A dipeptidyl peptidase 3 (human), isoforms 1, 2, and 4. [PRO:DNx, UniProtKB:Q9NY33]
EC 3.4.14.4;
Dipeptidyl aminopeptidase III;
Dipeptidyl arylamidase III;
Dipeptidyl peptidase III;
DPP III;
Enkephalinase B
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| flavone | Homo sapiens (human) | IC50 | 292.5000 | 1 | 1 |
| 3-hydroxyflavone | Homo sapiens (human) | IC50 | 188.2000 | 1 | 1 |
| 6-hydroxyflavone | Homo sapiens (human) | IC50 | 82.2000 | 1 | 1 |
| 3,6-dihydroxyflavone | Homo sapiens (human) | IC50 | 56.4000 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 74.1000 | 1 | 1 |
| apigenin | Homo sapiens (human) | IC50 | 54.0000 | 1 | 1 |
| luteolin | Homo sapiens (human) | IC50 | 22.0000 | 1 | 1 |
| kaempferol | Homo sapiens (human) | IC50 | 32.9000 | 1 | 1 |
| genistein | Homo sapiens (human) | IC50 | 36.6000 | 1 | 1 |
| chrysin | Homo sapiens (human) | IC50 | 123.1000 | 1 | 1 |
| fisetin | Homo sapiens (human) | IC50 | 24.9000 | 1 | 1 |
| galangin | Homo sapiens (human) | IC50 | 23.4000 | 1 | 1 |
| morin | Homo sapiens (human) | IC50 | 85.0000 | 1 | 1 |
| 3,7-dihydroxyflavone | Homo sapiens (human) | IC50 | 98.0000 | 1 | 2 |
| gosogliptin | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| aminopeptidase activity | molecular function | Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| metalloexopeptidase activity | molecular function | Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml] |
| dipeptidyl-peptidase activity | molecular function | Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| proteolysis | biological process | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah] |
| protein catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:mah] |