Page last updated: 2024-12-06

2,2',3,5',6-pentachlorobiphenyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

2,2',3,5',6-pentachlorobiphenyl is a highly chlorinated polychlorinated biphenyl (PCB) congener. It is a persistent organic pollutant (POP) that has been widely used in industrial applications, such as in electrical equipment, hydraulic fluids, and plasticizers. 2,2',3,5',6-pentachlorobiphenyl has been shown to be toxic to humans and wildlife. It can accumulate in the food chain and cause a variety of health problems, including cancer, reproductive problems, and developmental problems. The compound has been linked to several health issues, including immune suppression, endocrine disruption, and neurological effects. It is also known to bioaccumulate in the environment and has been found in human breast milk, blood, and adipose tissue. The persistence, bioaccumulation, and toxic properties of 2,2',3,5',6-pentachlorobiphenyl have led to its regulation and restriction in many countries. Research on this compound focuses on understanding its environmental fate, toxicology, and potential health effects. The development of analytical methods for its detection and quantification in environmental and biological matrices is also an active area of research.'

Cross-References

ID SourceID
PubMed CID38012
SCHEMBL ID4450570
MeSH IDM0102359

Synonyms (22)

Synonym
1,1'-biphenyl, 2,2',3,5',6-pentachloro-
2,3,6,2',5'-pentachlorobiphenyl
inchi=1/c12h5cl5/c13-6-1-2-8(14)7(5-6)11-9(15)3-4-10(16)12(11)17/h1-5
2,2',3,5',6-pentachlorobiphenyl
pcb 95
pcb-95
38379-99-6
1,2,4-trichloro-3-(2,5-dichlorophenyl)benzene
0yo8j06wcr ,
unii-0yo8j06wcr
SCHEMBL4450570
2,5,2',3',6'-pentachlorobiphenyl
2,2',3,5',6-pentachloro-1,1'-biphenyl #
GXNNLIMMEXHBKV-UHFFFAOYSA-N
2,2',3,5',6-pentachloro-1,1'-biphenyl
DTXSID3038301 ,
pcb no. 95 10 microg/ml in isooctane
pcb no. 95
2,2',3,5',6-pentachlorbiphenyl
Q27237354
CS-0451940
dtxcid1018301

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Time-mated Sprague-Dawley rats were dosed with PCB 95 (8 or 32 mg/kg/day) or corn oil vehicle via gavage on gestation days 10-16."( Long-term effects of developmental exposure to 2,2',3,5',6-pentachlorobiphenyl (PCB 95) on locomotor activity, spatial learning and memory and brain ryanodine binding.
Pessah, IN; Schantz, SL; Seo, BW; Wong, PW, 1997
)
0.55
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (43)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (2.33)18.7374
1990's4 (9.30)18.2507
2000's7 (16.28)29.6817
2010's27 (62.79)24.3611
2020's4 (9.30)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.62

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.62 (24.57)
Research Supply Index3.78 (2.92)
Research Growth Index5.41 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.62)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other43 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]