Proteins > Guanylate cyclase soluble subunit beta-2
Page last updated: 2024-08-07 12:45:44
Guanylate cyclase soluble subunit beta-2
A guanylate cyclase soluble subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75343]
Synonyms
GCS-beta-2;
EC 4.6.1.2
Research
Bioassay Publications (3)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| benzydamine | Homo sapiens (human) | EC50 | 1.0200 | 1 | 1 |
Drugs with Other Measurements
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| GTP binding | molecular function | Binding to GTP, guanosine triphosphate. [GOC:ai] |
| heme binding | molecular function | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| guanylate cyclase activity | molecular function | Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. [EC:4.6.1.2] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|
| guanylate cyclase complex, soluble | cellular component | Complex that possesses guanylate cyclase activity and is not bound to a membrane. [GOC:mah] |
Involved In
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|
| cGMP biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate. [ISBN:0198506732] |
| response to oxygen levels | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. [GOC:BHF, GOC:mah] |
| cGMP-mediated signaling | biological process | An intracellular signaling cassette that starts with production of cyclic GMP (cGMP), and ends with activation of downstream effectors that further transmit the signal within the cell. [GOC:signaling] |