A dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HCR9]
EC 3.1.4.35;
EC 3.1.4.53;
cAMP and cGMP phosphodiesterase 11A
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| dipyridamole | Homo sapiens (human) | Ki | 0.4000 | 1 | 1 |
| rolipram | Homo sapiens (human) | IC50 | 141.6064 | 2 | 11 |
| zardaverine | Homo sapiens (human) | IC50 | 99.7820 | 1 | 10 |
| tadalafil | Homo sapiens (human) | IC50 | 49.6329 | 11 | 21 |
| 9-(2-hydroxy-3-nonyl)adenine | Homo sapiens (human) | IC50 | 16.0000 | 1 | 1 |
| cilomilast | Homo sapiens (human) | IC50 | 50.2760 | 1 | 11 |
| rp 73401 | Homo sapiens (human) | IC50 | 36.7900 | 1 | 10 |
| roflumilast | Homo sapiens (human) | IC50 | 124.2002 | 1 | 10 |
| sch 351591 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| pf 04217903 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| sildenafil | Homo sapiens (human) | IC50 | 23.9848 | 8 | 17 |
| zaprinast | Homo sapiens (human) | Ki | 12.0000 | 1 | 1 |
| vardenafil | Homo sapiens (human) | IC50 | 6.0059 | 3 | 12 |
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| cyclic-nucleotide phosphodiesterase activity | molecular function | Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. [GOC:mah] |
| 3',5'-cyclic-nucleotide phosphodiesterase activity | molecular function | Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate. [RHEA:14653] |
| cGMP-stimulated cyclic-nucleotide phosphodiesterase activity | molecular function | Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP. [GOC:mah] |
| cGMP binding | molecular function | Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). [GOC:ai] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| 3',5'-cyclic-GMP phosphodiesterase activity | molecular function | Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+. [RHEA:16957] |
| 3',5'-cyclic-AMP phosphodiesterase activity | molecular function | Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+. [GOC:ai, RHEA:25277] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cellular_component | cellular component | A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex). [GOC:pdt] |
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| signal transduction | biological process | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11] |
| negative regulation of cGMP-mediated signaling | biological process | Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. [GOC:BHF, GOC:dph, GOC:tb] |
| negative regulation of cAMP-mediated signaling | biological process | Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling. [GOC:jl] |
| cAMP-mediated signaling | biological process | An intracellular signaling cassette that starts with production of cyclic AMP (cAMP), and ends with activation of downstream effectors that further transmit the signal within the cell. [GOC:signaling] |