Page last updated: 2024-08-07 15:39:28
Protein kinase C gamma type
A protein kinase C gamma type that is encoded in the genome of human. [PRO:CNA, UniProtKB:P05129]
Synonyms
PKC-gamma;
EC 2.7.11.13
Research
Bioassay Publications (71)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (23.94) | 18.2507 |
| 2000's | 39 (54.93) | 29.6817 |
| 2010's | 14 (19.72) | 24.3611 |
| 2020's | 1 (1.41) | 2.80 |
Compounds (55)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| edelfosine | Homo sapiens (human) | IC50 | 12.0000 | 1 | 1 |
| cgp 52411 | Homo sapiens (human) | IC50 | 80.0000 | 1 | 1 |
| bisindolylmaleimide i | Homo sapiens (human) | IC50 | 0.0300 | 1 | 1 |
| bisindolylmaleimide iv | Homo sapiens (human) | IC50 | 0.1900 | 1 | 1 |
| ro 31-8425 | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| go 6976 | Homo sapiens (human) | IC50 | 0.0020 | 1 | 1 |
| n-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide | Homo sapiens (human) | Ki | 15.0000 | 1 | 1 |
| n-(2-aminoethyl)-5-isoquinolinesulfonamide | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| 1-(5-isoquinolinesulfonyl)piperazine | Homo sapiens (human) | IC50 | 12.0000 | 1 | 1 |
| 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| staurosporine aglycone | Homo sapiens (human) | IC50 | 2.4500 | 2 | 2 |
| minaprine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 1-NA-PP1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| suramin | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| tetradecanoylphorbol acetate | Homo sapiens (human) | Ki | 0.0049 | 1 | 1 |
| phorbol 12,13-dibutyrate | Homo sapiens (human) | Ki | 0.0022 | 2 | 2 |
| staurosporine | Homo sapiens (human) | IC50 | 0.1167 | 16 | 18 |
| norharman | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| rebeccamycin | Homo sapiens (human) | IC50 | 175.0000 | 1 | 1 |
| 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride | Homo sapiens (human) | Ki | 6.0000 | 1 | 1 |
| indolactam v | Homo sapiens (human) | Ki | 0.1354 | 9 | 9 |
| cercosporamide | Homo sapiens (human) | IC50 | 5.8000 | 1 | 1 |
| ruboxistaurin | Homo sapiens (human) | IC50 | 0.3000 | 3 | 3 |
| birb 796 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| 7-octylindolactam v | Homo sapiens (human) | Ki | 0.0012 | 1 | 1 |
| sb 203580 | Homo sapiens (human) | IC50 | 75.0000 | 1 | 1 |
| enzastaurin | Homo sapiens (human) | IC50 | 0.7915 | 4 | 2 |
| 7-n-butyl-6-(4'-hydroxyphenyl)-5h-pyrrolo(2,3b)pyrazine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| purvalanol b | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| h 89 | Homo sapiens (human) | Ki | 31.7000 | 1 | 1 |
| 12-deoxyphorbol 13-acetate | Homo sapiens (human) | Ki | 0.1406 | 3 | 3 |
| purvalanol a | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| tamoxifen | Homo sapiens (human) | IC50 | 10.5000 | 2 | 2 |
| bms 387032 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| sf 2370 | Homo sapiens (human) | IC50 | 0.2500 | 1 | 1 |
| pd 407824 | Homo sapiens (human) | IC50 | 3.4000 | 1 | 1 |
| harmine | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| ophiocordin | Homo sapiens (human) | IC50 | 0.0148 | 3 | 9 |
| ophiocordin | Homo sapiens (human) | Ki | 0.0053 | 1 | 1 |
| alvocidib | Homo sapiens (human) | IC50 | 10.3333 | 3 | 3 |
| arcyriaflavin a | Homo sapiens (human) | IC50 | 50.1550 | 2 | 2 |
| pd 161570 | Homo sapiens (human) | IC50 | 23.0000 | 1 | 1 |
| a 419259 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| b 43 | Homo sapiens (human) | IC50 | 33.0000 | 1 | 1 |
| cgp 53353 | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| a 770041 | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| edotecarin | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| ct52923 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| ps1145 | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| ly 338522 | Homo sapiens (human) | IC50 | 0.2700 | 1 | 1 |
| PDGF receptor tyrosine kinase inhibitor III | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| N-[5-[[5-[(4-acetyl-1-piperazinyl)-oxomethyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[(3,3-dimethylbutan-2-ylamino)methyl]benzamide | Homo sapiens (human) | IC50 | 24.0000 | 1 | 1 |
| gsk2141795 | Homo sapiens (human) | IC50 | 0.7530 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| edelfosine | Homo sapiens (human) | ID50 | 12.0000 | 1 | 1 |
| phenidone | Homo sapiens (human) | Activity | 300.0000 | 1 | 1 |
| hypocrellin a | Homo sapiens (human) | PKC | 44.0000 | 1 | 1 |
Methyl 3-(3-(4-(2,4,4-Trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a Novel and Dual Malate Dehydrogenase (MDH) 1/2 Inhibitor Targeting Cancer Metabolism.Journal of medicinal chemistry, , 10-26, Volume: 60, Issue:20, 2017
Kinase inhibitors: not just for kinases anymore.Journal of medicinal chemistry, , Apr-10, Volume: 46, Issue:8, 2003
Isolation of Phorbol Esters from Euphorbia grandicornis and Evaluation of Protein Kinase C- and Human Platelet-Activating Effects of Euphorbiaceae Diterpenes.Journal of natural products, , 10-28, Volume: 79, Issue:10, 2016
Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth.Bioorganic & medicinal chemistry letters, , Apr-23, Volume: 11, Issue:8, 2001
Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP.Bioorganic & medicinal chemistry, , Jul-15, Volume: 19, Issue:14, 2011
Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 20, Issue:20, 2010
Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 13, Issue:18, 2003
The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding.Bioorganic & medicinal chemistry letters, , Mar-12, Volume: 11, Issue:5, 2001
Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V.Bioorganic & medicinal chemistry letters, , Sep-18, Volume: 10, Issue:18, 2000
Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 9, Issue:12, 1999
ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells.European journal of medicinal chemistry, , Jan-01, Volume: 161, 2019
Novel quinazoline derivatives bearing various 6-benzamide moieties as highly selective and potent EGFR inhibitors.Bioorganic & medicinal chemistry, , 05-01, Volume: 26, Issue:8, 2018
Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer.Bioorganic & medicinal chemistry, , 04-01, Volume: 25, Issue:7, 2017
Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3β of substituted quinolines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 24, Issue:15, 2014
Structure-based design, synthesis and biological evaluation of diphenylmethylamine derivatives as novel Akt1 inhibitors.European journal of medicinal chemistry, , Feb-12, Volume: 73, 2014
Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits.The Journal of biological chemistry, , Nov-09, Volume: 282, Issue:45, 2007
Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Novel indolylindazolylmaleimides as inhibitors of protein kinase C-beta: synthesis, biological activity, and cardiovascular safety.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases.Journal of medicinal chemistry, , Nov-18, Volume: 47, Issue:24, 2004
Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors.Bioorganic & medicinal chemistry letters, , Nov-03, Volume: 13, Issue:21, 2003
Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 13, Issue:18, 2003
Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta.Bioorganic & medicinal chemistry letters, , Jun-02, Volume: 13, Issue:11, 2003
Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase family.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
New dermatological agents for the treatment of psoriasis.Journal of medicinal chemistry, , Feb-01, Volume: 44, Issue:3, 2001
(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.Journal of medicinal chemistry, , Jul-05, Volume: 39, Issue:14, 1996
Design and physicochemical properties of new fluorescent ligands of protein kinase C isozymes focused on CH/pi interaction.Bioorganic & medicinal chemistry, , Jan-15, Volume: 16, Issue:2, 2008
Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes.Journal of medicinal chemistry, , Jan-10, Volume: 51, Issue:1, 2008
The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities.Bioorganic & medicinal chemistry letters, , Mar-12, Volume: 11, Issue:5, 2001
Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V.Bioorganic & medicinal chemistry letters, , Sep-18, Volume: 10, Issue:18, 2000
Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme selectivitJournal of medicinal chemistry, , Apr-25, Volume: 40, Issue:9, 1997
Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition.Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors.Journal of medicinal chemistry, , Sep-11, Volume: 46, Issue:19, 2003
(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.Journal of medicinal chemistry, , Jul-05, Volume: 39, Issue:14, 1996
Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition.Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta.Bioorganic & medicinal chemistry letters, , Jun-02, Volume: 13, Issue:11, 2003
[no title available],
HIV latency reversal agents: A potential path for functional cure?European journal of medicinal chemistry, , Mar-05, Volume: 213, 2021
Isolation of Phorbol Esters from Euphorbia grandicornis and Evaluation of Protein Kinase C- and Human Platelet-Activating Effects of Euphorbiaceae Diterpenes.Journal of natural products, , 10-28, Volume: 79, Issue:10, 2016
A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1.Journal of medicinal chemistry, , May-29, Volume: 35, Issue:11, 1992
Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry.Journal of medicinal chemistry, , Sep-08, Volume: 48, Issue:18, 2005
Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety.Journal of medicinal chemistry, , Jan-17, Volume: 40, Issue:2, 1997
Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A.Journal of medicinal chemistry, , Dec-20, Volume: 39, Issue:26, 1996
A review on flavones targeting serine/threonine protein kinases for potential anticancer drugs.Bioorganic & medicinal chemistry, , 03-01, Volume: 27, Issue:5, 2019
Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.Journal of medicinal chemistry, , Aug-29, Volume: 45, Issue:18, 2002
Structure-activity relationship studies of flavopiridol analogues.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors.Bioorganic & medicinal chemistry letters, , Nov-03, Volume: 13, Issue:21, 2003
Dianilinophthalimides: potent and selective, ATP-competitive inhibitors of the EGF-receptor protein tyrosine kinase.Journal of medicinal chemistry, , Apr-01, Volume: 37, Issue:7, 1994
(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.Journal of medicinal chemistry, , Jul-05, Volume: 39, Issue:14, 1996
Enables
This protein enables 9 target(s):
| Target | Category | Definition |
|---|
| protein kinase activity | molecular function | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [PMID:25399640] |
| diacylglycerol-dependent serine/threonine kinase activity | molecular function | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol. [EC:2.7.11.13] |
| calcium,diacylglycerol-dependent serine/threonine kinase activity | molecular function | Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. [GOC:mah] |
| protein serine/threonine/tyrosine kinase activity | molecular function | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [GOC:mah] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| protein serine kinase activity | molecular function | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989] |
| protein serine/threonine kinase activity | molecular function | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925] |
Located In
This protein is located in 11 target(s):
| Target | Category | Definition |
|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cell-cell junction | cellular component | A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] |
| postsynaptic density | cellular component | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density] |
| dendrite | cellular component | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] |
| calyx of Held | cellular component | The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system. [NIF_Subcellular:sao1684283879, PMID:11823805] |
| perinuclear region of cytoplasm | cellular component | Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid] |
| synaptic membrane | cellular component | A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. [GOC:BHF, PMID:20410104] |
| presynaptic cytosol | cellular component | The region of the cytosol consisting of all cytosol that is part of the presynapse. [GOC:dos] |
| postsynaptic cytosol | cellular component | The region of the cytosol consisting of all cytosol that is part of the postsynapse. [GOC:dos] |
Involved In
This protein is involved in 24 target(s):
| Target | Category | Definition |
|---|
| protein phosphorylation | biological process | The process of introducing a phosphate group on to a protein. [GOC:hb] |
| chemical synaptic transmission | biological process | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435] |
| learning or memory | biological process | The acquisition and processing of information and/or the storage and retrieval of this information over time. [GOC:jid, PMID:8938125] |
| chemosensory behavior | biological process | Behavior that is dependent upon the sensation of chemicals. [GOC:go_curators] |
| response to toxic substance | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:lr] |
| phosphorylation | biological process | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. [ISBN:0198506732] |
| negative regulation of protein ubiquitination | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah] |
| regulation of response to food | biological process | Any process that modulates the frequency, rate or extent of a response to a food stimulus. [GOC:add] |
| positive regulation of mismatch repair | biological process | Any process that activates or increases the frequency, rate or extent of mismatch repair. [GOC:vk] |
| negative regulation of protein catabolic process | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process. [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082] |
| regulation of circadian rhythm | biological process | Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. [GOC:dph, GOC:jl, GOC:tb] |
| response to morphine | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure. [GOC:ef, GOC:jl] |
| negative regulation of neuron apoptotic process | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis] |
| response to pain | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. [GOC:jid, PMID:10203867, PMID:12723742, PMID:12843304, Wikipedia:Pain] |
| rhythmic process | biological process | Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. [GOC:jid] |
| regulation of phagocytosis | biological process | Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. [GOC:ai] |
| long-term synaptic potentiation | biological process | A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse. [GOC:dgh, GOC:dph] |
| innervation | biological process | The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue. [GOC:dph, GOC:sart] |
| presynaptic modulation of chemical synaptic transmission | biological process | Any process, acting in the presynapse that results in modulation of chemical synaptic transmission. [GOC:dos] |
| negative regulation of proteasomal protein catabolic process | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198] |
| response to psychosocial stress | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism. [PMID:22922217, PMID:26458179] |
| regulation of synaptic vesicle exocytosis | biological process | Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. [GOC:obol] |
| intracellular signal transduction | biological process | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] |
| peptidyl-serine phosphorylation | biological process | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. [RESID:AA0037] |