Proteasome subunit beta type-1

A proteasome subunit beta type-1 that is encoded in the genome of human. [PRO:DNx]

Synonyms

Macropain subunit C5;
Multicatalytic endopeptidase complex subunit C5;
Proteasome component C5;
Proteasome gamma chain

Research

Bioassay Publications (45)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (8.89)	29.6817
2010's	30 (66.67)	24.3611
2020's	11 (24.44)	2.80

Compounds (26)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
emodin	Homo sapiens (human)	IC50	0.2400	1	1
vincaleukoblastine	Homo sapiens (human)	IC50	22.1400	2	2
bortezomib	Homo sapiens (human)	IC50	0.2149	18	18
sdz 283-910	Homo sapiens (human)	IC50	0.9000	1	1
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	Homo sapiens (human)	IC50	1.0852	8	8
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	Homo sapiens (human)	Ki	8.4083	6	6
mg 262	Homo sapiens (human)	Ki	48.0000	1	1
orlistat	Homo sapiens (human)	IC50	100.0000	1	1
benzyloxycarbonyl-phe-ala-fluormethylketone	Homo sapiens (human)	IC50	100.0000	1	1
lactacystin	Homo sapiens (human)	IC50	16.0863	3	3
clasto-lactacystin beta-lactone	Homo sapiens (human)	IC50	0.0490	1	1
benzyloxycarbonyl-isoleucyl-glutamyl(o-tert-butyl)-alanyl-leucinal	Homo sapiens (human)	Ki	14.0000	1	1
epoxomicin	Homo sapiens (human)	IC50	1.2500	2	2
marizomib	Homo sapiens (human)	IC50	0.1440	3	3
ridaifen-b	Homo sapiens (human)	IC50	6.3700	1	1
carfilzomib	Homo sapiens (human)	IC50	0.5937	7	7
tyropeptin a	Homo sapiens (human)	IC50	24.3800	3	3
pr-957	Homo sapiens (human)	IC50	14.3500	4	4
delanzomib	Homo sapiens (human)	IC50	0.0310	1	1
belactosin a	Homo sapiens (human)	IC50	1.4200	2	2
oprozomib	Homo sapiens (human)	IC50	0.0235	1	1
ixazomib	Homo sapiens (human)	IC50	0.0163	3	3
mln 9708	Homo sapiens (human)	IC50	0.0106	1	1
pi-1840	Homo sapiens (human)	IC50	30.0000	2	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
am 404	Homo sapiens (human)	EC50	28.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
chlorpromazine	Homo sapiens (human)	EC200	45.1250	4	4
bortezomib	Homo sapiens (human)	Ki50	0.0250	2	2
pr-957	Homo sapiens (human)	Ki50	1.6950	2	2

Enables

This protein enables 1 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]

Located In

This protein is located in 7 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
secretory granule lumen	cellular component	The volume enclosed by the membrane of a secretory granule. [GOC:rph]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
ficolin-1-rich granule lumen	cellular component	Any membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Part Of

This protein is part of 3 target(s):

Target	Category	Definition
proteasome complex	cellular component	A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. [GOC:rb, Wikipedia:Proteasome]
proteasome core complex	cellular component	A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. [GOC:rb, PMID:10806206]
proteasome core complex, beta-subunit complex	cellular component	The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus. [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]

Involved In

This protein is involved in 2 target(s):

Target	Category	Definition
proteasome-mediated ubiquitin-dependent protein catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:go_curators]
proteolysis involved in protein catabolic process	biological process	The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. [GOC:ai, GOC:dph, GOC:tb]