Page last updated: 2024-08-07 17:21:39
D
A D(1A) dopamine receptor that is encoded in the genome of cow. [OMA:Q95136, PRO:DNx]
Synonyms
Dopamine D1 receptor
Research
Bioassay Publications (24)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 9 (37.50) | 18.7374 |
| 1990's | 7 (29.17) | 18.2507 |
| 2000's | 8 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (26)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| buspirone | Bos taurus (cattle) | IC50 | 270.0000 | 1 | 2 |
| chlorpromazine | Bos taurus (cattle) | IC50 | 0.6460 | 4 | 4 |
| adtn | Bos taurus (cattle) | IC50 | 0.0060 | 1 | 1 |
| haloperidol | Bos taurus (cattle) | IC50 | 0.2509 | 2 | 2 |
| promazine | Bos taurus (cattle) | IC50 | 0.1300 | 1 | 1 |
| apomorphine | Bos taurus (cattle) | IC50 | 0.3385 | 11 | 13 |
| apomorphine | Bos taurus (cattle) | Ki | 0.0037 | 1 | 1 |
| pergolide | Bos taurus (cattle) | IC50 | 0.0603 | 2 | 3 |
| pergolide mesylate | Bos taurus (cattle) | IC50 | 0.0500 | 1 | 1 |
| quinpirole | Bos taurus (cattle) | Ki | 20.0000 | 1 | 1 |
| ipsapirone | Bos taurus (cattle) | IC50 | 12.0000 | 1 | 2 |
| n 0437, (-)-isomer | Bos taurus (cattle) | Ki | 0.5000 | 1 | 1 |
| etisulergine | Bos taurus (cattle) | IC50 | 0.0820 | 4 | 5 |
| gr 127935 | Bos taurus (cattle) | Ki | 10.0000 | 1 | 1 |
| pramipexole | Bos taurus (cattle) | Ki | 20.0000 | 1 | 1 |
| 2-methoxy-n-n-propylnorapomorphine | Bos taurus (cattle) | Ki | 0.0038 | 1 | 1 |
| n-n-propylnorapomorphine | Bos taurus (cattle) | Ki | 0.0015 | 1 | 1 |
| levosulpiride | Bos taurus (cattle) | Ki | 50.0000 | 2 | 2 |
| sch 23390 | Bos taurus (cattle) | Ki | 0.0138 | 2 | 4 |
| 5-methoxy-3-(di-n-propylamino)chroman | Bos taurus (cattle) | IC50 | 100.0000 | 1 | 2 |
| quinagolide | Bos taurus (cattle) | IC50 | 12.0760 | 6 | 10 |
| l 745870 | Bos taurus (cattle) | Ki | 9.9000 | 3 | 5 |
| (8R)-7-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Bos taurus (cattle) | IC50 | 0.8737 | 3 | 3 |
| (8R)-7-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Bos taurus (cattle) | Ki | 0.0022 | 1 | 1 |
| (8R)-7-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Bos taurus (cattle) | Ki | 0.0012 | 1 | 1 |
| fauc 213 | Bos taurus (cattle) | Ki | 5.5000 | 1 | 1 |
| fauc 113 | Bos taurus (cattle) | Ki | 12.0000 | 4 | 6 |
| clozapine | Bos taurus (cattle) | IC50 | 4.0900 | 2 | 2 |
| clozapine | Bos taurus (cattle) | Ki | 0.4200 | 8 | 13 |
Synthesis and pharmacological evaluation of conformationally restricted phenothiazine analogues.Journal of medicinal chemistry, , Volume: 25, Issue:1, 1982
Conformationally restricted phenothiazine neuroleptics. 1. 3-(Dimethylamino)-1,2,3,4-tetrahydroazepino[3,2,1-kl]phenothiazine.Journal of medicinal chemistry, , Volume: 23, Issue:8, 1980
Synthesis of 8-aryltetrahydroisoquinolines as dopamine antagonists and evaluation for potential neuroleptic activity.Journal of medicinal chemistry, , Volume: 23, Issue:9, 1980
Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
2H-[1]benzopyrano[3,4-b]pyridines: synthesis and activity at central monoamine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:3, 1989
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Aporphines. 39. Synthesis, dopamine receptor binding, and pharmacological activity of (R)-(-)- and (S)-(+)-2-hydroxyapomorphine.Journal of medicinal chemistry, , Volume: 25, Issue:8, 1982
Synthesis of 8-aryltetrahydroisoquinolines as dopamine antagonists and evaluation for potential neuroleptic activity.Journal of medicinal chemistry, , Volume: 23, Issue:9, 1980
Orally active analogues of the dopaminergic prodrug 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one: synthesis and pharmacological activity.Journal of medicinal chemistry, , Feb-13, Volume: 46, Issue:4, 2003
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: synthesis and dopamine receptor binding profiles.Bioorganic & medicinal chemistry letters, , Sep-04, Volume: 10, Issue:17, 2000
Enantio- and diastereocontrolled dopamine D1, D2, D3 and D4 receptor binding of N-(3-pyrrolidinylmethyl)benzamides synthesized from aspartic acid.Bioorganic & medicinal chemistry letters, , Mar-22, Volume: 9, Issue:6, 1999
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy.Bioorganic & medicinal chemistry letters, , Feb-25, Volume: 12, Issue:4, 2002
Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.Bioorganic & medicinal chemistry letters, , Jan-04, Volume: 9, Issue:1, 1999
Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
Aporphines. 39. Synthesis, dopamine receptor binding, and pharmacological activity of (R)-(-)- and (S)-(+)-2-hydroxyapomorphine.Journal of medicinal chemistry, , Volume: 25, Issue:8, 1982
2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356.Bioorganic & medicinal chemistry letters, , Aug-05, Volume: 12, Issue:15, 2002
Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy.Bioorganic & medicinal chemistry letters, , Feb-25, Volume: 12, Issue:4, 2002
Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213).Journal of medicinal chemistry, , Aug-16, Volume: 44, Issue:17, 2001
Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.Bioorganic & medicinal chemistry letters, , Jan-04, Volume: 9, Issue:1, 1999
Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy.Bioorganic & medicinal chemistry letters, , Feb-25, Volume: 12, Issue:4, 2002
2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356.Bioorganic & medicinal chemistry letters, , Aug-05, Volume: 12, Issue:15, 2002
Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213).Journal of medicinal chemistry, , Aug-16, Volume: 44, Issue:17, 2001
Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: synthesis and dopamine receptor binding profiles.Bioorganic & medicinal chemistry letters, , Sep-04, Volume: 10, Issue:17, 2000
Cyanoindole derivatives as highly selective dopamine D(4) receptor partial agonists: solid-phase synthesis, binding assays, and functional experiments.Journal of medicinal chemistry, , Nov-16, Volume: 43, Issue:23, 2000
Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.Bioorganic & medicinal chemistry letters, , Jan-04, Volume: 9, Issue:1, 1999
Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 9, Issue:21, 1999
Synthesis of 8-aryltetrahydroisoquinolines as dopamine antagonists and evaluation for potential neuroleptic activity.Journal of medicinal chemistry, , Volume: 23, Issue:9, 1980