Page last updated: 2024-08-07 15:23:40

Group 10 secretory phospholipase A2

A group 10 secretory phospholipase A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15496]

Synonyms

EC 3.1.1.4;
Group X secretory phospholipase A2;
GX sPLA2;
sPLA2-X;
Phosphatidylcholine 2-acylhydrolase 10

Research

Bioassay Publications (8)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (50.00)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80

Compounds (6)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
varespladibHomo sapiens (human)IC500.091888
amentoflavoneHomo sapiens (human)IC50100.000011
ochnaflavoneHomo sapiens (human)IC50100.000011
ym 26734Homo sapiens (human)IC500.900022
indoxamHomo sapiens (human)IC501.600011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
3-octylthio-1,1,1-trifluoro-2-propanoneHomo sapiens (human)XI500.000111
varespladibHomo sapiens (human)XI500.001077

Enables

This protein enables 7 target(s):

TargetCategoryDefinition
1-alkyl-2-acetylglycerophosphocholine esterase activitymolecular functionCatalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate. [EC:3.1.1.47]
phospholipase activitymolecular functionCatalysis of the hydrolysis of a glycerophospholipid. [ISBN:0198506732]
phospholipase A2 activitymolecular functionCatalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides. [RHEA:15801]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
calcium-dependent phospholipase A2 activitymolecular functionCatalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+. [EC:3.1.1.4]
phospholipid bindingmolecular functionBinding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. [ISBN:0198506732]
calcium ion bindingmolecular functionBinding to a calcium ion (Ca2+). [GOC:ai]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
acrosomal vesiclecellular componentA structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome. [ISBN:0124325653, ISBN:0198506732]
extracellular regioncellular componentThe space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
extracellular spacecellular componentThat part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
lysosomecellular componentA small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]

Involved In

This protein is involved in 32 target(s):

TargetCategoryDefinition
prostaglandin biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring. [GOC:ai]
production of molecular mediator involved in inflammatory responsebiological processThe synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]
phosphatidylserine metabolic processbiological processThe chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes. [ISBN:0198506732]
fertilizationbiological processThe union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). [GOC:tb, ISBN:0198506732]
positive regulation of macrophage derived foam cell differentiationbiological processAny process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:dph, GOC:tb]
positive regulation of lipid storagebiological processAny process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. [GOC:BHF, GOC:dph, GOC:tb]
arachidonic acid metabolic processbiological processThe chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. [ISBN:0198506732]
hair follicle morphogenesisbiological processThe process in which the anatomical structures of the hair follicle are generated and organized. [GOC:ln]
positive regulation of prostaglandin secretionbiological processAny process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell. [GOC:mah]
low-density lipoprotein particle remodelingbiological processThe acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
phosphatidylcholine catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. [GOC:jp]
intestinal stem cell homeostasisbiological processAny biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells. [GOC:nhn, PMID:22042863, PMID:22608824]
macrophage activationbiological processA change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149, PMID:14506301]
cholesterol homeostasisbiological processAny process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators]
regulation of macrophage activationbiological processAny process that modulates the frequency or rate of macrophage activation. [GOC:jl]
erythrocyte maturationbiological processA developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. [GOC:devbiol, GOC:jl]
negative regulation of DNA-binding transcription factor activitybiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:jl]
phosphatidylethanolamine metabolic processbiological processThe chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes. [GOC:curators, ISBN:0198506732]
phosphatidylcholine metabolic processbiological processThe chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. [ISBN:0198506732]
phosphatidylglycerol metabolic processbiological processThe chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes. [ISBN:0198506732]
phosphatidic acid metabolic processbiological processThe chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. [ISBN:0198506732]
arachidonic acid secretionbiological processThe controlled release of arachidonic acid from a cell or a tissue. [GOC:ai]
negative regulation of inflammatory responsebiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. [GOC:ai]
positive regulation of protein metabolic processbiological processAny process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. [GOC:ai]
defense response to virusbiological processReactions triggered in response to the presence of a virus that act to protect the cell or organism. [GOC:ai]
platelet activating factor catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of platelet activating factor, 2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine. [PMID:16371369]
positive regulation of arachidonic acid secretionbiological processAny process that increases the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue. [GOC:BHF, GOC:dph, GOC:tb]
negative regulation of cholesterol effluxbiological processAny process that decreases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. [GOC:dph, GOC:tb, GOC:yaf]
negative regulation of cytokine production involved in inflammatory responsebiological processAny process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response. [GOC:TermGenie]
cellular response to leukemia inhibitory factorbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. [PMID:12801913]
positive regulation of acrosome reactionbiological processAny process that activates or increases the frequency, rate or extent of the acrosome reaction. [GOC:obol]
phospholipid metabolic processbiological processThe chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732]