (Norway rat) | Ki | 0.0016 | 1 | 1 |
| 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1h-1,2,4-triazole | Rattus norvegicus (Norway rat) | IC50 | 0.6900 | 1 | 1 |
| am 1241 | Rattus norvegicus (Norway rat) | Ki | 0.2800 | 1 | 1 |
| fauc 365 | Rattus norvegicus (Norway rat) | Ki | 0.0008 | 1 | 1 |
| n-(piperidin-1-yl)-5-(4-methoxyphenyl)-1-(2,4-dichlorophenyl)-4-methyl-1h-pyrazole-3-carboxamide | Rattus norvegicus (Norway rat) | Ki | 0.0041 | 1 | 2 |
| n-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide | Rattus norvegicus (Norway rat) | IC50 | 0.0003 | 1 | 1 |
| hu 308 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 2 | 2 |
| 1-deoxynojirimycin hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| gne 477 | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 1 | 1 |
| jwh 250 | Rattus norvegicus (Norway rat) | Ki | 0.0110 | 1 | 1 |
| gilteritinib | Rattus norvegicus (Norway rat) | IC50 | 0.0007 | 1 | 1 |
Drugs with Activation Measurements
Synthesis and carbonic anhydrase isoenzymes I, II, IX, and XII inhibitory effects of dimethoxybromophenol derivatives incorporating cyclopropane moieties.Journal of medicinal chemistry, , Jan-22, Volume: 58, Issue:2, 2015
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity.Journal of medicinal chemistry, , Feb-13, Volume: 46, Issue:4, 2003
Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists.Journal of medicinal chemistry, , Feb-25, Volume: 42, Issue:4, 1999
3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data.Journal of medicinal chemistry, , Jan-26, Volume: 49, Issue:2, 2006
Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase.Journal of medicinal chemistry, , Sep-26, Volume: 40, Issue:20, 1997
Oxa-adamantyl cannabinoids.Bioorganic & medicinal chemistry letters, , 04-15, Volume: 38, 2021
Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties.European journal of medicinal chemistry, , Apr-13, Volume: 112, 2016
C-ring cannabinoid lactones: a novel cannabinergic chemotype.ACS medicinal chemistry letters, , Apr-10, Volume: 5, Issue:4, 2014
Synthesis and pharmacology of 1-methoxy analogs of CP-47,497.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
1-Bromo-3-(1',1'-dimethylalkyl)-1-deoxy-Δ(8)-tetrahydrocannabinols: New selective ligands for the cannabinoid CB(2) receptor.Bioorganic & medicinal chemistry, , Nov-15, Volume: 18, Issue:22, 2010
3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data.Journal of medicinal chemistry, , Jan-26, Volume: 49, Issue:2, 2006
1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 15, Issue:18, 2005
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.Journal of medicinal chemistry, , Aug-11, Volume: 48, Issue:16, 2005
Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase.Journal of medicinal chemistry, , Sep-26, Volume: 40, Issue:20, 1997
A novel probe for the cannabinoid receptor.Journal of medicinal chemistry, , May-29, Volume: 35, Issue:11, 1992
Synthesis and pharmacological evaluation of ether and related analogues of delta 8-, delta 9-, and delta 9,11-tetrahydrocannabinol.Journal of medicinal chemistry, , Volume: 34, Issue:11, 1991
Structure-activity relationship studies of novel pyrazole and imidazole carboxamides as cannabinoid-1 (CB1) antagonists.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 21, Issue:16, 2011
Characterization of a novel and selective CB1 antagonist as a radioligand for receptor occupancy studies.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 21, Issue:22, 2011
Synthesis and biological evaluation of bivalent ligands for the cannabinoid 1 receptor.Journal of medicinal chemistry, , Oct-14, Volume: 53, Issue:19, 2010
Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: potent, orally-active 1,4-disubstituted imidazoles.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 19, Issue:18, 2009
Discovery of 1-[9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Tetrazole-biarylpyrazole derivatives as cannabinoid CB1 receptor antagonists.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 18, Issue:7, 2008
Aminopyrazine CB1 receptor inverse agonists.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 18, Issue:11, 2008
Hemopressin is an inverse agonist of CB1 cannabinoid receptors.Proceedings of the National Academy of Sciences of the United States of America, , Dec-18, Volume: 104, Issue:51, 2007
Biarylpyrazole inverse agonists at the cannabinoid CB1 receptor: importance of the C-3 carboxamide oxygen/lysine3.28(192) interaction.Journal of medicinal chemistry, , Oct-05, Volume: 49, Issue:20, 2006
Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity.Journal of medicinal chemistry, , Feb-13, Volume: 46, Issue:4, 2003
Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists.Journal of medicinal chemistry, , Feb-25, Volume: 42, Issue:4, 1999
Oxa-adamantyl cannabinoids.Bioorganic & medicinal chemistry letters, , 04-15, Volume: 38, 2021
Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators.Journal of medicinal chemistry, , 01-23, Volume: 63, Issue:2, 2020
Oximes short-acting CB1 receptor agonists.Bioorganic & medicinal chemistry, , 10-01, Volume: 26, Issue:18, 2018
Characterization of a novel and selective CB1 antagonist as a radioligand for receptor occupancy studies.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 21, Issue:22, 2011
Discovery and optimization of a novel series of N-arylamide oxadiazoles as potent, highly selective and orally bioavailable cannabinoid receptor 2 (CB2) agonists.Journal of medicinal chemistry, , Aug-28, Volume: 51, Issue:16, 2008
3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data.Journal of medicinal chemistry, , Jan-26, Volume: 49, Issue:2, 2006
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.Journal of medicinal chemistry, , Aug-11, Volume: 48, Issue:16, 2005
Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013
Structural modifications of the cannabinoid side chain towards C3-aryl and 1',1'-cycloalkyl-1'-cyano cannabinoids.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 16, Issue:6, 2006
3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data.Journal of medicinal chemistry, , Jan-26, Volume: 49, Issue:2, 2006
Adamantyl cannabinoids: a novel class of cannabinergic ligands.Journal of medicinal chemistry, , Jul-14, Volume: 48, Issue:14, 2005
Novel conformationally restricted tetracyclic analogs of delta8-tetrahydrocannabinol.Bioorganic & medicinal chemistry letters, , Aug-02, Volume: 9, Issue:15, 1999
Synthesis and pharmacological evaluation of ether and related analogues of delta 8-, delta 9-, and delta 9,11-tetrahydrocannabinol.Journal of medicinal chemistry, , Volume: 34, Issue:11, 1991
( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes.Journal of medicinal chemistry, , 10-11, Volume: 61, Issue:19, 2018
Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties.European journal of medicinal chemistry, , Apr-13, Volume: 112, 2016
3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data.Journal of medicinal chemistry, , Jan-26, Volume: 49, Issue:2, 2006
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.Journal of medicinal chemistry, , Aug-11, Volume: 48, Issue:16, 2005
Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
Semiplenamides A-G, fatty acid amides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena.Journal of natural products, , Volume: 66, Issue:10, 2003
Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase.Journal of medicinal chemistry, , Mar-11, Volume: 42, Issue:5, 1999
Unique analogues of anandamide: arachidonyl ethers and carbamates and norarachidonyl carbamates and ureas.Journal of medicinal chemistry, , Jun-03, Volume: 42, Issue:11, 1999
Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor.Journal of medicinal chemistry, , Feb-28, Volume: 40, Issue:5, 1997
Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand.Journal of medicinal chemistry, , Oct-25, Volume: 39, Issue:22, 1996
(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability.Journal of medicinal chemistry, , Jun-10, Volume: 37, Issue:12, 1994
Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.Journal of medicinal chemistry, , Aug-11, Volume: 48, Issue:16, 2005
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.Journal of medicinal chemistry, , Aug-11, Volume: 48, Issue:16, 2005
Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor.Journal of medicinal chemistry, , Feb-28, Volume: 40, Issue:5, 1997
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.Journal of medicinal chemistry, , Aug-11, Volume: 48, Issue:16, 2005
Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor.Journal of medicinal chemistry, , Feb-28, Volume: 40, Issue:5, 1997
Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties.European journal of medicinal chemistry, , Apr-13, Volume: 112, 2016
Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013
Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase.Journal of medicinal chemistry, , Mar-11, Volume: 42, Issue:5, 1999
Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor.Journal of medicinal chemistry, , Feb-28, Volume: 40, Issue:5, 1997
Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase.Journal of medicinal chemistry, , Mar-11, Volume: 42, Issue:5, 1999
Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor.Journal of medicinal chemistry, , Feb-28, Volume: 40, Issue:5, 1997
3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data.Journal of medicinal chemistry, , Jan-26, Volume: 49, Issue:2, 2006
High affinity electrophilic and photoactivatable covalent endocannabinoid probes for the CB1 receptor.Journal of medicinal chemistry, , Oct-06, Volume: 48, Issue:20, 2005
Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists.Journal of medicinal chemistry, , 04-08, Volume: 64, Issue:7, 2021
Classical/nonclassical hybrid cannabinoids: southern aliphatic chain-functionalized C-6beta methyl, ethyl, and propyl analogues.Journal of medicinal chemistry, , Sep-10, Volume: 41, Issue:19, 1998
Design, synthesis, and pharmacological properties of new heteroarylpyridine/heteroarylpyrimidine derivatives as CB(2) cannabinoid receptor partial agonists.Journal of medicinal chemistry, , Feb-14, Volume: 56, Issue:3, 2013
7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as selective CB(2) cannabinoid receptor ligands: structural investigations around a novel class of full agonists.Journal of medicinal chemistry, , Jul-26, Volume: 55, Issue:14, 2012
Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity.Journal of medicinal chemistry, , Jan-14, Volume: 53, Issue:1, 2010
1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 15, Issue:18, 2005
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.Journal of medicinal chemistry, , Aug-11, Volume: 48, Issue:16, 2005
Three-dimensional quantitative structure-activity relationship study of the cannabimimetic (aminoalkyl)indoles using comparative molecular field analysis.Journal of medicinal chemistry, , Nov-05, Volume: 41, Issue:23, 1998
Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase.Journal of medicinal chemistry, , Mar-11, Volume: 42, Issue:5, 1999
Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand.Journal of medicinal chemistry, , Oct-25, Volume: 39, Issue:22, 1996
(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability.Journal of medicinal chemistry, , Jun-10, Volume: 37, Issue:12, 1994
Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.Journal of medicinal chemistry, , Aug-11, Volume: 48, Issue:16, 2005
Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase.Journal of medicinal chemistry, , Mar-11, Volume: 42, Issue:5, 1999
Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand.Journal of medicinal chemistry, , Oct-25, Volume: 39, Issue:22, 1996
New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity.European journal of medicinal chemistry, , Jun-05, Volume: 97, 2015
Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013
1-Bromo-3-(1',1'-dimethylalkyl)-1-deoxy-Δ(8)-tetrahydrocannabinols: New selective ligands for the cannabinoid CB(2) receptor.Bioorganic & medicinal chemistry, , Nov-15, Volume: 18, Issue:22, 2010
3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data.Journal of medicinal chemistry, , Jan-26, Volume: 49, Issue:2, 2006
Structural modifications of the cannabinoid side chain towards C3-aryl and 1',1'-cycloalkyl-1'-cyano cannabinoids.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 16, Issue:6, 2006
Adamantyl cannabinoids: a novel class of cannabinergic ligands.Journal of medicinal chemistry, , Jul-14, Volume: 48, Issue:14, 2005
Novel C-Ring-Hydroxy-Substituted Controlled Deactivation Cannabinergic Analogues.Journal of medicinal chemistry, , 07-28, Volume: 59, Issue:14, 2016
3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data.Journal of medicinal chemistry, , Jan-26, Volume: 49, Issue:2, 2006
Enantioselective synthesis and pharmacology of 11-hydroxy-(1'S,2'R)-dimethylheptyl-delta 8-THC.Bioorganic & medicinal chemistry letters, , Aug-18, Volume: 8, Issue:16, 1998
Synthesis and structure-activity relationship of a novel series of aminoalkylindoles with potential for imaging the neuronal cannabinoid receptor by positron emission tomography.Journal of medicinal chemistry, , Sep-08, Volume: 48, Issue:18, 2005
Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor.Journal of medicinal chemistry, , Oct-06, Volume: 48, Issue:20, 2005
Three-dimensional quantitative structure-activity relationship study of the cannabimimetic (aminoalkyl)indoles using comparative molecular field analysis.Journal of medicinal chemistry, , Nov-05, Volume: 41, Issue:23, 1998
Cannabidiol (CBD) and its analogs: a review of their effects on inflammation.Bioorganic & medicinal chemistry, , Apr-01, Volume: 23, Issue:7, 2015
Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013