Proteins > Retinoic acid receptor RXR-gamma
Page last updated: 2024-08-07 16:44:08
Retinoic acid receptor RXR-gamma
A retinoic acid receptor RXR-gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48443]
Synonyms
Nuclear receptor subfamily 2 group B member 3;
Retinoid X receptor gamma
Research
Bioassay Publications (21)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (38.10) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 6 (28.57) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
Compounds (20)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Design, synthesis and structure-activity relationship of novel RXR-selective modulators.Bioorganic & medicinal chemistry letters, , Mar-22, Volume: 14, Issue:6, 2004
Design and synthesis of novel RXR-selective modulators with improved pharmacological profile.Bioorganic & medicinal chemistry letters, , Nov-17, Volume: 13, Issue:22, 2003
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation.Journal of medicinal chemistry, , 02-28, Volume: 62, Issue:4, 2019
Scaffold hopping from synthetic RXR modulators by virtual screening and MedChemComm, , Aug-01, Volume: 9, Issue:8, 2018
Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.Journal of medicinal chemistry, , 03-22, Volume: 61, Issue:6, 2018
Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-Journal of medicinal chemistry, , 10-13, Volume: 59, Issue:19, 2016
Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3-L1 cells.Journal of medicinal chemistry, , Feb-25, Volume: 42, Issue:4, 1999
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity.Journal of medicinal chemistry, , Aug-18, Volume: 38, Issue:17, 1995
Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid.Bioorganic & medicinal chemistry letters, , Jan-20, Volume: 13, Issue:2, 2003
An improved synthesis of the C-linked glucuronide of N-(4-hydroxyphenyl)retinamide.Bioorganic & medicinal chemistry letters, , Sep-02, Volume: 12, Issue:17, 2002
Stereoselective synthesis and receptor activity of conformationally defined retinoid X receptor selective ligands.Bioorganic & medicinal chemistry letters, , Feb-22, Volume: 9, Issue:4, 1999
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells.Journal of medicinal chemistry, , Jul-05, Volume: 39, Issue:14, 1996
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.Journal of medicinal chemistry, , Aug-30, Volume: 39, Issue:18, 1996
Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity.Journal of medicinal chemistry, , Aug-18, Volume: 38, Issue:17, 1995
Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties.Journal of medicinal chemistry, , Feb-04, Volume: 37, Issue:3, 1994
Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid.Bioorganic & medicinal chemistry letters, , Jan-20, Volume: 13, Issue:2, 2003
Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.Journal of medicinal chemistry, , Jul-05, Volume: 44, Issue:14, 2001
Stereoselective synthesis and receptor activity of conformationally defined retinoid X receptor selective ligands.Bioorganic & medicinal chemistry letters, , Feb-22, Volume: 9, Issue:4, 1999
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.Journal of medicinal chemistry, , Aug-30, Volume: 39, Issue:18, 1996
Identification of the first retinoid X, receptor homodimer antagonist.Journal of medicinal chemistry, , Aug-16, Volume: 39, Issue:17, 1996
Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells.Journal of medicinal chemistry, , Jul-05, Volume: 39, Issue:14, 1996
Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity.Journal of medicinal chemistry, , Aug-18, Volume: 38, Issue:17, 1995
Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties.Journal of medicinal chemistry, , Feb-04, Volume: 37, Issue:3, 1994
Design, synthesis and structure-activity relationship of novel RXR-selective modulators.Bioorganic & medicinal chemistry letters, , Mar-22, Volume: 14, Issue:6, 2004
Design and synthesis of novel RXR-selective modulators with improved pharmacological profile.Bioorganic & medicinal chemistry letters, , Nov-17, Volume: 13, Issue:22, 2003
Enables
This protein enables 8 target(s):
| Target | Category | Definition |
|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | molecular function | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018] |
| nuclear steroid receptor activity | molecular function | Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. [GOC:signaling, PMID:14708019] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| molecular condensate scaffold activity | molecular function | Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate. [PMID:28225081] |
| sequence-specific double-stranded DNA binding | molecular function | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. [GOC:dos, GOC:sl] |
| nuclear receptor activity | molecular function | A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. [GOC:txnOH-2018, PMID:23457262] |
| retinoic acid-responsive element binding | molecular function | Binding to a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind. [GOC:jl, GOC:vw, GOC:yaf, PMID:11327309, PMID:19917671] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
Part Of
This protein is part of 2 target(s):
| Target | Category | Definition |
|---|
| chromatin | cellular component | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130] |
| RNA polymerase II transcription regulator complex | cellular component | A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. [GOC:tb] |
Involved In
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|
| steroid hormone mediated signaling pathway | biological process | The series of molecular signals mediated by a steroid hormone binding to a receptor. [PMID:12606724] |
| retinoic acid receptor signaling pathway | biological process | The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. [GOC:dgh] |
| anatomical structure development | biological process | The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. [GO_REF:0000021] |
| response to retinoic acid | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. [GOC:sl] |
| cell differentiation | biological process | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732] |
| positive regulation of transcription by RNA polymerase II | biological process | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH] |