Page last updated: 2024-08-07 16:44:08
Retinoic acid receptor RXR-gamma
A retinoic acid receptor RXR-gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48443]
Synonyms
Nuclear receptor subfamily 2 group B member 3;
Retinoid X receptor gamma
Research
Bioassay Publications (21)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (38.10) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 6 (28.57) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
Compounds (20)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| lg 100268 | Homo sapiens (human) | Ki | 0.0120 | 2 | 2 |
| bexarotene | Homo sapiens (human) | Ki | 0.0186 | 2 | 2 |
| hx 600 | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| tretinoin | Homo sapiens (human) | IC50 | 0.3500 | 1 | 1 |
| tretinoin | Homo sapiens (human) | Ki | 0.1365 | 3 | 3 |
| alitretinoin | Homo sapiens (human) | IC50 | 0.0040 | 1 | 1 |
| alitretinoin | Homo sapiens (human) | Ki | 0.0127 | 3 | 3 |
| lg 100567 | Homo sapiens (human) | Ki | 0.1646 | 1 | 2 |
| fenretinide | Homo sapiens (human) | Ki | 6.0000 | 1 | 1 |
| 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| lg100754 | Homo sapiens (human) | Ki | 0.0140 | 1 | 1 |
| lg 1506 | Homo sapiens (human) | Ki | 0.0615 | 2 | 2 |
| hx 630 | Homo sapiens (human) | Ki | 0.6200 | 1 | 1 |
| way 252623 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| oxaprozin | Homo sapiens (human) | EC50 | 40.1000 | 1 | 1 |
| pirinixic acid | Homo sapiens (human) | EC50 | 31.0000 | 1 | 1 |
| bexarotene | Homo sapiens (human) | EC50 | 0.0448 | 6 | 6 |
| dehydroabietic acid | Homo sapiens (human) | EC50 | 42.0000 | 1 | 1 |
| isopimaric acid | Homo sapiens (human) | EC50 | 33.0000 | 1 | 1 |
| tretinoin | Homo sapiens (human) | EC50 | 0.8568 | 4 | 4 |
| tretinoin | Homo sapiens (human) | Kd | 0.1530 | 2 | 2 |
| alitretinoin | Homo sapiens (human) | EC50 | 0.1016 | 5 | 5 |
| alitretinoin | Homo sapiens (human) | Kd | 0.0193 | 3 | 3 |
| lg 100567 | Homo sapiens (human) | EC50 | 0.0770 | 1 | 1 |
| 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| valerenic acid | Homo sapiens (human) | EC50 | 43.0000 | 1 | 1 |
| lg100754 | Homo sapiens (human) | EC50 | 0.0040 | 1 | 1 |
| nrx 194204 | Homo sapiens (human) | EC50 | 0.0001 | 1 | 1 |
| nrx 194204 | Homo sapiens (human) | Kd | 0.0038 | 1 | 1 |
| agn 194204 | Homo sapiens (human) | Kd | 0.0018 | 1 | 1 |
| bms 687453 | Homo sapiens (human) | EC50 | 25.0000 | 1 | 1 |
Enables
This protein enables 8 target(s):
| Target | Category | Definition |
|---|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | molecular function | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018] |
| nuclear steroid receptor activity | molecular function | Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. [GOC:signaling, PMID:14708019] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| molecular condensate scaffold activity | molecular function | Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate. [PMID:28225081] |
| sequence-specific double-stranded DNA binding | molecular function | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. [GOC:dos, GOC:sl] |
| nuclear receptor activity | molecular function | A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. [GOC:txnOH-2018, PMID:23457262] |
| retinoic acid-responsive element binding | molecular function | Binding to a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind. [GOC:jl, GOC:vw, GOC:yaf, PMID:11327309, PMID:19917671] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
Part Of
This protein is part of 2 target(s):
| Target | Category | Definition |
|---|---|---|
| chromatin | cellular component | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130] |
| RNA polymerase II transcription regulator complex | cellular component | A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. [GOC:tb] |
Involved In
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| steroid hormone mediated signaling pathway | biological process | The series of molecular signals mediated by a steroid hormone binding to a receptor. [PMID:12606724] |
| retinoic acid receptor signaling pathway | biological process | The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. [GOC:dgh] |
| anatomical structure development | biological process | The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. [GO_REF:0000021] |
| response to retinoic acid | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. [GOC:sl] |
| cell differentiation | biological process | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732] |
| positive regulation of transcription by RNA polymerase II | biological process | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH] |