Rap guanine nucleotide exchange factor 3

A Rap guanine nucleotide exchange factor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95398]

Synonyms

Exchange factor directly activated by cAMP 1;
Exchange protein directly activated by cAMP 1;
EPAC 1;
Rap1 guanine-nucleotide-exchange factor directly activated by cAMP;
cAMP-regulated guanine nucleotide exchange factor I;
cAMP-GEFI

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (620)

Drugs with Potency Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)
dinitrochlorobenzene	Homo sapiens (human)	Potency	79.4328	1
protocatechuic acid	Homo sapiens (human)	Potency	125.8920	1
aminocaproic acid	Homo sapiens (human)	Potency	125.8920	1
pentachlorophenol	Homo sapiens (human)	Potency	125.8920	1
pyrazinoic acid	Homo sapiens (human)	Potency	100.0000	1
urea	Homo sapiens (human)	Potency	125.8920	1
beta-resorcylic acid	Homo sapiens (human)	Potency	79.4328	1
3,4-dichloroisocoumarin	Homo sapiens (human)	Potency	89.1251	1
4-aminopyridine	Homo sapiens (human)	Potency	28.1838	1
ambroxol	Homo sapiens (human)	Potency	125.8920	1
benzbromarone	Homo sapiens (human)	Potency	39.8107	1
carisoprodol	Homo sapiens (human)	Potency	35.4813	1
dipyridamole	Homo sapiens (human)	Potency	89.7164	2
efavirenz	Homo sapiens (human)	Potency	112.2020	1
embelin	Homo sapiens (human)	Potency	84.2180	2
felbamate	Homo sapiens (human)	Potency	100.0000	1
fenbendazole	Homo sapiens (human)	Potency	3.1623	1
fluconazole	Homo sapiens (human)	Potency	100.0000	1
flucytosine	Homo sapiens (human)	Potency	125.8920	1
guaifenesin	Homo sapiens (human)	Potency	112.2020	1
hexachlorophene	Homo sapiens (human)	Potency	70.7946	1
amrinone	Homo sapiens (human)	Potency	100.0000	1
ketamine	Homo sapiens (human)	Potency	125.8920	1
vitamin k 3	Homo sapiens (human)	Potency	25.1189	1
nisoldipine	Homo sapiens (human)	Potency	89.1251	1
masoprocol	Homo sapiens (human)	Potency	50.1187	1
oxeladin	Homo sapiens (human)	Potency	89.1251	1
primidone	Homo sapiens (human)	Potency	56.2341	1
quetiapine	Homo sapiens (human)	Potency	125.8920	1
sulfadimethoxine	Homo sapiens (human)	Potency	31.6228	1
thyroxine	Homo sapiens (human)	Potency	50.1187	1
estrone	Homo sapiens (human)	Potency	112.2020	1
methyldimethylaminoazobenzene	Homo sapiens (human)	Potency	89.1251	1
uridine	Homo sapiens (human)	Potency	125.8920	1
4-hydroxypropiophenone	Homo sapiens (human)	Potency	125.8920	1
gibberellic acid	Homo sapiens (human)	Potency	100.0000	1
tetrabromobisphenol a	Homo sapiens (human)	Potency	79.4328	1
purpurin	Homo sapiens (human)	Potency	50.1187	1
skimmianine	Homo sapiens (human)	Potency	2.8184	1
9,10-phenanthrenequinone	Homo sapiens (human)	Potency	8.9125	1
acriflavine chloride	Homo sapiens (human)	Potency	33.9508	2
7-amino-4-hydroxy-2-naphthalenesulfonic acid	Homo sapiens (human)	Potency	31.6228	1
2-nitrotoluene	Homo sapiens (human)	Potency	8.9125	1
pyronine	Homo sapiens (human)	Potency	55.6101	2
6-methylcoumarin	Homo sapiens (human)	Potency	50.1187	1
xanthenes	Homo sapiens (human)	Potency	125.8920	1
3,4-xylidine	Homo sapiens (human)	Potency	89.1251	1
4-methyl-3-nitrobenzoic acid	Homo sapiens (human)	Potency	125.8920	1
fentichlor	Homo sapiens (human)	Potency	100.0000	1
methylaniline	Homo sapiens (human)	Potency	70.7946	1
4-aminodiphenylamine	Homo sapiens (human)	Potency	25.1189	1
adiponitrile	Homo sapiens (human)	Potency	100.0000	1
1-amino-4-hydroxyanthraquinone	Homo sapiens (human)	Potency	56.2341	1
5-amino-2-naphthalenesulfonate	Homo sapiens (human)	Potency	50.1187	1
2,4-dihydroxybenzophenone	Homo sapiens (human)	Potency	75.0594	2
20-alpha-dihydroprogesterone	Homo sapiens (human)	Potency	50.1187	1
quinestrol	Homo sapiens (human)	Potency	79.4328	1
lithocholic acid	Homo sapiens (human)	Potency	50.1187	1
nandrolone	Homo sapiens (human)	Potency	7.9433	1
glaucine	Homo sapiens (human)	Potency	35.4813	1
9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-7h-furo(3,2-g)(1)benzopyran-7-one	Homo sapiens (human)	Potency	125.8920	1
hematoxylin	Homo sapiens (human)	Potency	50.1187	1
2,3-dimethylphenol	Homo sapiens (human)	Potency	100.0000	1
acetylsalicylsalicylic acid	Homo sapiens (human)	Potency	125.8920	1
myristic acid	Homo sapiens (human)	Potency	56.2341	1
neutral red base	Homo sapiens (human)	Potency	100.0000	1
pentabromophenol	Homo sapiens (human)	Potency	70.7946	1
erythromycin	Homo sapiens (human)	Potency	100.0000	1
1,4-androstadiene-3,17-dione	Homo sapiens (human)	Potency	125.8920	1
2-hydroxybenzothiazole	Homo sapiens (human)	Potency	89.1251	1
estradiol valerate	Homo sapiens (human)	Potency	49.2885	2
d-alpha tocopherol	Homo sapiens (human)	Potency	5.0119	1
benperidol	Homo sapiens (human)	Potency	100.0000	1
3-aminofluoranthene	Homo sapiens (human)	Potency	68.5561	2
Bis(2-furanylmethyl) disulfide	Homo sapiens (human)	Potency	10.0000	1
carboxin	Homo sapiens (human)	Potency	56.2341	1
1,3,7-trimethyl-8-(phenylmethyl)purine-2,6-dione	Homo sapiens (human)	Potency	100.0000	1
aseanostatin p5	Homo sapiens (human)	Potency	81.1603	2
6,7-Dimethyl-9-(2-acetoxyethyl)isoalloxazine	Homo sapiens (human)	Potency	69.6219	2
4-(4-dimethylaminophenylazo)benzoic acid	Homo sapiens (human)	Potency	79.4328	1
hydroxyzine pamoate	Homo sapiens (human)	Potency	19.9526	1
pyrazophos	Homo sapiens (human)	Potency	28.1838	1
3-methyl-2-quinoxalinol	Homo sapiens (human)	Potency	39.8107	1
danazol	Homo sapiens (human)	Potency	3.1623	1
cetyldimethylethylammonium bromide	Homo sapiens (human)	Potency	81.1603	2
rafoxanide	Homo sapiens (human)	Potency	39.8107	1
(7S,9S)-7-[(4-amino-5-hydroxy-6-methyl-2-oxanyl)oxy]-6,9,11-trihydroxy-9-(2-hydroxy-1-oxoethyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione	Homo sapiens (human)	Potency	112.2020	1
frentizole	Homo sapiens (human)	Potency	56.2341	1
2-n-octyl-4-isothiazolin-3-one	Homo sapiens (human)	Potency	70.7946	1
procymidone	Homo sapiens (human)	Potency	89.1251	1
ribavirin	Homo sapiens (human)	Potency	89.1251	1
methyldopa	Homo sapiens (human)	Potency	10.0000	1
2-Acetyl-7-methoxybenzofuran	Homo sapiens (human)	Potency	25.1189	1
iem 611	Homo sapiens (human)	Potency	44.6684	1
Nanaomycin	Homo sapiens (human)	Potency	31.6228	1
closantel	Homo sapiens (human)	Potency	50.1187	1
s-2678	Homo sapiens (human)	Potency	42.2090	2
colforsin	Homo sapiens (human)	Potency	100.0000	1
chaetochromin	Homo sapiens (human)	Potency	41.6920	2
nsc 330770	Homo sapiens (human)	Potency	89.1251	1
topotecan hydrochloride	Homo sapiens (human)	Potency	14.1254	1
adenosine	Homo sapiens (human)	Potency	125.8920	1
Pronetalol hydrochloride	Homo sapiens (human)	Potency	125.8920	1
Allyl nonanoate	Homo sapiens (human)	Potency	50.1187	1
5-Aminoacenaphthene	Homo sapiens (human)	Potency	53.8909	2
diacetylfluorescein	Homo sapiens (human)	Potency	23.7434	2
o-(6)-methylguanine	Homo sapiens (human)	Potency	44.6684	1
benzoclidine	Homo sapiens (human)	Potency	44.6684	1
physodic acid	Homo sapiens (human)	Potency	39.8107	1
toxoflavin	Homo sapiens (human)	Potency	19.9526	1
2-amino-7-naphthol	Homo sapiens (human)	Potency	89.1251	1
2,3-trimethylene-4-quinazolone	Homo sapiens (human)	Potency	25.1189	1
clomipramine hydrochloride	Homo sapiens (human)	Potency	112.2020	1
sertraline	Homo sapiens (human)	Potency	35.4813	1
bithionol sulfoxide	Homo sapiens (human)	Potency	39.8107	1
2,4-dimethoxybenzaldehyde	Homo sapiens (human)	Potency	12.5893	1
etidin	Homo sapiens (human)	Potency	100.0000	1
suksdorfin	Homo sapiens (human)	Potency	79.4328	1
2,2'-((3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)diimino)bis-benzoic acid	Homo sapiens (human)	Potency	79.4328	1
coumarin 153	Homo sapiens (human)	Potency	37.6188	2
berberrubine	Homo sapiens (human)	Potency	70.7946	1
methyl fluorone black	Homo sapiens (human)	Potency	72.6796	2
9-hydroxyphenylfluoron	Homo sapiens (human)	Potency	8.9125	1
1,10-phenanthroline-5,6-dione	Homo sapiens (human)	Potency	7.9433	1
lobaric acid	Homo sapiens (human)	Potency	50.1187	1
2-chloranil	Homo sapiens (human)	Potency	79.4328	1
ergocornine	Homo sapiens (human)	Potency	100.0000	1
2-(4-Morpholinyl)benzothiazole	Homo sapiens (human)	Potency	39.8107	1
n,n'-2-phenylenedimaleimide	Homo sapiens (human)	Potency	39.8107	1
2-butyl-6-(butylamino)-1h-benzo(de)isoquinoline-1,3(2h)-dione	Homo sapiens (human)	Potency	67.8334	2
sennoside B	Homo sapiens (human)	Potency	35.4813	1
7-ketocholesterol	Homo sapiens (human)	Potency	100.0000	1
trimethylphenylammonium iodide	Homo sapiens (human)	Potency	112.2020	1
coumarin 7	Homo sapiens (human)	Potency	64.3552	2
cb 1837	Homo sapiens (human)	Potency	39.8107	1
osajin	Homo sapiens (human)	Potency	37.6188	2
9,10-phenanthrenequinone monoxime	Homo sapiens (human)	Potency	79.4328	1
2-(4-hydroxyphenyl)-5,6,7,8-tetrahydroxy-4H-1-benzopyran-4-one	Homo sapiens (human)	Potency	6.3096	1
nitrophenylgalactosides	Homo sapiens (human)	Potency	100.0000	1
2-(3'-methoxy-4'-hydroxybenzylidene)cyclopentene-1,3-dione	Homo sapiens (human)	Potency	79.4328	1
dihydrocapsaicin	Homo sapiens (human)	Potency	112.2020	1
tanshinone	Homo sapiens (human)	Potency	79.4328	1
phacidin	Homo sapiens (human)	Potency	56.2341	1
3'-deamino-3'-hydroxydaunorubicin	Homo sapiens (human)	Potency	56.2341	1
gyrophoric acid	Homo sapiens (human)	Potency	56.2341	1
sch 45752	Homo sapiens (human)	Potency	10.0000	1
oxidopamine hydrochloride	Homo sapiens (human)	Potency	35.4813	1
cryptotanshinone	Homo sapiens (human)	Potency	72.3342	2
epiberberine	Homo sapiens (human)	Potency	112.2020	1
tanshinone ii a	Homo sapiens (human)	Potency	79.4328	1
enniatin b	Homo sapiens (human)	Potency	70.7946	1
sb 216763	Homo sapiens (human)	Potency	28.3708	2
diisooctyl phthalate	Homo sapiens (human)	Potency	89.1251	1
nsc 36398	Homo sapiens (human)	Potency	44.6684	1
2-[2-[2-(2-aminophenoxy)ethoxy]ethoxy]aniline	Homo sapiens (human)	Potency	89.1251	1
beta-thujone	Homo sapiens (human)	Potency	100.0000	1
nsc 95397	Homo sapiens (human)	Potency	39.8107	1
1-phenyl-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one	Homo sapiens (human)	Potency	17.7828	1
2-(2,4-dichlorophenoxy)-N-(3-pyridinyl)acetamide	Homo sapiens (human)	Potency	35.4813	1
1-(4-chlorophenyl)-3-(2-ethoxyphenyl)urea	Homo sapiens (human)	Potency	10.0000	1
2-[[[4-(methylthio)anilino]-oxomethyl]amino]benzamide	Homo sapiens (human)	Potency	100.0000	1
nsc228155	Homo sapiens (human)	Potency	35.4813	1
hematoxylin	Homo sapiens (human)	Potency	100.0000	1
1,3(2h,4h)-isoquinolinedione	Homo sapiens (human)	Potency	56.2341	1
4,5,7-trihydroxy-9,10-dioxo-2-anthracenecarboxylic acid	Homo sapiens (human)	Potency	50.1187	1
nsc668394	Homo sapiens (human)	Potency	50.1187	1
7-(4-methoxyphenyl)-5-phenyl-1,7-dihydrotetrazolo[1,5-a]pyrimidine	Homo sapiens (human)	Potency	39.8107	1
n,n-dimethyldaunorubicin	Homo sapiens (human)	Potency	58.6544	2
naringenin	Homo sapiens (human)	Potency	112.2020	1
tosylphenylalanyl chloromethyl ketone	Homo sapiens (human)	Potency	89.1251	1
saquinavir	Homo sapiens (human)	Potency	125.8920	1
doxorubicin hydrochloride	Homo sapiens (human)	Potency	100.0000	1
oleic acid	Homo sapiens (human)	Potency	5.0119	1
t0901317	Homo sapiens (human)	Potency	8.9125	1
trimethylcolchicinic acid	Homo sapiens (human)	Potency	63.0957	1
visnadin	Homo sapiens (human)	Potency	44.6684	1
1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione	Homo sapiens (human)	Potency	100.0000	1
(2S)-2-[[[4-[[[(2S)-1-[(2-methylpropan-2-yl)oxy]-1-oxo-3-phenylpropan-2-yl]amino]-oxomethyl]-1H-imidazol-5-yl]-oxomethyl]amino]-3-phenylpropanoic acid tert-butyl ester	Homo sapiens (human)	Potency	28.6288	2
meso-dihydroguaiaretic acid	Homo sapiens (human)	Potency	28.1838	1
3-methoxycinnoline	Homo sapiens (human)	Potency	3.5481	1
hei 713	Homo sapiens (human)	Potency	112.2020	1
2-(1-piperazinyl)-4-amino-6,7-dimethoxyquinazoline	Homo sapiens (human)	Potency	79.4328	1
idarubicin hydrochloride	Homo sapiens (human)	Potency	72.3342	2
2'-hydroxychalcone	Homo sapiens (human)	Potency	100.0000	1
3-Hydroxy-1-(4-hydroxyphenyl)-1-propanone	Homo sapiens (human)	Potency	31.6228	1
dibenzylidene acetone	Homo sapiens (human)	Potency	70.7946	1
cardamonin	Homo sapiens (human)	Potency	70.7946	1
calmidazolium	Homo sapiens (human)	Potency	50.1187	1
6-amino-2-methyl-8-phenyl-1,6,8,8a-tetrahydroisoquinoline-5,7,7-tricarbonitrile	Homo sapiens (human)	Potency	44.6684	1
3-(2-oxo-1,3-benzoxazol-3-yl)-N-phenylpropanamide	Homo sapiens (human)	Potency	89.1251	1
2-[[3-cyano-6-(2-furanyl)-4-(trifluoromethyl)-2-pyridinyl]thio]propanoic acid ethyl ester	Homo sapiens (human)	Potency	70.7946	1
4-methyl-5-thieno[3,2-b]pyrrolecarboxylic acid [1-oxo-1-(2-phenylethylamino)propan-2-yl] ester	Homo sapiens (human)	Potency	39.8107	1
6-(hexylthio)-4-(4-hydroxyphenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carbonitrile	Homo sapiens (human)	Potency	14.1254	1
N-[4-(4-fluorophenyl)-2-thiazolyl]-2-[(4-methylphenyl)sulfonylamino]benzamide	Homo sapiens (human)	Potency	79.4328	1
8-(2-furanyl)-6-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-3,3-dimethyl-1,4-dihydrothiopyrano[3,4-c]pyridine-5-carbonitrile	Homo sapiens (human)	Potency	50.1187	1
5-(3-butoxyphenyl)-1,3,4-thiadiazol-2-amine	Homo sapiens (human)	Potency	125.8920	1
2-cyano-N-(3-methoxypropyl)-2-[3-(1-pyrrolidinyl)-2-quinoxalinyl]acetamide	Homo sapiens (human)	Potency	100.6636	2
2-cyano-N-(2-furanylmethyl)-2-[3-(4-morpholinyl)-2-quinoxalinyl]acetamide	Homo sapiens (human)	Potency	110.4056	2
2-cyano-2-[3-(4-morpholinyl)-2-quinoxalinyl]acetic acid cyclohexyl ester	Homo sapiens (human)	Potency	53.8083	2
2-[5-[(2,4-dichlorophenyl)methylthio]-4-(2-furanylmethyl)-1,2,4-triazol-3-yl]pyridine	Homo sapiens (human)	Potency	71.2642	2
2-cyano-2-[3-(4-morpholinyl)-2-quinoxalinyl]acetic acid hexyl ester	Homo sapiens (human)	Potency	39.8107	1
(4-chloro-5-hydroxy-3-benzofuranyl)-phenylmethanone	Homo sapiens (human)	Potency	39.8107	1
9,10-dimethoxy-2-(2-pyridinylmethylamino)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	Homo sapiens (human)	Potency	56.2341	1
(3aR,6aS)-3-(2-chlorophenyl)-5-(2,5-dimethoxyphenyl)-3a,6a-dihydropyrrolo[3,4-d]isoxazole-4,6-dione	Homo sapiens (human)	Potency	44.6684	1
Glyceryl lactopalmitate	Homo sapiens (human)	Potency	32.4648	2
2-[3-(2-furanylmethyl)-4-imino-6,6-dimethyl-2-oxo-5,8-dihydropyrano[2,3]thieno[2,4-b]pyrimidin-1-yl]-N-phenylacetamide	Homo sapiens (human)	Potency	39.8107	1
5-(3-chlorophenyl)-N-[2-methyl-5-(3-methyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)phenyl]-2-furancarboxamide	Homo sapiens (human)	Potency	100.0000	1
7-chloro-5-(4-morpholinyl)-2,1,3-benzoxadiazol-4-amine	Homo sapiens (human)	Potency	19.9526	1
N-(4-fluorophenyl)-4-methyl-1-piperidinecarbothioamide	Homo sapiens (human)	Potency	15.8489	1
N-(4-fluorophenyl)-2,1,3-benzothiadiazole-5-carboxamide	Homo sapiens (human)	Potency	3.5481	1
4-phenyl-N-(3-pyridinyl)-2-thiazolamine	Homo sapiens (human)	Potency	3.5481	1
n-phenyl-n'-2-pyridylthiourea	Homo sapiens (human)	Potency	64.4679	2
1-(2,4-dimethylphenyl)-4-(1-piperidinylsulfonyl)piperazine	Homo sapiens (human)	Potency	4.4668	1
LSM-34582	Homo sapiens (human)	Potency	2.8184	1
acetic acid [4-[oxo-(2-phenylethylamino)methyl]phenyl] ester	Homo sapiens (human)	Potency	2.8184	1
4-(2-furanylmethyl)-3-pyridin-4-yl-1H-1,2,4-triazole-5-thione	Homo sapiens (human)	Potency	100.0000	1
[3-fluoro-4-(4-morpholinyl)phenyl]-(4-methylphenyl)methanone	Homo sapiens (human)	Potency	89.1251	1
3-chloro-1-(3,4-dichlorophenyl)-4-(dimethylamino)pyrrole-2,5-dione	Homo sapiens (human)	Potency	39.8107	1
1-[[(1-methyl-2-benzimidazolyl)amino]methyl]-2-naphthalenol	Homo sapiens (human)	Potency	63.0957	1
3-amino-4-(4-chlorophenyl)-6-cyclopropyl-2-thieno[2,3-b]pyridinecarbonitrile	Homo sapiens (human)	Potency	79.4328	1
2-[[(3-methylphenyl)-oxomethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid	Homo sapiens (human)	Potency	100.0000	1
N-(3-phenyl-1,3-benzothiazol-2-ylidene)-2-propenamide	Homo sapiens (human)	Potency	15.8489	1
2-[[4-(1-pyrrolidinylsulfonyl)phenyl]hydrazinylidene]propanedinitrile	Homo sapiens (human)	Potency	17.7828	1
3-(4,5-dimethyl-3-thiophenyl)-4-(2-methylphenyl)-1H-1,2,4-triazole-5-thione	Homo sapiens (human)	Potency	112.2020	1
2-(4-fluoro-N-methylsulfonylanilino)-N-(3-methylphenyl)acetamide	Homo sapiens (human)	Potency	89.1251	1
2-[(1-ethyl-2,5-dimethyl-3-pyrrolyl)methylidene]indene-1,3-dione	Homo sapiens (human)	Potency	67.8334	2
4-chloro-3-ethoxy-N-(4-ethylphenyl)benzenesulfonamide	Homo sapiens (human)	Potency	69.6219	2
2-[(3-methyl-4-oxo-2-quinazolinyl)thio]-N-phenylacetamide	Homo sapiens (human)	Potency	100.0000	1
2-[4-(pyridin-4-ylmethylsulfamoyl)phenoxy]acetic acid methyl ester	Homo sapiens (human)	Potency	100.0000	1
4-acetamidobenzoic acid (2-chlorophenyl)methyl ester	Homo sapiens (human)	Potency	100.0000	1
1-cyclohexyl-3-(3-ethylphenyl)urea	Homo sapiens (human)	Potency	100.0000	1
1,6-dimethyl-3-(2-pyridinyl)pyrimido[5,4-e][1,2,4]triazine-5,7-dione	Homo sapiens (human)	Potency	2.8184	1
5-hydroxy-7-(4-nitrophenyl)-1,3-benzoxathiol-2-one	Homo sapiens (human)	Potency	39.8107	1
N,N-dimethyl-2-[(2-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)thio]ethanamine	Homo sapiens (human)	Potency	3.5481	1
3-[(2,5-dimethylanilino)methyl]-6-methoxy-1H-quinolin-2-one	Homo sapiens (human)	Potency	3.5481	1
1-(phenylmethyl)-3-[4-(trifluoromethoxy)phenyl]thiourea	Homo sapiens (human)	Potency	89.1251	1
2-(2-ethoxyphenyl)-5,6-dimethyl-1,3-dihydroisoindole	Homo sapiens (human)	Potency	63.0957	1
N-(3-methoxyphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide	Homo sapiens (human)	Potency	78.1171	2
1-(1-naphthalenylmethoxy)benzotriazole	Homo sapiens (human)	Potency	100.0000	1
umi-77	Homo sapiens (human)	Potency	56.2341	1
3-amino-N-(2-fluorophenyl)-6-(phenylmethyl)-4-(trifluoromethyl)-2-thieno[2,3-b]pyridinecarboxamide	Homo sapiens (human)	Potency	100.0000	1
N-[(3-acetylanilino)-sulfanylidenemethyl]-5-bromo-3-pyridinecarboxamide	Homo sapiens (human)	Potency	35.4813	1
4-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-3-quinolinecarboxylic acid ethyl ester	Homo sapiens (human)	Potency	89.1251	1
(4-anilino-1,1-dioxo-2H-1$l^{6},2-benzothiazin-3-yl)-phenylmethanone	Homo sapiens (human)	Potency	50.1187	1
1-methoxy-N-[4-(pyridin-4-ylmethyl)phenyl]-2-naphthalenecarboxamide	Homo sapiens (human)	Potency	100.0000	1
N-(3,5-dimethylphenyl)-4-(3-methoxyphenyl)-1-piperazinecarbothioamide	Homo sapiens (human)	Potency	39.8107	1
[4-(2-methoxyphenyl)-1-piperazinyl]-[5-(4-methylphenyl)-3-isoxazolyl]methanone	Homo sapiens (human)	Potency	100.0000	1
3-(2-chloro-6-fluorophenyl)-N-(3-fluoro-4-methylphenyl)-5-methyl-4-isoxazolecarboxamide	Homo sapiens (human)	Potency	3.5481	1
N-[3-chloro-4-[[2-furanyl(oxo)methyl]amino]phenyl]-2,3-dihydro-1,4-benzodioxin-6-carboxamide	Homo sapiens (human)	Potency	50.1187	1
3-[[2-[[6-fluoro-2-(4-fluorophenyl)-4-quinazolinyl]thio]-1-oxoethyl]amino]benzoic acid	Homo sapiens (human)	Potency	70.7946	1
(E)-4-Phenyl-2-(3-(thiophen-2-yl)acrylamido)thiophene-3-carboxylic acid	Homo sapiens (human)	Potency	31.6228	1
N-(2-furanylmethyl)-2-(4-oxo-6-phenyl-3-thieno[2,3-d]pyrimidinyl)acetamide	Homo sapiens (human)	Potency	15.8489	1
2-(3-methylphenyl)-N-[4-(4-morpholinyl)phenyl]-4-quinazolinamine	Homo sapiens (human)	Potency	44.6684	1
5-(2,4-dichlorophenyl)-N-(4-methyl-2-thiazolyl)-2-furancarboxamide	Homo sapiens (human)	Potency	89.1251	1
N-(1,3-benzothiazol-2-yl)-2-(3-methoxyphenyl)-4-quinolinecarboxamide	Homo sapiens (human)	Potency	89.1251	1
2',4',6'-Trihydroxydihydrochalcone	Homo sapiens (human)	Potency	100.0000	1
3-(4-methoxyphenyl)-2-(4-methoxyphenyl)imino-4-thiazolidinone	Homo sapiens (human)	Potency	89.1251	1
(4-chlorophenyl)-[4-(7-chloro-4-quinolinyl)-1-piperazinyl]methanone	Homo sapiens (human)	Potency	100.0000	1
1-methylsulfonyl-N-(6,7,8,9-tetrahydrodibenzofuran-2-yl)-2,3-dihydroindole-5-sulfonamide	Homo sapiens (human)	Potency	112.2020	1
1-[[4-(dimethylamino)phenyl]methyl]-1-(2-furanylmethyl)-3-(4-methoxyphenyl)thiourea	Homo sapiens (human)	Potency	100.0000	1
N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-6,8-dimethyl-2-(3-pyridinyl)-4-quinolinecarboxamide	Homo sapiens (human)	Potency	89.1251	1
N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide	Homo sapiens (human)	Potency	50.1187	1
6,8-dimethyl-N-[4-[(5-methyl-3-isoxazolyl)sulfamoyl]phenyl]-2-(2-pyridinyl)-4-quinolinecarboxamide	Homo sapiens (human)	Potency	89.1251	1
4-methoxy-N-[2-(4-morpholinyl)phenyl]-3-nitrobenzamide	Homo sapiens (human)	Potency	31.6228	1
2-[[[3-methyl-4-[[2-(3-nitrophenoxy)-1-oxoethyl]amino]phenyl]-oxomethyl]amino]benzoic acid	Homo sapiens (human)	Potency	100.0000	1
4-[[(4-bromo-2-ethyl-3-pyrazolyl)-oxomethyl]amino]benzoic acid propan-2-yl ester	Homo sapiens (human)	Potency	63.0957	1
1-[2,3-bis(2-furanyl)-6-quinoxalinyl]-3-[4-(4-morpholinyl)phenyl]thiourea	Homo sapiens (human)	Potency	35.4813	1
N-[[4-(4-chlorophenoxy)anilino]-sulfanylidenemethyl]benzamide	Homo sapiens (human)	Potency	100.0000	1
4-methoxy-N-[5-(4-methoxyphenyl)-4-(4-nitrophenyl)-2-thiazolyl]benzamide	Homo sapiens (human)	Potency	100.6636	2
N-cycloheptyl-2-[[2-(1,3-dioxo-2-isoindolyl)-1-oxoethyl]amino]benzamide	Homo sapiens (human)	Potency	100.0000	1
N-[3-(1,3-benzothiazol-2-ylthio)-4-hydroxyphenyl]-4-chlorobenzenesulfonamide	Homo sapiens (human)	Potency	112.2020	1
N-[(6-methoxy-2-oxo-1H-quinolin-3-yl)methyl]-N-propan-2-yl-2-furancarboxamide	Homo sapiens (human)	Potency	39.8107	1
[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]-thiophen-2-ylmethanone	Homo sapiens (human)	Potency	39.8107	1
2-[2-(2,4-dichloro-5-propan-2-yloxyanilino)-2-oxoethyl]sulfinyl-N-[3-(trifluoromethyl)phenyl]acetamide	Homo sapiens (human)	Potency	50.1187	1
5-[1-[(4-methylphenyl)methyl]-3-pyrazolyl]-2-phenylthiazole	Homo sapiens (human)	Potency	112.2020	1
3-[4-ethyl-5-[(4-methylphenyl)methylthio]-1,2,4-triazol-3-yl]-1-phenyl-4-pyridazinone	Homo sapiens (human)	Potency	39.8107	1
3-phenyl-2H-1,4-benzoxazine	Homo sapiens (human)	Potency	39.8107	1
2-(benzenesulfonylmethyl)-5-(4-chlorophenyl)cyclohexane-1,3-dione	Homo sapiens (human)	Potency	100.0000	1
3-methyl-N-[oxo-[(2,4,6-trimethyl-3-pyridinyl)amino]methyl]benzamide	Homo sapiens (human)	Potency	89.1251	1
6-fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3-one	Homo sapiens (human)	Potency	35.4813	1
N-[4-(4-fluorophenyl)-2-thiazolyl]-4-methylbenzenesulfonamide	Homo sapiens (human)	Potency	39.8107	1
epalrestat	Homo sapiens (human)	Potency	89.1251	1
1-amino-3-[3-(2-sulfanylidene-3H-1,3,4-oxadiazol-5-yl)phenyl]thiourea	Homo sapiens (human)	Potency	89.1251	1
1-[2-[(4-methyl-2-oxo-1-benzopyran-7-yl)oxy]-1-oxoethyl]-4-phenyl-4-piperidinecarboxylic acid	Homo sapiens (human)	Potency	25.1189	1
chlorogenic acid	Homo sapiens (human)	Potency	31.6228	1
6-[[(4-chlorophenyl)thio]methyl]-2-phenyl-1,7-dihydropyrazolo[3,4-b]pyridine-3,4-dione	Homo sapiens (human)	Potency	56.2341	1
N-(9-ethyl-3-carbazolyl)-2-[[4-ethyl-5-(2-furanyl)-1,2,4-triazol-3-yl]thio]acetamide	Homo sapiens (human)	Potency	35.4813	1
N-[3-(benzenesulfonyl)-1-cyclohexyl-2-pyrrolo[3,2-b]quinoxalinyl]benzenesulfonamide	Homo sapiens (human)	Potency	39.8107	1
(4,7-dichloro-1,3-benzothiazol-2-yl)hydrazine	Homo sapiens (human)	Potency	3.5481	1
3-methyl-4-oxo-1-phthalazinecarboxylic acid [2-(7-ethyl-1H-indol-3-yl)-2-oxoethyl] ester	Homo sapiens (human)	Potency	50.1187	1
N-(4,5-dihydrothiazol-2-yl)-2-thiophen-2-yl-4-quinolinecarboxamide	Homo sapiens (human)	Potency	25.1189	1
2-(2-furanyl)-4-quinolinecarboxylic acid [2-[4-amino-1-methyl-3-(2-methylpropyl)-2,6-dioxo-5-pyrimidinyl]-2-oxoethyl] ester	Homo sapiens (human)	Potency	56.2341	1
2-[[5-[(1,3-benzothiazol-2-ylthio)methyl]-4-ethyl-1,2,4-triazol-3-yl]thio]-1-(3,4-dihydroxyphenyl)ethanone	Homo sapiens (human)	Potency	8.9125	1
1-cyclopropyl-7-[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1-piperazinyl]-6-fluoro-4-oxo-3-quinolinecarboxylic acid	Homo sapiens (human)	Potency	79.4328	1
4,5-dimethoxy-2-[[(2-methoxyanilino)-oxomethyl]amino]benzoic acid methyl ester	Homo sapiens (human)	Potency	25.1189	1
2,6-dichloro-N-[2-(methylthio)-1,3-benzothiazol-6-yl]benzenesulfonamide	Homo sapiens (human)	Potency	39.8107	1
2-[3-[(4-chlorophenyl)-oxomethyl]-6-methoxy-4-oxo-1-quinolinyl]-N-(4-fluorophenyl)acetamide	Homo sapiens (human)	Potency	56.2341	1
2-(2,4-dioxo-1H-pyrimidin-6-yl)-N-[2-(4-morpholinyl)ethyl]acetamide	Homo sapiens (human)	Potency	17.7828	1
2,2,2-trifluoro-N-(5-oxo-1-phenyl-4H-pyrazol-3-yl)acetamide	Homo sapiens (human)	Potency	89.1251	1
2-bromo-N-[3-(1-oxopentylamino)phenyl]benzamide	Homo sapiens (human)	Potency	25.1189	1
N-[4-(dibutylsulfamoyl)phenyl]-2-thiophen-2-ylacetamide	Homo sapiens (human)	Potency	89.1251	1
N-[[(cyclohexylamino)-sulfanylidenemethyl]amino]carbamic acid tert-butyl ester	Homo sapiens (human)	Potency	100.0000	1
6-bromo-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-(2-pyridinyl)-4-quinolinecarboxamide	Homo sapiens (human)	Potency	35.4813	1
N-[[[[4-[(2-methyl-1-oxopropyl)amino]phenyl]-oxomethyl]hydrazo]-sulfanylidenemethyl]-2-thiophenecarboxamide	Homo sapiens (human)	Potency	89.1251	1
2-[[5-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]-4-oxo-2-phenyl-1-benzopyran-7-yl]oxy]acetic acid tert-butyl ester	Homo sapiens (human)	Potency	56.2341	1
2-nitrobenzoic acid [1,1,1,3,3,3-hexafluoro-2-[4-[(4-methylphenyl)sulfonylamino]phenyl]propan-2-yl] ester	Homo sapiens (human)	Potency	11.2202	1
1-(3-chlorophenyl)-3-[2-(thiophen-2-ylsulfonylamino)phenyl]urea	Homo sapiens (human)	Potency	31.6228	1
2-(2-chlorophenyl)-N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-4-quinolinecarboxamide	Homo sapiens (human)	Potency	79.4328	1
2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]thio]-N-(2-furanylmethyl)acetamide	Homo sapiens (human)	Potency	56.2341	1
2-pyridin-4-yl-N-[4-(2-thiazolylsulfamoyl)phenyl]-4-quinolinecarboxamide	Homo sapiens (human)	Potency	79.4328	1
1-(2-fluorophenyl)-1-cyclopentanecarboxylic acid [2-oxo-2-(4-sulfamoylanilino)ethyl] ester	Homo sapiens (human)	Potency	35.4813	1
3-[(4-methyl-1-piperazinyl)sulfonyl]-N-(4-phenyl-2-thiazolyl)benzamide	Homo sapiens (human)	Potency	19.9526	1
(2S)-2-[[(3,5-dimethoxyphenyl)-oxomethyl]amino]-3-methylbutanoic acid [2-[(3-cyano-2-thiophenyl)amino]-2-oxoethyl] ester	Homo sapiens (human)	Potency	89.1251	1
2-[5-(1-pyrrolidinylsulfonyl)-2-thiophenyl]-N-[2-(4-sulfamoylphenyl)ethyl]acetamide	Homo sapiens (human)	Potency	89.1251	1
[4-(2-ethoxyphenyl)-1-piperazinyl]-(1-oxido-4-pyridin-1-iumyl)methanone	Homo sapiens (human)	Potency	28.1838	1
N2-[5-(4-chlorophenyl)-2-phenyl-3-pyrazolyl]benzene-1,2-diamine	Homo sapiens (human)	Potency	89.1251	1
2-phenyl-5-thiophen-2-yl-3-pyrazolecarboxylic acid [2-(3-nitroanilino)-2-oxoethyl] ester	Homo sapiens (human)	Potency	12.5893	1
2-chloro-1-[1-[2-(4-chlorophenyl)ethyl]-2,5-dimethyl-3-pyrrolyl]ethanone	Homo sapiens (human)	Potency	39.8107	1
(2S)-3-methyl-2-[[(3-methylphenyl)-oxomethyl]amino]butanoic acid (4-oxo-2-pyrimido[2,1-b][1,3]benzothiazolyl)methyl ester	Homo sapiens (human)	Potency	14.1254	1
2-[[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]thio]-1-(1H-pyrrol-2-yl)ethanone	Homo sapiens (human)	Potency	100.0000	1
N-(4-tert-butyl-2-thiazolyl)-6-quinoxalinecarboxamide	Homo sapiens (human)	Potency	79.4328	1
2-[(2,3,4-trifluorophenyl)sulfonylamino]acetic acid [2-(3,4-dimethoxyanilino)-2-oxoethyl] ester	Homo sapiens (human)	Potency	100.0000	1
5-[[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)thio]methyl]-2-furancarboxylic acid methyl ester	Homo sapiens (human)	Potency	39.8107	1
4-methyl-N'-(4-quinazolinyl)benzohydrazide	Homo sapiens (human)	Potency	112.2020	1
2-[[(3-methylphenyl)-oxomethyl]amino]benzoic acid (3,5-dimethyl-4-isoxazolyl)methyl ester	Homo sapiens (human)	Potency	112.2020	1
4,5-dichloro-2-[2-[2,5-dimethyl-1-(2,2,2-trifluoroethyl)-3-pyrrolyl]-2-oxoethyl]-3-pyridazinone	Homo sapiens (human)	Potency	100.0000	1
N-[3-(4-morpholinyl)propyl]-3-(3-pyridinyl)-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine	Homo sapiens (human)	Potency	89.1251	1
4-(dimethylsulfamoyl)-N-(3-methylphenyl)benzamide	Homo sapiens (human)	Potency	39.8107	1
N-[2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]-2-fluorobenzamide	Homo sapiens (human)	Potency	3.9811	1
3-(diethylsulfamoyl)-N-(3,5-dimethylphenyl)benzamide	Homo sapiens (human)	Potency	50.1187	1
Pregnenolone acetate	Homo sapiens (human)	Potency	112.2020	1
2-(1-piperidinyl)-6-thiophen-2-yl-4-(trifluoromethyl)-3-pyridinecarbonitrile	Homo sapiens (human)	Potency	35.4813	1
N-(7-methoxy-4,5-dihydrobenzo[e][1,3]benzothiazol-2-yl)-2-furancarboxamide	Homo sapiens (human)	Potency	39.8107	1
1-[[2-[5-[3,5-bis(trifluoromethyl)phenyl]-2-tetrazolyl]-1-oxoethyl]amino]-3-(4-chlorophenyl)thiourea	Homo sapiens (human)	Potency	79.4328	2
3-(tert-butyl)-1-methyl-4,5-dihydro-1H-pyrazol-5-one	Homo sapiens (human)	Potency	79.4328	1
3-(tert-butylsulfamoyl)-4-phenyl-5-(trifluoromethyl)-2-thiophenecarboxylic acid methyl ester	Homo sapiens (human)	Potency	8.9125	1
5-oxo-3-(4-phenylphenyl)-2H-furan-4-carbonitrile	Homo sapiens (human)	Potency	56.2341	1
2-chloro-N-(7-methyl-9-oxo-2-thioxanthenyl)benzamide	Homo sapiens (human)	Potency	89.1251	1
LSM-20838	Homo sapiens (human)	Potency	39.8107	1
2-[bis(2-methylpropoxy)phosphoryl]-3,3,3-trifluoro-2-[(4-methylphenyl)sulfonylamino]propanoic acid ethyl ester	Homo sapiens (human)	Potency	56.2341	1
ssya10-001	Homo sapiens (human)	Potency	44.6684	1
2-[[2-[[5-(4-tert-butylphenyl)-2-methoxycarbonyl-3-thiophenyl]amino]-2-oxoethyl]thio]acetic acid	Homo sapiens (human)	Potency	79.4328	1
5-tert-butyl-N-[5-(dimethylsulfamoyl)-2-methylphenyl]-2-(phenylmethyl)-3-pyrazolecarboxamide	Homo sapiens (human)	Potency	100.0000	1
N-(4-cyano-1-phenyl-1H-pyrazol-5-yl)-2-(4-methylpiperazino)acetamide	Homo sapiens (human)	Potency	89.1251	1
3-(2,4-dimethoxyphenyl)-6-phenyl-2-sulfanylidene-1H-thieno[2,3-d]pyrimidin-4-one	Homo sapiens (human)	Potency	79.4328	1
2-{5-[2-(Phenylthio)acetyl]-2-thienyl}acetic acid	Homo sapiens (human)	Potency	79.4328	1
2-(2-furanyl)-4-thiazolidinecarboxylic acid	Homo sapiens (human)	Potency	70.7946	1
1-anilino-3-[4-(3-anilino-2-hydroxypropoxy)phenoxy]-2-propanol	Homo sapiens (human)	Potency	10.0000	1
1-(1-benzotriazolyl)-3-(10-phenothiazinyl)-2-propanol	Homo sapiens (human)	Potency	50.1187	1
N-[3-(2-furanyl)-3-phenylpropyl]-4-methylbenzenesulfonamide	Homo sapiens (human)	Potency	100.0000	1
2-(3-hydroxyphenyl)-6-(1-piperidinyl)benzo[de]isoquinoline-1,3-dione	Homo sapiens (human)	Potency	37.6188	2
1-[4-(3,4-dihydroxyphenyl)-6-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidin-5-yl]ethanone	Homo sapiens (human)	Potency	56.2341	1
4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1h-pyrazol-1-yl)benzenesulfonamide	Homo sapiens (human)	Potency	7.0795	1
1-(1,3-benzodioxol-5-yl)-3-(5-tert-butyl-2-methoxyphenyl)urea	Homo sapiens (human)	Potency	112.2020	1
4-fluoro-N-[3-[2-nitro-4-(trifluoromethyl)anilino]propyl]benzamide	Homo sapiens (human)	Potency	56.2341	1
1-[4-[4-[[6-bromo-2-(3-pyridinyl)-4-quinolinyl]-oxomethyl]-1-piperazinyl]phenyl]ethanone	Homo sapiens (human)	Potency	89.1251	1
2-[[(4-chlorophenyl)thio]methyl]-5-methylimidazo[1,2-a]pyridine	Homo sapiens (human)	Potency	100.0000	1
5-bromo-N-[1-(2,5-dimethylphenyl)ethyl]-2-furancarboxamide	Homo sapiens (human)	Potency	3.1623	1
N-[3-chloro-2-(1-piperidinyl)phenyl]-4-(4-morpholinyl)-3-nitrobenzamide	Homo sapiens (human)	Potency	22.3872	1
5-(2-nitrophenyl)-N-(2-thiazolyl)-2-furancarboxamide	Homo sapiens (human)	Potency	100.0000	1
2-cyano-N-(phenylmethyl)-2-[3-(1-pyrrolidinyl)-2-quinoxalinyl]acetamide	Homo sapiens (human)	Potency	79.4328	1
1-(benzenesulfonyl)-2-benzimidazolamine	Homo sapiens (human)	Potency	14.1254	1
1-(4-nitrophenyl)sulfonyl-2-benzimidazolamine	Homo sapiens (human)	Potency	5.0119	1
orlistat	Homo sapiens (human)	Potency	89.1251	1
asterric acid	Homo sapiens (human)	Potency	28.1838	1
n-methylnandigerine	Homo sapiens (human)	Potency	5.6234	1
n-(2-naphthalene)sulfonyl-dl-tryptophan	Homo sapiens (human)	Potency	28.1838	1
9-hydroxyiminofluorene-2,7-disulfonamide	Homo sapiens (human)	Potency	50.1187	1
4-methyl-2-[3-methyl-4-(3-methylphenyl)azo-5-oxo-4H-pyrazol-1-yl]-5-thiazolecarboxylic acid ethyl ester	Homo sapiens (human)	Potency	3.5481	1
2-[(4-chlorophenyl)-[2-[5-(4-chlorophenyl)-2-thiazolyl]-5-methyl-3-oxo-1H-pyrazol-4-yl]methyl]propanedinitrile	Homo sapiens (human)	Potency	39.8107	1
5-methyl-N-(3-methylphenyl)-4-nitro-1H-pyrazol-3-amine	Homo sapiens (human)	Potency	2.8184	1
4-[[3-[(4-methylanilino)-oxomethyl]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl]amino]-4-oxobutanoic acid	Homo sapiens (human)	Potency	39.8107	1
3-nitro-N-(pyridin-4-ylmethyl)benzenesulfonamide	Homo sapiens (human)	Potency	100.0000	1
N'-(9-acridinyl)-2-hydroxybenzohydrazide	Homo sapiens (human)	Potency	56.2341	1
3-[5-[bis(3-methyl-5-oxo-1,2-dihydropyrazol-4-yl)methyl]-2-furanyl]benzoic acid methyl ester	Homo sapiens (human)	Potency	2.8184	1
1,6-dimethyl-3-propylpyrimido[5,4-e][1,2,4]triazine-5,7-dione	Homo sapiens (human)	Potency	14.1254	1
N1-butan-2-yl-N4-[2-(3,4-dimethoxyphenyl)ethyl]-N4-(thiophen-2-ylmethyl)benzene-1,4-disulfonamide	Homo sapiens (human)	Potency	112.2020	1
CID 3192987	Homo sapiens (human)	Potency	39.8107	1
4-(2-fluorophenyl)-1-[[1-[(4-methoxyphenyl)methyl]-5-tetrazolyl]methyl]-4-piperidinol	Homo sapiens (human)	Potency	100.0000	1
N-[2-(3-fluorophenyl)-5-phenyl-7-pyrazolo[1,5-a]pyrimidinyl]-N',N'-dimethylpropane-1,3-diamine	Homo sapiens (human)	Potency	39.8107	1
2-[[5-(6-methyl-1H-benzimidazol-2-yl)-2-pyridinyl]thio]-N-(4-methyl-2-thiazolyl)acetamide	Homo sapiens (human)	Potency	89.1251	1
6-(2-chlorophenyl)-N-(2-furanylmethyl)-N-methyl-4-quinazolinamine	Homo sapiens (human)	Potency	89.1251	1
5-amino-1-[2-(2-ethoxyanilino)-2-oxoethyl]-N-(2-furanylmethyl)-4-triazolecarboxamide	Homo sapiens (human)	Potency	35.4813	1
2-(6-benzimidazolo[1,2-c]quinazolinylthio)-N-(2-furanylmethyl)acetamide	Homo sapiens (human)	Potency	89.1251	1
LSM-18934	Homo sapiens (human)	Potency	63.0957	1
5-bromo-2-thiophenecarboxylic acid 1,3-benzothiazol-2-ylmethyl ester	Homo sapiens (human)	Potency	100.0000	1
N,N-diethyl-4-[[5-oxo-6-(phenylmethyl)-7H-pyrrolo[3,4-b]pyridin-7-yl]amino]benzenesulfonamide	Homo sapiens (human)	Potency	100.0000	1
[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-(7-methoxy-2-furo[2,3-b]quinolinyl)methanone	Homo sapiens (human)	Potency	56.2341	1
7-(5-chloro-2-methoxyanilino)-6-[(4-methoxyphenyl)methyl]-7H-pyrrolo[3,4-b]pyridin-5-one	Homo sapiens (human)	Potency	50.1187	1
N-(3,4-dimethylphenyl)-2-[N-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]-4-methoxyanilino]acetamide	Homo sapiens (human)	Potency	15.8489	1
3-(4-methylphenyl)-N-phenyl-1-pyrrolidinecarboxamide	Homo sapiens (human)	Potency	35.4813	1
N-cyclopentyl-4-(3,4-dimethoxyphenyl)-6-(trifluoromethyl)-2-pyrimidinamine	Homo sapiens (human)	Potency	14.1254	1
2,5-dimethyl-N-[(S)-[(1S,2R)-1-methyl-2-[(2R)-1-(2-naphthalenylamino)-1-oxopropan-2-yl]cyclopropyl]-phenylmethyl]-3-pyrazolecarboxamide	Homo sapiens (human)	Potency	44.6684	1
3-(2-furanyl)-N-[3-(2-furanyl)-4-methylpentyl]-4-phenylbutanamide	Homo sapiens (human)	Potency	79.4328	1
5-nitro-2-thiophenecarboxylic acid [2-oxo-2-(1-phenylethylamino)ethyl] ester	Homo sapiens (human)	Potency	112.2020	1
2-[(1-oxo-3-phenylpropyl)amino]-3-thiophenecarboxylic acid methyl ester	Homo sapiens (human)	Potency	50.1187	1
1-(6-methyl-2-pyridinyl)-3-[3-(trifluoromethyl)phenyl]thiourea	Homo sapiens (human)	Potency	79.4328	1
N-(4-methoxyphenyl)-2-(N-methylanilino)-2-(6-nitro-1,3-benzodioxol-5-yl)acetamide	Homo sapiens (human)	Potency	28.1838	1
N-[4-(difluoromethoxy)phenyl]-4-(phenylmethyl)-1-piperazinecarbothioamide	Homo sapiens (human)	Potency	2.8184	1
2-amino-7-methyl-4-(5-nitro-2-furanyl)-5-oxo-4H-pyrano[3,2-c]pyran-3-carbonitrile	Homo sapiens (human)	Potency	79.4328	1
2-[(5-chloro-1,3-benzothiazol-2-yl)thio]-N-[3-(4-morpholinylsulfonyl)phenyl]propanamide	Homo sapiens (human)	Potency	89.1251	1
2-[[3-(2-methoxyethyl)-6-methyl-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]thio]-N-(2-oxolanylmethyl)acetamide	Homo sapiens (human)	Potency	100.0000	1
7,8-Dihydroxy-3,7-dimethyl-6-oxo-7,8-dihydro-6H-isochromene-5-carbaldehyde	Homo sapiens (human)	Potency	94.5626	2
1-(Chloroacetyl)-3-(1H-indol-3-yl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-4-ol	Homo sapiens (human)	Potency	50.1187	1
1-(4-butylphenyl)-3-[4-chloro-3-(dimethylsulfamoyl)phenyl]thiourea	Homo sapiens (human)	Potency	100.0000	1
N-cycloheptyl-4-(2-oxolanylmethoxy)benzamide	Homo sapiens (human)	Potency	17.7828	1
4-(4-chlorophenyl)-N-[3-[(4-methoxyphenyl)sulfamoyl]phenyl]-4-oxobutanamide	Homo sapiens (human)	Potency	89.1251	1
2-methyl-5-[(4-phenyl-1-piperazinyl)-(3,4,5-trimethoxyphenyl)methyl]-6-thiazolo[3,2-b][1,2,4]triazolol	Homo sapiens (human)	Potency	28.1838	2
2-[4-[(4-chlorophenyl)-oxomethyl]-2,3-dihydro-1,4-benzoxazin-3-yl]acetic acid methyl ester	Homo sapiens (human)	Potency	100.0000	1
6-bromo-1-(dibromomethyl)-5,5-dimethyl-N-(6-methyl-2-pyridinyl)-4-bicyclo[2.1.1]hexanecarboxamide	Homo sapiens (human)	Potency	22.3872	1
8-[[4-[2-furanyl(oxo)methyl]-1-piperazinyl]methyl]-1,3-dimethyl-7-propylpurine-2,6-dione	Homo sapiens (human)	Potency	31.6228	1
1-(phenylmethyl)-3-(1,2,3,4-tetrahydronaphthalen-1-yl)thiourea	Homo sapiens (human)	Potency	3.5481	1
3-methyl-2-methylene-1,5-diphenylpentane-1,5-dione	Homo sapiens (human)	Potency	79.4328	1
1-ethyl-3-[[2-[(1-methyl-2-benzimidazolyl)thio]-1-oxoethyl]amino]thiourea	Homo sapiens (human)	Potency	3.5481	1
4-(5-bromo-2-thiophenyl)-6-methyl-2-(1-pyrrolyl)pyrimidine	Homo sapiens (human)	Potency	89.1251	1
4-(2-methylcyclohexyl)-3-(3-pyridinyl)-1H-1,2,4-triazole-5-thione	Homo sapiens (human)	Potency	100.0000	1
3-benzoyl-1,5-bis(2-methoxyphenyl)-3a,6a-dihydropyrrolo[3,4-c]pyrazole-4,6-dione	Homo sapiens (human)	Potency	112.2020	1
2-Chloro-1-[5-(3,4-dimethoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one	Homo sapiens (human)	Potency	2.8184	1
LSM-31277	Homo sapiens (human)	Potency	100.0000	1
4-[(2-hydroxy-3-nitrophenyl)-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methyl]-5-methyl-2-phenyl-1H-pyrazol-3-one	Homo sapiens (human)	Potency	56.2341	1
N-(2-chlorophenyl)-4-[[(2-methoxy-4-nitroanilino)-sulfanylidenemethyl]hydrazo]-4-oxobutanamide	Homo sapiens (human)	Potency	100.0000	1
1-(Chloroacetyl)-5-[4-(difluoromethoxy)-3-methoxyphenyl]-3-thien-2-yl-4,5-dihydro-1H-pyrazole	Homo sapiens (human)	Potency	89.1251	1
or486	Homo sapiens (human)	Potency	100.0000	1
2-[(4-hydroxy-3-nitrophenyl)sulfonylamino]benzoic acid [2-(4-methoxyphenyl)-2-oxoethyl] ester	Homo sapiens (human)	Potency	56.2341	1
N-(3,5-dichloro-2-pyridinyl)-2-[(4-methyl-2-quinolinyl)thio]propanamide	Homo sapiens (human)	Potency	2.8184	1
1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-piperidinecarboxylic acid [2-[2-chloro-5-(trifluoromethyl)anilino]-2-oxoethyl] ester	Homo sapiens (human)	Potency	35.4813	1
N-[4-[cyano-[3-(3-hydroxypropylamino)-2-quinoxalinyl]methyl]sulfonylphenyl]acetamide	Homo sapiens (human)	Potency	100.0000	1
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-2-(3-pyridinyl)ethyl]-2-thiophenesulfonamide	Homo sapiens (human)	Potency	35.4813	1
2-[[2-[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]-1-oxo-5-isoquinolinyl]oxy]propanoic acid ethyl ester	Homo sapiens (human)	Potency	56.2341	1
2-[(6-methyl-4-spiro[3,4-dihydro-2H-1-benzopyran-2,1'-cyclopentane]yl)thio]-N-(2-phenylethyl)acetamide	Homo sapiens (human)	Potency	50.1187	1
N-[3-[3-(1-piperidinylsulfonyl)anilino]-2-quinoxalinyl]benzenesulfonamide	Homo sapiens (human)	Potency	100.0000	1
4-(1-phenylethyl)-3-(5-propyl-3-thiophenyl)-1H-1,2,4-triazole-5-thione	Homo sapiens (human)	Potency	56.2341	1
4-(3,4-dimethylphenyl)-3-(5-methyl-3-isoxazolyl)-1H-1,2,4-triazole-5-thione	Homo sapiens (human)	Potency	79.4328	1
5-methyl-4-[(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-(3-nitrophenyl)methyl]-2-phenyl-1H-pyrazol-3-one	Homo sapiens (human)	Potency	100.0000	1
1-(5-methyl-2-furanyl)-2-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)-1H-[1]benzopyrano[2,3-c]pyrrole-3,9-dione	Homo sapiens (human)	Potency	31.6228	1
6-amino-5-cyano-2-[[(3-cyano-6-methyl-7,8-dihydro-5H-1,6-naphthyridin-2-yl)thio]methyl]-4-(4-fluorophenyl)-4H-pyran-3-carboxylic acid methyl ester	Homo sapiens (human)	Potency	89.1251	1
5-methyl-4-[(3-methyl-5-oxo-1,2-dihydropyrazol-4-yl)-[1-(1-naphthalenylmethyl)-3-indolyl]methyl]-1,2-dihydropyrazol-3-one	Homo sapiens (human)	Potency	89.1251	1
3-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-4-thiazolidinone	Homo sapiens (human)	Potency	56.2341	1
1-(5-nitro-2-thiophenyl)piperidine	Homo sapiens (human)	Potency	70.7946	1
N-[2-(2,4,6-trinitrophenyl)ethyl]aniline	Homo sapiens (human)	Potency	39.8107	1
2-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]thio]-N-(9,10-dioxo-2-anthracenyl)acetamide	Homo sapiens (human)	Potency	89.1251	1
2-furanyl-[4-[(6-hydroxy-2-methyl-5-thiazolo[3,2-b][1,2,4]triazolyl)-thiophen-2-ylmethyl]-1-piperazinyl]methanone	Homo sapiens (human)	Potency	28.1838	1
3-(2-methylphenyl)-2-(2-thiazolyl)-5,6,7,7a-tetrahydro-3H-pyrrolo[1,2-c]imidazol-1-one	Homo sapiens (human)	Potency	39.8107	1
6-(2,3-dihydro-1,4-benzodioxin-3-yl)-3-(phenoxymethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Homo sapiens (human)	Potency	50.1187	1
N2,N6-bis[4-(dimethylamino)phenyl]pyridine-2,6-dicarboxamide	Homo sapiens (human)	Potency	10.0000	1
2-Chloro-1-[3-(4-methylphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone	Homo sapiens (human)	Potency	89.1251	1
2,6-difluoro-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide	Homo sapiens (human)	Potency	89.1251	1
3-amino-4-[(4-chlorophenyl)thio]benzoic acid methyl ester	Homo sapiens (human)	Potency	89.1251	1
N-[3-(1-azepanylsulfonyl)phenyl]-2-[4-(1H-indol-3-ylmethyl)-2,5-dioxo-1-imidazolidinyl]acetamide	Homo sapiens (human)	Potency	100.0000	1
5-nitro-2-thiophenecarboxylic acid [2-oxo-2-[(phenylmethyl)amino]ethyl] ester	Homo sapiens (human)	Potency	79.4328	1
4-(1-azepanylsulfonyl)-N-[5-[(4-chlorophenyl)sulfamoyl]-2-hydroxyphenyl]benzamide	Homo sapiens (human)	Potency	28.1838	1
5-ethoxy-3-methyl-2-benzofurancarboxylic acid [1-(carbamoylamino)-3-methyl-1-oxobutan-2-yl] ester	Homo sapiens (human)	Potency	44.6684	1
5-nitro-2-thiophenecarboxylic acid [2-oxo-2-[[oxo-[(phenylmethyl)amino]methyl]amino]ethyl] ester	Homo sapiens (human)	Potency	50.1187	1
2-[(2,6-dichlorophenyl)sulfonylamino]-3-methylbutanoic acid [2-(1H-indol-3-yl)-2-oxoethyl] ester	Homo sapiens (human)	Potency	28.1838	1
2-[(2-chlorophenyl)methoxy]-N-(4,5-dihydrothiazol-2-yl)benzamide	Homo sapiens (human)	Potency	100.0000	1
3,7-dichloro-N-[3-(1-imidazolyl)propyl]-6-methoxy-1-benzothiophene-2-carboxamide	Homo sapiens (human)	Potency	25.1189	1
2-(2-chloro-4-methylanilino)-N-[3-(dimethylsulfamoyl)phenyl]acetamide	Homo sapiens (human)	Potency	5.6234	1
5-nitro-N-[(4-propan-2-ylphenyl)methyl]-2-pyridinamine	Homo sapiens (human)	Potency	100.0000	1
2-[8-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-1,3-dimethyl-2,6-dioxo-7-purinyl]acetic acid methyl ester	Homo sapiens (human)	Potency	44.9647	2
2-(2',5'-dioxo-1'-spiro[3,4-dihydro-2H-1-benzopyran-4,4'-imidazolidine]yl)-N-[4-[ethyl(propan-2-yl)amino]phenyl]acetamide	Homo sapiens (human)	Potency	89.1251	1
3-[1-butyl-5-(diethylsulfamoyl)-2-benzimidazolyl]propanoic acid	Homo sapiens (human)	Potency	89.1251	1
N-(4-methoxyphenyl)sulfonyl-N-(2-oxo-5-benzo[g][1,3]benzoxathiolyl)-2-furancarboxamide	Homo sapiens (human)	Potency	89.1251	1
2-[2-(7-methoxy-2-oxo-1H-quinolin-3-yl)ethyl]isoindole-1,3-dione	Homo sapiens (human)	Potency	70.7946	1
1-[2-[(4-pentoxyphenyl)methylthio]ethyl]-3-phenylthiourea	Homo sapiens (human)	Potency	100.0000	1
1-[4-chloro-3-(4-morpholinylsulfonyl)phenyl]-3-phenylurea	Homo sapiens (human)	Potency	10.0000	1
[5-[(3,5-dimethyl-4-nitro-1-pyrazolyl)methyl]-2-furanyl]-[5-hydroxy-3-methyl-5-(trifluoromethyl)-4H-pyrazol-1-yl]methanone	Homo sapiens (human)	Potency	125.8920	1
5,6-dimethyl-1-octyl-4-benzimidazolamine	Homo sapiens (human)	Potency	79.4328	1
4-tert-butyl-N-[3-[4-[3-[[(4-tert-butylphenyl)-oxomethyl]amino]propyl]-1-piperazinyl]propyl]benzamide	Homo sapiens (human)	Potency	79.4328	1
bergaptol	Homo sapiens (human)	Potency	89.1251	1
luteolin	Homo sapiens (human)	Potency	44.6684	1
vitamin k semiquinone radical	Homo sapiens (human)	Potency	79.4328	1
retinol palmitate	Homo sapiens (human)	Potency	39.8107	1
luteolin-7-glucoside	Homo sapiens (human)	Potency	12.5893	1
quercetin 3-o-methyl ether	Homo sapiens (human)	Potency	31.6228	1
vitamin d 2	Homo sapiens (human)	Potency	7.9433	1
sulfuretin	Homo sapiens (human)	Potency	79.4328	1
daphnoretin	Homo sapiens (human)	Potency	64.7758	2
amentoflavone	Homo sapiens (human)	Potency	70.7946	1
baicalein	Homo sapiens (human)	Potency	31.6228	1
morusin	Homo sapiens (human)	Potency	56.2341	1
myricetin	Homo sapiens (human)	Potency	15.8489	1
myricitrin	Homo sapiens (human)	Potency	89.1251	1
wogonin	Homo sapiens (human)	Potency	125.8920	1
acteoside	Homo sapiens (human)	Potency	63.0957	1
ellagic acid	Homo sapiens (human)	Potency	10.0000	1
tectochrysin	Homo sapiens (human)	Potency	39.8107	1
astragalin	Homo sapiens (human)	Potency	39.8107	1
n-oleoyldopamine	Homo sapiens (human)	Potency	45.3736	2
menatetrenone	Homo sapiens (human)	Potency	7.0795	1
indocyanine green	Homo sapiens (human)	Potency	28.1838	1
prostaglandin f2 methyl ester	Homo sapiens (human)	Potency	50.1187	1
cyclosporine	Homo sapiens (human)	Potency	2.5119	1
phenoxybenzamine hydrochloride	Homo sapiens (human)	Potency	112.2020	1
acitretin	Homo sapiens (human)	Potency	70.7946	1
estropipate	Homo sapiens (human)	Potency	22.3872	1
vitamin k 1	Homo sapiens (human)	Potency	56.2341	1
fenretinide	Homo sapiens (human)	Potency	56.2341	1
2-(5-methyl-4,5,6,7-tetrahydroindazol-2-yl)-N-[3-(2-oxo-1-pyrrolidinyl)propyl]acetamide	Homo sapiens (human)	Potency	89.1251	1
3,4-dihydro-1H-isoquinolin-2-yl-(4-ethyl-5-thieno[3,2-b]pyrrolyl)methanone	Homo sapiens (human)	Potency	7.0795	1
2-[[oxo-(5-propyl-3-isoxazolyl)methyl]amino]benzoic acid methyl ester	Homo sapiens (human)	Potency	14.1254	1
1-[[2-(3-chlorophenyl)-5-methyl-4-oxazolyl]methyl]-N-[1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]-3-piperidinecarboxamide	Homo sapiens (human)	Potency	89.1251	1
N-[3-[4-(2,5-dimethylphenyl)-1-piperazinyl]propyl]-2-(6-methyl-3-oxo-4H-1,4-benzoxazin-2-yl)acetamide	Homo sapiens (human)	Potency	100.0000	1
N-[4-[(4-methyl-1-piperidinyl)methyl]phenyl]-1-[5-(1-pyrrolyl)-1,3,4-thiadiazol-2-yl]-4-piperidinecarboxamide	Homo sapiens (human)	Potency	31.6228	1
5-[(4-methoxyphenyl)sulfonylmethyl]-N-(3-methoxypropyl)-2-furancarboxamide	Homo sapiens (human)	Potency	89.1251	1
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[[4-(4-fluorophenyl)-5-[(1-methyl-2-pyrrolyl)methyl]-1,2,4-triazol-3-yl]thio]acetamide	Homo sapiens (human)	Potency	89.1251	1
5-amino-1-[(3-methoxyphenyl)methyl]-N-(4-methylphenyl)-4-triazolecarboxamide	Homo sapiens (human)	Potency	56.2341	1
6-[2-oxo-2-(4-phenyl-1-piperazinyl)ethyl]-3-(phenylmethyl)-7-triazolo[4,5-d]pyrimidinone	Homo sapiens (human)	Potency	15.8489	1
1,3-dimethyl-2,4-dioxo-N-(4-propan-2-ylphenyl)-5-pyrimidinesulfonamide	Homo sapiens (human)	Potency	31.6228	1
6-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]-3-(4-ethoxyphenyl)-7-triazolo[4,5-d]pyrimidinone	Homo sapiens (human)	Potency	50.1187	1
su 6656	Homo sapiens (human)	Potency	31.6228	1
salazinic acid	Homo sapiens (human)	Potency	31.6228	1
4-[(3aR,4S,9bS)-8-[(4-methoxyphenyl)sulfamoyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid	Homo sapiens (human)	Potency	15.8489	1
ag 538	Homo sapiens (human)	Potency	8.9125	1
tyrphostin ag 555	Homo sapiens (human)	Potency	31.6228	1
ag 183	Homo sapiens (human)	Potency	89.1251	1
semaxinib	Homo sapiens (human)	Potency	15.8489	1
5,7-dihydroxy-4-methylcoumarin	Homo sapiens (human)	Potency	100.0000	1
cefixime	Homo sapiens (human)	Potency	70.7946	1
thunberginol b	Homo sapiens (human)	Potency	79.4328	1
vx680	Homo sapiens (human)	Potency	39.8107	1
quinaldine red	Homo sapiens (human)	Potency	70.7946	1
2-(dimethylaminostyryl)-1-ethylpyridinium	Homo sapiens (human)	Potency	50.1187	1
chloride of pseudoisocyanine	Homo sapiens (human)	Potency	56.2341	1
[4-(3-chlorophenyl)sulfonyl-3-nitrophenyl]-[4-(2-pyridinyl)-1-piperazinyl]methanone	Homo sapiens (human)	Potency	100.0000	1
2-[[5,6-bis(2-furanyl)-1,2,4-triazin-3-yl]thio]-1-(4-methoxyphenyl)ethanone	Homo sapiens (human)	Potency	50.1187	1
2-[[5,6-bis(2-furanyl)-1,2,4-triazin-3-yl]thio]-N-(3-methylphenyl)acetamide	Homo sapiens (human)	Potency	31.6228	1
N-(3-methylphenyl)-4-[4-(4-morpholinyl)-3-nitrophenyl]-1-phthalazinamine	Homo sapiens (human)	Potency	35.4813	1
hesperidin	Homo sapiens (human)	Potency	125.8920	1
lasalocid sodium	Homo sapiens (human)	Potency	63.0957	1
sclerotiorin	Homo sapiens (human)	Potency	50.1187	1
chaetoglobosin A	Homo sapiens (human)	Potency	89.1251	1
kolavenic acid	Homo sapiens (human)	Potency	44.6684	1
fomene	Homo sapiens (human)	Potency	25.1189	1
1-(2-methoxy-5-methylphenyl)-3-pyridin-4-ylurea	Homo sapiens (human)	Potency	100.0000	1
N-[3-(7-methyl-2-imidazo[1,2-a]pyridinyl)phenyl]-2-thiophenecarboxamide	Homo sapiens (human)	Potency	100.0000	1
2-methyl-5-[(2-oxo-1H-benzo[cd]indol-6-yl)sulfonylamino]-3-benzofurancarboxylic acid butyl ester	Homo sapiens (human)	Potency	50.1187	1
2-[[6-[(5-chloro-2,4-dimethoxyanilino)-oxomethyl]-1,2,3,4-tetrahydroacridin-9-yl]thio]acetic acid	Homo sapiens (human)	Potency	89.1251	1
(2R,4R)-4-(1-acetyl-3-indolyl)-2-[[4-(hydroxymethyl)phenyl]methoxy]-N-(phenylmethyl)-3,4-dihydro-2H-pyran-6-carboxamide	Homo sapiens (human)	Potency	100.0000	1
13-epi-sclareol	Homo sapiens (human)	Potency	112.2020	1
N-(5-methyl-3-isoxazolyl)-2-[[6-(4-methylphenyl)-3-pyridazinyl]thio]acetamide	Homo sapiens (human)	Potency	100.0000	1
n-(4-methylthiazol-2-yl)-2-(6-phenylpyridazin-3-ylthio)acetamide	Homo sapiens (human)	Potency	70.7946	1
4-[[[4-[(4-fluorophenyl)methyl]-2,3-dihydro-1,4-benzothiazin-6-yl]-oxomethyl]amino]-1-piperidinecarboxylic acid ethyl ester	Homo sapiens (human)	Potency	100.0000	1
N-(1,3-benzodioxol-5-yl)-2-(4-methylphenyl)-3-imidazo[1,2-a]pyrazinamine	Homo sapiens (human)	Potency	79.4328	1
6-[(2-fluorophenyl)methyl]-5-methyl-N-(3-methylbutyl)-7-oxo-1H-pyrazolo[1,5-a]pyrimidine-3-carboxamide	Homo sapiens (human)	Potency	17.7828	1
qx-314 bromide	Homo sapiens (human)	Potency	19.9526	1
(S)-fluoxetine hydrochloride	Homo sapiens (human)	Potency	35.4813	1
lissamine rhodamine b	Homo sapiens (human)	Potency	81.5478	2
1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	Homo sapiens (human)	Potency	56.2341	1
garcinone e	Homo sapiens (human)	Potency	56.2341	1
biapigenin	Homo sapiens (human)	Potency	56.2341	1
chromazonarol	Homo sapiens (human)	Potency	45.8577	2
calcimycin	Homo sapiens (human)	Potency	46.7791	2
2-hydroxyapomorphine, (r)-isomer	Homo sapiens (human)	Potency	35.4813	1
4-iodoclonidine	Homo sapiens (human)	Potency	100.0000	1
N-[5-[2-(5-chloro-2-methylanilino)-4-thiazolyl]-4-methyl-2-thiazolyl]heptanamide	Homo sapiens (human)	Potency	100.0000	1
[5-Chloranyl-3-[(1E,3E)-3,5-dimethylhepta-1,3-dienyl]-7-methyl-6,8-bis(oxidanylidene)isochromen-7-yl] ethanoate	Homo sapiens (human)	Potency	79.4328	1
2-diethylaminoethyl 4-nitrobenzoate hydrochloride	Homo sapiens (human)	Potency	39.8107	1
(3E,9E)-5,6-Dihydroxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-3,9,12-triene-2,18-dione	Homo sapiens (human)	Potency	89.1251	1
dehydrocurvularin	Homo sapiens (human)	Potency	50.1187	1
malyngamide A	Homo sapiens (human)	Potency	89.1251	1
3,6-diamino-10-methylacridinium chloride hydrochloride	Homo sapiens (human)	Potency	59.6649	2
microcolin a	Homo sapiens (human)	Potency	22.1060	2
[4-(diphenylmethyl)-1-piperazinyl]-(5-methyl-4-nitro-3-isoxazolyl)methanone	Homo sapiens (human)	Potency	89.1251	1
5-chloro-2-[(3-methylphenyl)methylsulfonyl]-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)-4-pyrimidinecarboxamide	Homo sapiens (human)	Potency	100.0000	1
3-[3,5-dimethyl-1-[6-(1-piperidinyl)-3-pyridazinyl]-4-pyrazolyl]-N-(3-fluoro-4-methylphenyl)propanamide	Homo sapiens (human)	Potency	100.0000	1
5-methyl-5-pentyl-2-phenyl-1,2,4-triazolidine-3-thione	Homo sapiens (human)	Potency	25.1189	1
2-[4-[(6-ethoxy-2-quinolinyl)methyl]-1-(3-thiophenylmethyl)-2-piperazinyl]ethanol	Homo sapiens (human)	Potency	79.4328	1
GS4012	Homo sapiens (human)	Potency	44.6684	1
1-butyl-3-[2-(4-ethyl-1-piperazinyl)-4-methyl-6-quinolinyl]-1-methylthiourea	Homo sapiens (human)	Potency	2.8184	1
7-methyltryptamine hydrochloride	Homo sapiens (human)	Potency	10.0000	1
2-[6-[(2-fluorophenyl)methyl]-5,7-dimethyl-4-oxo-3-pyrrolo[3,4-d]pyridazinyl]-N-(2,3,5,6-tetrafluorophenyl)acetamide	Homo sapiens (human)	Potency	39.8107	1
(2S)-4-methyl-2-[[oxo-[5-[oxo-[(phenylmethyl)amino]methyl]-1H-imidazol-4-yl]methyl]amino]pentanoic acid tert-butyl ester	Homo sapiens (human)	Potency	50.1187	1
(2S)-2-[[[5-[[5-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]pentylamino]-oxomethyl]-1H-imidazol-4-yl]-oxomethyl]amino]propanoic acid tert-butyl ester	Homo sapiens (human)	Potency	31.6228	1
(2S)-4-methyl-2-[[oxo-[5-[oxo-[(phenylmethyl)amino]methyl]-1H-imidazol-4-yl]methyl]amino]pentanoic acid (phenylmethyl) ester	Homo sapiens (human)	Potency	28.1838	1
quercetin	Homo sapiens (human)	Potency	7.0795	1
[5-(4-bromophenyl)-3-(2-hydroxyphenyl)-3,4-dihydropyrazol-2-yl]-pyridin-4-ylmethanone	Homo sapiens (human)	Potency	79.4328	1
5-chloro-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-(phenylmethyl)sulfonyl-4-pyrimidinecarboxamide	Homo sapiens (human)	Potency	79.4328	1
xi-3-Hydroxy-5-phenylpentanoic acid O-beta-D-Glucopyranoside	Homo sapiens (human)	Potency	39.8107	1
6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde	Homo sapiens (human)	Potency	70.7946	1
2-amino-N-[3-methoxy-5-[oxo-[3-(trifluoromethyl)anilino]methyl]phenyl]-4-pyridinecarboxamide	Homo sapiens (human)	Potency	70.7946	1
4-[[[5-[[[(2S)-1-[(2-methylpropan-2-yl)oxy]-6-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-1-oxohexan-2-yl]amino]-oxomethyl]-1H-imidazol-4-yl]-oxomethyl]amino]benzoic acid ethyl ester	Homo sapiens (human)	Potency	50.1187	1
1-[1-(4-butan-2-ylphenyl)ethyl]-3-[(4-fluorophenyl)methyl]thiourea	Homo sapiens (human)	Potency	112.2020	1
N-(3-acetylphenyl)-5-(3-methyl-5-isoxazolyl)-2-thiophenesulfonamide	Homo sapiens (human)	Potency	89.1251	1
2-(4-fluorophenyl)-1,2-benzothiazol-3-one	Homo sapiens (human)	Potency	22.3872	1
4'-epichaetoviridin A	Homo sapiens (human)	Potency	50.1187	1
montelukast sodium	Homo sapiens (human)	Potency	79.4328	1
cyclic amp, monosodium salt	Homo sapiens (human)	Potency	11.2947	2
calcium dobesilate monopotassium salt	Homo sapiens (human)	Potency	112.2020	1
acid blue 129	Homo sapiens (human)	Potency	50.1187	1
cortisol succinate, sodium salt	Homo sapiens (human)	Potency	125.8920	1
cym51010	Homo sapiens (human)	Potency	100.0000	1
N-[5-Ethyl-1-(2-morpholin-4-ylethyl)-2-oxo-3H-indol-3-yl]acetamide;hydron;chloride	Homo sapiens (human)	Potency	56.2341	1
N-[5-Bromo-1-(2-morpholin-4-ylethyl)-2-oxo-3H-indol-3-yl]acetamide;hydron;chloride	Homo sapiens (human)	Potency	22.3872	1
N-[5-Fluoro-1-(2-morpholin-4-ylethyl)-2-oxo-3H-indol-3-yl]acetamide;hydron;chloride	Homo sapiens (human)	Potency	25.1189	1
(3S)-4-oxo-3-phenyl-3-propan-2-yldiazetidine-1,2-dicarboxylic acid dimethyl ester	Homo sapiens (human)	Potency	100.0000	1
(5S)-1-heptyl-5-(2-methylpropyl)-N-phenyl-4,5-dihydroimidazol-2-amine	Homo sapiens (human)	Potency	100.0000	1
N-[[1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-3-azetidinyl]methyl]-2,6-difluorobenzenesulfonamide	Homo sapiens (human)	Potency	28.1838	1
N-[1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-3-pyrrolidinyl]-2,6-difluorobenzenesulfonamide	Homo sapiens (human)	Potency	3.1623	1
LSM-27979	Homo sapiens (human)	Potency	3.5481	1
6-(2-chlorophenyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine	Homo sapiens (human)	Potency	89.1251	1
6-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine	Homo sapiens (human)	Potency	17.7828	1
6-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-[(4-methyl-2-thiophenyl)methyl]-4-quinazolinamine	Homo sapiens (human)	Potency	44.6684	1
4-[(1-methyl-5-tetrazolyl)thio]-5-(4-phenylphenyl)thieno[2,3-d]pyrimidine	Homo sapiens (human)	Potency	112.2020	1
5-(1,3-benzodioxol-5-yl)-4-(1-methyltetrazol-5-yl)sulfanylthieno[2,3-d]pyrimidine	Homo sapiens (human)	Potency	31.6228	1
1-[[(2S,3R)-10-[[(cyclohexylamino)-oxomethyl]amino]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl]-1-methyl-3-[4-(trifluoromethyl)phenyl]urea	Homo sapiens (human)	Potency	29.6982	2
2-bromo-6-[(2,4-difluorophenyl)methyl]-4-methyl-5-thieno[3,4]pyrrolo[1,3-d]pyridazinone	Homo sapiens (human)	Potency	100.0000	1
N-[(5-bromo-8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]acetamide	Homo sapiens (human)	Potency	50.1187	1
5-[[4-(4-acetylphenyl)-1-piperazinyl]sulfonyl]-3,3-dichloro-1H-indol-2-one	Homo sapiens (human)	Potency	50.1187	1
sphaeropsidin a	Homo sapiens (human)	Potency	11.2202	1
oxytetracycline, anhydrous	Homo sapiens (human)	Potency	31.6228	1
N-(2-aminophenyl)-4-hydroxy-2-oxo-1-pentyl-3-quinolinecarboxamide	Homo sapiens (human)	Potency	50.1187	1
methacycline monohydrochloride	Homo sapiens (human)	Potency	15.8489	1
hematein	Homo sapiens (human)	Potency	10.0000	1
3-amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6-diol	Homo sapiens (human)	Potency	89.1251	1
N-tert-butyl-3-(3-tert-butyl-1-methyl-7-oxo-4H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxybenzenesulfonamide	Homo sapiens (human)	Potency	79.4328	1
lomofungin	Homo sapiens (human)	Potency	79.4328	1
pyridoxal 4-methoxybenzoyl hydrazone	Homo sapiens (human)	Potency	100.0000	1
2-(4-fluoroanilino)-6-methyl-5-(3-methylbutyl)-1H-pyrimidin-4-one	Homo sapiens (human)	Potency	8.9125	1
N-(4-acetylphenyl)-2-[(4-oxo-1H-quinazolin-2-yl)thio]butanamide	Homo sapiens (human)	Potency	39.8107	1
4-[[(4-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)thio]methyl]benzoic acid methyl ester	Homo sapiens (human)	Potency	19.9526	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cyclic amp, monosodium salt	Homo sapiens (human)	EC50	5.6200	1	1

Enables

This protein enables 4 target(s):

Target	Category	Definition
guanyl-nucleotide exchange factor activity	molecular function	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
protein domain specific binding	molecular function	Binding to a specific domain of a protein. [GOC:go_curators]
cAMP binding	molecular function	Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). [GOC:ai]

Located In

This protein is located in 7 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
microvillus	cellular component	Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. [ISBN:0815316194]
endomembrane system	cellular component	A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. [GOC:lh]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
lamellipodium	cellular component	A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. [ISBN:0815316194]
filopodium	cellular component	Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. [GOC:mah, GOC:pr, ISBN:0815316194]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Involved In

This protein is involved in 19 target(s):

Target	Category	Definition
angiogenesis	biological process	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]
adaptive immune response	biological process	An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
adenylate cyclase-activating G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
associative learning	biological process	Learning by associating a stimulus (the cause) with a particular outcome (the effect). [ISBN:0582227089]
Rap protein signal transduction	biological process	An intracellular signaling cassette in which a small monomeric GTPase of the Rap subfamily relays a signal. [GOC:mah]
regulation of actin cytoskeleton organization	biological process	Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:mah]
negative regulation of syncytium formation by plasma membrane fusion	biological process	Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. [GOC:mah]
intracellular signal transduction	biological process	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
positive regulation of GTPase activity	biological process	Any process that activates or increases the activity of a GTPase. [GOC:jl, GOC:mah]
regulation of angiogenesis	biological process	Any process that modulates the frequency, rate or extent of angiogenesis. [GOC:go_curators]
positive regulation of angiogenesis	biological process	Any process that activates or increases angiogenesis. [GOC:go_curators]
positive regulation of protein export from nucleus	biological process	Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm. [GOC:bf]
positive regulation of stress fiber assembly	biological process	Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. [GOC:ai]
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]
positive regulation of syncytium formation by plasma membrane fusion	biological process	Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. [GOC:dph]
establishment of endothelial barrier	biological process	The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. [GOC:dph]
cellular response to cAMP	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. [GOC:mah]
Ras protein signal transduction	biological process	An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal. [GOC:bf]

chemdatabank.com