aprotinin and Necrosis

Early treatment with gordox of white rats with experimental pancreonecrosis reduces amylasemia and prevents dissemination of steatonecroses. The drug appreciably improves pancreatic microcirculation. Similarly to the control, the injured part of the gland undergoes necrosis. However, the severity of hemorrhagic component is minimal. The treatment with gordox enhances leukocytic infiltration aimed at elimination of necrotic tissues.

Topics: Amylases; Animals; Aprotinin; Ascitic Fluid; Drug Evaluation, Preclinical; Male; Necrosis; Pancreas; Pancreatitis; Rats; Time Factors; Trypsin Inhibitors

The experience in the treatment of 1800 patients with acute pancreatitis is described. Destructive forms were found in 36% of cases during the last five years. The main methods of treatment and the mortality rate following the methods used are analyzed. The authors believe cytostaticotherapy with the infusion of 5-phthoruracil into the celiac artery and forced diuresis with the infusion of fluids into the celiac artery to be the most perspective methods. The use of the above methods decreased the lethality in destructive forms to 8,3%. The intraaretrial infusion of 5-phthoruracil with antibiotics allowed coping processes of the pancreatic tissue autolysis and avoiding broad sequestration and severe suppurative complications of pancreatitis.

Topics: Acute Disease; Aprotinin; Drainage; Enzyme Inhibitors; Humans; Hypothermia, Induced; Necrosis; Pancreas; Pancreatitis; Peritoneal Dialysis; Thoracic Duct; Trypsin Inhibitors